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🧵 Thread (194 tweets)
They literally canceled a test on if butyrate (butter/ghee/gut bacteria fermentation byproduct) improves schizophrenia...Because you can't double blind it.ARE YOU FUCKING KIDING ME?https://t.co/3hN0zhipYV https://t.co/7sMDQjPcwX
"The existing evidence for dysbiosis as a factor in the pathogenesis of schizophrenia is underwhelming."https://t.co/4RtE8FzewY https://t.co/rJW9yssKns
risperidone literally increases the levels of butyrate..."Increased serum levels of butyric acid might be associated with a favorable treatment response in drug-naïve, first episode schizophrenia. The clinical implications of our findings were discussed"https://t.co/6cxpdm6FcH
I see no science here.https://t.co/9N2AwQDDfE
Did you know that cannabis often upregulates Akkermansia Muciniphila? It's called that beause it likes mucus. Butyrate upregulates mucus.Its a common self-medication used by schizophrenics.https://t.co/cotNOk1Bjz
"with either risperidone or olanzapine had altered levels of Lachnospiraceae, Akkermansia, and Sutterella compared to controls [135]. A systematic review highlighted the limited evidence [...] More research will be needed" [2020] https://t.co/i08BgSAoDJ https://t.co/rvyjXEjeqJ
The suffering will continue until the microbiome improves somewhat.And yet you destroy your microbiome?! I am very intelligent.https://t.co/RpnvrIsqtd
Screaming out my ass here.https://t.co/Ly2NxkL601
My ass here..."Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production"https://t.co/iNB73d5bGhhttps://t.co/sUXKAabQtm
"suggest that SCFAs play an essential role in supporting β-cell metabolism and promoting survival under stressful conditions. [...] novel mechanism by which enhanced dietary fiber intake contributes to the reduction of Western diseases such as diabetes." https://t.co/2gk3KqDjPs
What's a β-cell, precious? What is a β-cell eh?Why would I know about this? what do you mean diabetes (/gut dysbiosis) is a risk factor for autism and schizophrenia?https://t.co/kiTZceIMRF
What if I told you that all of this research is promulgated on a hypothesis that I can cure my girlfriend's type 2 diabetes thru diet by using various terpenes to bias her microbiome... and all this about dicks is proxy research to hormone-microbe ties.https://t.co/zZ9obc2BGY
Kill me now. The ride never ends.https://t.co/WPlYtkJOih
"Stop the world! I wanna get off!I can't take this bullsh*t!It stinks so bad, it's making me coughThis place is a f**king hell!I'm so tired of the bullsh*t smellMess with me, I'm bound to get toughStop the world, I wanna get off!" 🎶https://t.co/VqvDfU6Mc1
Everything smells bad.https://t.co/ZXqVbhgozU
"Understanding the effect the menstrual cycle can have on psychiatric illness, such as premenstrual exacerbations, is important for the holistic care of women with schizophrenia."https://t.co/67pmiLCbFhhttps://t.co/OedbzvSthy
@Vorvayne Pelligaci goes to the doctor with GF, doctor says low iron is from menses. Pelligaci starts crying. Doctor asks why.Pelligaci says "she's already on prescription iron pills".(how I learned kidney dysfunction leads to vitamin C/D problems & can cause iron absorption issues)
*breaths in calmness* https://t.co/vXrRIQvwrX
I am interested in this bacteria.https://t.co/bXqrw2ARQg
I keep having dreams about it.https://t.co/NlXM47EiCz
It is a very fascinating bacteria.https://t.co/yBOggQCH45
Someone on /r/microbiome/ asked about use of cannabis as it relates to fungal infection. I couldn't answer directly, but did end up summarizing the role of fungus as it relates to Multiple Sclerosis and IBS/Crohn's & possible mechanisms of action.https://t.co/8iaQ4nZrtS
"A. muciniphila has been reported to convert dietary fiber into acetate, propionate, and butyrate; these metabolites can have effects on glucose and lipid homeostasis"https://t.co/2BI8USErFG
"The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option" [2017]citation 5 is on Akkermansia Muciniphilait also mentions other fun neurological disorder.https://t.co/5LjFAAL4ND https://t.co/rpo7a8zb4Z
I am excited to learn more about my poop soon.https://t.co/2didootFV3
"alteration of microbiota composition and warrants additional prospective cohort studies to evaluate the association of bacterial changes with ASD symptoms, which would provide further evidence for the precise microbiological treatment of ASD." https://t.co/OFcHpF0pwA https://t.co/rnCivu2kYM
Gaba seems to help here. So presumably Taurine would too.https://t.co/AnYxW0sRrc
Gene expression changes from that bacteria would be cool to see. https://t.co/x8ehTIGoku
Butyric acid smells like rancid butter.https://t.co/m73VLErbuu
"These bacteria produce carbon dioxide and a number of compounds that account for the unique odour: pungent (propionic acid), rotten-egg (hydrogen sulfide), rancid-butter (butyric acid), and vinegary (acetic acid)"https://t.co/kdvacJllKUSounds Delicioushttps://t.co/VGq4IiWZjH
Sure wish there was an explanation for why a mucus promoting bacterial metabolite could impact this space /s"Butyrate is the smallest anticancer agent and is a known HDAC inhibitor with histone acetylation properties" https://t.co/xLsOTy7ZJshttps://t.co/yb1IMimPGP
$1.78 million dollar grant to do a medical trial where they give schizophrenia people 'Prebiotin™' and then see if the levels of butyrate in their blood increase. https://t.co/1t0NVcm2cF
Prebiotin™ is a Chicory Root Derived Oligofructose Enriched Inulin. You can buy 30 day supply from amazon for $25.99I am not a doctor, but I don't think it should take $1.78 million to ask schizophrenic people to take prebiotics & report their results.https://t.co/1myj2khIv1
What do you mean pathways associated FGF2 and FGF17 seems to impact schizophrenia within GWAS, and are somehow manipulatable via a prebiotic fiber that might upregulate butyrate. https://t.co/WzMXyeJXdpSure seems weird.https://t.co/oPNJUKTvlf https://t.co/KkUw2CmKY7
Brb, looking up if I can schizophrenia with bananas.https://t.co/4PJ9TZjVkp
"For example, bananas contain resistant starch and inulin-type fructans, while apples are a source of pectin. Thus, diets rich in plant-based foods provide many different types of dietary fibers thereby supporting a more diverse microbiota composition."https://t.co/xEjusZgkUl
I think this paper is saying that a pharmaceutical (tributyrin) that gets metabolized into butyrate is able to regulate the epigenetic landscape and alter factors associated with cancer and brain development.https://t.co/SlM4CidxDO
"Due to the difficulties of using butyrate in practice (i.e., offensive odor and absorption in the upper gut), different forms of butyrate, [...] have been developed and examined"https://t.co/IoZVRbowtC
In another thread, @OhMalG found a patent (BE1024170B1) on a choline+butyrate salt that might help.Choline itself can help treat schiz, but doing a bunch of comparative studies with blinding might be more viable with salt forms of butyrate.https://t.co/gP3HrsdkzK
Should be able to also find equivalent food safe forms of propionate and acetate salts so we can get the major trifecta of bacterially derived SCFAs to explore their impact.Measuring levels in blood to verify efficacy is related to absorption would be the most challenging part.
Mass Spectrometry fees to measure SCFAs should be fairly cheap. I can't see how it would cost > million dollars to get a lab to do this. https://t.co/FMjlgJ5W4N
I suppose it would depend on where you get it done, but This doesn't look more than $500 per sample, tops https://t.co/YN47GhvdlN
One day I hope to have a Mass Spectrometry machine of my own to test this kind of stuff.But an interesting way to get around the need for that is to use some kind of odor detection device mirrored after how smell works in the nose. Lots of promise here.https://t.co/tynYqdAOdz
I want to be able to bless things one day.https://t.co/uzmJmz95AR
Someone found a blessed doggo tweet.https://t.co/KjRg5ARdth
I should follow up on this old idea on butyrate from honey.https://t.co/k2Br4UonlM
DNA damage and repair.https://t.co/oBzquRfeic
@johnhemming4mp @statto I heavily suspect that butyrate's ability to act like a powerful HDAC inhibitor may be the underlying reason for my eye damage recovery.If red light can also heal the eyes, I would expect results toward DNA repair via similar mechanisms. https://t.co/V8ZMmmfggd
You may be able to an entire schizophrenia with bananas? "Radiation-Induced Neuropsychiatric Manifestations in a Patient with Brain Metastasis: A Diagnostic and Therapeutic Challenges for Consultation-Liaison Psychiatrist" [2018] https://t.co/CMPwSl1vCghttps://t.co/twEld27bwY
"[🍌] emit .01 millirem (0.1 microsieverts) of radiation. This is a very small amount [...] you would need to eat about 100 bananas to receive the same amount of radiation exposure [per day in the U.S.] from natural radiation in the environment." https://t.co/OYOam4hHxR
Going bananas right now actually."Implementation of a study on schizophrenia spectrum disorders in Chernobyl accident victims is of significance for both clinical medicine and neuroscience." [2005]https://t.co/TS3OOKG9hd
B A N A N A S"However, recent findings indicate that the patients are characterised by impaired DNA repair pathways, which may suggest that these DNA lesions could be also a result of their insufficient repair." [2019] https://t.co/6WNEdSmw20
You see, schizophrenics have poor wound healing because of their 'life style choices'. And it has nothing to do with their impaired gut microbiome not making enough of SCFAs. Nope. They just bad choices. /shttps://t.co/KG7iQGMowD https://t.co/zgNzSxxUHV
Did you know glyphosate was originally marketed as an antibiotic? I wonder what bacteria it kills in the gut ;)https://t.co/nSbwoASR5n
Can't test butyrate cuz it smells bad.If I had a place to live I'd be trying to figure out how to safely eat glyphosate to see what it did to my gut health.Why? because fuck you, thats why.https://t.co/2YAndTlETh
"Controlled studies treating with known concentrations of glyphosate would be required. [...] with a lack of such research it is difficult to fully elucidate the consequences glyphosate has on both the gut microbiome and human health in general." [2023]https://t.co/vcgUK9jz14
I would need a safe place to store my shit so I could perform autologous FMT after testing the loss of gut microbes from Glyphosate.https://t.co/FvdEVOdUTm
Tired: Building a freezer to store my fecal samples over the winter to show shifts in gut microbial populations reflect hydrogen sulfide levels, to prove I can hibernate.Wired: Building a freezer to show I can change the color of my poop, so I can shit rainbows like a unicorn.
Did you know Ivermectin can treat lung issues caused by γ-radiation damage?"Ivermectin modulates lung toxicity induced by γ-radiation viaTLR4/ NF-κβ /MAPK pathways" [2023]https://t.co/XSaUkXEbi7https://t.co/ksd6HV2nJd
Sure would be cool if we could figure out why ivermektin seems to randomly cause liver failurehttps://t.co/EH8nOo4o6t
Why does something like that cause psychosis?https://t.co/82vTqODVJ8
but also seem to treat it in rats?"Ivermectin improved behavioral and molecular deficits of poly I: C-Induced schizophrenia model in rats"https://t.co/ImtzreOrKs
If we could figure that out, maybe we could also figure out what Ivermectin is doing to treat cancer https://t.co/2MkmXVWKaQ
Anyway.... Did you know that hitting TRPA1 activates DNA repair pathways?https://t.co/Ss9ERuszgt
@Zillarax I've put tons of thought into this. I was even able to predict certain antiparasitic chemicals that impact TRPA1 as working to treat parasites via bile function. It is how ivermectin works too. Gut bacteria I focus on in my gut act on FXR signaling. https://t.co/3JlALtTLbP
Anyway, FMT fixed my GF's liver failure after fluconazolehttps://t.co/ZgzqmHazpJ
Eat the sun.https://t.co/tC0nHObMIb
I said once that I think my spit could cure cancer.https://t.co/x0E7pbXVve
Ignore me tho, i'm retarded.https://t.co/VLKrfAPWTY
"Making mental retardation sentimental did not eliminate all the incentives for obscuring its connection to autism. It should not be surprising that parents and professionals often maligned mental retardation in hopes of lessening the stigma of autism." https://t.co/dU4l6tv6Xc
"Our findings reveal the profound impact that SARS-CoV-2 infection has on cellular biology, threatening the most important cellular constituent: nuclear DNA. The accumulation of DNA damage is known to be associated with cancer and aging" [2023]https://t.co/YdayKYbSvX
"accelerated epigenetic aging is associated with the risk of SARS-CoV-2 infection and developing severe COVID-19. In addition, the accumulation of epigenetic aging from COVID-19 may contribute to the post-COVID-19 syndrome" [2022] https://t.co/RmsfC8drjGhttps://t.co/tabk7M77eJ
@NateB_Panic @bryan_johnson @drgurner The weird telomeres may be due to impaired DNA repair pathways. So... we predictably see more cancer!"People hospitalized with severe COVID-19 are at increased risk of being diagnosed with cancer in the following months, according to new research" [2023]https://t.co/5MI5bWzrzb
Exactly what you would expect if butyrate producing species went missing due to gut disruption. A sudden increase in DNA damage due to missing repair functionality.https://t.co/dhSByDeWyf
@ahandvanish @el__duende Now the real kicker here? I can predict without looking, that both ME/CFS and Long Covid has markers of accelerated aging... because of telomeres. Another parallel.Long covid: https://t.co/RmsfC8drjGME/CFS:https://t.co/Dq03TaxLwGBTW, I also got younger.
"We here discuss potential neurobiological and environmental factors as well as a number of challenges in ascribing a causal pathogenic relationship between SARS-CoV-2 infection and new-onset psychosis." [2023] https://t.co/l486rExonw
"Inflammation is a key common player in COVID-19 and [the acute radiation syndrome], and drives the multi-system damage that dramatically alters biological homeostasis." https://t.co/j2Y5OcN1trSo, what do we do about inflammation? https://t.co/Eq5rP4aV07
This is neat. Could the reason why vigorous exercise was messing me up before be due to poor butyrate production in my gut => inflammation?This is a major chemical I focused on to helped treat my crohn's disease (before the FMT).https://t.co/Sq35Z1UZedhttps://t.co/ulMYAfUYm5
What what."No available therapy has, as yet, proven effective to treat acute radiation proctitis (ARP) following radiation therapy [...] Topical sodium butyrate, unlike other therapeutic regimens used so far, proved effective in the treatment of ARP." https://t.co/lLC69W8PKZ
In the butt?"The principle is that in the case of hemophilia induced by radiation, the related atrophy of mucosa may interfere with mitochondrial fatty acid oxidation, and SCFA supplementation in the form of enema can overcome this" [2021]https://t.co/tvhblUWxdE
What could be happening here?"Researchers of a new letter are highlighting the rare potential of acquired hemophilia A (AHA) following COVID-19 and COVID-19 vaccination." https://t.co/IQaDGBaXr4
Maybe it is microbiome's role in SCFAs, being disrupted? 'In this review, we present recent advances in the understanding of the cellular mechanisms of inhibitor formation and highlight some areas of uncertainty requiring further investigation." [2020]https://t.co/uvMSORd038 https://t.co/CNSoj42rGg
More research needed. It's always more research needed.Research my ass. Literally.https://t.co/DbHmfAV9vg
I have been hoping to work w/ medical researchers to try and get proper safety trials done before releasing the process to the public for review.But I believe in explaining how seriously I took this process I can dissuade people from doing it themselves.https://t.co/rqYR6tcvjF
Tired: biopiracy.Wired: butt-piracy.https://t.co/fvsoL4LhaB
Really makes you think.https://t.co/N384TXcVeY
Trying to figure out how to remove radiation. "In these published studies, children and teens from high cesium regions of Belarus showing signs of radiation-linked cardiovascular illness took daily oral apple pectin powder." https://t.co/OEbWhpNWsc https://t.co/wf8z4R1ZZq
Lawrence Welk and His Orchestra - "Apples and Bananas" 1965 / 1967 STEREOhttps://t.co/NNonB841JDhttps://t.co/6SIEYIjJue
Pectin is fascinating. https://t.co/ifIWgfXH2c
"For example, bananas contain resistant starch and inulin-type fructans, while apples are a source of pectin. Thus, diets rich in plant-based foods provide many different types of dietary fibers thereby supporting a more diverse microbiota composition."https://t.co/xEjusZgkUl
I should see if pectin makes me constipated still.https://t.co/GOpE89MC6P
Neat"Regarding SCFAs, acetate levels rapidly increased with incubation with pectin, and butyrate levels also increased after 6 h of incubation. The results suggest that pectin fermentation increases bacterial species belonging to Clostridium cluster XIV" https://t.co/EKWq4YctKS
That was cited by this:"Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics" [2022]https://t.co/eg38sHIAO9Lots of other things about butyrate within.
Butyrate, motherfucker, do you produce it?Say butyrate again! I dare you. I double dare you.https://t.co/peA9FuK19i https://t.co/jLRVFDOEgy
"Blessed is he who, in the name of charity and good will, shepherds the weak through the valley of darkness, for he is truly his brother's keeper and the finder of lost children."https://t.co/OUGzUZ5t6t
"Furthermore, the intake of viscous and fermentable fibers (i.e., β-glucan and arabinoxylans from wholegrain, pectins from fruit, vegetables, and legumes) should be increased by virtue of its prebiotic effect towards butyrate-producing bacteria" [2022] https://t.co/MLjqvObX09
If you got long COVID, its like you are trying to survive being irradiated by depleted uranium?B A N A N A Shttps://t.co/0YilA6YX2Thttps://t.co/Bj8MJCbTxf
Out heal the damage.https://t.co/fT6LGvOHUC
It is your desire to stay as you are that limits you.Entropy attacks your cells and drives noise and malformation. They commit apoptosis or turn into cancer.To regenerate, you must cancel out the noise. You must constantly out heal the damage. https://t.co/Yw20jpsA4t
"In aging, DNA damage increases and DNA repair decreases. This is exacerbated in disease, as post-mortem tissue from patients diagnosed with mild cognitive impairment (MCI) or Alzheimer’s disease (AD) show increased [DNA double-strand break]s." https://t.co/UeOYe1fSTX
Autism as Childhood Alzheimer's strikes again.https://t.co/sZM20I8vVW
Your brain is always breaking.https://t.co/gkDV7Qz397
What matters if if you can unbreak it faster than it is breaking."Coffee consumption rapidly reduces background DNA strand breaks in healthy humans: Results of a short-term repeated uptake intervention study"https://t.co/KF8iCLuo1ihttps://t.co/iej6EV9Rkq
Don't do drugs. https://t.co/KKbUyiDtmPDon't even think about it. https://t.co/eIO9gVrCAhUnless you have increased bloodflow in your brain https://t.co/uqdEAhTLJIBecause coffee may counter act a bit. https://t.co/GqAO3gPn54Caffeine is common schizophrenia self-medication.
Maybe you can leverge gut health to out heal the damage?"The activities of SCFAs can be thought of as maintaining and/or re-establishing homeostasis by targeting genes and signaling pathways that contribute to multiple hallmarks of cancer." https://t.co/z08n8QbEMI
Weird?"causal relationship between genetic predisposition to schizophrenia and cancer, with schizophrenia increasing lung […] thyroid […], colorectal […], ovarian […], breast […] and reduced the risk of malignant neoplasm of the stomach" [2023]https://t.co/m9qdZiwnM2
So... A drug commonly used as self medication by schizophrenics hits a TRP receptor that activates DNA repair? Why would they do that? /shttps://t.co/HLEFrMVgJO
Huh.Why would bisphenol A act like gamma radiation?Further, nattokinase helps fight it? Wild.https://t.co/MimmmXDcLjhttps://t.co/9NPOzTIrRI
What ever could be going on here, ape says to himself knowingly."Effects of a high-γ-polyglutamic acid-containing natto diet on liver lipids and cecal microbiota of adult female mice" [2021]https://t.co/1UtLL2wUg1 https://t.co/NWITouhFYB
Sure would be interesting if we found that species of gut bacteria that can produce nattokinase are seen as acting weird in people with neruopsychiatric disorders.https://t.co/4vJsSjXQIt https://t.co/RDnGiBVSCp
Sure would be interesting to find out that SCFAs tied to that species end up having an impact on liver health problems seen in schizophrenia.https://t.co/wfflEFGEfJ
BDNF shows up in Alzheimers, Autism, and Schizophrenia, as well as many forms of depression.You can trace the effects across papers and see that it's all the same constellation. Liver damage / Bile problems seems to be a proximate cause from my vantage.https://t.co/ZLvi6Apx24
Maybe there's a connection between Nattokinase related gut bacteria assoc. brain dysfunctions? "Nattokinase prevents β-amyloid peptide (Aβ1-42) induced neuropsychiatric complications, neuroinflammation and BDNF signalling disruption in mice" [2023] https://t.co/5MgUPNanTR
Do you think there may be a connection between gut health factors tied to butyrate and liver health?I do. I write about it a lot! https://t.co/vAJJpsO6PF
Now BPA / bisphenol A? That is indeed a rabbit hole.https://t.co/suD8wgBT2O
Thankfully BPA lining in aluminum soft drink cans is going away. Funny to think that it was causing...*checks notes*Liver damage in pigs.https://t.co/EO8tQnsWhphttps://t.co/N6jWnR2Rvr
@HohlyMohly @mike_d_ok @BioavailableNd Tho that is technically a 'resin' and not a plastic. Both are polymers. It was more common in the past to have BPA based (resin) liners. Many companies are switching over the the BPA free resin ones like above.The term "plastic" is often used for synthetic resins.
If the link between BPA and changes in gender hormone expression is because of liver disruption, it would explain a lot of things https://t.co/hyV7AboUhw
@eigenrobot It would seem that gene mutations I have around CYP17A1 and CYP19A1 are being expressed in my liver and causing me to produce a lot of testosterone, but it gets converted into estrogen too quickly. I was treating this with menopause herbs https://t.co/gVIYkwAxaE
The common denominator in this space is SCFA production by gut bacteria.https://t.co/eZdRTRlZYB
@jsundmanus @eigenrobot @rivatez @officialmcafee @Jacobiome @zefrank It's also possible that sometimes the rise of schizophrenia in a temporary state is oen of those NAFLD indcucing bacterium that produce alcohol. It could be transitory.It would cause hallucinations.https://t.co/TK4f4bQQDD
NAFLD is highly linked to mental illness.https://t.co/mHY8425CYV
"There is a significant burden of gastrointestinal and liver disease amongst patients with schizophrenia. Better levels of support from all members of the medical team are essential to ensure that appropriate, timely care is provided." https://t.co/vJqW4OmYko
Liver health is all encompassing.https://t.co/8EMy5v6hCb
Again. the thing that seems to help is... the SCFA butyrate."In liver organoids, butyrate could reduce drug-induced hepatotoxicity" https://t.co/osum2iQqE7 https://t.co/gCQCrt7sPr
Is it any wonder that we are seeing accelerated aging in people with covid?https://t.co/Akt0j5DiQN
Or why cancer patients also seem to have accelerated aging? https://t.co/yjLgFXM09g
REMARKABLY? My ass."Remarkably, butyrate could ameliorate some markers of kidney and liver damage caused by chemotherapy or cancer itself" [NOV 2023] https://t.co/zbj5Qy7kXYhttps://t.co/7crauXo31X
I've started putting collagen peptides in my protein shake in hopes that it will increase butyrate. I may be reducing my chances of liver & colon cancer at the cost of pancreatic cancer risk. Good thing I got hardcore pancreas/insulin management genes.https://t.co/CxEOwNlPfA