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UltimApe@ultimapeβ€’ over 3 years ago

This checks out. Will be neat to see if changing my mom's gut fixes her muscle pain like mine went away. https://t.co/SM3ROhddEz

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𝕄𝕒𝕝 π”Ύπ•–π•€π•€π•–π•£π•šπ•₯@OhMalGβ€’ over 3 years ago

ok TRPs detect capsaicin, heat, menthol, cold and pain. they detect pain by the interiors of burst cells attaching as ligands to it. so fibromyalgia is just extra bursty cells? explains why poking hurts. the what but not the why or treatment but I have to leave some for others πŸ’…πŸ»

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8/19/2022
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UltimApe@ultimapeβ€’ over 3 years ago
Replying to @ultimape

This study on gut bacteria in Mice impact that Lysophosphatidylcholines thing https://t.co/x7aiyFHhk8 and drives colitis (a kind of IBD) symptoms.This may explain why acting on TRPs helped me deal with crohn's before the FMT seemed to fix it.https://t.co/jWRfKCf0wX

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8/19/2022
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UltimApe@ultimapeβ€’ over 3 years ago
Replying to @ultimape

The question then becomes if the FMT was a direct fix for the gut bacteria in question, or if the LysoPCs is mediated by something else. Like did immune function shifts leading to less production/better metabolism of it? https://t.co/7tUS85brwZ

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8/19/2022
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UltimApe@ultimapeβ€’ over 3 years ago
Replying to @ultimape

That TRPA1 binding -> pain effect would perhaps also be occurring due to just general muscles cell death / immune activation phenomena.So did what I believe fixed my muscles do something here?

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8/19/2022
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UltimApe@ultimapeβ€’ over 3 years ago
Replying to @ultimape

It's also possible my mom doesn't have Fibromyalgia (misdiag?), and all her symptoms are just M.S.

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8/19/2022
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UltimApe@ultimapeβ€’ over 3 years ago
Replying to @ultimape

"These data suggest that altered metabolic function may underlie failure of remyelination in multiple sclerosis lesions and that mTOR signaling may be of therapeutic potential for promoting remyelination." https://t.co/sPIUDwlaoy

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8/19/2022
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UltimApe@ultimapeβ€’ over 3 years ago
Replying to @ultimape

which suggests IBD + M.S. mimic fibromyalgia pain because of shared TRPA1 associated weirdness?

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8/19/2022