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William Lagakos@caloriesproper2• 10 months ago

Circadian gene Bmal1 KO mice have a significantly reduced lifespan. Restoring it only in skeletal muscle drastically improves survival https://t.co/inupEug4Xx

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UltimApe@ultimape• 10 months ago
Replying to @caloriesproper2

@caloriesproper2 This is one of the reasons why I think fixing my gut health has improved my skeletal muscle so much. https://t.co/h0EloXF4ve

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UltimApe@ultimape• over 1 year ago

@Hair_Artiste If you don't like mice studies, do you like organoids? Someone was able to show that the SCFAs impact BMAL1 & PER2 gene expression due via inhibiting histone deacetylase. https://t.co/gjdupZR3ba

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

@caloriesproper2 Elite athletes are able to metabolize lactate back into butyrate thru gut health factors. As butyrate is acting to modulate BMAL1 it's partly responsible for why having a healthy gut is tied to longevity. https://t.co/WmBWqcfNwc

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UltimApe@ultimape• about 1 year ago

@Mangan150 You can get more gains if you focus on recovery and gut health tied to lactate recycling. If you get the fully chain of metabolite conversion from lactate to butyrate, it even helps regrow the muscles faster. It promotes natural HMB, BHB, etc.https://t.co/RVV2h9UjVr

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

@caloriesproper2 I have been acting on this not thru exercise, but by fermented foods that add lactate into the body, and timing my intake with IGF-1 rhythms. https://t.co/1iFi5dST5t

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UltimApe@ultimape• about 1 year ago

@Grimhood I reverse engineered how to grow my muscles back in 2019, I just couldn't explain it. I figured out why my fast and gut shift from 2018 made my grip increase.Lots of funny words in this tweet. Also that link is to a literal music video on flexing.https://t.co/6sNE0C8EEH

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

@caloriesproper2 There's huge levers that can be pushed here, and its why circadian rhythms matter, but these rhythms are often entrained in us by gut bacteria, so light isn't the only thing we need to keep them working.https://t.co/Rg0i1kjtKa

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UltimApe@ultimape• over 1 year ago

@BlueLightDiet If we were to translate this to humans, it'd likely be thru altered gut indirectly impacting BMAL1 transcription ala hydrogen peroxide levels in the intestinal mucus fluxing with diet's impact on SCFAs. https://t.co/QnkyGP51m7

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