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BRB, learning about Glioblastoma... 😢Rip @EcuadorMacrohttps://t.co/QZtjg0rksG https://t.co/7VpMjzGXjy
The first thing I do when I wanna learn about something is type it into my twitter search, then scroll to the bottom.https://t.co/Tv4avC7qkx
This caught my eye.https://t.co/QqlNOdtFF5
"more research using large numbers of tumor tissues from patients throughout the world, coordinated by independent laboratories with no stake in the presence of CMV in gliomas, will be necessary before CMV can definitely be ruled out as a player" https://t.co/aWw5j5O0FH
"In glioblastoma, he has noticed that the majority of patients are affluent, and he speculates that people infected with latent CMV might be more likely to get tumors if they grow up in hygienic environments." https://t.co/0maia2P5y1
"In this review, we will discuss the role of [Cytomegalovirus] in [glioblastoma]. The controversies around the detection of CMV in glioma samples, and the possible implications of CMV in the role of glioma-genesis or treatment resistance will be reviewed" https://t.co/6OYyk5nGQL
Glimmer of gold on Cytomegalovirus.Synesthesia. I saw a path. Sonic Hedgehog.(gotta go fast?)https://t.co/Quzjr9SM80
"Overexpression of Gli1 under the control of the cytomegalovirus (CMV) promoter renders these cells resistant to cyclopamine-induced apoptosis. Thus, our analysis [indicates] the hedgehog pathway is frequently activated in advanced gastric adenocarcinomas"https://t.co/XmxdOL9jWt
But why?"Starvation-induced cancer sensitization to radio- or chemotherapy leads to extended survival in the in vivo glioma models [...] indicate that fasting and fasting-mimicking interventions could enhance the efficacy of existing cancer treatments" https://t.co/fBxaNO9BjB
"adipose tissue as a location of viral infection leading to a sustained and lifelong adaptive immune response mediated by CD8 T cells that correlates with hyperglycemia [...] a mechanistic link between metabolic syndrome and chronic infection[?]" https://t.co/S0G0xq70Aj
Suspicions cytomegalovirus lives in the fat.https://t.co/QKXk43BC5d https://t.co/CsyPdaCZ8i
Found in brown adipose tissue/ BAT in rats, too.https://t.co/aYbGAmeHm5
"A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer’s Disease, Glioblastoma and Lung cancer" https://t.co/mpdToJCW8Whttps://t.co/rU2yW1Nmu2
Fascinating."Our 3D-bioprinted model could be the basis for potentially replacing cell cultures and animal models as a powerful platform for rapid, reproducible, and robust target discovery; personalized therapy screening; and drug development." https://t.co/BXPA9d2js3
"Notable Labs cuts down on the guesswork and testing time in the lab with the use of predictive analytics from another YC-backed startup, Atomwise. It then uses a customized machine that can test thousands of combinations of drugs within the lab" https://t.co/JtegWyu1cn
Last two results came from arena's search.https://t.co/iFwEdYxKaA
Another entry from arena quotes this."Increasing Prevalence of malignant glioma is a key factor driving the adult malignant glioma therapeutics market"https://t.co/ZMQD4DIqdM
"Alterations in microbial constituents promote inflammation and immunosuppression. Recently, in immune-oncology, specific microbial taxa have been described to enhance the effects of therapeutic modalities. However, the effects of microbial dysbiosis on glioma are still unknown."
All our 'personalized medicine' methods to detect pharmaceutical interventions seem woefully underspecified when it comes to detecting the actual role of gut microbiota & inflammation in cancer development. And we have next to no studies on it.
"four grades of glioma, and each has different types of cells present and different treatment strategies. A glioblastoma is a grade IV glioma, which is the most aggressive form. [...] all glioblastomas are gliomas, but not all gliomas are glioblastomas" https://t.co/TJ7AcUl9y4
"glia noun\ ˈglē-ə , ˈglī-ə \plural gliasupporting tissue intermingled with the essential elements of nervous tissue especially in the brain, spinal cord, and ganglia" https://t.co/Lb3VE7ZXTN
"glial adjectivegli·al | \ ˈglē-əl , ˈglī- \of, relating to, or constituting glia"https://t.co/awLx5rwNLO
"Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells." https://t.co/KrYAarJMmS
"GLI and the Hedgehog Pathway [...] Aberrant activation of the hedgehog pathway has been shown to promote oncogenic activities, such as metastasis, DNA damage repair, stem-ness, and chemotherapeutic resistance, in a variety of types of cancer"https://t.co/hsbKmMphek https://t.co/kReOnT8pCP
In before a bunch of drugs pulled from an AI black box and tested on a 3d printed brain end up having spill over effects on other areas of the body that no one bothered to test for.https://t.co/owpeomROHM
Me."The aberrant downregulation of SMO-SHH signals contributes to the proteolytic cleavage of GLI (glioma-associated homolog) into GLI3 (repressor)"https://t.co/dji7gJwNhj
Me."Researchers studying two seemingly unrelated conditions — autism and cancer — have unexpectedly converged on a surprising discovery. Some people with autism have mutated cancer or tumor genes that apparently caused their brain disorder." https://t.co/OQXVh0RR4w
"demonstrated associations, along with increasing evidence that PTEN is a regulator of the central immune system, prompted us to explore gut microbes and class II HLA molecules as potential contributors to autoimmunity in [PTEN Hamartoma Tumor Syndrome]"https://t.co/8Ltn2wKtcR
"Glioblastoma (GBM) is the most lethal type of human brain cancer, where deletions and mutations in the tumour suppressor gene PTEN (phosphatase and tensin homolog) are frequent events and are associated with therapeutic resistance." https://t.co/1qlj52yu7k
Demon Core. This."The causes of most glioblastomas are unknown. Established risk factors include inherited genetic syndromes and therapeutic ionizing radiation but account for only a small fraction of cases"https://t.co/h8LVilNXLn
What does ionizing radiation do to gene expression and DNA damage / repair factors associated with gut bacteria and histone expression changes driven by epigenetics?https://t.co/1g7OETNHym
" This review highlights the importance of considering the influence of ionizing radiation exposure on gut microbiota, especially when considering the side effects [...]. Better knowledge of these effects, with larger population studies, is needed." https://t.co/umR41p9B2P
Tired: god of the gaps reasoning.Wired: god of the farts, seasoning.https://t.co/9mXr2qKTUb
"Patients usually lose the sense of smell years before a brain scan shows the presence of a growth" [1984] https://t.co/rZh8rBtvbs
Me."[glioblastoma] had olfactory dysfunction significantly more often compared to the control cohort (p = 0.003). Tumor location could not explain this finding [...] However, validation of these results in an independent cohort is needed." [2020]https://t.co/EbIikJMuFW
"Skin-microbiome interactions can cause persistent, psychosocially devastating body smell despite good hygiene."https://t.co/si1rnNSuq0
Triangulate forgotten facts. https://t.co/udm9SZwQOZ
Oh, that's why I knew this space. I was exploring VEGF's role in microglia and TBI/Multiple Sclerosis and it turns out that also plays a role in immune function signaling.So... Cancer."VEGF as a modulator of the innate immune response in glioblastoma"https://t.co/YTsk6aaKYz
Did I fucking st-st-stutter?"A region in the left frontal brain is hypoactive, whereas the corresponding region in the right hemisphere is hyperactive. However, the cause of this imbalance is unclear."https://t.co/7uzxw1VqIfhttps://t.co/Dn6l8j3JPB
"Blood vessel condition tied to MS, with caveats[...]The researchers found that people with MS were indeed more likely to have the narrow blood vessels -- about 13 times more likely." https://t.co/UzodrKCBKS
Blood blood blood."In conclusion, our studies demonstrate the presence of VEGF receptors on VSMCs that are functional. These studies also indicate that in vivo, VEGF may play a role in modulating the response of VSMCs."https://t.co/NsbBTfkRO0https://t.co/YuBpJW9OE3
I enjoy falling sand games.This isn't the first time that I figured out a medical issue from that game. The double vision I get in my left eye (seen in quote tweet) also went away.Why?https://t.co/gDw9mH9g4I
The reason why measurements of narrow blood vessels in M.S. is controversial is because Vascular endothelial growth factor (VEGF) and immune activation of vascular smooth muscle cells (VSMCs) vary just like they do in crohn's symptoms.Fools.
Immune system impacts blood flow.Blood flow impacts stuttering.So what is interesting here?Zidovudine (antiretroviral) stops stuttering in an HIV/AIDs patient.https://t.co/4JW07urY80Neat eh.
So... lets do that thing where we remember forgotten facts. Zidovudine should help with cancer?https://t.co/PSKYdFnNQpNeat eh.
So Zidovudine should intreact with VEGF?Yes. https://t.co/u0GxcT9VC0
This suggests it does apoptosis and cell death. So..."Activation of the MAPK pathway together with inhibition of SAPK/JNK activity by VEGF appears to be a key event in determining whether an endothelial cell survives or undergoes programmed cell death."https://t.co/isgp2LmT7i
Blood bending tho."Here, we discuss the potential as biological markers of diagnosis and prognosis of TRPC6, TRPM8, TRPV4, or TRPV1/V2 being associated with glioma patient overall survival. "https://t.co/QBi9hxlNms
"In summary, our study identified that VEGF promoted the angiogenesis and provided evidence for mitochondria as new therapeutic target of VEGF signaling in the angiogenic vascular disorders."https://t.co/C7WnnHTycf
"The present review summarizes the known mitochondrial DNA alterations related to [Glioblastoma], their cellular and metabolic consequences, and their association with diagnosis, prognosis, and treatment."https://t.co/DSSCvkTWLo
"in this review, we highlight and summarize the various molecular mediators that regulate [Glioblastoma] angiogenesis with focus on recent clinical research on the potential of exploiting angiogenic pathways as a strategy in the treatment" [2020]https://t.co/i3JDxvIdgI
Why would an antiparasitic like mebendazole have an impact on survival in glioblastoma multiforme? https://t.co/1gkJqtsLFO
Maybe this?" In summary, this study identified mebendazole as a USP5/c-Maf inhibitor that could be developed as a novel antimyeloma agent."https://t.co/d2NUkUdjbK
What is USP5/c-Maf? Hmm..."This comprehensive summary aims to improve our understanding of the complex [Deubiquitinases]/[Regulated Cell Death] regulatory axis comprising various molecular mechanisms for diverse physiological processes."https://t.co/B7a7Wn6y4U
Hmmm."Further understanding of these processes may provide answers to multiple remaining questions on [Deubiquitinases] functions and lead to the development of DUB-targeting strategies to expand the repertoire of molecular therapies against cancer."https://t.co/zcAY28pfzq
BRB, loading up some Deadmau5 DUB step, because memory palace."Get In The October Cart, Pig"https://t.co/nnoxPwCCmP
Who could have guessed? Me."Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs."https://t.co/g9ajz5dvt9https://t.co/YpRnWW96Gc
@ThegreatBarbos1 @FrankeyDr @4chanGreentxts Its useful to remember that ivermectin was derived from a species of Streptomyces that is very similar to commensal ones we have in our gut. It's effects may be more widespread than simply attacking the helminth. https://t.co/E2oU7ZUyy9
MM... Apple flavored horse dewormer might cure brain cancer by the same pathway that ubiquinol impacts neurodegenerative disease like Multiple Sclerosis?Fake news.https://t.co/GwB7rAzesD https://t.co/vttbdx2Dvk
Wild how I can just by ivermectin from a farm supply store. I would have bought some a couple years ago when I first learned it might help Multiple Sclerosis.https://t.co/g0Q3rsVDGFI should figure out how to translate dosages if the dog shit or garlic doesn't seem to work.
4% survival rate. 😢Literal Brain Surgery.https://t.co/kv1c07zlGM https://t.co/bvCwQ7mBub
LOL farts."Wired: god of the farts, seasoning."https://t.co/nJYwDgnE7p
Do antihelmetics work if mouse is "germ free"?"Intestinal microbiota is involved in immune response and metabolism of the host. The frequent use of anthelmintic compounds for parasite expulsion causes disturbance to the equine intestinal microbiota."https://t.co/ZSW8pCXzWd
If spider venom works, what about snake venom?https://t.co/t8pg3hRNUf
@visakanv @sunofdopamine "Herein we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against the pathophysiological conditions including cancer and pain." [2019]https://t.co/uCrdBTpU5t
Hmm, not directly. What drives this?"That’s where antivenoms come in. They speed up the immune system’s clearance of toxins, because antivenoms are, themselves, antibodies pulled from the blood of large animals, usually horses, that have been injected"https://t.co/trikcmynI8
Huh."My arm was all red and doughy with a sack of liquid hanging from it and I could see the blood vessels appear. It was like something out of Evil Dead. It’s evolution telling you to stay away. "https://t.co/GFJFSynFRt
I just binged this, so that metaphor is gonna stick."Give me some sugar, baby."https://t.co/C9Xnt2008q
"Hey princess bubblegum, when we bring the dead back to life, will they be filled with worms?[...]Give me some sugar, baby..."https://t.co/DpQQIsWnY4
"Give me some sugar, baby...[...]What does that mean?"https://t.co/CUDeuu06f7
Me."The ubiquitin-proteasome system (UPS) is often disturbed in many neurodegenerative diseases, demonstrating a potential therapeutic target [26]. A potential key target within this system are the deubiquitinating enzymes (DUBs)"https://t.co/GWPLFupE68
Snakes. Ear wyrms."Do You Hear What I Hear - Raiders of the Lost Beats"https://t.co/9tLw7Byln8
If aspects of these herbs help with DNA damage associate with ionizing radiation, its conceivable they might be useful to treat glioblastoma?https://t.co/uO2Nt7ZQFO
"review [...] radioprotective potential of plant and herbal extracts. The results [...] indicate that several botanicals [...] protect against radiation-induced lethality, lipid peroxidation and DNA damage." https://t.co/wIMG8IH2D5https://t.co/8K5HJtvqpU https://t.co/LZqhQ15glk
"In this review, we discuss the significance of DNA repair mechanisms in tumour formation, aggression and treatment resistance. We identify an underlying trend in the literature, wherein alterations in DNA repair pathways facilitate glioma progression" https://t.co/Z1kmtrG1Vp
Or rather, could prevent it to begin with? The weirdness about cancer is often that the DNA repair pathways actually reinforce the localized mutations that drive tumorigenesis and thwart normal apoptosis/regulated cell death (like p53 genes). https://t.co/ln6CDUhOOG
I swear, thinking I can cure cancer using literal autism.I gotta be nuts right?https://t.co/Q7bsaQwt1M
"Methylation within the promoter regions of tumor suppressor genes causes their silencing, and methylation within the gene itself can induce mutational events. [...] may play a fundamental role in [...] a large and diverse number of human cancers."https://t.co/anCydJshwF
If antihelmetics have an impact on cancer, could gut derived chemicals act similarly to how "avermectin" is made by Streptomyces avermitilis?https://t.co/tkq4yjhDqg
Its funny how many of these things all trace back to soil bacteria."History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents"https://t.co/5VFbc3Z5JHhttps://t.co/jYm1ay2k1i
"These results show that mimicking the biotic interactions present in this ecological niche is a promising avenue of research to explore the metabolic capacities of Streptomyces and fungi." [2021]https://t.co/yZZvOdVkhWYou can predict this, lmao.https://t.co/ffz9qZHrVy
TL:DR; something like E.O. Wilson's studies on resiliency of island populations, but in context of forces acting on the gut, and perhaps comparative physiology. Learning about how important nitrogen (protein?) is in promoting bacterial health makes me wonder.Thought context: https://t.co/AzstVLBAUb
We are idiots."In this review we give an overview of the mechanisms of Notch signaling, its networking pathways in gliomas, and discuss its potential for designing novel therapeutic approaches."https://t.co/KkJM9N3xEdhttps://t.co/LpDr1V6fqN
Don't care. The upside of helping people I care about outweighs any risks.https://t.co/fAMl7SXTIn
"Summary: Researchers say the gut microbiome may be a viable targetable biomarker to improve immunotherapy responses in those with glioblastoma and a range of other cancers."https://t.co/XcyRJTFZpL#FuckCancer https://t.co/P5bGbL5j0X
Thank you @LorentzianJelly for remembering I spoke about that in the past.https://t.co/U8rKW0R81e
@LorentzianJelly @coookwithchris @WokeFloridian That there may be interactions between microbes and omegas and their role in immune system function / inflammation has been postulated as a theory for why we see mixed results in anti-cancer research https://t.co/tNcA49XA9i
Figuring out how to mitigate the side effects and optimize the function checkpoint inhibitors is a really good thing.A small study on them just demolished every cancer in the trial.https://t.co/ZUlJuVh2s5 https://t.co/CBlmubg0Wb
Muscle weakness. Difficulty Swallowing. Chewing?inb4 mTOR pathways driven by gut bacteria associated lipid disruption.https://t.co/9uB7qP6XPu
I also found out that the times when my hands are at their worse also seems to coincide with problems with swallowing. That's another unstable system I need to avoid. Also solved by powders/drinks.Living alone and choking on a pill is really scary.https://t.co/yhRhmMyKw8
Kinda need good B and T cell function if you wanna fight cancer.https://t.co/ILxyQa5201
@VivicorpCEO @Tipsycaek Immune cells play a role in helping to manage the expression and structure of organ formation. As such promoting healthy T & B cell differentiation via gut health & lipid digestion will likely go a long way to avoid malformations that can lead to cancer. https://t.co/clIPgJOGjY
Thanks to @wegohealth, being sponsored by $BMY to send me ads via #InfluencerMarketing (for a drug that lowers immune function), I now know that the endocannabinoid system touches S1P and SHH and all of this could may be involved in brain cancer.https://t.co/xJWBS3iWY4
We've had our model of snake bites wrong haha."found that mast cells produce proteases that break down a different toxic component in each of them." https://t.co/2nXukUTO7Fhttps://t.co/PHKt7GcaM4
There's a chemical called cardiotoxin that comes from snake venom. They use it to test wound healing during hibernation for some reason?In the hibernating ground squirrel, they didn't develop scar tissue from it. "Remarkably" Tho it took longer to heal. https://t.co/EGIfIbht7n https://t.co/2koameKnFV
I can't stop thinking about a scene from the witcher where he lowered his metabolism to help deal with a toxin.https://t.co/eVPFV8EwCR
Grass, Lord of the Tree (vines => snakes). Agriculture. Associates with wine?Was this a snake god because the snake protected us from mice eating grain, thus providing agriculture and (to Sumerians) the main source of beer/wine.https://t.co/4bfmiQ3qhShttps://t.co/UKKEXYOflj
Was Ningirima (water snake?) the dual of Ningishzida (tree snake?) and conflated with Ninkilim -> lord of rats, (the mongoose) because of the relationship between them?Naming an anti-pest dog after a mongoose would also tie together sin with ishtar. https://t.co/L6XWdTJvr5
If I were the goddess of the hunt, It'd totally name one of my dogs after a renowned snake killer.https://t.co/ulhOiG4boN
"It's not impossible for a mongoose to get sick or even die from a cobra bite, but mongooses make a glycoprotein that binds to the protein in the venom so a moderate amount of snake venom won't hurt them."https://t.co/ZlpPeR4e65
> glycoproteinOh hey. I know this one.https://t.co/vvyDISAVMB
"Our findings challenge the dogma of venom sterility and indicate an increased primary infection risk in the clinical management of venomous animal bite wounds." https://t.co/AcfhTS4cdjHMMMMMMMhttps://t.co/ELum7QEUgO
What if you could culture these bacteria that are immune to snake venom and seed it for HGT with bacteria that protect mongoose?Could you then figure out a way to get these species to be mammalian compatible and maintain them by drinking snake venom?https://t.co/d7k5OZ06Bx https://t.co/NrbRhr9b79
Would love to see if putting Steve Ludwin's poop in a mouse ala FMT allows the mice to become resistant to snake venom. Would probably confirm unequivocally that the resistance is driven from adaptations taking place in gut bacteria. https://t.co/ShvvPBq08r
"It is a striking case of modern-day scientific alchemy: The most highly evolved of natural poisons on the planet are creating a number of effective medicines with the potential for many more." https://t.co/jPmLFalktGQuite a brand! https://t.co/3EvDUdUezm
Is @SteveLudwin impacting mast cells and having knock on effects to gut bacteria thru immune activation?"Changing the [mast cell] population and activity in the tissues during aging is associated with age-related changes of the skin and mucous membranes"https://t.co/pcNEPDteJN https://t.co/KcVKXOtdi4
I wonder what he eats.https://t.co/l8CuZkGDAF
lmao. Of course it is!https://t.co/mlSuxN668I https://t.co/V56qXAdag2
This is also likely the same mechanism as Bee based sting therapy. May also help? https://t.co/KgWMGogAIE
Which implies formic acid as part of method-of-action?Does that mean Nettles?https://t.co/x6p72ZSUu4
@OhMalG @embryosophy ah, that's the same as the bee sting? I knew nettles were formic acid, but not the connection. really cool! I'll have to re-read my notes on using bees for RA to see if its usable here. IIRC, would be same idea as I'm saying -> activating anandamide. https://t.co/P6iBytsUfT
hehe, liposaccharide again, LPS."Polyphenols in Chronic Diseases and their Mechanisms of Action" => "Chapter 33 - Immunomodulatory Ethnobotanicals of the Great Lakes"https://t.co/p7TEzHkhWx https://t.co/H7Uq6RLxYG
whoops, I meant lipopolysaccharide.https://t.co/pAgIqLrLnS
I bet snake venom / bee venom / stinging nettles all fight Alzheimer's by way of reduced inflammation from LPS.https://t.co/Ej10G8SyxH