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This is fun, having better cholesterol function might help neutralize the impact of lipopolysaccharide by directly neutralizing it? (in mice) https://t.co/X45xsIlZQ3 https://t.co/wrf0fIPRsg
... impaired lipid function in diabetes type II as risk factor for Alzheimer's?"update current findings that implicate GI tract microbiome-derived LPS as an important internal contributor to inflammatory degeneration in the CNS."https://t.co/YYF9r0Zp7vhttps://t.co/0z1AiGFULn
This is a neat question. I have no idea!https://t.co/QKnEl95Yzl
Mixing ideas together like a kind of mental alchemy.https://t.co/aXZwZ8aACY
Restoring gut bacteria that impact lipid function, by undoing stress-induced immune system changes and disruption.https://t.co/pNWOdZjhuI
High cholesterol in blood plasma from the body not getting enough, being seen as heart disease risk?Do you:1) eat less cholesterol?2) eat more cholesterol?3) optimize cholesterol absorption pathways to let the body regulate better by improving bile salts and liver function?
Stress does weird things to the body.What if to undo the damage, we don't simply have to reduce stress... but we have to fix gut bacteria in some people?https://t.co/p71vh4DANW
trauma + stress => metabolic downregulation => immune system stop => more sickness.the immune system shuts down during hibernation.It's Robert Sapolsky's Ideas but applied thru a lens of gut bacteria playing a role in the regulation of metabolism. https://t.co/v0KM0exTgT
"increasing evidence that chronic exposure to stress is a risk factor for AD and may also adversely affect the course of the disease. [...] we present the current literature on the association of specific personality traits and the risk of developing AD."https://t.co/eyLxjWoPbx
"The authors also found that an SGDG dramatically suppresses LPS-induced gene expression & pro-inflammatory cytokines in macrophages & microglia via the NF-ĪŗB pathway." ala @agingdoc1https://t.co/d1by1Wgra1https://t.co/QcTRDOR8P8
It's lipids. It's bile.https://t.co/S7zSwIU0XX
All of these problems.https://t.co/w6AxSkMB75
Pollutionā”ļøtrpa1/trpv1 in lung ā”ļø???ā”ļøtrpa1/trpv1 in gutā”ļøbacteria problems+inflammation (crohn's?)ā”ļøpoor intestinal absorption of lipidsā”ļøbrain issues.So pollutionā”ļølower IQ. If we can figure out the ??? Bit.TL:DR: substance peepeepoopoo.https://t.co/hMbOii4yAR
When you can't get enough fat to feed the 'ants' that protect your body, they start eating you instead. Your brain cells are tasty fat storage.https://t.co/PAFv97zoVh
Glucose ala mTORC1 via AMPKhttps://t.co/zbGY9r2Mot
mTORC1 impacts => liver metabolism shifthttps://t.co/M8lnhAqpTT
How bout them apples.https://t.co/sxktFUZszI
Or at least working on your gut microbiome thru diet.https://t.co/xjF3GLq1Q3
@_gg_eashwarran "Keywords: THC, CBD, EAE, Multiple sclerosis, Gut microbiome, Akkermansia muciniphila, SCFAs, LPS"šNeat that they're going into LPS too.I think this bacteria is at a nexus of EAE and IBD. Same autoimmune/cytokine profile. https://t.co/ShM2Irtlvp
Hey @rivatez can you ask Alex Jones if he's been brown pilled yet? The globalists want to destroy our gut bacteria.https://t.co/CqBQJlSi7g
I gotta research those herbal supplements of his again.āAn examination of his business seems to indicate that the vast majority of Infowarsā revenue comes from sales of these dietary supplements. Infowars isnāt a media empireāitās a snake-oil empire.āhttps://t.co/Wsl0IuqXpN
Some snake oil is REEEEEEEEEEalhttps://t.co/jn1WdwyBQC
Snake oil doesn't work if you can't digest the oil.It's a lipid.https://t.co/AUi0PKdC7H
What kind of lipids tho?https://t.co/ki4bFhoJM6
I wanna make rats smarter too, but not by injecting human brains. that's dumb.https://t.co/3iwKfKKNNY
Idea fusion. It's like sensor fusion within a sensor network, but about ideas within the space of the social network.https://t.co/mjj1SO3H8I
Learning about Immune systems by studying how ants store memories in the environment and path find as a form of collaborative (stable) diffusion.https://t.co/GSGMLwyUMj
"immune response requires immune cells to search efficiently and effectively [...] just as different species of ants have evolved diverse search strategies to forage effectively for a variety of resources in a variety of habitats."https://t.co/aJMIY242ohhttps://t.co/2rfpS84U31
I may know more about pathfinding than anyone on the planet.https://t.co/5T2pI8lqA2
I am so good at using search engines, I can usually depend on the first entry being exactly what I want.https://t.co/4TgPQN7wLP
Optimal foraging behaviors.I hallucinate this kind of stuff in my dreams.https://t.co/nXkbh8ZxUAhttps://t.co/Sd0WsywaU8
The fun way to make people laugh is to keep a whole bunch of weird ass shit in your head and find interesting connections between them.https://t.co/oFHzuavELF
Weird ass shit? The joke's write themselves.https://t.co/PfQdu21jge
Defective analogies, get it? It's about pooping..."This highlights the relationships amongst good jokes, defective analogies, and frame blends. "https://t.co/lzptTAAK0g
Defecation of analorgies.I can type poop jokes into google to hit papers published by Hofstadter.I can find paths between ideas, and I don't even know what 'slippage humor' is.https://t.co/vhMfpEQsvV https://t.co/rKcRpGEoY5
"a frame blend results when elements extracted from two distinct frames are spliced together to yield a new hybrid frame."What does that even mean? I'm just mashing up ideas together until it makes me laugh.https://t.co/YWMBPwbc4J
Frame blends? What even is that? I just think it's funny to make poop jokes and shitpost about freudianisms.https://t.co/YYXCbVz45n
All this stuff about LPS impacting disease states via fats is just a really elaborate fart joke cuz I thought it was funny that gram-negative bacteria are immune to THC https://t.co/XEJyU9wFoxhttps://t.co/0drsxQgKVc
Trees aren't real and can't hurt you.https://t.co/tWmzq97MwA
My farts smell like skunk cuz i'm in ketosis and I'm burning fat."However, this group has recently acquired evidence that under conditions where fat metabolism is greatly increased there is a substantial release of THC from fat stores into the blood." https://t.co/D30MWC4Gfz
I am still burning off all the lipids that I saved up some THC with.https://t.co/6pWbL0cP42
@mchapiro I can literally smell my own self change when I am in ketosis. I start leaking chemicals trapped in my body fat and it changes my arm pit smell. After a couple of weeks my skin starts smelling of cheese (antiinflammatory butryate/propinate producing bacteria)
I made a joke once about becoming a midwife. Thats why I was learning about how LPS can induce preterm births in mice & the role endocannabinoids play in uterine contraction.So tell me, what happens if you don't get enough omega-3 fats in your system?https://t.co/yGVuLxgXLw
"Our results provide a distinct line of evidence supporting the conclusion that sufficient omega-3 intake can reduce the risk of [preterm birth]"https://t.co/KI5CSiRe2k
That's right, I just used frame blends to go from hofstader and freudian anal-orgies all the way back to the mainline ideas in this thread about LPS and fat by way of my mom being fucked.So now I can say LPS might have caused my autism.https://t.co/ZhGXsSKUBF
I just found out that while I was breast fed for the first month of my life, my mom switched me over to Enfamil Soy formula. It turns out that the first DHA supplemented soy formula was released in 2002.Whelp. I guess I was lucky to have the colostrum?https://t.co/HhW15RswVu
Am I giving you a head ache yet?The first link here is actually an ad. Someone is trying to advertise a class action lawsuit against tylenol.But look, the first organic link is what I wanted to show you. Duck duck go fuck yourself. https://t.co/RUlCyQk0bc
First scientific article on duckduckgo for "Tylenol LPS" is spooky."Thus, the ending to this tale is that, like Dr. Jekyll and Mr. Hyde, the two villains appear to be different but seen in the proper light, they might be recognized as one in the same."https://t.co/O3PK0OlxBC https://t.co/TAXVF1L0ap
Rosehips reduce inflammation.https://t.co/lwqq34SPyHIts funny how that works. Maybe it's terpenes?https://t.co/pWksfSV5ikAlmost like these are connected somehow.https://t.co/QBe8D4m9gs
Tylenol is (the d)evil.https://t.co/0iiy0Us772
Tylenol is against my religion now."Turmeric (curcumin) appears to [maybe be usable] as a stand-alone analgesic, or in analgesic combinations as part of opioid-, NSAID- or paracetamol (acetaminophen)-sparing strategies." https://t.co/bR0QXgF1EMhttps://t.co/Toscyht5x2
Fix your cox to improve your fertility.https://t.co/Khndyc4buO
"While itās more difficult to assess sperm quantity and quality in non-Western countries, the researchers say, anecdotal and clinical evidence suggest men in developing countries may be struggling as well."https://t.co/IP9JHKqvus(h/t @autismepi) https://t.co/J9dIGqi0fS
Don't smoke the wacky-tobaccy, that I'll make your dick not work and your sperm impaired.. Use Tylenol instead!and other absurdities of advertisment driven propaganda of the modern western world.https://t.co/lmHyCvBy4G
LETS FUCKING GO!https://t.co/lM7We6sXbC
I am more confident that tylenol can cause autism than I am that dog shit would fix my mTOR and cause me to not have crohn's symptoms. And I haven't had crohn's disease symptoms for nearly 11 months because I literally ate dog shit.https://t.co/0J8gFOlK4K
I want to become resistant to pain meds in the water.https://t.co/MH5EIIFCmQ
My autistic scREEEEEEching will continue until muh water quality improves.https://t.co/wbpvrpXkRB
What neutralizes Tylenol?https://t.co/k518qS4nYI
"introduce the hairy root cell culture of A. rusticana L. as a suitable model system to study the fate of acetaminophen in plant tissues. Our first results point to the direction of plants being able to take up and detoxify the model substrate paracetamol"https://t.co/J83qErH4sY
Did you know you can grow your own horseradish?https://t.co/LjWgyTiKjE
"Lung Epithelial TRPA1 Mediates Lipopolysaccharide-Induced Lung Inflammation in Bronchial Epithelial Cells and Mice" https://t.co/uKkZAYkX5FTaste like Tylenol.https://t.co/tGk6kaf7p2
Yep, it burns. I Know what pain tastes like."Our study provides a molecular mechanism for the antinociceptive effect of acetaminophen and discloses spinal TRPA1 activation as a potential pharmacological strategy to alleviate pain."https://t.co/mPwrW0ShbT
Please stop poisoning babies.https://t.co/JR0C09dcMA
Tylenol is evil because inconclusive results are because we don't take into account gut bacteria's impacts on medication.https://t.co/vf35CwUKcW
JJ's razor applies.https://t.co/nfox1SJ5Md
Tired: real authentic snake oil lowers inflammation by improving cholesterol function to fight LPSWired: real authentic snake venom lowers inflammation by knocking down mast cell activation and histamine response to LPShttps://t.co/CPKVHkd7Zl
Careful with Turmeric, it can cause liver problems. Interestingly it can also be mitigated by NAC, much like Tylenol.https://t.co/TaKNSQcNrY
Why would taking turmeric for a month straight cause the same problem as Tylenol? Can you treat it with garlic (SAC)?https://t.co/DHXcxOMlR1
If you destroy rat's gut bacteria, garlic and taurine don't help much."Supplementation with N-acetylcysteine and taurine failed to restore glutathione content in liver of streptozotocin-induced diabetics rats but protected from oxidative stress"https://t.co/ry830KSFL6
Tho the effect from streptozotocin is possibly indirect and the impacts on gut might be via the induction of diabetes itself?"Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice"https://t.co/OXOoi2388d
Oh neat, the TRP pathway that is commonly mutated it autistics is sensitive to LPS.https://t.co/eQjL4YEOz8
Green Tea does neat things to LPShttps://t.co/szBvrReZUahttps://t.co/ZwWZEZbs1G
"Green tea and resveratrol may prevent the formation of Alzheimer's plaques" https://t.co/OIuc1eXRJN
"Resveratrol inhibits LPSāinduced inflammation through suppressing the signaling cascades of TLR4āNFāĪŗB/MAPKs/IRF3" https://t.co/Gxu1T9nlhY
Sure do wonder what's going on here."Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimerās Disease"https://t.co/b1flEF2CULhttps://t.co/Ej10G8SyxH
So... Does garlic impact Alzheimer's via attenuating LPS induced inflammation by way of immune cell regulation, nitric oxide levels, and blood brain barrier degradation (oh, and ameliorating lipid disfunction). Asking for a friend. https://t.co/Cocw2r8MM5
Is garlic protecting my veins?"The effects of allicin on lipopolysaccharide (LPS)-induced vascular oxidative stress and inflammation in cultured human umbilical vein endothelial cells (HUVECs) and the mechanisms underlying these effects were studied." https://t.co/EV62npSSCv
If it's an inflammatory disorder involved in gut problems, then stinging nettles / formic acid would help.https://t.co/CPKVHkd7Zl
I really wanna see what black mountain ant tastes like.https://t.co/qU3KfypCxB
Have you tried garlic, to solve the problem?"Proteomic Analysis of the Effects of Aged Garlic Extract and its FruArg Component on Lipopolysaccharide-induced Neuroinflammatory Response in Microglial Cells"https://t.co/CPQQqfcqvGhttps://t.co/iK9rmPV1s0
"If we simply increased the number of microglial cells, we also would increase the amount of nitric oxide in the brain. Excessive production of nitric oxide leads to brain cell damage and promotes neurodegenerative diseases [...]However" https://t.co/I4CZxwfGsa
"Metal induced neurodegeneration can also be attenuated and cognitive abilities of patients suffering from neurological diseases can be ameliorates by allicin administration." https://t.co/Dse1AABBCQ
What is garlic doing that helps with all of this stuff tied to neurodegeneration? It seems like a miracle cure.https://t.co/fUNpXOi5Vi
"Green tea extract (GTE) due to its content of catechins reveals strong antioxidative activity, which is manifested by its ability to inhibit free radical generation, scavenge free radicals and chelate transition metal ions" https://t.co/E646zcXApU
"Resveratrol prevents oxidation of LDL by chelating copper" https://t.co/JhqJtsi9QA
"Children exposed to long-term use of paracetamol during pregnancy had substantially adverse developmental outcomes at 3 years of age." [2013]https://t.co/scrRYpzIjmhttps://t.co/BfrGRlaESJ
"Long-term exposure to paracetamol in utero was associated with modestly increased risks of motor milestone delay and impaired communication skills among children at 18 months." [2016] https://t.co/XYTrxR7pLMhttps://t.co/zUX1zhvwK4
Lead poisoning directly affects the impacts of inflammation. "Kishikawa et al. (1998) had previously shown that Pb exposure increases mRNA and IL-6 protein levels in the brains of adult mice treated with lipopolysaccharide (LPS)" https://t.co/4lqaEm75UI
Could lead poisoning be mimicking the impact of the increased LPS response we see from Tylenol?With Tylenol driving more, and stuff like Lead making us more sensitive to it?https://t.co/gozOfY4Am5
"identified autism-associated abnormalities in cells that support neurons in the brain and spinal cord. [...] autism brains, the microglia appeared to be perpetually activated, with their genes for inflammation responses turned on."https://t.co/qYY4JhowKBhttps://t.co/PPNWAjebUo
Fun fact: Garlic (mentioned earlier in this thread) is an effective natural chelator of lead!If it also neutralizes LPS, and acts on ACE related problems seen in GI issues in autistics, then it might be really helpful here.Someone should test it.https://t.co/xOKT5xTmUr
"If garlic is so effective at pulling lead out of chickensā bodies, why not more directly exploit āgarlic feedingā by eating it ourselves? Well, there had never been a study on the ability of garlic to help lead-exposed humans untilā¦2012?" https://t.co/zLTr2nYjIe https://t.co/62jnJqPXt0
In other news, I now own 60 lbs of raw honey, and I know how to use it. :3https://t.co/QGqe6geHrj https://t.co/4TpMjrZKec
Performing a ritual with garlic and honey to cure the demons in my gut, like one does.https://t.co/zVdHTvqg96
