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I've got an itch to scratch.TRPM8 seems to play a role in our response to skin irritation.Cold makes me itch well before any of my skin has a chance to experience dryness. I suspect folk wisdom has the causal chain reversed.https://t.co/BwmDLSWUKU https://t.co/FZQgu8IqN4
I've got an itch to scratch.TRPM8 seems to play a role in pain sensitivity and inflammation associated with colitis in mice.https://t.co/yXeSwCHD88 https://t.co/M6q7FhdqlN
I've got an itch to scratch.I find it odd that TRPM8 seems to be triggered by Menthol AND immune system issues. If true that many 'serious mental illness' is immune system related as I suspect, then this could be an interesting link.https://t.co/i1P0TuaURk https://t.co/yUxTkWJIbh
I've got an itch to scratch.and an unrelated study from the year before noted that pain response and inflammation is affected by TRPM8 related signaling induced by menthol.https://t.co/uwwJS5TN5T https://t.co/Gw9uMJksMb
I've got an itch to scratch, and I wanna suck something.It is very curious to me that peppermint has high levels of menthol, as have been implicated to effect estrogen regulation.But more interestingly, it might effect blood flow? How is it doing this?https://t.co/HyPUrcDzDp https://t.co/YE2r1q9PIT
I've got an itch to scrach, but before I take care of it I really gotta pee.Interesting that TRPM8 plays a role in bladder function and seems to contribute to why being cold makes you have to pee.https://t.co/7c38fONhzO https://t.co/XpROhfTaod
Scratching an itch about bear piss. Ahh, that feels better.Medication that targets TRPM8 signaling for bladder function also has strange side effects. Like... both increasing or decreasing body temperature.https://t.co/8VPx8Osygm
I love the internet; where else can I find detailed maps of TRP channels and how they respond to temperature.https://t.co/StrKWZS5uu https://t.co/tBZTOZZ1de
I hate modern science practices.A paper on exactly the thing I was looking for -> how insulin sensitivity and thermoregulation correlate in grizzly bears? Retracted.https://t.co/FbEhNxN79aAnd the bears they are studying are dying :(https://t.co/jwUGF0kcqO
Are there indications that skin microbiome play a role in hair growth?Reading about TRPV3 genes and its impact on on hair being tied to calcium and temperature.https://t.co/dRD2Y4ZRMnInteresting associations with skin issues and thermal pain response.https://t.co/AE5tzS6kuw
There are indications that COPD (a lung issue) may be related to a number of gene signaling changes (including TRPV3) thru an epigenetic mechanism. https://t.co/P0D1bpSl4Ihttps://t.co/5SsZFmyplZ
I basically don't exercise, and yet I was able to run the distance of a peewee football field (~300ft) and keep pace with the house's pupper (beagle). A year ago I couldn't do 50ft without lungs burning.How does one actually measure these things? Think pooch is out of shape.
"Very little research has been done on the role played by the microbiota in inflammation of the lung in COPD."https://t.co/F5DnwmnWFx
The whole TRP* set of genes seems to play an interesting role in the lungs.I've seen indications that cystic fibrosis may be lung microbiome related.https://t.co/FebpvThPmg https://t.co/4WD2LIrnOx
"The effect of cold temperatures on respiratory health has been the subject of study for quite some time, and researchers have even found direct links between cold weather and COPD hospital admissions."https://t.co/nqLBTFTHxX
"Our findings demonstrate that TRPV3 was overexpressed in NSCLC [Non-Small Cell Lung Cancer] and correlated with lung cancer progression."https://t.co/oiPPDhpa5I
"No published studies to date describe longitudinal analysis of serial respiratory specimens from healthy controls, so the relative stability or dynamic nature of the “normal” lung microbiome is unknown." [2013]https://t.co/HcBSvAInu2 https://t.co/wIe4mV3m8X
Homeostasis?"Here we assessed if environment-related adaptive changes of GCM [gut commensal microbiota] modulate the expression of colonic Toll-like receptors (TLRs) and sensory-related systems in rats."https://t.co/3e6ZL53CrO https://t.co/F2Z2VNwfnZ
How does our skin know to release grease?Fun fact: The "Sebacean" species in Farscape is a fictional version of humans where they can't properly regulate their temperature. Their Sebaceous Glands don't work right so they are prone to overheating.
Postulate: our bodies use the bacteria on our skin (including gut/lung 'skin') as an embodied sensory network - responding to changes in populations (chemical signaling) as a feedback loop to help homeostatic systems know how to respond to the environment.https://t.co/X4bFJmFBU5
Wanna bet that Capsazepine, as an pharmacological 'Synthetic Analogue' helps diabetic people with impotence caused by inflammation?https://t.co/kaojagrgN5
Capcsaicin acts as a triggering molecule on the Corpus Cernosum that causes erections? https://t.co/PlKQ5JyW07
"Localization and Function of Cannabinoid Receptors in the Corpus Cavernosum: Basis for Modulation of Nitric Oxide Synthase Nerve Activity" Whats that?https://t.co/XSQusZBiQd
Heart failure, related to *MY* penis? It's more likely than you think.https://t.co/k3LunZrgom
Piperine, Piperine,marchin' in her own parade!Piperine , she's like one in a million!Piperine, Piperine,much too cool for TRP channel cascades.https://t.co/UvXRShj4Av
Heh, Placebo controlled double blind herbal supplement shows results. I wonder if it replicates. Notably, it didn't have hidden sildenafil (so no cheating).https://t.co/PTjBKfA2AG https://t.co/cVFXv19Vtn
There's a lot of questionable herbal remedies on the market that are actually just disguised forms of Sildenafil. https://t.co/Qxx7PQd3A0
Capsaicin is fascinating.https://t.co/2ZOKo5gGuf
Capsaicin is really fascinating.https://t.co/8ZqXYSAQ8x
Black Pepper (piperine) too.https://t.co/u6kRLbCFd5
Glucose metabolism ala piperine."Our findings demonstrate that piperine promoted beneficial metabolism during exercise by regulating carbohydrate/fat metabolism and redox signals."https://t.co/89UA6hN8Vb
What if I told you that all of this research is promulgated on a hypothesis that I can cure my girlfriend's type 2 diabetes thru diet by using various terpenes to bias her microbiome... and all this about dicks is proxy research to hormone-microbe ties.https://t.co/zZ9obc2BGY
Just nonchalantly producing pointed medical hypothesis like it ain't no thing.I've never read this before: https://t.co/mMWQXLJmeG
Spookyhttps://t.co/0bPY4YP8Gh
A chemical in Allspice has been shown to play role in down-regulating prostate cancer proliferation. https://t.co/QF6J9VkW9Hand Allspice is one of a number of plants that inhibit α-amylase and useful for diabetics. https://t.co/CzVoHPWtd3Happy Halloween!https://t.co/D2rEadcN66
My theory is all here on twitter. You just have to know where to look.https://t.co/wGxTkMqmnG
Oh, hey, I forgot about those.https://t.co/2mG9Q27pzh
Found them. You can learn a lot about a field if you can successfully separate the wheat from the chaff. IIRC this foray 3 months ago is what lead me to do a deep dive into 'honey urine' and way that different cultures may have interacted with diabetes.https://t.co/4ozgNi7BUj
Scratch"S. aureus colonizes the lesional skin of ∼90% of atopic dermatitis [...] Further studies are needed to understand the role of S. aureus PSMs including δ-toxin and other QS-regulated virulence factors in the pathogenesis of [atopic dermatitis]."https://t.co/OkdN9OVAXA
What if deadening the IL-31 chemical's scratch making behavior is actually bad?https://t.co/n1iMFkZyUwhttps://t.co/iQRG1FmppP
If Interleukin-31 is a signal of allergic reactions, and you make it so you don't itch from it... Treating IL-31 for Atopic Dermatitis might make you more susceptible to hives. Itching is how I know I touched something bad for me. Folly?https://t.co/sqzR9LdmvN
It's almost like these chemicals are part of a complex regulatory system our body uses to modulate protective behaviors against infestation of external parasites and bacterial interlopers, which are occasionally co-opted to work against us.
3 years later.~if we use the IL-31 inhibitor to stop AD in rats, other rats don't see the scratching behavior and so are more likely to transfer other itch associated dermatological diseases. But we only ever tested it on isolated Sprague Dawley rats so never noticed...~
If you aren't testing in colonies of wild-type rats, what are you even testing?https://t.co/ulQJfTs68X
Lets just go ahead and arbitrarily change a visible signaling behavior. What could go wrong? Its not like social networks form meta-level patterns to avoid the spread of disease... oh wait.https://t.co/8ja4S2qIib
Spoopyhttps://t.co/9ey5RytT6W
"current evidence suggests that inflammation and atrophy are involved in prostate [cancer] and suggests a role for the microbiome in establishing an inflammatory prostate microenvironment that might promote prostate cancer development and progression"https://t.co/5T0zNmAYzZ
Scratching posts for horses."Stop the damage to barns, fences, equipment and animals, plus, SAVE MONEY on costly vet bills and treatments..."https://t.co/gBTBO9Wt7C https://t.co/6QKHJJMGK5
Animal Massage Therapisthttps://t.co/muDSNduNBDBut in vans?https://t.co/fBNdxbkvw6More likely than you think.https://t.co/vMqNUS4Q6S
How do you do veterinary care on the road, if you're a nomad with a pet?https://t.co/UbT1TMweNj
GP: Depressed & Diabetic? Refer to:Psychiatrist: Here's med that influences metabolism (that might treat your depression). Exercise!Endocrinologist: Here's med that impacts muscles recovery from exercise that may help weight. Eat Better!*2 month later*GP: y u gain 20lb tho?
"The risk of diabetes mellitus in patients with bipolar disorder is increased. Our findings add to the growing literature on this topic. Increasing evidence for shared disease mechanisms suggests new disease models that could explain the results" [2016]https://t.co/wtZkVEvwVr
"Based on the findings, hippocampal atrophy “may contribute to the neuroprogressive nature of bipolar disorder,” particularly in those also affected by diabetes."https://t.co/mKDmlmEpwzI'm just bullshitting causal effects for biolar disorder now.https://t.co/VMaODMk1GV
Mood swings, in MY Multiple Sclerosis?more likely than you think."White matter microstructural abnormalities in bipolar disorder: A whole brain diffusion tensor imaging study"https://t.co/SDP4APIherhttps://t.co/embAmGgSPA
Turning up the volume on the social motivation theory of autism.https://t.co/J5WUxlzuWA
It's too loud, its too loud! I can't hear myself think over the volume. Too much amygdala.https://t.co/7hDLUsbeQy
"The mouse doesn’t see another mouse scratching and then think it might need to scratch, too, [...] Instead, its brain begins sending out itch signals using GRP as a messenger."https://t.co/3OpJrELPA5https://t.co/dP1jcvWjuU
3 years later.~if we use the IL-31 inhibitor to stop AD in rats, other rats don't see the scratching behavior and so are more likely to transfer other itch associated dermatological diseases. But we only ever tested it on isolated Sprague Dawley rats so never noticed...~
This showed up on my phone today; How a 'male enhancement supplement' was laced with pharmaceuticals that impact blood sugar https://t.co/mMwUcokPFGI'd bet money they were using those as off-label competition to sildenafil.https://t.co/JloyNIN7eghttps://t.co/R4avbeOpIp
I found my thread on dicks and diabetes.Viagra works afaict because it fixes blood pressure weirdness associated with smooth muscle tissue and vascular contraction. IIRC it operates on nitric oxide associated pathways. https://t.co/B3F5763hJdhttps://t.co/X0jIJCVg0p
What could they mean by this?https://t.co/vAIVQRymc8https://t.co/FRkakm30BG
Ants will collect pine tree resin to help keep their fungal colonies from being infected.https://t.co/WsJxMZaxbg
Pine trees are neat.https://t.co/pQtjPZbwCJ
Pine trees are manipulating your microbes by changing how your body's vagus nerve senses them, and this seems to have large scale impacts on your immune function as a result.How does pinene expression change during winter?What does a dying Christmas tree smell like?
pycnogenol + L-arginine seems to boost nitric oxide and might act similarly to the vasodialation effect of Viagra.https://t.co/zma0lcLykShttps://t.co/XUxUggxl7SI am living in a pine forest. softwood make me hard? 😂https://t.co/CQQlTwyvR7
Why would they think a particular pine tree extract would improve ADHD symptoms?https://t.co/aKmiQZ66IG
Modern medical science be like:High levels of insulin resistance is bad, let's edit the genes that cause insulin resistance.https://t.co/vkRx9OaWWtWe know what they are!https://t.co/GlFT7nIfhlWhat could go wrong?https://t.co/TlXR93nuMfOh https://t.co/l7AmZEZLsPHmm.
They call it an everlasting gobstopper because if you stick one in a child's mouth, it stops them from wagging their gob (Irish slang(?) for mouth).I wonder if sucking eases anxiety via some kind of TRP pathway https://t.co/CROFZ4WEJvhttps://t.co/fioM8Mn45H
"These findings provide a cellular basis for the inhibition of itch by chemical counterstimuli and suggest that kappa opioids may be a broadly effective therapy for pathological itch."https://t.co/TQCe2VCbirhttps://t.co/eZgQ1efG2A
Itch and pain.Relief by sex? Via dynorphin which hits the same space as TRPM8.https://t.co/rPFJJxNZLo
So basally Kellogg correctly observed that masturbation relieves pain, and then blamed pain for driving excessive masturbation.I see nothing directly wrong in his reasoning or observations, only that he's framing it as a moral failure and a vice and not just basic biology. https://t.co/4ltlsmNBC7
"demonstrate that TRPM8, a menthol- and cold-activated ion channel, is essential for cooling to relieve itch, suggesting that pharmacologic TRPM8 activation should be explored further as an antipruritic strategy."https://t.co/AMgkI9hqgO
I'm on fire right now.https://t.co/Kix0qAVIkH
"The oldest law of genetics says that gametes combine randomly, but experiments hint that sometimes eggs select sperm actively for their genetic assets."https://t.co/oKNrxJVJgzhttps://t.co/rWIol9BQgk
Tiny sack of nutrients.https://t.co/sw2ykjEE0E
Amazing how complex nature can be.https://t.co/LR4KLsOeWY
A dance with TRP receptors regulate sperm Ca2+ in mouse oocyte. https://t.co/yNAMSo3tqI
> "Calcium is an essential ion which regulates sperm motility, capacitation and the acrosome reaction (AR), three processes necessary for successful fertilization. The AR enables the spermatozoon to penetrate into the egg." https://t.co/lKGsfkVS04
That mouse TRP2 gene is a homologue to TRPC2 in humans. Pseudogenes are fucking weird (hah).https://t.co/EYfsmypIWc
TRPC, being a cellular receptor family, does a lot more than interact with sperm function. https://t.co/cQP9dSI2Ct https://t.co/CagD0bzd4D
We are only now discovering the vast array of impacts that TRPC* can have on a cell. Largely thanks to Knock Out (KO) mice.https://t.co/0IehtKwrp5
*squeaks and runs away*https://t.co/LMuczwiXDU
There is a good chance anything you think you know about genetics and sexual selection is probably wrong in some subtle but profound way. https://t.co/VRFTNcVMbY
Gonna dig thru herbal TCM recipes for fertility to see if I can find stuff that acts on sperm health.https://t.co/sHUDDhKC0K
Finally found a set of books that attempts to extrapolate TCM and Ayurveda and connects eastern traditions with more recent western findings on the gut microbiome.Author doesn't have a big web presence, but found a talk https://t.co/9EXNI3tgwqhttps://t.co/uwxXdWCNRO https://t.co/9nIn2tRqI4
Learned about Rosemary Gladstar's "Zoom Balls" yesterday. She said it let you walk for hours without rest & it would be good for a long night of fucking (though she phrased it with less vulgarity).https://t.co/tETyMDm6fBI know this, it's a unix system.https://t.co/6S5uJpsNQP
I wonder how many semen health relevant TRP pathways I can hit at the same time.https://t.co/4ELuqkFGwx
Get stronger. Channel vital heat.https://t.co/C0T6F0lw0y
Ha"mTOR [...] particularly its role on spermatogonial stem cell (SSC) maintenance and differentiation, [...] physiology of Sertoli cells (SCs), responsible for blood–testis barrier maintenance/restructuring and the nutritional support of spermatogenesis."https://t.co/mE1DQAQhG9
Eat Dog's Balls to avoid needing to go full dog butt.https://t.co/k5jPfe8Obs
mTOR -> Thymus -> T Cell Developmentlol dog butts"The present study also implies that long-term usage of [rapamycin] might increase the risk of autoimmunity by impairing thymic epithelial cell] maturation and function." https://t.co/6NqYFh2ltIhttps://t.co/cQfTp64zCk https://t.co/rd2vS8Gx2O
Look, I can call these things whatever I want.https://t.co/wK2y1YIR43https://t.co/k9clQ8cfry
"folk names for the plants they regularly used, like eye of newt for mustard seed or wool of bat for moss. Many historians believe that witches used these gruesome sounding names so that their spells and herbal remedies could not be easily copied."https://t.co/z5CZboRn1l
Fresh dogs balls and a spicy red rocket for what ails yeah. https://t.co/Rvy5o8E56Z https://t.co/2X89vVmED5
When you go to Wikipedia to look it up, they show you horseradish flowers.https://t.co/o0ZJ43TQzM https://t.co/ODqZdvL5ui
What no body tells you, is those flowers are hung like a horse.https://t.co/EbSemhg8iv
That's the joke. The berries look like inflamed testes and hot peppers vaguely like tiny cocks.I'm just being very silly and immature on a serious level.https://t.co/kiTZceIMRF.
What if I told you that all of this research is promulgated on a hypothesis that I can cure my girlfriend's type 2 diabetes thru diet by using various terpenes to bias her microbiome... and all this about dicks is proxy research to hormone-microbe ties.https://t.co/zZ9obc2BGY
I want to "single handedly" solve some hard problems...You know what I'm saying?Don't get it yet? Got fuck yourself.https://t.co/WhGomcUDOD
"Regularly eating a small serving of dried goji berries may help prevent or delay the development of age-related macular degeneration, or AMD, in healthy middle-aged people" https://t.co/RBWOc3DnnX🤣https://t.co/WMLh8D1JOC