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🧵 Thread (88 tweets)
Watching this to see if they mention anything about human hibernation or limb regrowth / wound healing. https://t.co/fvgTIwML9Z
Hehe. Starts out asking about channeling animal spirits.https://t.co/kAFPtfESXc
Channeling them spirits.https://t.co/Rwx47ok7rY
A very particular kind of channeling is happening here.https://t.co/ep8kY7Yn7M
(I'm intentionally ignoring the reference to Keynes)https://t.co/M7OFCsIgVm
How do we monetize opensource?https://t.co/lTHuKfEvEv
Do we want to monetize health?https://t.co/5hSdypUmbC
Neoliberal 'hand of the free market' ideology suggests that what can't be monetized can't be funded.https://t.co/aC3EhKdbDh
Spending time on this.https://t.co/Ru0XlGPwuq
Wasting my time researching ways to make it less costly to do research.https://t.co/yM1ETlMMgT
Vitalik mentioned molechdao as an example of novel funding models <3https://t.co/SOEvG7ez7u
"DAOs aren't as optimal as they could be [...] what kind of common flaws do you observer in them today, and how would you like to see them fixed in the future"https://t.co/z0ENqJXude
"I think people are not imaginative enough with governance mechanisms..."yes.https://t.co/oxfODbGu0g
I also want people to be more open minded.https://t.co/HzdFyyXRcp
"These people are fundamentally curiosity driven. In otherwords: They're not really working for social good at all... They understand that their discoveries [...] may eventually have humanitarian benefits, but they don't do things/ choose what to work on for that purpose..." 😈
I decide what to research by asking myself what would be funny.The nature of having skin in the game helps bias my investigations toward health, but that is a side effect.https://t.co/HZeHH7hlk6
Now they're talking about Rapmycin.Specifically about how the profit and Intelectual property motive isn't there to fund trials.https://t.co/IoA4ARfWePI think mTOR is interesting, but I am going about it in a completely tangential way.https://t.co/k5jPfe8Obs
mTOR -> Thymus -> T Cell Developmentlol dog butts"The present study also implies that long-term usage of [rapamycin] might increase the risk of autoimmunity by impairing thymic epithelial cell] maturation and function." https://t.co/6NqYFh2ltIhttps://t.co/cQfTp64zCk https://t.co/rd2vS8Gx2O
Aubrey is talking about how metformin has been used for ages and has no IP around it due to being off-patent."you're not going to get any investors, or people with profit motive, to fund that... and thats why there has been a couple of years of delay"
He's saying they don't' have to do safety tests because the work has already been done.You fucking what.https://t.co/KQ0iHVSsIt
Do you even know what "Metformin-induced Pseudoporphyria" even is?Just because the FDA has gone and done clinical testing on limited populations doesn't mean it's safe to use in non-standard dosages to treat aging.A blind spot.https://t.co/NoNlh7E4vm
Do you notice how often Aubrey is Coughing?https://t.co/r9bb2xzjr4It's safe tho. right? https://t.co/tzRnAc3r3S
DO YOU EVER DISAGREE WITH ONE OF THE LEADING FIGURE HEADS OF ANTIAGING RESEARCH? and can cite sources about why he's dumb?https://t.co/5zcaRkieDk
"Rapamycin — unlike metformin — has some pretty severe side effect" — Aubrey de Grey *coughs*You fucking what.https://t.co/fvfr5AVAIT
I can't breath because I'm laughing so hard. It's totally not the smooth muscle tissues in my lungs leading to pervasive wheezing associated with COPD.What are the fungal and bacterial driven epigenetic pathways anyway?https://t.co/5frgh7VX6d
Tim Peterson asks: "Do you have any thoughts her on how cryptocurrencies can help here to improve this grant-to-drug hit rate?"yes, yes, I do.https://t.co/3pQbmOBiXE
Every time I think about this, I get really really excited.The idea of using a NFT as an anchor for impromptu decentralized crowdsourced research project funding platform is why I know so much about crowdfunding!https://t.co/GhBPKWDfit
Been a long time coming. I've been thinking about how to do this since I learned about the ideas that inspired Vitalik.https://t.co/syIdHj4pfl
Disrupt all the things.https://t.co/d9EmN4I6KO
Excess use of rapamycin completely destroys glucose metabolism. This suggests it might destroy skeletal muscles due to not being able to get glucose in at all?https://t.co/m4L4OmMaoM
If PPARgamma (PPARγ) activation can reverse that effect as discussed in that paper, it suggests low dose CBD might be useful to mitigate rapamycin overuse.https://t.co/oxTc8BpDwk
I don't understand the fetish we have for anti-aging research. Looking at it under a naïve lens, its just about money and funding for pharmaceutical options. Seems short sighted.https://t.co/NFdCiXxGbQ
Further, what is the deal with NMDA contamination in metformin?And why is it in so many other pills? Did someone fuck up a bio-reactor? https://t.co/JTIrkJYokZ
Did you know lactic acid bacteria can metabolize N-Nitrosodimethylamine (NDMA) and prevent it's toxicity?https://t.co/94DTN2xgcPhttps://t.co/Jgl4JWIwUp
@Catgirl_agorism @againstutopia Geez"The highest NDMA detection from the tested samples was 1565 ng per tablet, which, when commonly taken four times a day, is 65 times the United States Food and Drug Administration (FDA) acceptable daily intake limit."https://t.co/6Sof2AossB
We don't know how NMDA causes cancer? "International Agency for Research on Cancer (IARC) classifies NDMA as a group 2A carcinogen. This means it’s “probably carcinogenic to humans,” and there is sufficient evidence that it causes cancer in humans." https://t.co/NDhJgKydLC
HuhWhat a funny filename "C:\unzipped\CIC-38\CICAD38-N-nitrosodimethylamine0.PDF"This says soil bacteria can make it from amines and nitrates/nitrites.So did a nitrate based preservative get dirty?https://t.co/fL7VRfaElj https://t.co/soPgTc99Fb
In researching Hydrazine production by various soil bacteria, I found out that NDMA may be produced by a common sterilization procedure targeting exactly those kinds soil bacteria contaminates. 🤔https://t.co/gWFjQddBgu
Gonna learn a bunch of different ways to synthesize metformin and also try to find out where production facilities are and try see how they deal with their water.https://t.co/cNUwxwL54y
In learning about ways for removing hydrogen sulfide using copper, I realized that the traditional chlorine shock method to oxidize hydrogen sulfide may also be acting similarly as ozone.https://t.co/qqCWqyUShD
"3–5 mg Cl2 per L fully eliminated DMZ and its ozone–NDMA-formation potential [...] but ammonia or dissolved organic matter decreased the elimination efficiency [... was a feasible option to eliminate N,N-dimethylhydrazine-type ozone–NDMA precursors."https://t.co/VC3aDlVeK8
Not sure, but this this implies copper/brass/bronze pipes could help here, with added antibacterail action.But IF this is true, biofilm formation on pipes would hamper this process over time.https://t.co/FB3GyN7vnt
I already know hydrogen sulfide corrodes copper, but it seems that hydrazine and copper interacts in quite complex ways. May even make copper nanoparticles somehow. https://t.co/y9aC96gSr9This may not actually be a good idea. https://t.co/lwMRkzbGPL
Jump around and find out.https://t.co/2uIGxtBBx4
We're not accounting for metabolite transformation in wastewater."The results show six new NDMA precursor compounds that have not been previously reported in the literature, including compounds with hydrazone and carbamate moieties." https://t.co/Zh9ehiCEgP
N-nitroso-diemthylamineN-nitroso-irbesartanN-nitroso-quinaprilhttps://t.co/FMZo1ebjje3 times is a pattern. There is something deeply wrong with how these meds are being made for this to keep happening. Get your shit together.
This method for detection of NDMA precursors using ion chromatography should be translatable to the other nitrosamines.https://t.co/j7ousb9HOD
Time to get my GF off Losartan incase we see N-Nitroso-N-methyl-4-aminobutyric acid again.https://t.co/6uOZk2Y9T9
I still can't get over the fact that bacteria and fungus are making *rocket fuel* (hydrazine) as a form of energy storage. I thought ATP was weird.https://t.co/TdJWaTASm6
"Anammox bacteria produce hydrazine similar to the two-step industrial Olin-Raschig process developed in 1906. So could we use the protein to speed up industrial hydrazine production? No"https://t.co/BXpFigfKzS
"Another point on our bucket list is to have anammox produce rocket fuel on a large scale. To achieve this, we will need to know how to circumvent the enzyme even more efficiently" https://t.co/UfedTpF4UQhttps://t.co/iGDzTrPvKz
Drink up. I'm sure the water's fine.https://t.co/z0RIcv3UBF
I love how many ways I've found where we're basically poisoning ourselves.https://t.co/sqE5kUMuJ1
Funny things happen in mice when you try to tweak their mTOR.Can you imagine basing all your findings on 80 years of ignorant mouse studies biasing models of disease?https://t.co/5IDrKBihua
"Unexpectedly, inhibition of the mTOR pathway both by chronic rapamycin treatment and by genetic means decreases longevity of Terc−/− mice, in marked contrast to lifespan extension in similarly treated wild-type mice."https://t.co/Nd0cLKRg6Phttps://t.co/goFCS57EHv
My ideas are bigger than my capabilities.https://t.co/r6wvetz4aD
Fasting -> Inhibits mTORFasting -> lipid metabolism regulationFasting -> P-Glycoprotein expression changesFasting -> Immune system shiftsFasting -> Blood Brain Barrier function + toxin clearance.Fasting -> Better Intestinal barrier functionFasting? Nah. Acute Aestivation. https://t.co/RWydlod7x9
Have you tried reframing the question to try and solve the problem?https://t.co/uSQdyBb9qk
A funny thing, a name.https://t.co/46XeBX1FP8
A rose by any other name would still smell like feces.But if you haven't got the sense (of smell) to call it what it is... You'll bias your thinking toward your map, and ignore the territory.Wake up and smell the roses.https://t.co/23qcxcJJqv
Running circles."Targeted Regulation of PI3K/Akt/mTOR/NF-κB Signaling by Indole Compounds and their Derivatives: Mechanistic Details and Biological Implications for Cancer Therapy"https://t.co/tQS8wlRUAohttps://t.co/KOLFy1Na30
"Went to school and I was very nervousNo one knew me, no one knew meHello, teacher, tell me what's my lessonLook right through me, look right through me"🎶https://t.co/jWVSg2qDTv
"The Therapeutic Prospects of Naturally Occurring and Synthetic Indole Alkaloids for Depression and Anxiety Disorders" https://t.co/t4BXngsWm5https://t.co/cCdkMQhvFn
IL-6 and cortisol are in a weird relationship, and its easier to think of this as mediated by emotions."indicative of anxiety-specific effects on inflammatory activity, and highlight a pathway by which anxiety may increase risk for inflammatory diseases"https://t.co/kSDja7hFfr
I run in circles because the world is mad.https://t.co/4uvQKCg5Ln
It looks like you are trying to bootstrap a decentralized cryptocurrency based science funding model.Would be a shame if someone were to come along and parasite off of the secondary market by focusing on return-on-investment.https://t.co/02uFTIRT98
So many mice fall out.https://t.co/7nV5PDNcZG
There's more than one way to shift your metabolic setpoint and gear your body prefer lipid signaling, my fren.https://t.co/6UnfBg7z2ahttps://t.co/PBz2WvRYhl https://t.co/hmh9mtMbUr
This looks like a neat way to bootstrap something akin to a patron system for open source. Reminds me many open source places are using Open Collective.May have to do if I wanna fund DIY bio tools via @PraetorLabs and not depend on grant chasing.https://t.co/sgOgsPapsn
Reduction of biological age up to 11 years you say?https://t.co/7XWSpYlhivSure is funny that it's exactly the way I found to do it without eating dog feces.https://t.co/dea0L3SSSE https://t.co/WgnYmH52Cy
@nosilverv @no_identd Woman goes to a wellness retreat, aligns chakra, heals stomach lining, gets gut massages, reduces stress related pathways tied to insulin & gut inflammation. Hitting TRPs tied to inflammation + plant based liquid diet. Leaves cured of ulcerative colitis.https://t.co/6e5rdjw45T
I literally have all of these nutrients right now in the room with me.https://t.co/YwANMlu3A9I have been exploring ancient healing traditions... and make shitposts about it.https://t.co/42SDRUREko https://t.co/Gv6AVqtGLW
My entire inspiration for anti-aging was figuring out that ant's gut bacteria modulate their DNA!You can learn a lot about health and disease by studying the ant.https://t.co/dNVuNl4kI6
"Bi-directional effects of vitamin B12 and methotrexate on Daphnia magna fitness and genomic methylation""links between nutrition, DNA methylation and caste determination have been identified in social insects such as honeybees and ants."https://t.co/cZ1Y5SzmHU https://t.co/CZv19wW1iT
Even my earlier attempt at fixing my gut health was inspired by studying ant epigenetics and how what they eat impacts their physiology.https://t.co/OzA53DPw9s
What's your favorite? Mine is rosehip because it's oil neutralizes Malassezia, which is suspected of being one of of the causes of Crohn's disease. https://t.co/ExWBuND3wdhttps://t.co/VaazfwUKtp
Blue Zones are kinda cool too. Lots of neat fermented foods in Blue Zones.https://t.co/UxL4TW9FE6
@garyvee My right hook? I ate dog feces in a pill for 30 days. I got younger as a result. Have a blood test showing it.My model of thinking aligns w/ findings from gut microbiome studies in people who live 100+ and it's impact on bile.Aging like a fine wine :)https://t.co/UK0bnWxmOg
My entire shtick with the dog shit is that it's fixing my bile acid function via gut bacteria shifts combined wit FXR signaling + diet.https://t.co/37NYQfC52g
My hunch is that when and older person has a surgery, they rapidly decrease their bile acid output due to the stress and antibiotics, leading to accelerated aging and health decline.https://t.co/k6bS1MrYex
Aajonus Vunderplants was right about wanting to avoid being giving antibiotics, even if his reasoning was based on weird ideas about intracellular detergent.His entire focus was on improving bile. Because of a childhood Vagotomy meaning he struggled to produce Hydrocloric Acid.
I seek out people with neat ideas about aging and diet.https://t.co/36ZElgaIYt
Are you keeping up?https://t.co/FHerHE0z1Z
I have learned what energetics are within the domain of herbalism. And there are correspondences between them and TCM/Ayurvedic medical uses of plants.And I have learned that I already know them. I just have to translate between memetic frames.https://t.co/7EkN6uNtTy
"Dr. Fitzgerald is the author of Younger You and a naturopathic physician specializing in functional medicine."How wonderful. Glad to see I am choosing well.https://t.co/fQcUQYNshJ
It's amazing how often this pattern shows up.Anti-aging drug operates via gut microbiota.https://t.co/tU0r0bPqg3
It's amazing how fast you can find answers if you reject the common modeling of a sick society that can't get anywhere because of restrictions around funding. The herbal route I was exploring earlier in this thread even has results.https://t.co/l7LwsqvOsX
Just dump in more drugs. I'm sure that will work (to increase the share holder's bottom line).https://t.co/zeVnwMssUR