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🧵 Thread (21 tweets)
If life gives you ketamine, find out what happens if it's fed to bees."In the news podcast, could Chinese scientists have found the mechanism that gives ketamine its antidepressant effect?" [2024]https://t.co/Vzcjtpp5VU https://t.co/jl7M4O0m4K
Chaserhttps://t.co/eJuCtAvXUL
@NulluSum997 @MrOmodulus @Bonecondor "Now that we’ve proven we can addict ants and that the neurochemical pathways are similar to mammals, what’s most exciting to me is the next step" https://t.co/eSnjizVXdbDo you think the addiction is because of their gut microbiome shifting? https://t.co/vt3g5OJN7d
You can just email scientists.https://t.co/JkHZfrw9vU
> "The ability to modulate the duration of ketamine action based on the biophysical properties of ketamine–NMDAR interactions opens up new opportunities for the therapeutic use of ketamine." https://t.co/nR8a4BFEnH
> "The anti-N-methyl-D-aspartate receptor (anti-NMDAR) autoantibody is a typical synaptic protein that can bind to synaptic NMDA glutamate receptors, leading to dysfunctional glutamate neurotransmission in the brain that manifests as psychiatric symptoms"https://t.co/xv9NI1zo0o
Hmm. So does being in a k-hole impact hearing?https://t.co/YPr4NYtN7I
Does that mean if we impact glutamate thru gut health we'd shift depression by acting on the habenula thru down-regulating glutamate receptor sensitivity?https://t.co/gcr5BpWYo9
@eigenrobot myo-inositol as a gauge of impact of psilosybin on brain inflammation."In sum, our findings show some degree of area-specificity of acute psilocybin effects that are mostly related to the hippocampus via TNF-α and glutamate/tCr."https://t.co/oXwSWxjT64https://t.co/YwpX8Pd541 https://t.co/VuMvPv4poi
> inb4 shifting gut health cures major depression the same way it might treat schizophrenia.https://t.co/1NkD6P0THx
We may need insect models of schizophrenia. 😅https://t.co/yJvesmBrX8
> "expression of [myo-inositol] transporters and schizophrenia and bipolar disorder, and suggest that brain region-specific aberration of one or more of these transporters determines the partial behavioral phenotypes and/or [symptoms] of these disorders." https://t.co/JsV1iMYs6n
What could be going on here? one wonders...https://t.co/yaYuvn1RQQ
Have you considered eating the poopie?https://t.co/LFeHjZMFgG
Scientists used to feed LSD to spiders.We should be feeding weird shit to ants and making yogurt out of them.Make science great again.https://t.co/LOadTDpzbH
@jack_meditates2 @whatisaging “If the nomads want to make yogurt and cannot find enough starter culture to make yogurt, they crush the tiny eggs of the ants sheltering under the stones in their palms. When you put this into the milk […], that milk becomes yogurt.” https://t.co/5kUmK5TB1j
She wants the D(-serine)"Accordingly, senescent rats chronically treated with the reducing agent N-acetyl-cysteine to prevent oxidative damage, show intact NMDAR activation linked to preserved D-serine levels and SR expression." https://t.co/JyMNDIJGmn
@mike_lustgarten I'm trying to trace down what might be causing Fibrogen and the closest thing I've got are shifts in D-Serine, which I saw shows up in aging tied to changes in serine racemase (with some indications gut bacteria impact levels of this).https://t.co/YqAyXBNESn
Bad gut health means poor bile signaling which changes TRPA1 activation, which impacts regulation of D-serine, which changes glutamate receptor activity.It's a feedback loop.https://t.co/WOfkQr5oZN
Whelp. No science, only doge. ¯\_(ツ)_/¯> "To our knowledge, such studies have not yet been conducted."https://t.co/pfIUgcqmE2https://t.co/Zd7yHwENZ3 https://t.co/cReiyvz12y
Did you know you can just do your own bees? If you find or build a hollow log you can just hang it up in a tree like the ancient Sumerians.https://t.co/Wutl5DZ4p2