🧵 View Thread
🧵 Thread (241 tweets)
Are you sure about that?I ate dog shit in a pill for for a month and I gained 60lbs worth of grip strength and all my age related proteins expressions (mTOR, IGF-1 AMPK, Sirtins) changed and I have a blood test to prove it.I don't exersize. https://t.co/mMXPtRVqBE
Skeletal muscle mass in dogs is thru the woof.https://t.co/1uYi4ukFUQ
Do you even mediate Sarcopenia via gut microbiota manipulation of lipid function to fight age related muscle decline?https://t.co/k5NdO25wro
Ain't nobody got time for that.https://t.co/Qv9ejOnCIF
N-of-1. Don't actually eat dog shit. it could kill you."More work is needed to understand how sustained changes to the microbiome occur, resulting in differences that have been reported in cross sectional studies of athletes and non-athletes."https://t.co/21BQbsV2rn
I love peter. Learning how he's obsession with exercise has helped me understand where all the medical doctors are overlooking the complex regulatory factors associated with lipid function in western society.I don't like shaming fat people though.https://t.co/B76wtlW6GE
My mom has a fibromyalgia diagnosis. Doctors just keep telling her to exercise and assume she hasn't tried that. She would exercise and then be fucking bed-ridden for weeks.https://t.co/alUfbgxQQB
"the gut microbiota may play a role in fibromyalgia within the emerging field of the gut-musculoskeletal axis. Further investigations into the relationship between the gut microbiota, gut dysfunction and fibromyalgia are warranted." [11 March 2020]https://t.co/WmNgfiCnMa
Only thing that helped her was cannabis. Surprise surprise, cannabis interacts with an immune system regulation factor that directly acts on... mTOR!My family has skin problems and trouble making anandamide.https://t.co/e31EkWkusS
"In human skeletal muscle, an anabolic stimulus in the form of RE down-regulated CB1 expression. The negative change in CB1 expression was associated with increased phosphorylation of mTOR signaling proteins."https://t.co/zfFadcAbNW#eatshit
Gosh, I sure do wonder what hapepns if your body can't digest / convert cholesterol over to vitamin D."Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain"https://t.co/oVrNR6HRoN
Lipids, mother fucker, do you digest them?https://t.co/fgUyEziEoq
@microRNAnoob Some people get shits from eggs, I think this can be fix by bacteria by farnesoid-X-receptor (FXR) paired with the vitamin D receptor (VDR). see it's role in bile https://t.co/2h7r3JGXXVGlutathione helps kidney function in turn promotes sun induced vitamin D bioavialiblity.
Telling a fat person w/ diabetic dyslipidemia that they just need to exercise more without helping them fix their gut so they can actually make anti-inflammatory endocannabinoids? In my mind this is a form of sadistic torture perpetuated by doctors who don't know shit about fuck.
After years of suffering, including going on and off drugs for side effects (and symptoms that were probably just M.s.). One doctor finally suggested the very drug that would help my mom not be bed-ridden. She'd be forced to go homeless if she used it.https://t.co/3gpbWddoM8
My "May you have dog shit energy" T-shirt has people asking a lot of questions already answered by my shirt.https://t.co/I1beM7GBde
How do I get healthier without exercise?https://t.co/pxngVsjEmy
"Its not like how much can squat and dead lift... It's like grips strength, dead hang... how long can you do like an air squat. [...] How quickly you can do five reps up and down from a chair... I mean it's really simple stuff."https://t.co/yhmKn8aTul
I need to beat the world record for grip strength by about double if I wanna live up to my chosen name.https://t.co/Nez8b2I8PI
A chimpanzee is estimated to be 1,250 to 2,000 lbs bench and 441 lbs grip strength. (according to unsourced zooologist[dot]com: https://t.co/4Vc27FHMIM ). Seems a big factor is their tendons are stronger.Gorillas can apparently crush crocodiles. https://t.co/3HupFDasqI
Gonna look into how to measure a proper dead hang. Looks like something who calls himself UltimApe should be really good at.I need to check if I still have a fear of heights. https://t.co/pyXWcf6LDr
I need to beat 3 minutes 10 seconds to out do Attia according to the embedded Instagram post here. https://t.co/xOqEdGaLk0
I visited my dad a while back and he had like 150lbs on the meter I'm using. I'll be happy to get that strong.I only need another 25lbs to get on the top 300 list of baseball players. https://t.co/Jimf6oz9uJ
According to this, a vascular reactivity test may be a good marker for cardiovascular disease risk.https://t.co/StT6ol0fYOI can just build something and take measurements periodically.https://t.co/qvdCrunZVe
"The research was observational and doesn't reveal cause and effect. The study didn't look at any possible biological mechanisms that might explain the link between poor balance and longevity."https://t.co/yj0Vsoj50z
Poor balance and is tied to impaired longevity you say?So what does it mean that I went from being unable to stand to being able to balance on my tip toes?https://t.co/hkL6u61ymr
"we summarize the implications of gut microbiota in [neurodegeneration], which will be beneficial for understanding the etiology and progression of [neurodegeneration] that may in turn help in developing [neurodegeneration] interventions" [Feb 14, 2022] <3https://t.co/XSl18eEmod
Tell me please, what happens if you fix your gut so your body naturally regulates all the interesting chemicals like butyrate, various endocannabinoids, gaba, glutamate and other things essential for bile function / nutrient absorption? https://t.co/GNG4A9pPwb
“microbes collected from an old mouse […] capacity to support neural growth in a younger mouse, […] surprising and very interesting observation, especially since we can mimic the neuro-stimulatory effect by using butyrate alone.” https://t.co/eVenjJ1L0qhttps://t.co/UbwPRiTNWv
People are going to be trying to teach themselves to balance more because they hear it improves their health.You need to fix your body's ability to repair nerves and blood flow in the brain if you want to get real gains.https://t.co/fdDDct0Tud
I got stronger after my experiment with keto + fasting in 2018. I wanted to know why.https://t.co/cqUmcb8XnB
I'm trying to convert fat into muscle by using diet to tweak signals my body uses to induce muscle destruction to counter aspects of autism. https://t.co/hLsxrXTMYPI'm slowly becoming an Übermensch, growing muscle via diet alone.https://t.co/vYU8cZyn9Qhttps://t.co/fTIEG1y0Kn
I love reading these studies and realizing that I figured out how to gain muscle and lose body fat and shift my metabolic set point by tweaking gut bacteria.https://t.co/37ENI09qtx
Remember, I am insane.https://t.co/nhd9ZZjNwW
@sly_clank @Oo_O_o00o_O_oO @0xa59a2d @Cernovich @zooko For my next magic trick, I'm going to be eating dog shit to show that mTOR related muscle gain in dogs is partly driven by gut bacteria.I even found a parasite free source of canine feces. Working toward a stable environment to do a proper test.https://t.co/uM9gPovp2z
Have you tried shifting your metabolic set point?https://t.co/NeLeOrvfkX
How do you manipulate your body heat anyway?https://t.co/wDDBGmyQiY
"Results from our study indicate that the reduced food intake and anti-obesity effect of CAP had been observed regardless of TRPV1 channel activation, and which is mediated by changes in the gut microbiota populations and SCFAs concentrations." (in mice)https://t.co/xi3PKaAxP2
You mean, you can just run colder by shutting down TRPM8?https://t.co/5aJYHpIUG4
This is all horseshit.https://t.co/FB6IbCSelf
Must be muh autism.https://t.co/DNWhk5rlLa
Fun fact: the TRPM8 receptor that is responsible for sensing cold AND pressure, known to release oxytocin, is heavily influenced by β-estradiol. Might be tied to autism symptoms..https://t.co/J2wluQhFZR https://t.co/e2pSkSxiREmay explain this phenomena: https://t.co/8s58S2h7VV
Did I mention I got younger by eating the dog shit?https://t.co/CrTiNxQgjT
I lost weight and gained muscle by exercising less and eating more.https://t.co/ESyGjROocE
Tired: obesity is a risk factor for heart diseaseWired: obesity is a risk factor for gut dysbiosis leading to microbiome induced inflammation that impacts heartInspired: Do bears get heart attacks?Hired: How can we get humans to hibernate?Desired: https://t.co/NJlwfmXpiW
Hot take: Carbohydrate insulin models AND Energy Balance models are wrong about obesity.https://t.co/mf1uO1Jb13
I have no idea what I'm doing.https://t.co/g0tsERlBnD https://t.co/xZhVOpM1Vf
@Bajuwandres @balajis It's amazing how much gut bacteria and inflammation factor into testosterone.We are only now doing serious explorations of this in people. Here's a study on Type II Diabetes from March https://t.co/MZPxWKkBAd for example.FMT is lindy.https://t.co/o53a7ypBm0
How I imagine people reading my tweets are responding. https://t.co/QWq8b56dl0
While everyone is messing around with gene editing bullshit, I'm over here just arbitrarily upregulating my muscle growth by tweaking my gut bacteria.https://t.co/ziGCii4Hnjhttps://t.co/Bf4jhH0AYi
The jokes write themselves.https://t.co/QFq7tiUMxc
Do you ever have a paranoia that some government agency will frame you for being a conspirator, throw you in jail, threaten your entire family's lives, and then force you to work on super soldier programs as part of the war effort?I stan Léon Theremin.https://t.co/TTaeoAIpLw
I have walked where I crawled.My next shitpost miracle will be to hibernate. I estimate 5 years.Then I will perform stigmata.https://t.co/Eo3K8JCouD
@lovecryption Oh, they blocked me. I thought they were being playful. :(I was going to ask them if they would accept healing from stigmata wounds as proof of miracle. I'm working on healing bone breaks, and made progress recently because of a tip from @The_Lagrangian https://t.co/bkxWTfArJK
Imagine working out or getting gene editing serum when you could just impact the metabolic pathways that myostatin inhibits by changing your gut bacteria.https://t.co/jpy3u2c9Ir
I honestly believe our obsession with gene editing is going to kill us all.https://t.co/rlW3Cd9BCK
I only hope I am fast enough.https://t.co/ecgI05ivjd
Oh cool, we finally have some evidence in humans that DNA methylation changes associated with exercise are inheritable to their offspring.https://t.co/wVdhqHzZxu
"Our study provides the first evidence showing exercise training reprograms the sperm methylome. Whether these DNA methylation changes are inherited to future generations warrants attention."https://t.co/0GHQlPjgemhttps://t.co/xQEoOqtBFP
We see this in mice."Hence, the evidence suggests that exercise‐induced epigenetic changes can be observed in offspring and may play a pivotal role among the multifactorial intergenerational‐health impact of exercise."https://t.co/2Vkwm5IkEU
If I'm right that my FMT has impacted DNA repair and methylation shifts that are acting via mitochondria... Then we should expect to see that FMT impacts epigenetic changes in mice sperm that operate similarly as the exercise ones.
@sabbatical Yep.I managed to get 122.8 (right hand) just now to test it.This is within the first hour or two of me waking up which would be plagued by spasticity otherwise. https://t.co/u3C2jHD3xr
@sabbatical I have an operating hypothesis that many of the 'placebo' things are about oxytocin related trust behaviors reducing inflammation by way of brain-immune pathways that we are only just now uncovering.Lots of stuff we call 'placebo' seems to be mediated by something modifiable.
@sabbatical It gets mixed into other things tho. There's an entire sub-controversy about this among autism research that is fascinating. Care providers themselves end up falling for placebo when an autistic child is medicated. https://t.co/h8HHYMNiHt
Diet + Fasting to treat mitochondrial function helped my grip go from 40lbs to 60lbs. FMT to compensate for years of gut problems associated with Crohn's and M.S. let me go from 60lbs to 120lbs.https://t.co/cqUmcbqyf9
I'm trying to convert fat into muscle by using diet to tweak signals my body uses to induce muscle destruction to counter aspects of autism. https://t.co/hLsxrXTMYPI'm slowly becoming an Übermensch, growing muscle via diet alone.https://t.co/vYU8cZyn9Qhttps://t.co/fTIEG1y0Kn
What should I do next?https://t.co/FTKkZvxBjt
I think I shall try IFhttps://t.co/DUwrGKEHSS
Solve your autism with this one weird trick.Doctors hate him!https://t.co/hsJ9ythxj9
Imagining a blind scientist arguing with another blind scientist.Snake Camp: if I'm right it is a snake, we should expect scales!Tree Camp: Oh no, there are scales on this tree???Snake Camp: This is further proof I am right that this is a snake.
Meanwhile, the "elephant" giggles after it takes a dump and another scientist come along and decides that they are looking at dead trees cuz of the rotting folliage.This also spawns another blind scientist who thinks they are looking at an ant colony.
Jokes on you, the elephant is actually a maned wolf with mange, so it has scales on it's legs. The snake was it's cock, and there was actually an ant hill!https://t.co/KQBlBHuYZy
I wonder if anyone digs up ant hills and uses their frass / refuse piles to make strange fermented foods.Also, apparently stressed out maned wolf poop is full of Glucocorticoids and Thyroid hormones. Might change the quality of their resulting wines.https://t.co/UB15FBZbmi
The blind scientists and the maned wolf, and other jokes about getting high on ideas.https://t.co/4zVoat0K95
Do you think if I eat de-parasitized maned wolf puppy poop in a pill for a month that I'll become taller? https://t.co/OqumZlELtr
Everybody is talking about insulin resistance and exercise.I'm over here telling them to eat shit.https://t.co/jiVdCX3sdV
This is neat. Could the reason why vigorous exercise was messing me up before be due to poor butyrate production in my gut => inflammation?This is a major chemical I focused on to helped treat my crohn's disease (before the FMT).https://t.co/Sq35Z1UZedhttps://t.co/ulMYAfUYm5
"Based on the studies summarized in this article, exercise training can increase the biodiversity of beneficial microbial species, [...] these factors together possibly reduce telomeric shortening." [JUN 2022] https://t.co/3tZC3wQqmthttps://t.co/je5XpWlUn4
"Namely, frailty was associated with reduced microbiota biodiversity, and lower representation of butyrate-producing bacteria. [...] link between microbiota and physical fitness is still uncertain [...] However" [2019]https://t.co/sApY1iaCj5
"The majority [...] distinct families within the Firmicutes, but members of nine other phyla, especially from Actinobacteria, Bacteroidetes, Fusobacteria, Proteobacteria, Spirochaetes, and Thermotogae, were also identified as potential butyrate producers"https://t.co/bA0uuCxTDl https://t.co/QpSwI2nkt0
Have you tried studying the ant?https://t.co/q4gaR45tvM
"Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention" [Nov 2019] https://t.co/6P9f2z66Wohttps://t.co/u3mlxVLiPT
I made a joke a while back about getting access to Tom Brady's shit. But I wasn't joking. His work to get healthier despite R.A. Symptoms may mean his gut bacteria holds a cure. The Spice must flow! https://t.co/Aa2H7hP0oh
I want an FMT from The Rock. https://t.co/N8zXCKB6d0https://t.co/JguMAPBJB5
I took another Viome sample because.... I started another round of 30 dog pills to deal with some stresses I had over the holidays.https://t.co/F6PVzwnlE1
I took another Viome test on January 7th. Compared to my first one it's huge!It seems after a year I now have so much microbe diversity that it is 100% compared to low and average before.Similar for my "Biofilm, Chemotaxis, and Virulence Pathways" improved. https://t.co/VLT4ks4HVD
I was down to 103 the day I started. I had been 90s during Christmas when the stress was it's worst and some of my GI symptoms were returning. https://t.co/Cbz842E2pS
I have now reached higher than I've ever been able to get. My grip strength is just shy of 130 lbs in my right hand. https://t.co/vqRzwvtxKc
Mice who get and recover from a bacterial gut infection end up gaining weight due to a shift in carbohydrate metabolism related factors unrelated to food intake.https://t.co/eLZVY7h7CY
But sure... masturbate about how weight gain is because of not getting exercise to treat obesity.Weird stuff like this may explain why even after some people lose weight they struggle to keep it off. https://t.co/DMcmDii4T4
"The real strength of this study was in the 8 to 10 years of observation, in which lower grip strength predicted faster biological aging measured up to a decade later"https://t.co/w43OKNRNda(h/t @AlexJournal2019)https://t.co/czSjJSwmUD
"N-Now th-that that don't kill meCan only make me strongerI need you to hurry up now'Cause I can't wait much longerI know I got to be right now'Cause I can't get much wronger" 🎶https://t.co/OhFrAJlbrq
Grip strength in right hand 129 lbs from the day I took my last pill.(+bonus pupper) https://t.co/PQM3tXotG8
I need to get stronger.https://t.co/G2W17vk2PE
This chemical impacts mTOR and SIRT pathways related to brain aging, cancer, and muscle development. It's fascinating.https://t.co/ZoCNzbeNMn
Bruh, your back pain is because you don't lift?Well, my sides hurt from laughing.🤣https://t.co/ZjI4kvBAxR
I think it's exactly backwards. I just picked up @PeterAttiaMD's new book on sale for the intention of understanding why fixates on exercises like that. https://t.co/TRvsJjJsX1
Goodhart's law.https://t.co/UFJBcMq5ZD https://t.co/5VzHKBYAPm
Also, has anyone measured calories burned by the immune system doing their repair processes? Things like autophagy and cellular regeneration probably account for more calories than just the exercise alone. https://t.co/RMCIzOkKVz
One of the neat things about bears and their hibernation? They can heal wounds during that state. The immune system is "shutdown" in some sense, but I bet it's because they are acting in repair mode and its part of why we see them maintaining some warmth. https://t.co/EgXtXZJOro
My thinking about this is the reason why I was unable to gain muscle wasn't the lack of exercise ( if anything exercise made me weaker), but poor immune function / metabolic function leading to cheap emergency patch jobs.Fixing my lipid function via the FMT reversed this.
Metabolic set point? Bah.Resting Energy Expenditure? Hah.Listening to some crazed autistic fuck on the internet rant about sonic hedgehog causing his autism and how he's mitigated it by eating dog shit to hit mTOR and in the process changed his R.E.E.? Ayy LMAO
These aren't my readings. They were taken on the 7th and 26th.Replication. Get.And we're not even done yet.https://t.co/jlBeP0T7a1 https://t.co/JIWZFgycHl
Until I did my FMT, I had this phenomena going on. https://t.co/gBSOF8DpTN
I had some results in the past doing a fasting regmine and eating better. That let me go from 40lb to 60lbs grip. But it was fragile and I easily got into PEM states.https://t.co/stFCJGjMDM
I made a joke about this before I did my FMT.https://t.co/B76wtlW6GE
Telling me to exercise and lift weights when it would just make me sicker, it was maddening.But I was encouraged to keep going on my path. https://t.co/6yBU02KJ4I
We haven't even begun to touch the edge of truth.https://t.co/FX83FhqoNx
If you want your gut to eat lactate for you, you kinda need to know how to convert it between different forms.https://t.co/GBn8hhJX3D
Interesting rabbit hole I now need to dig down: to find out if the strains in my kefir brand end up producing an excess of Lactate racemase and end up transforming D-lactate, or if my avoiding sugar is simply sidestepping the fermentation entirely. https://t.co/vo6FNDWtMX
Getting the body in a state that helps it metabolize lactate is hard.https://t.co/ujzKz4QGKU
One of the things that shows up again and again in autistic types is poor grip strength.https://t.co/K0bmsdJXIN
"lactate [...] is a potent endogenous inhibitor of TRPV1."https://t.co/KChw644cWE"High lactate levels [...] one in five children with ASD may indicate involvement of the mitochondria in energy metabolism and brain development. "https://t.co/vfrEVSbbeIhttps://t.co/Qv3xQNeUBA
I pretended autism was an age related disease driven by mitochondria dysfunction. And then found the levers in my gut that I needed to push to reverse it. https://t.co/QRXXS1n0aG
@PaulWhiteleyPhD It's all the same thing."Studies suggest that oxidative stress-induced mechanisms and reduced antioxidant defense, mitochondrial dysfunction, and impaired energy metabolism (NAD+, NADH, ATP, pyruvate, and lactate), are major causes of ASD." https://t.co/JqTxYdM4SF
So I set out to recreate rapamycin's effects with gut bacteria. https://t.co/gXNX2sVSW0
Suddenly, I am younger, and stronger. Imagine that.https://t.co/XvBc1egopD
@37point78 The chart in the lower right is particularly interesting.The link to this with mTOR is"TRPV1 caused an increase in intracellular calcium concentrations ([Ca2+]i) and that this activated mammalian target of rapamycin (mTOR) and promoted muscle hypertrophy" https://t.co/iX4tLDcwr8
I kept going. https://t.co/2xlK9wpP8H
@RapaNews @tszzl I set out to recreate rapid healing and no pain phenomena of that women with the weird FAAH enzyme expression. I wanted wolverine healing factors.mTOR is just one factor in optimizing lipid homeostasis to fuel T & B cell function and their roll in healthy cellular pruning.
You all focused on some studies on rapamycin that shows a measly 30% gain in longevity in mice.You're like a little baby.https://t.co/azMenq9Qaq https://t.co/tFfV47WyjW
I need a lactate measuring device that can find out how much of the lactate I excrete into my intestines is being metabolized by my gut bacteria.https://t.co/G9ad9EyaBx
"The even broader distribution of the nickel-based maturation system suggests a function beyond activation of the lactate racemase and possibly linked with other undiscovered nickel-dependent enzymes." [2014] https://t.co/7EUPQyZanQ
"Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells" [2009]https://t.co/ojwWgX8RqRStopped my lung from burning by improving cystine function ala SAC (garlic NAC analog).Dog is left in the dust now.https://t.co/vpi39IHUXf https://t.co/A5zbjKCdmX
These things are all connected.https://t.co/I194VjeQOf
Working on metal chelation not because I want to eat mercury and lead, but because understanding HOW I could hypothetically eat mercury and lead actually improves an entire metabolic subsystem tied to longevity & aging.https://t.co/EuDVC2sTVr
What, you don't use your gut bacteria to regulate allergies to nickel so that you can improve metal chelation factors tied to producing an enzyme associated lactate digestion?https://t.co/Klulnrn4O1
Did you know nickel allergies were tied to being overweight, and may be due to gut bacteria? We have studies on this that never left biorxiv. No one wants to know why we see these phenomena? https://t.co/8U3aRUdGth
I'm sure its just that these women don't exercise enough! /s https://t.co/IuQYaBA8sT
... AND of course it's T cells. And somethign we haven't had the ability to see in the past.https://t.co/sNfGHa3oaF https://t.co/F5noVGyiPH
Dog shit fixed my allergies too, btw. "But there is scientific evidence that this disease is not a fabrication of a patient’s mind. We clearly see a difference in the way healthy and chronic fatigue syndrome immune cells process stress."https://t.co/TDXffK2aXy
"these applications, though theoretically possible, are a long way from delivery, and a lot of additional work is needed to translate this naturally evolved mechanism safely and effectively to humans"https://t.co/sunq80Jv2pUrea recycling, in my anus?https://t.co/ESyGjROocE
Tired: obesity is a risk factor for heart diseaseWired: obesity is a risk factor for gut dysbiosis leading to microbiome induced inflammation that impacts heartInspired: Do bears get heart attacks?Hired: How can we get humans to hibernate?Desired: https://t.co/NJlwfmXpiW
Working on crowdfunding stuff today. I wanna be able to tame some squirrels and eat their poop to see if I can get swole.https://t.co/vUJnHbDIVS
My GF's endocrinologist looked at her blood work, seeing fixed Testoterone, fixed hba1c, fixed TSH, and improved vitamin D.... And just assumed it was from exercising & losing weight.She's exercised less and weight loss occurred AFTER her PCOS fixed.https://t.co/HpMRJN2rxO
GF no longer has PCOSGF no longer has Type II diabetesGF no longer has chronic pain and inflammation that impairs her movement.She's getting strongerShe's starting to get feeling back in her fingers and heal her dry cracked skin.Fix. your. gut.https://t.co/kiTZceIMRF