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We're all going to fucking diehttps://t.co/AYAM0n8xxn
Congratulations humanity, your fear of death and panic over vaccines means we'll all soon be consuming a concoction of gene editing pills that can be pissed out into our environment and kill entire ecosystem of bacteria. This is a grey goo scenario.
Imagining a situation where they kill Staphylococcus Aureus to prevent staph infections, but neglect to mention that it doesn't just target Aureus (MRSA), but also accidentally Staphylococcus hominis and Staphylococcus epidermis... thus making you more susceptible to reinfection.
We're all going to die because nobody knows how anything works and the only mechanism we have to stop all this bullshit is misguided mechanisms of shame based on tribal politicking. Most of us worried about gene editing babies is because of folkore and myths from pop culture.
In most microbiome associated diseases, its not 'bad bacteria', but ecosystem destruction. Getting rid of the 'bad bacteria' won't magically rejuvenate the gut.There is another option.https://t.co/nqweUCxuuu
I'm not even against using CRISPR to target disease via microbes, but you've got to work WITH the bacteria in a way that supports internal evolution and feedback cycles. This avoids large swaths of ecosystem risk that causing mutations in vivo could cause.https://t.co/y4jEhMlFNB
bacteria, viruses, fungus... at war in your gut. We have a word for probiotics.Do we have a word for pro-fungal species, or friendly viruses?https://t.co/dmnGL5f7tC
bacterialcidal pesticides and fungal boosting antibiotics in the water? What could go-oh shit. "a singularly apocalyptic fungus that’s unrivaled in its ability not only to kill animals, but to delete entire species from existence."https://t.co/9AUxzW76oN
Lets, uh, CRISPR the bacteria... I mean, what are the chases that ends up mutating a Bacteriophage and make it so we're even less able to defend against it?https://t.co/yXxzjzimez
I can imagine the headlines "gut bacteria target with CRISPR to be attacke by immune system ends up transferring it's mutation to virus, now weaponized by rogue bacteria"https://t.co/wfoxP3lP0x
"Even with limited longitudinal short-read sequence data, significant evolutionary dynamics—shaped by both positive and negative selection—can be detected on human microbiomes. This may only be the tip of the iceberg"https://t.co/jtVU33zu4I
"Future efforts to combine metagenomic- and isolate-based approaches, e.g., by incorporating long-range linkage information [41, 89, 90], will be crucial for building a more detailed understanding of these evolutionary processes."https://t.co/cpRBXo5GDQ https://t.co/krVLIyyOgk
TL:DR; we don't really have any idea how any of this works, but some startup has decided it's a good idea to go ahead and use a tool that viruses use to inject mutations. Mutations that may be subject to lateral gene transfer.https://t.co/ErBVEsVYOo
The best case scenario is it does nothing."While one bacterial strain may be killed by expansion of a specific cognate phage, closely related bacteria may still be present in those same metagenomes because they will have similar niche preferences."https://t.co/5O3pUVqE12
"Viruses are utilizing bacterial components to enter target cells, while bacteria capitalize on the destructive nature of virus replication to gain footholds into previously inaccessible regions. Throughout the body these microorganisms can collaborate"https://t.co/ntTAdlNmyC
Nobody is looking for this stuff. The only one who is is a journalist who's intentionally seeking novelty at the frontier across multiple silos of science.https://t.co/tyf6xRUcZi
Interplay between fungal and bacterial colonies in the gut... less than 6 months old."These results are a first step toward understanding of the functional connections between fungi and bacteria in the gut."https://t.co/W8LTLZ2V8d
"bacteria aren’t the only problem: new research suggests that potentially deadly fungal infections are becoming more drug resistant as well. [...] humans are using so many of these antibiotics that they are getting into the environment and affecting it."https://t.co/Dju5IbCLx6
"Yet even as world health leaders have pleaded for more restraint in prescribing antimicrobial drugs to combat bacteria and fungi [...] gluttonous overuse of them in hospitals, clinics and farming has continued."https://t.co/abKMO7eKf0
I just saw that this targets 'immune compromised' people. This means babies, elderly, and my mom. Can you imagine if this keeps spreading and children start dying everywhere. https://t.co/Tu5ouH9UpB
That is a black swan level event on the scale of the 1918 flu.https://t.co/AqVxRzaPLo https://t.co/wHMl7qaYYr
Of course, something that has infested western centralized hospital systems isn't really has dangerous as the flu - which spreads differently. But there are knock on effects similar to the impact of MRSA on healthcare outcomes.TL;DR: invest in midwifes systems.
We have ways to screen for it.https://t.co/JVTBEyv15U
But it seems odd that the only way we have to 'treat' it is with more anti-fungals.This seems like a bad thing "Because this organism appears to develop resistance quickly"https://t.co/i9YHtgKD7qThis is idiotic?
It hate reading all of these ways to fight various candida infections, only to read that the main way we are fighting this stuff in the wild is thru more antibiotics/fungicides.https://t.co/DZyLrGLPWp
Combing thru Reddit, I found an article that has a map of areas where C auris has been reported.https://t.co/wgJ8738uTH which references https://t.co/g1dokobpsNI'm... right on the border of New York. Yay! 😭 https://t.co/fUuKSpZSKW
I'm sure antibiotics in the water aren't helping this at all. But hey if funguses are killing of the things that eat the insects, maybe we'll see the insects come back?https://t.co/qkGZDxfiWM
“if you sat down and thought, ‘What would I design to kill bats, and how would I design it?’ and you took time to think about the worst possible combination of factors that a pathogen would have, this would be it,”https://t.co/i2XiOYs5lk
"Bruce Ames, one of the key founders of the field of toxicology back in the 1970s, wrote a landmark paper in 1990 called Dietary pesticides (99.99% all natural), in which, he showcased some of the many naturally-occurring pesticides we ingest every day" 🤔https://t.co/AerS1PZ4pj
I hate when my ideas collide, be cause now i'm thinking about how babies (and the mother's immune system changes) might be an overlooked factor in our quest to CRISPR immune system targeting bacteria.https://t.co/dPI0RrT4ic
I'm excited about shotgun sequencing of microbiome/virome/mycobiome genome because I think it's far more fruitful to illuminate this space in terms of the byproducts that diverse colonies of microbes can possibly produce (and then work back from there).
As it stands we're only just becoming able to do that research. In the meantime this kind of thing seems like the phenomena of the lamp-post (get it... illuminate? I made a pun) https://t.co/q2RWnjqGtp
Our approach of trying implicate one particular microbe seems a hold-out from the germ theory of disease trying to finger specific disease actors. Further entrenched by entire pharmacological industry (+grant system) focused on finding specific microbes to vaccinate against.
Same sort of problem is evident in mouse/rat research on the microbiome - we're testing against sterile uniform mice, but the problem seems to be an ecosystem thing and we're "missing the forest for the trees".https://t.co/OLZxd3LxJR
I'm left wondering what it means to have an immune system at all.https://t.co/AGzXS3flM0
Right now there are bits of viral dna floating around in the air waiting to glom with another virus, infiltrate your body and infect your cells.Some virus have their own immune system bits.https://t.co/MsHLBQ89zeSome virus infect other virus.https://t.co/upNqziuNdj
Wonderful image showing the general case of how antibiotics get into our foodsupply. From"Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems"https://t.co/zECXnjZG6I (h/t @OxonAndrew) https://t.co/Du3kNq1HKp
One of the things I am profoundly and utterly dismayed by: How all of the efforts to test drug safety (on mice) are largely overlooking the large scale impact of fecal and urine in the water system, and impacts on things outside of one "model" species.https://t.co/CRSKYi7MiK
So we isolate rodents — a poor surrogate for human serotonin, gut microbiota, brain structure, & microglia / immune system function — then test 'em by torturing & seeing how long they struggle.This is foundation of pharmaceutical science?Is that right? Am I missing something?
Let's put some CRISPR'd bacteria in bats.What could go wrong?https://t.co/3Rl2IzuzW1
We could use a bunch of bats as incubators to bio engineer viruses, and then see if we can invent/test CRISPR based cures against them.https://t.co/l7JjT9inQo
Oh no, wait. We're just doing this without CRISPR in expedited trials on humans.https://t.co/yGPRSAUqFPTho we can use CAS13 to detect who has it, which is pretty interesting.https://t.co/f803VW85ya
I'm not freaking out about global supply chain issues, you are.https://t.co/YgSObMP48g
How to DIY vaccines? I ask myself."This DNA for making flu virus HA antigen is then combined with a baculovirus, a virus that infects invertebrates. This results in a “recombinant” virus."You fucking wat?https://t.co/zo99pqAevVhttps://t.co/YA06uYvTGr
“We don’t think of snails as particularly mobile, but the genetic evidence we found — that snails can traverse substantial distances — is a reminder of just how difficult it is to contain and control infectious diseases carried by animals and insects,”https://t.co/NL3GpW665b
"approach is different because the therapeutic proteins are encoded in the chicken's DNA and produced as part of the egg white"https://t.co/2mkgiSYZJACheckpoint DNA testing for genetic contamination, when? TL;DR: Why I'm never eating anything again.https://t.co/wdhq85SSyU
biohack the planet.https://t.co/Bk0bQqb58O
I wanna program RNA vaccines to elevate CD8+ T-cells, that sounds like a great plan. https://t.co/yZom3Dth89Maybe that will work against coronav... oh fuck mehttps://t.co/vcEgfVQtU9https://t.co/Dyg9WXEYD0
Cytokine storm? In my T cells?https://t.co/LZ6WaYhrEY
What we need is 30-50 feral hogs."In a new study published by Nature on Wednesday, those researchers highlight the possibility of deadly coronavirus transmission from bats to domesticated animals and, in turn, to humans." [2018]https://t.co/U1MG4We42D https://t.co/1v7wzjWYKE
FDA news on covid-19 related supply chain disruption.https://t.co/xM0i8rxRmbAnd their page specifically on drug shortages.https://t.co/tYCXlhChZCGlad they are on top of this.
Air pollution -> T Cellshttps://t.co/pMly6TP8BsMasks for pollution -> V Blood Pressurehttps://t.co/7jf7fCHdTvCD8+ T Cells -> ^ High Blood Pressurehttps://t.co/Kd5njBl22Q"CD8+ T cells [predominant] in human MS lesions"https://t.co/Ovs6G7687Uhttps://t.co/DSsTTEDFHO
(Well acthually) wearing N95+ masks improves your chances of surviving coronavirus by helping to prevent air pollution from prematurely exhausting CD8+ T Cells and may increase survival rate?https://t.co/QKzhT4t0EL
Instead of getting an N95+ mask. Consider instead spending that $ on a box fan and some air filters. Improving the air quality in your home may do more to improve your chances of survival than wearing a mask.https://t.co/xBj9nbdrSM
Home Depot sells air filters. One or two ought to last a long time (months if you don't smoke). 20inch x 20inch will fit a box fan near perfectly.https://t.co/ip4MgMkVJ6
You'll love my nuts. https://t.co/wpi4WSDUIJhttps://t.co/u3P3RPNUbO
36 eggs a day."The majority of studies have demonstrated significantly lower levels of Se in biological matrices of children with ASD compared to controls"https://t.co/id3Mdm2M81
"interventions designed to diminish oxidative damage and support methylation capacity could improve the health of individuals afflicted with ASD"https://t.co/PSPPb8vt7T
"moderate levels of ROS are necessary for the proper regulation of multiple facets of T cell biology, high levels of ROS can be damaging to T cells [...] cellular antioxidant mechanisms is critical for the maintenance of effective T cell-mediated immunity"https://t.co/yMlzeGZ0mM
"These results suggest that a combination of genetic and epigenetic factors, taking place during perinatal periods, results in a mtDNA template in children with autism similar to that expected for older individuals."https://t.co/xvn4Efk0lMhttps://t.co/pk9TFlcSMB
Bacteria farts.https://t.co/DoJVSEmEzh
and a side of red wine."Resveratrol, one of the most abundant polyphenols, with poor oral bioavailability, is considered as a scavenger of ROS and other free radicals."https://t.co/8n2eM6HbP9https://t.co/Vd05mSDKMm
@Mangan150 That B3 is particularly fascinatingIt's been shown to reduce obesity effects from high-fat diets https://t.co/TgAyiIUDVQ And may have synergistic effects https://t.co/KdLiwH7s2aAnd seems to operate similarly to resveratrol (red wine ingredient)https://t.co/xCI0VkyehT
"These results clearly highlight the antiglycation activity of niacin and its potential in preventing disease progression in diabetes."https://t.co/GIhPA2gi3vBRB, going to activate my T cells.https://t.co/A7wjpHQDgg
Fuck fuck fuck fuck fuck."The in vitro effect of some antibiotics on T-cells has been investigated. Clearly, a lot of them are able to modulate T-cell functions." [1987]https://t.co/cVTlEd38Wvhttps://t.co/kQbJ5w4kwm
What does a novel coronavirus have to do with a 380 tweet long thread I started in 2016?https://t.co/XKNP55hNHk
Music is a virus.And I'm dancing.Have you tried DMT?https://t.co/L14U9yoWaOYou know... dance music therapy.https://t.co/dxN8jliYwY
Dance Music Therapy improves immune function.https://t.co/cBbeMiwwFXand so does DMThttps://t.co/fYmIyUsedvhttps://t.co/8gJABdY4kq
I wonder what Tim Ferris knows about dancing.https://t.co/kwCuZfxahIhttps://t.co/4OOgoJyWgf
Madness is spending hours looking for how to maximize immune function in such a way as to avoid my lungs becoming engulfed in death.My current question; How do emotions and nutritional envirinoment impact T cell production?https://t.co/P3yGvWxQKt
Or a proxy of "Why does stress cause cancer?"Speaking in tongues.https://t.co/sQRInSTJXz
Remember that time we cut CDC funding back in 2017 and 2 years later that fungus they were worried about kept spreading?"We rely heavily on the Centers for Disease Control to protect New Yorkers from global health threats"https://t.co/NcxFq6Iqd5 https://t.co/f1kLSQ2om8
I don't care about politics. I care about viruses.https://t.co/TjyBmZU709
I care about ideas, how they spread, and metacontagion.https://t.co/v5x9xuYxJ2
I care about viruses because I want to know how cells, and by extension brain cells, communicate.https://t.co/Pxz6G3WaOa
The world is so much bigger than the way we frame disease vectors.https://t.co/ekgiE6n5sS
I dream about markets as bodies, and cells as humans, and wonder about ATP and other signaling molecules as emergent money. As signaling goods that cells build to trade ideas and share energy. https://t.co/4EfGR6Id0M
In the homeostatic systems taht control our internal immune system, we have to find a balance between reaction and over reaction. Too slow and we die, too fast and we die.Goldilocks zoneshttps://t.co/VVFXtlXn9J
Take initiative. You are part of a clueless unskilled mob. But it doesn't have to be that way.I believe in you.https://t.co/CZiXySRw6r
Take initiative. You are part of a clueless unskilled mob. But it doesn't have to be that way.I believe in you.https://t.co/zpbnrLlGAf
"That result, along with others included in a paper released last weekend—in preprint form and not yet peer-reviewed—suggests that we may be entering an era of developing new Crispr-based weapons against deadly viruses,"https://t.co/IqvtihNZDC
Coating myself with salt as a protection charm against evil.https://t.co/ANsL7tCtYz
I'm trying to figure out how to engineer my skin to feed a colony of microbes that produce erythromycin and other anti-viral compounds to act as a barrier against disease.Don't need to wash your hands if your body's holobiont is naturally antiviral. 😇🤫https://t.co/1rvJi1yNwG
And making jokes about orgies.https://t.co/vpkjK8NGhZ
Salty Boi"skin is a dry, acidic, lipid-rich, high-salt environment without exogenous nutrient sources, and therefore has low microbial biomass. By contrast, the gut is moist and has abundant nutrients and a thick layer of mucin"https://t.co/NtSdgWyiqqhttps://t.co/k3Dvgpg29E
Gargling with salt to get the thought of semen out of my brain.https://t.co/ZlILgRP7lr
"The next step is to take lab-made DNA that codes for the designed protein, stick it into E. coli bacteria, and wait for the bugs to follow the genetic instructions, manufacturing the desired protein like a tiny, living assembly line"https://t.co/xfdKvgfOre
Nano-particle protein printer go brrr.https://t.co/s3gebDYp0x
"then modified the proteins to make inorganic materials, such as gold nanoparticlesand quantum dots, to grow on the biofilms. By doing so, the researchers engineered self-growing E. coli biofilms that could conduct electricity or emit fluorescence."https://t.co/artgTxuBNV
Watched a Youtube video by the head of an engineering department at google, on building a dual-use medical devices.Occurred to me the 4chan DIY build thread were just as good (if not better) and the designs shared predated it by at least 10 days.Oh no.https://t.co/hL9GVDnfQm
Echoing. Echoing.https://t.co/476IBLIoDI
"None of this begins to explore the coming challenges stemming from advances in human genomic modification or the unintended consequences or active misuse of CRISPR gene-editing technologies."https://t.co/SKI0mWrN3F
This week's highlights include:Seeing a synthetic plants made from 9 different genomesLearning about a microscopic needle made from origami that can pierce individual cells.I may one day complete my wish of becoming able to eat the sun.
I saw this a year or two ago.https://t.co/QOlibAMDqo while exploring novel virus ideas. Not sure if it cites that paper directly, but lots of fun papers about it in the description.https://t.co/WwhGM7G7CI
Viroids are related to prions in terms of their weird ability to replicate.https://t.co/KtE4pkkAht
While investigating skin bacteria a bit, I found a human dwelling bacteria strain that — when infected by a bacteriophage — can end up becoming pathogenic via a horizontal gene transfer effect.https://t.co/HcA1gkSF9P https://t.co/sGpL1B8Y2J
I think a lot about the fact that we're at a point with technology where we can beam *descriptions* of viruses around the world via the internet, and a lab can recreate them.Selfish Replicators going to replicate.https://t.co/v3ELwsLxBE https://t.co/XnftXguMWX
(oirginal: https://t.co/HS7DIv1OAP) https://t.co/kTWbWF5mmS
I got a bacterial infection while trying to ramp my immune system up to fight viruses. Phages that live in your mucus are important for regulating the gut microbiota and it's not a good idea to kill them. Your virome is your friend. https://t.co/J2bqqAdmPthttps://t.co/961jzVZaZu
At least I think I had a bacterial infection. I had all the symptoms of one. I may have over-done it with zinc ala https://t.co/hrXYR2zTPF and triggered something weird thanks to mucosa related GI issues.No way to know for certain; no healthcare. https://t.co/ZMJP9M29s8
Def had all the symptoms of bacterial gastroenteritis. It was miserable.Phage therapy is fascinating tho. https://t.co/70sQUJhryA
"This discovery provides strong evidence that fluoxetine directly causes multi-antibiotic resistance via genetic mutation, based on a laboratory study using E.coli as a model microorganism."https://t.co/GytpdHy8Rzs/pesticides/SSRIs/https://t.co/sqE5kUMuJ1
"the most frequently detected antidepressants in fish brains were fluoxetine, norfluoxetine (a transformation product of fluoxetine), sertraline, and norsertraline (a transformation product of sertraline)."https://t.co/2VIEdI3jA8
"that we’re being unwittingly drugged when we drink a glass of ordinary tap water smacks of dystopian science fiction or political conspiracy theory. [...] Whether or not this psychoactive waste has any effect on the human nervous system remains unclear" https://t.co/flPQfMpm5Y
"Antidepressant and antianxiety medications are found everywhere, in sewage, surface water, ground water, drinking water, soil, and accumulating in wildlife tissues. [...] potential ability to disrupt [...] aquatic organisms is extensive."https://t.co/Fnw8tg8dj9
Tired: making the f**** **y.Wired: making the fish docile.https://t.co/wNbTueaF51
Fish heads, fish heads; eat them up, yum!https://t.co/E4BDW4SHTRhttps://t.co/0mhx79eFCO
@wrathofgnon @lovecryption This also happens with tylenol.The idea that SSRIs/SNRIs impact empathy is the foundational thinking within the documentary "I am fish head".I have a hunch on how this operates. I suspect anything that negatively impacts vagus nerve function (oft via gut bacteria) will do it.
I had this neat idea: What if the reason why eating fish makes me feel better is that I'm getting fluoxetine via my diet? And now I'm wondering what would happen if I ate fish from the stream. https://t.co/6zpTdA1B9n https://t.co/HzB1SKm3aT
And I thought the only thing I had to worry about with canned fish was the histamines.https://t.co/E86Itwyfld
@Grimhood @GSommerlund Oh yeah, absolutely. I love sardines and canned salmon. Great way to get healthy lipids (cholesterol helps with vitamin D production when in the sun), collagen w/ skin, and cooked bones are an easy way to get calcium when absorbed w/ bile acid. Mayo is a great way to get eggs.
I wonder if anyone has looked at antidepressant levels in wild bears.https://t.co/fQfiAiUDYF
Tired: making the F**** **y.Wired: making the fish trans bullies."Prozac is seeping out of sewage treatment plants and into rivers and lakes, turning male minnows into female murderers"https://t.co/jaUOUjPqKF
"These field results mirrored those gathered in the lab, giving some degree of confidence that lab-based experiments may be providing good information about the effects of drugs in the wild." https://t.co/qdDaYfShpk
"Herein, we have reviewed the literature (1990–2018) illustrating the rising environmental pharmaceutical contamination concerns as well as remediation efforts emphasizing adsorption."https://t.co/hzyKEbIu0I
"Then it just gets weirder. The feathers contained a half dozen other drugs: Prozac, an antihistamine, a fungicide, a sex hormone, and caffeine. Why doesn’t the poultry industry just say no? "https://t.co/KphKNw0qYM