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This what happens when you give mega-dose vitamin B1 to an 84 year old with Dementia 🧵 https://t.co/MbZAAIFkTo
@EO_Nutrition The B1 has knock on impacts on gut health as well, so it can def improve things. Focusing on gut health should help augment it."Dietary Vitamin B1 Intake Influences Gut Microbial Community and the Consequent Production of Short-Chain Fatty Acids"https://t.co/nsxF8iN5yY
@EO_Nutrition B1 helping gut health may also explain findings around improved liver health. There is currently a trial exploing using FMTs to fix liver cirrosis/ suspected mechanism of action is Butyrate.Thiamine/B1 seems to be improving gut to make SCFAs better.https://t.co/wpEdUKZrV5
@kitten_beloved @sonikudzu @Scaevolus @seconds_0 Maybe we could understand root cause for Thiamine going low & fix it across this constellation fo disorders."underscore the need for prompt, effective thiamine supplementation in all patients with chronic liver failure." [2008]https://t.co/M0yhUo8Z2Lhttps://t.co/MMUHP1kE7T
@EO_Nutrition When you see that one of the main things B1 does is act on gut health, and that gut bacteria themselves can make B1, it explains a lot of seemingly unrelated findings.https://t.co/W5SVu0hjU2
@EO_Nutrition You can then start using auxiliary therapies to help augment and restore the gut function and make the B1 supplementation work even better.https://t.co/jtf8kiNXan
@DavidPerlmutter Reduce the risk of Alzheimer's by promoting gut health.> "In conclusion, we show that kefir in natura, as well as its fractions may be promising therapeutic source against AD, modulating amyloidogenic related pathways."https://t.co/pLbIKrmoGEhttps://t.co/VcyTCVYAYi
@EO_Nutrition The weirdest thing I Found is that while B1 levels in teh blood stay fairly stable, the levels of B1 excreted into the gut can still be low. If you take a megadose of B1, once the body researches saturation it will give the rest to our gut frens.https://t.co/hSVEqXcE35
@EO_Nutrition My own constipation started going away once I realized that B1 problems tied to Crohn's could be partly mitigated by avoiding "anti-nutrients" from plants. Keto helped me there. Putting B1 back in also made the problems less intense.
@EO_Nutrition Had luck with external fermentation and heavily controlled diet, but didn't get remission until an FMT.Now my body doesn't have problems digesting plants. Gut seems to compensate for anti-nutrients if you let it. Feeding missing nutrients is a key insight to accelerate this.
@ultimape Reading your posts, it looks like we connected many of the same dots. It reference all of the studies you mentioned: Here is the abstract https://t.co/NSJqCNpDys
@EO_Nutrition Ah fantastic. Did you see Akkermansia muciniphila is able to support niacin + choline production? That may be one of the bigger ones improved gut health ala B1 ends up supporting. It showed up in a year on it's own after my FMT. Helps Nicotinic acetylcholine receptor activity.
@EO_Nutrition There's secondary things this may be impact on in particular around colonocyte health. Butyrate and Niacin seem to be key to functional NAD+ health.https://t.co/ZjMzVoOD5J
@EO_Nutrition This may explain why: https://t.co/kT2rmW9YBC
