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🧵 Thread (295 tweets)

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UltimApe@ultimapeabout 7 years ago

It'd be really funny if, in order to fix my sleep issues, I have to destroy the concept of paradigm shifts in science and reformulate the theory of evolution in terms D’Arcy Wentworth Thompson's theories thru a foundation in autopoeisis.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

I'm currently undermining aspects of Darwin's theories on the origins of man, and language, because of an interest in female bear penises.https://t.co/3h0uHaA3mq

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UltimApe@ultimapeover 8 years ago

Hofstadter Pinker Dennet Wilson and Dawkins are all arguing over who's map is correct. They're locked into a system of prestige.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Basically, I'm assuming Darwin's theories on sexual selection and language were wrong and biased, but his prestige and influence make people hesitant to doubt.TL;DR: I'm pulling a Feynman on Darwin using gay bears.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Let me tell you a story about shape shifting dinosaurs & systems of prestige + categorizations neuter explorations of truth: https://t.co/icQ16KIbrZ

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

The concept of paradigm shifts being a non-linear phenomena seems due to science itself being turned into a prestige based academic club.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

I'm not a big fan of Kuhn's thinking as a much better explaining seems rooted in theories about network contagion and social reputation systems, and how information spreads and is filtered by networks.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Once you start looking at it in terms of cybernetics and information theory, Kuhn's ideas seem antiquated. If anything Girard and Durkheim seem to have been closer to the idea of discovery and invention of ideas than Kuhn.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Networks of ideas percolating up and filtered by a system built on the back of rich white colonists perpetuating institutions and rituals built on the back of the systems of priesthood.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

A more real world example of this effect happening due to networks - consider Mary Anning's story https://t.co/ywhENYHI2U and how her discoveries https://t.co/qLWWXciZ4S filtered up thru into Charles Darwin's theories of evolution. https://t.co/LcIjjPqFVL

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Studying Darwin's early childhood and collegiate career, you quickly see how Museums influenced his early habits of collecting and identifying species of plants. A cultural interest in fossils and working in museums influenced how he was able to reach conclusions that he made.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

The other half of the story can be seen in how his ideas on sexual selection and language development are based on hunches stemming from his experiences with his wife.https://t.co/Y3oTyucOvU

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Words evolved as a sexual selection ritual? Nah.https://t.co/6ZN4STworW

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UltimApe@ultimapeabout 8 years ago

What *ARE* Words, Seriously.https://t.co/vBlJuisoUU

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

if we want to improve the situation, we have to have a more accurate view of the phenomena and not this stupid myth of an idea that is little more than a long winded version of collective unconscious bullshit psychology Kuhn tried to ram into sociological explanations of science.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

In the mean time, that prestige thing seems like forced scarcity. If it really is a network, why are we imposing centralized hierarchy based prestige systems? This doesn't strike me as useful for a flourishing scientific system in the digital age.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

So I'm reading research on bear shit and bear dicks and bacterial influences on gender and plants. Undermining popular notions of gender in the process. Because fuck the patriarchy or something.https://t.co/CXTEnIRNYE

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UltimApe@ultimapeabout 7 years ago

Tired: using vegan poop for FMTWired: using hibernating bear poop for FMT, avoiding the need to peeInspired; using hibernating bear bacteria to recycle urine for missions to mars.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Because I'm rejecting a sort of cultural hegemony that has creeped in around these systems of prestige among high level scientific thought.https://t.co/SeZfSTXiJa

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Another way to say: fuck that noise.https://t.co/gVsFZ10gKz

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UltimApe@ultimapeover 8 years ago

"As a result, there is a considerable amount of intellectual tyranny in the name of science." — Feynmanhttps://t.co/FDR6v9YRjB https://t.co/chlScxpQ6t

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

In other news, can someone tell me how scientists get the bear shit they feed to mice? I may or many not be trying to influence my microbiome so that I don't have to pee anymore.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Everybody's like "oh look at me I'm doing the Feynman method".Oh, rly? Me too! Why I'm researching bears shittin plant bacteria to study how a circadian rhythm works...https://t.co/Y9qB31NC79

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UltimApe@ultimapealmost 9 years ago

"Study hard what interests you the most in the most undisciplined, irreverent and original manner possible." — Feynman

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Oh wait, you mean the other Feynman method. The one that everyone cargo-cults because of a cult of personality around him. My bad.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Current status: reading research on how plant bacterial process nitrogen's in the soil and turn them into proteins. Doing this as a proxy for trying to figure out what kind of soil bacteria bears might be eating in the fall via roots.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

I suspect the feedback loops in their gut related to urea => protein synthesis is also simultaneously driving with feedback loop that allows them to sleep for so long.Circadian rhythm is partly controlled by adipose tissue and as such has strong metabolic factors. Hibernate?

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

So in the end, the underlying assumption I have: that gender itself is really a game theoretic process about metabolic costs feeding into and risk/reward dynamics of groups of animals. All of it feeding into genetic and microbial adaptions.TL;DR:https://t.co/NXKbSsXaGW

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

So when I read titles like"Abnormal Sexual Differentiation in Black Bears (Ursus americanus) and Brown Bears (Ursus arctos)" https://t.co/F6ALvZlr5jAll I can think is "your hetronormative bias is showing, lulz"

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

And remember that even Darwin struggled with ants.https://t.co/DZMrnF75Kp

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

"A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.” https://t.co/2GbiLZJBNn

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Squint enough at memetics and mimetics, and after a while you see that they same basic forces being described by two different silos of thought. Or perhaps, two competing cultures.https://t.co/vAi5hm6C07

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Memetics ought be a strong foundational theories by which we describe how Habitus evolves & how societies react to forces in the environment. But of course thats not going to happen. They're locked behind two dueling silos of prestige, policing each other endlessly. Ivory towers.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Memetic theory as the study of how the symbolic and narrative forces both propagate and mutate? Studying how people imitate each other?

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

A body of memes that influence how you act, evolving thru cultural transmission, what's that? As I see it, these are the underlying systems that lead to the concepts of Cultural Hegemony. Its the same fucking thing.https://t.co/YP6cSLYGrE

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UltimApe@ultimapeabout 9 years ago

mutation : shitposting, clickbaiting, & insight pornmeme flow : cultural appropriationmemetic drift : schoolnatural selection: dank memes

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

My current obsession: Steelmaning social constructionism using gametheoretic models of risk/reward systems. Trying to merge it w/ evo-psych and the emerging understanding of gene/culture feedback loops.https://t.co/Os40FGZfpK

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UltimApe@ultimapeover 9 years ago

My idea: understanding genetics, biochemistry, behavior psychology, and sociobiology, are at the core of identifying their "best selves".

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Exploring epigenetics as vertical transfer of microbiome + other forms of contagion when splayed against food norms. How cultural ritual + memetics (mimesis) adapt to resource density & environment.https://t.co/ES3IZ5SsSI

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UltimApe@ultimapeabout 7 years ago

Spatial Temporal Autopoesis.Networks of Agents.Performative Mimiesis.https://t.co/rww7raAoYa

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Smash the lexical boundaries that reinforce linguistic silos.https://t.co/PhsQXT7iCt

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UltimApe@ultimapealmost 8 years ago

Refining learning modes of an organization to make better use of collective smarts and reducing silos. What's that?https://t.co/LvBXBmK4gc

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

FUCK wordshttps://t.co/ARSpsFBzkP

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UltimApe@ultimapeabout 9 years ago

TL;DR: language is hard. I don't know how to word.TL;DR: fuck language, words are dumb.TL;DR: we get signal? https://t.co/uxzypFArd5

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Call things by which they are not.Bridge the gap of inferential distance.Make rope bridges and ladders on the ivory towers.Turn the world into your playground.https://t.co/w9qOw0wQSt

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UltimApe@ultimapeabout 9 years ago

Breaking free of leaky categorical boundaries. Pipe, this is not. Words are tyranny over the curious mind. Ooblek!!!https://t.co/mSKueO8PKz

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

"Sometimes he could be such a dick: He was a big fan of puns and word games, and Folio 44 of his Codex Arundel contains a long list of playful synonyms for penis."

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Exhume history. Consume history. Recapitulate. Let them eat cake.Navigating maps of meaning, cybernetics to change the heading.Exploring the future with an eye on the past. Adjust. Adjust.Expanding meta narrative templates forever in a loop.METAtics.https://t.co/5NDXTEa8i7

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UltimApe@ultimapeover 8 years ago

Reading my old work & remember how I discovered memetics: via researching tradition & myths thru lens of skepticism.https://t.co/KdXabDXfcp https://t.co/SEEQvXVylU

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Cannibalizing dead ideas.

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7/17/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

If science advances one funeral at a time...We can advance it faster by cannibalizing ideas before they've expired?https://t.co/YvE8iNNPEg

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UltimApe@ultimapealmost 8 years ago

Fuck your medical research silos and institutional norms around publication demands and systems of prestige. I'm going to do what I want.https://t.co/1wCZ5DNJ9q

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7/20/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

And perhaps expire some ideas entirely.https://t.co/ceIirqI9lY

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UltimApe@ultimapeover 9 years ago

"Darwin's conundrum: how selection could favour individually costly behaviours" #ants #beeshttps://t.co/3SqW4RJTd2 https://t.co/q8pbrs74xS

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7/20/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Missing the forest for the trees.https://t.co/m03twABa8I

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UltimApe@ultimapealmost 9 years ago

A major failures of imagination in our renaissance of genetic testing: to see that genes themselves cooperate and defect to reproduce.

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7/20/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

So in the end, the underlying assumption I have: that gender itself is really a game theoretic process about metabolic costs feeding into and risk/reward dynamics of groups of animals. All of it feeding into genetic and microbial adaptions.TL;DR:https://t.co/2cS2Bhcb3t

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7/20/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

There's a breed of turtles who breath thru their butt in low oxygen environments.There's a breed of turtles who pee thru their mouth in high salt environments.There's prob something out there that breaths thru eyeballs. 👏Nature👏don't👏give👏a👏fuck👏https://t.co/L7gyfacOAK

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UltimApe@ultimapeabout 9 years ago

@MADinMelbourne Throwing away preconceived notions & words like life, that blind us; and instead using "systems": https://t.co/wXEoM0hbXm

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7/20/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Just ordered a light therapy lamp:https://t.co/8ZzOXemQhIand blue light blocking glasses:https://t.co/OShd1vAhupNot much evidence it helps with S.A.D. but seem it might help with general depression, and could help me with Hypernychthemeria.Been saving up for a few months.

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9/13/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

I'm operating under a suspicion that Melatonin / light response is mediated by gut microbes via a response ala: https://t.co/8NLpQ7OJmy and possibly a strange socially mediated / immune interaction with insulin/serotonin ala https://t.co/wPkdvHmZKfAnd that humans can hibernate.

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9/13/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Hypothesis: reason we can smell chocolaty oil and swimming pools really well is that chocolate is derived from lactic acid producing bacteria and we are ureotelic - We're using scent not to hunt, but to monitor where other humans live? See also scent driven Westermarck effect.

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Or if we use it to hunt, we are long distance trackers hunting other large mammalian game animals as they migrate/ tracking eating monkies. Suggests bird bones frequency would be relatively recent finding among human dig sites?

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

I'm thinking about pissing in jugs to grow mass amounts of algea in the local mosquito puddles. This will grow more mosquitoes. Which will attract an influx of dragonflies which will bottom out the population. https://t.co/mMAVbTVl5T

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UltimApe@ultimapealmost 8 years ago

TL;DR: I think I'm basically proving out Peter Turchin's theories of elite overproduction as side-effect of a theory about swarm dynamics. https://t.co/HIigvUJBqJ

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

I gotta get ahold of this bacteria first: https://t.co/2njo4SOYv0

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

After the population bottoms out, I can use this bacteria to prevent them from re-growing.https://t.co/yOftmM4Whf

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

All the extra algea from the urea might attract more frogs. Which will eat the dragonflies. Tl;DR: there might be a resurgence of Belostomatidae. This will make people want to build fewer water features in their backyard. Problem solved.https://t.co/9i89VTUrOt

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UltimApe@ultimapeabout 8 years ago

You may be wondering why I am trying to breed tadpoles / catch a frog. Now you know: https://t.co/91CG1B3xzs

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Is it against the law to dump urine in random puddles?Maybe.https://t.co/oNAiqDiGvh

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UltimApe@ultimapeabout 8 years ago

Did you know if you wanna buy land in Vermont, you have to have a permit to build a compostable toilet? Or pay $$$https://t.co/kPbE4LQe1y

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Hmm. Instead I should change my skin microbes?"After completing such a study with Anopheles gambiae, we would then need to test other mosquitoes. You might be surprised to learn that there are no fewer than three thousand species of mosquitoes on Earth"https://t.co/zK851654CV

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Rob Rhinehart got nothing on me. I already figured out how to do this without abusing medicine - Just working on the details."They also don't recommend abusing medicine so you stop shitting."https://t.co/KRPE6PSYTYhttps://t.co/503o4Opuf9

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UltimApe@ultimapeover 8 years ago

Always In my head:Rob Rhinehart's no poop via reduction of bacteria,Tim Ferris's poop weighs,Feynman's Trees:https://t.co/ALZseqao6b

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Funny that Bill Gates released a bunch of mosquitoes into a ted talk and it became famous. But some autistic kid in vermont saving up jugs of urine to dump in the local stagnant water would prob just get me thrown in jail. Both strike me as socially repugnant behavior.

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Tired: Making the frogs gay by manipulating their bacterial envirionmentWired: Making the mosquitoes gay by manipulating their bacterial environmenthttps://t.co/3MHbFgrw06

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UltimApe@ultimapeabout 7 years ago

There is apparently a way to use the dual signaling/toxicity of the Cane Toads against them. The poison that makes them unpalatable doubles as mechanism for tadpoles to hunt eggs. https://t.co/HOfO5GPFw0

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Oh, I forgot to talk about why I'm adding this talk about mosquitoes. I found out that we can fuck with mosquitoes by messing with their melatonin signaling. https://t.co/YQ5zVQNm7s which might be acting via the same mechanisms I noted here: https://t.co/3WfDgW2TT7

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UltimApe@ultimapeabout 7 years ago

I'm operating under a suspicion that Melatonin / light response is mediated by gut microbes via a response ala: https://t.co/8NLpQ7OJmy and possibly a strange socially mediated / immune interaction with insulin/serotonin ala https://t.co/wPkdvHmZKfAnd that humans can hibernate.

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

No comment...https://t.co/zD0swiMMCZ

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

I'm really just mad that humming birds in the backyard come to feed at same time that the mosquitoes start to bite. I also realized they are very sensitive to sunlight, atmospheric pressure, and humidity. Got me thinking that it might be happening in bees. https://t.co/RNenZRlskg

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9/15/2018
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UltimApe@ultimapeabout 7 years ago
Replying to @ultimape

Also 23andMe updated my gene report to confirm I have the super-attractive-to-mosquitoes genes I thought I did. I never actually bothered to look those up in the raw data, so it was serendipity.

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9/15/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

OK GOOGLE, HOW DO I BUY MEDICAL GRADE MOSQUITOES ON AMAZON.https://t.co/whIlOWCF7L

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UltimApe@ultimapealmost 7 years ago

@mwiik I have to figure out a way to do this in a controlled environment first, but in a way that doesn't involve manually feeding mosquitoes using my own blood. It seems I have the genes that make the immune response last extra long.https://t.co/Bq4d8Czn8u

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9/17/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

I bet if I search for Crispr mosquitoes a bit, Google's ad system will tell me the answer of where to by medical grade mosquitoes.https://t.co/LMuczwiXDU

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UltimApe@ultimapeabout 9 years ago

Google advert for knock-out mice... Thus begins rise of cargo-cult baas gene firms fueled by democratization of CRISPR & growthhacking. :(

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9/17/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Oh hey, I already have a solution to getting a supply of blood to feed mosquitoes. Thanks internet!https://t.co/otMYaRYOz6

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UltimApe@ultimapeabout 9 years ago

@literalbanana It's just my general curiosity about the internet: It's easier to buy an entire goat than it is to buy gallons of goat blood.

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9/17/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

"The physiological pattern of the sleep-wake cycle is influenced by external synchronizing agents such as light and social patterns" hmmmmmm https://t.co/DsixBAloXE https://t.co/lcvBjIzPwE

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UltimApe@ultimapeabout 7 years ago

I'm operating under a suspicion that Melatonin / light response is mediated by gut microbes via a response ala: https://t.co/8NLpQ7OJmy and possibly a strange socially mediated / immune interaction with insulin/serotonin ala https://t.co/wPkdvHmZKfAnd that humans can hibernate.

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9/21/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Searching 3 different ideas and I keep getting this thread as a strange attractor.This seems to belong here, but I don't know why.Words fail me.Recapitulating social phoenixes and historical memeplexes storied on the brain. Ideas time has forgotten, lost. A song in round. https://t.co/xJVUL8wwT5

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10/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

"Taken together, these models add up to a broad view that gender egalitarianism was not just part of the package but a fundamental aspect of what made us modern humans."https://t.co/DycXQJRfx4

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10/20/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

If humans can hibernate, you'd think it'd be embedded in our oral history; acting as instructions. Stories about lotus flowers, sirens, fae feeding parasite ridden food that makes you sleep. Goblins like Midgna who use sleep as a weapon. Sleeping Beauty bewitched by fae adjacent.

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11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Heh. Hibernating thru winter? yeah."the wicked fairy godmother is winter, who puts the Court to sleep with pricks of frost until the prince (spring) cuts away the brambles with his sword (a sunbeam) to allow the Sun to awaken sleeping princess (nature)."https://t.co/rwF1L8oqFd

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11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

One of the survival channels I'm following on YouTube recently released a video on tracking down bears and eating their shit to get extra calories.https://t.co/cvC0qTZqkU

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11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

In the YouTube video: "if you taste it, you know if it's a male or a female bear"... cc @The_Lagrangian @literalbananahttps://t.co/cHvcF6UgDw

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UltimApe@ultimapealmost 7 years ago

I can see the headline now..."Austistic man dies trying to harvest bear poop from grizzly den."This does give me ideas though. https://t.co/6VpiHtKBiq

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11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

I lived in the woods for a few months as a child while my family went homeless.Things are aligning quite nicely.https://t.co/NlxquR7HLo

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UltimApe@ultimapealmost 7 years ago

@The_Lagrangian No body seems to know how to get bear poop, i'm really mad.https://t.co/CXTEnIRNYE

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11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Is it legal to sell freshly harvested bear poop? I mean... Coffee is just a kind of cherry right? If you can sell coffee fermented via civet GI tract, imagine the premium i could get harvesting bear shit.https://t.co/d0ZhcX9Kho

4 0
11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Cody's lab has a video where he uses cherries to dissolve gold. I wonder if he's interested in making some interesting coffee.https://t.co/lfu0LgcVSV

2 0
11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Naturally harvested coffee beans, fermenting in a female bear's anus for an entire hibernation cycle!

1 0
11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Brands of coffee might include: brown, grizzly, and polar, and perhaps sloth.I bet I could sell this specialty coffee at the Vermont Teddy Bear Company.https://t.co/KF4fOcvw5k

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UltimApe@ultimapealmost 7 years ago

An exploration of coffee. I compiled together all the notes I've collected on coffee/tea and added some auxiliary bits to explore the history.https://t.co/P5H1Gsk4FV

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2 0
11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

The joke here is that he was really just eating blueberries mixed with some homemade pemmican. https://t.co/xQOOSuml9H

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UltimApe@ultimapealmost 7 years ago

One of the survival channels I'm following on YouTube recently released a video on tracking down bears and eating their shit to get extra calories.https://t.co/cvC0qTZqkU

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1 0
11/10/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Did you know that there is a very very small chance that an infertile mule can still have a child using female only dna transfer? https://t.co/H1gzYQZicN

1 0
12/2/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Now... what if the whole mitochondria dna thing where occasionally it's the male copy... happens?https://t.co/4GrgNUGiJM

2 0
12/2/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Genes are a mindfuck.https://t.co/KD6lYUGH1L

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12/2/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Oh wait. "genetic analysis of the gynandromorphs also discovered that one bee had 4 parents (three fathers and a mother) [...] This is the first report of a phenomena of a bee with two fathers and no mother in hymenoptera"https://t.co/MR9JTLQsfg

4 0
12/2/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Right now there are bits of viral dna floating around in the air waiting to glom with another virus, infiltrate your body and infect your cells.Some virus have their own immune system bits.https://t.co/MsHLBQ89zeSome virus infect other virus.https://t.co/upNqziuNdj

5 0
12/2/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Virus, just falling from the sky.https://t.co/pYuXKlpwnOWe're making tools that take samples from the air to see what we're coming in contact with.https://t.co/j3cUDWgKoAViruses, just fucking shit up because they can.https://t.co/1LvMtOjPLr

2 0
12/2/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

Vibrant Matter."Thus, we can argue, that for DNA based organisms, the introduction of infective collectives of RNA groups are a central driving force of evolution."https://t.co/gmNe2tspb3

1 0
12/2/2018
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UltimApe@ultimapealmost 7 years ago
Replying to @ultimape

"Psychological Hibernation"🐻https://t.co/dxoGzJg008

3 0
12/9/2018
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

How strange, who could have guessed."The microbiome is required for sexual dimorphism in gene expression and metabolism [...] Microbiota-derived metabolites and ghrelin likely drive these alterations"https://t.co/kIW1tBSOJMhttps://t.co/RYza7nDUHl

2 0
3/18/2019
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

So... yeah.https://t.co/STp0xJgUoy

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UltimApe@ultimapealmost 7 years ago

@Leon_Vandenberg @GMDxCo Ghrelin is interesting. I think H Pylori is doing weird things I can only describe as pushing the 'meta-Lamarckian' buttons in the immune system.https://t.co/CYRWJCH15Rhttps://t.co/uA9vavrmwMhttps://t.co/yPPjYACuOThttps://t.co/QPxA1hhSFX(h pylori -> stomach cancer.)

1 0
3 0
3/18/2019
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

Filling my brain up with odd connections between ideas, and then pruning away the ones that don't hold up to scrutiny.https://t.co/7QT1qTB90f

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UltimApe@ultimapeabout 7 years ago

Insulin regulation genes => Metformin => longevity 1) intermittent fasting => longevity (note: BDNF) https://t.co/KoBfP82ogi2) Fasting => improves Diabetes type II https://t.co/wQ1sST4pbm3) metformin + Type II => BDNFhttps://t.co/IByPYc8iV1https://t.co/xMKN8fXL3L

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2 0
3/18/2019
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

I wonder how many of the drugs we test are differently metabolized due to differing gut microbiome ecosystems. How many drugs have we just tossed away into the bin because of indeterminate effect sizes and other oddness? How many drugs are subject to other drug's impact on gut?

8 0
3/18/2019
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

How many drugs were tested on mice, but didn't work because it was metabolized by their gut before it could enter their bloodstream?https://t.co/RxUUCoCwRF

6 0
3/18/2019
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

its a cold adaptation. human hibernation next?https://t.co/DAXOal582X

3 0
6/11/2019
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

Ah yes the **checks notes** four genders.https://t.co/V1ZN0ZHnf3

6 1
6/11/2019
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

"have effectively four sexes, from their chromosomes to their reproductive behavior. It’s a striking finding that testifies to the power of using long-term field data to put genomics in the context of organismal biology."https://t.co/3ZpV6zrsrthttps://t.co/m03twABa8I

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UltimApe@ultimapealmost 9 years ago

A major failures of imagination in our renaissance of genetic testing: to see that genes themselves cooperate and defect to reproduce.

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2 0
6/11/2019
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

(found via someone who followed me on https://t.co/pvfP6oVwFv upon them adding one of my channels into their exploration of co-operation https://t.co/QXkcKl3hmb )

1 0
6/11/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

I like this model. It matches my own.https://t.co/6U4Qan8r5U

2 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Wonder weirdly, not too much, mostly sloth butts.https://t.co/nLpoJweK2y

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UltimApe@ultimapeover 6 years ago

If you were a sloth who's main way of cruising for chicks was floating down river, you'd also want to protect your flotation giving poop and avoid excreting it as long as possible.https://t.co/eIcXdIa9if

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0 1
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

What am I doing with my life? Meme'ing people into helping me in harvesting bear poop.https://t.co/Hx8aHqKZzu

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UltimApe@ultimapeabout 7 years ago

I read this paper, and think three things in quick succession: 1) If I understand this correctly... are they feeding mice bear poop? 2) How did the scientists acquire said bear poop. 3) Does this work on humans. https://t.co/oeCBndQoS5

3 1
0 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

That darwin, pretty cool guy. Had some neat ideas. Most of them wrong, but in new and interesting ways! Ain't afraid of nothing.https://t.co/l3srFYapU4

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UltimApe@ultimapeabout 6 years ago

To really get to the core of western science's framing of the world, you have to question the origin of many of our social mores and taboos. These manifest themselves in what we are 'allowed' to research. I see two major ones: sex/gender, and cannibalism. https://t.co/TOqmbt6WKp

2 0
1 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

It's a... Violent Pornography."The chorus is repeating itself like a Nabisco advertising. This is to show how advertising is brainwashing people."https://t.co/cBfwU3ilwdhttps://t.co/RgZKW6y8SA

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UltimApe@ultimapeover 6 years ago

We rethought serotonin signaling once. From "turning mice gay" to "this is just aggression & dominance behavior playing out". Just take it a step further."more mice will [be tortured] before scientists figure out exactly what role serotonin plays." https://t.co/fRh9F4Jq6t

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1 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Linguistic Intertextuality. Lewd'n up brains by encoding ideas ala relating ideas."They've got the Discovery Channel, don't they?We ain't nothin' but mammals—well, some of us, cannibalsWho cut other people open like cantaloupes"https://t.co/j1otXcEu0Vhttps://t.co/K4kMfN23I3

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UltimApe@ultimapeover 6 years ago

Mind vomit is just so much easier to remember over "memory palace" https://t.co/2oZdCoSBJT

1 0
0 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

NeuroLudeology. The study of mind games."Game studies, or ludology, is the study of games, the act of playing them, and the players and cultures surrounding them."Metagaming by meme'ing about games played at the level of culture.https://t.co/lddVolJr0H

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UltimApe@ultimapeover 8 years ago

Guys, maybe it's time for some metagame theory?

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0 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Stand back. I'm̶ D̶o̶i̶n̶g̶ ̶s̶c̶i̶e̶n̶c̶e̶ Perpetuating the heteropartriacy by way of embedding culture in the way we frame knowledge.Self-edifying constructs of divine bullshit. Jumping out of the system. https://t.co/oOFCESwQiL

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UltimApe@ultimapeabout 6 years ago

Survivorship bias in the applications of the theory of mimesis.https://t.co/qpTALCXau3

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2 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

JOOTSing myself with "bad" memes.JUICEing myself with "bad" memes.What if that's good? https://t.co/lbXbyHXVAj

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1 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Identifying boundaries of well tempered impostor syndrome vs valid self-criticism.Doubting oneself because of rationality, vs doubting oneself because of the systematic patriarchy.Gas-lighting: you think you're dumb. A system screaming at you about how you've no brain. https://t.co/3wU0VqFz8a

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1 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Poor Dorthy, we're not in Kansas - and by Kansas I mean your comfortable version of black-and-white faux-reality your social group uses to hide themselves of the wicked witchers of the world. https://t.co/kPTVJsDCEQ

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1 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Glimpseshttps://t.co/mXyvX5VXNx

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UltimApe@ultimapeover 8 years ago

Fleeting glimpses at clowns behind the curtain. Playing attention to the games being payed. Manipulation of the fear in your subconscious. https://t.co/sGoq07FhwZ

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0 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

To see the world from behind the veil.https://t.co/mi6yHnaask

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UltimApe@ultimapeabout 7 years ago

Pay no attention to "the man" behind the curtain.A systemic infection, hiding you from the rage.A behavior I'm seeing, of this I am certain.A coordinated infection, keeping you in your cage.

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0 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Splashing around in the kiddie pool.https://t.co/5tZfvlNQh8

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UltimApe@ultimapeover 6 years ago

Building scientific castles on sand and wondering why the ideas are falling into the encroaching ocean's wavefront.https://t.co/onIurRhZbU

1 0
1 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Pissing myself with laughter as I watch the adults trying to prevent their narrative sand castles from collapsing in the oncoming storm.https://t.co/onIurRhZbU

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UltimApe@ultimapeover 6 years ago

In @KevinSimler's explorative model of how networks interact to spread information https://t.co/A2SWThqKae his exploration of the way that incumbent (The "careerist") disrupt is fundamentally a wave-break phenomena? https://t.co/0p7vsjmNfE

5 1
0 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

“Ah you think sand is your ally?You merely adopted the sand.I was born in it, molded by it.I didn't see the rock until I was already a man,by then it was nothing to me but rigid!”🐜🦞🦀https://t.co/0hYPyNHMwh

0 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Laughing so hard I am parched.https://t.co/pka9dFyEUq

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UltimApe@ultimapealmost 7 years ago

Solitary red river ants dig mud holes to avoid drying out. #cuteoffhttps://t.co/dqcZMJIOT4 https://t.co/5sQG5R9ILf

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0 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Drowning in my tears. 😂https://t.co/XeGBr3KoqIhttps://t.co/RBqeKof5wwhttps://t.co/Cja0ku2lIUhttps://t.co/GBfkuaecOV

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UltimApe@ultimapeabout 7 years ago

And remember that even Darwin struggled with ants.https://t.co/DZMrnF75Kp

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0 0
7/1/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

I need to figure out how to store mice poop microbes for long enough to be able to get meaningful bacterial samples out of them. https://t.co/IobEzdo8CJ

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UltimApe@ultimapeabout 6 years ago

I think I figured out human hibernation, but I need to see if I can induce it in mice first (without torturing them).Let's just say: TH17 and impact on neuroinflammation and neurodegeneration at intersection of immune system & diet is very interesting.https://t.co/U3LiQZsmkr

4 0
0 0
8/24/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Tired: Descent with modification.Wired: Descent with cross pollination."indicated that horizontal gene transfer is more common than we expected in the human genome. This study provided insight into potential mechanisms of HGT in the human genome."https://t.co/VfUrNxT52v

2 0
8/28/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Inspired: viruses are just proto-spermatozoa.Hired: Gametes as safely controlled mutual parasitic infection to defend against entropic decay.https://t.co/9gd8eMzip0

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UltimApe@ultimapeabout 6 years ago

I'm left wondering what it means to have an immune system at all.https://t.co/AGzXS3flM0

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1 1
8/28/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

What is life? What does it mean to speciate?What would it take to cut off my arm and grow a new human like the starfish can?https://t.co/yB3XrhkXU0

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UltimApe@ultimapeabout 6 years ago

"Researchers agree it’s a long shot, but transmissible cancers could theoretically evolve into independent species. Certain weird parasites might be living proof."https://t.co/clVp53v6kP😆😂😢😭

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1 0
8/28/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

What even are plants anyway?https://t.co/FNKWb25SFD

1 0
8/28/2019
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UltimApe@ultimapeabout 6 years ago
Replying to @ultimape

Proto-gamete idea keeps popping up in my head.I don't even remember writing this: https://t.co/aFUPrdxapr

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UltimApe@ultimapeover 6 years ago

Been thinking about viruses as a sort of proto-gamete mechanism as a surrogate for genetic mutation/sexual differentiation off offspring. My thinking is that it would happen less often during binary fission. I should dig into how bacteria actually evolve on a mechanical level. https://t.co/g2MR7037bO

3 1
0 0
8/28/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

“Huxley was on to something back then, but his ideas have largely been ignored for a lack of understanding [...] this new research places affection between members of a pair, and mate fidelity, on a strong evolutionary footing.”https://t.co/IypdlgVEEP

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UltimApe@ultimapealmost 6 years ago

Been watching birds do bird things outside windows.Been wondering about pair bonding in crows & sparrows.Been waiting for someone to show that there are multiple successful strategies in mate choice.Been hoping someone would show (some) crows are poly.https://t.co/eehZbyicrw

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0 0
10/15/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"This is all much more complicated than the standard story of sperm meets egg, yet the result is still a healthy child. “It goes against so many of the rules of biology you’ve memorized in school,”https://t.co/FdtZ37sBUc

0 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I wonder how many people have two fathers. XYY but nothing is wrong?Technically speaking, if you're female, there's a good chance some of your genes came from your dad's mom. So you have two moms in a way.But this violates the narrative.https://t.co/cnAeU1L4Si

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UltimApe@ultimapealmost 7 years ago

Oh wait. "genetic analysis of the gynandromorphs also discovered that one bee had 4 parents (three fathers and a mother) [...] This is the first report of a phenomena of a bee with two fathers and no mother in hymenoptera"https://t.co/MR9JTLQsfg

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2 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What gender is an ant colony?No.What proportion of an ant colony's alates are flying sperm machines, and what proportion are reproductive MCVs. And does that differ in ant species with gamergates (reproductive workers)? And does it vary thru thru time?https://t.co/OJs3WG3mmj

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UltimApe@ultimapeabout 7 years ago

So in the end, the underlying assumption I have: that gender itself is really a game theoretic process about metabolic costs feeding into and risk/reward dynamics of groups of animals. All of it feeding into genetic and microbial adaptions.TL;DR:https://t.co/NXKbSsXaGW

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2 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I think about this a lot. On gender bending spoons and the nature of metaphor within the matrix. Glitching the social roles we play because it's hilarious to think about humans as ants.https://t.co/LMA7L8r8RK https://t.co/wZZxmrb8Zb

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UltimApe@ultimapeabout 6 years ago

Become the gender malfunction you want to see in the world

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0 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I think a lot about how people see a autistic female dog acting with gender non-confirming traits, project their particular cultural norms onto it, and then get mad about people not respecting the dogs perceived gender.

0 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I'm training the house's dog to lift up one leg to avoid having hip problems from squatting. I don't care about your gender sensitivities. I do care about hip dysplasia common in her breed.I'm going to laugh when people assume their gender.https://t.co/RRjHAzTg8I

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UltimApe@ultimapeabout 6 years ago

We live in a society where people get real mad if you misgender their dog. Dog please, I misgender myself.I look in a mirror and don't recognize me. If I am shaved w/ long hair, I refer to myself in my culturally imbued femme pronouns.Fuck language. https://t.co/bbA6QaNeaz

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1 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Like a broken record we get three responses when a dog doesn't perform their gender to human standards.People assume dog has hormone problems.People assume dog is asserting their dominanceSome asshat like me wonders about the dog's hips being inflamed.https://t.co/XPyNHVIuQ3

0 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I literally found a science paper that just excluded a dog that was likely autistic. Wiping normal dog variation under the rug so that they could tie their narrative up with a nice ribbon. This effect, compounded over, 100s of years is why we are biased.https://t.co/8oN4GvetO6

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UltimApe@ultimapealmost 10 years ago

“Since this dog was a persistent outlier, its salivary cortisol values were excluded from the data set.” https://t.co/otKEYniVv3

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2 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Using animals as slaves and emotional surrogates to raise children to treat them under the dominate narrative.https://t.co/bPs0sWTVKG

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UltimApe@ultimapeover 8 years ago

The pets we keep to help train our children how to treat other people like shit.https://t.co/Is5O0o4Pr1

2 0
2 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Scientists also wonder why evolution would bother making genes from scratch when so much gene-ready material already exists. Such basic questions are a sign of how young the field is." https://t.co/uIhVOxAxfq

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Do De novo mutations in human genetic disease?"What if you only see De Novo mutations because you're only testing for disease. Spot light effect much?https://t.co/vjBsqiOf7x

1 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Bacteria tweaking your father's immune system, evolving your genes."the de novo events we report are largely and perhaps almost entirely germline in origin and this affects our assessment of the contribution of new mutation to autism."https://t.co/sShYSdsB3s

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"no studies have comprehensively investigated the contribution of rapid, active changes in methylation (in contrast to passive changes during cell replication) to the regulatory programs induced by innate immune cells in response [infection]" [2015]https://t.co/DjXWBRdEuY

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Tired: finding the god in in the gapsWired: why are these gaps filled with life giving bacteria?Inspired: Farting is how I worship the sun.https://t.co/cDG5tjSLUO

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UltimApe@ultimapeover 6 years ago

Tired: Signing bowls to harmonize yourself with surrounding environment.Wired: Signing bowels to harmonize yourself with surrounding environment.Inspired: Culturally appropriating all the religions under a deluded sense of the mimeses of creation.https://t.co/qkYBcaEL6K

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4 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Insights from ants, applied to humans.if ants are able to selectively mash up genes as a side effect of Methylation driven by gut microbes [and this likely impacts their evolution] what would humans be doing to get the same effect?https://t.co/sQyTA0CV6r

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UltimApe@ultimapealmost 9 years ago

I hate MTHFR thing; it crops up in food conspiracy theories. But it also interests me b/c of ants & epigenetics: https://t.co/kX9R6Whtxj

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3 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

It must be. It has to be. There is not other thing that makes as much sense.https://t.co/1C94KrBSEC

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UltimApe@ultimapealmost 6 years ago

There are all sorts of weird network associated behaviors in ants that seem to be how they modulate their colony's defense against disease and parasites.https://t.co/WNXYdqFV11It shows up in humanshttps://t.co/g8MNGMEaqI

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2 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

It must be. It has to be. There is no other thing that makes as much sense.https://t.co/ER6meNGVvA

1 0
10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

A science news article was published with a headline about how smelling farts can make you live longer, prevent cancer, cure disease. They were talking about hydrogen sulfide. They were talking about hibernation.https://t.co/IobEzdo8CJ

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UltimApe@ultimapeabout 6 years ago

I think I figured out human hibernation, but I need to see if I can induce it in mice first (without torturing them).Let's just say: TH17 and impact on neuroinflammation and neurodegeneration at intersection of immune system & diet is very interesting.https://t.co/U3LiQZsmkr

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What is a complex system?https://t.co/p8tL7UYXG6

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UltimApe@ultimapeabout 6 years ago

@othercriteria @selentelechia More specifically Hydrogen Sulfide impacts mitochondiral function and regulate gut bacteria populations. Downsteram of this is a direct impact on TH17 regulation of the immune system and impacts on NMDA function in the brain.

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Farting in the general direction of a gap in the science literature, a complex system so big you could drive an entire bear thru it.https://t.co/4yk1ysx5Ew

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UltimApe@ultimapeabout 6 years ago

I wonder what this bacteria does.https://t.co/CBndACrMiG

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Gender is a social construct that has woven it's way thru western medical science since Darwin. Unwinding that thread has let me see a thing no one else seems to realize.https://t.co/tyYZKhS3XH

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UltimApe@ultimapeover 6 years ago

Why am I resarching female bear dicks and the possibility of human hibernation? Aside from the obvious links of helping with Type II Diabetes and insulin management..."The Bacteria That Help Bears Hibernate Could Help Cancer Patients"https://t.co/78VbzYUXvC

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I'm half expecting we find that bacteria can influence a giraffe's neck growth in response to food and can be passed on to offspring via immune stress or horizontally transferred. Lamarck+Darwin both wrong. Darwin was more right.https://t.co/7gv0nEAj4Vhttps://t.co/dpWvRVmjeq

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UltimApe@ultimapeabout 7 years ago

It'd be really funny if, in order to fix my sleep issues, I have to destroy the concept of paradigm shifts in science and reformulate the theory of evolution in terms D’Arcy Wentworth Thompson's theories thru a foundation in autopoeisis.

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What do you mean female lions can have manes. What do you mean stress from competition+food scarcity can change the expression of gender related hormones even if associated gene isn't passed on. https://t.co/MhJB3No0Kh

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UltimApe@ultimapeabout 6 years ago

Why does lion's mane impact insulin?https://t.co/a1tUCRZyqh

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What do you mean our view of gender divides is biased by platonic idealism stemming from greek phlosophy's impact on western science and can be undermined by looking at ant sexuality?https://t.co/Cja0ku2lIU

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Ecdysteroids and Aromatase development in insects paralleling human's evolution of Testosterone and Aromatase is why I literally guessed that Neonicotinoid probably cause breast cancer by disruption of hormones in humans. https://t.co/TC7XeAb6A5

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

The question you have to ask yourself is... Why is testosterone immunoreactive?https://t.co/HioaJpCDCf

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

And why does the insect equivalent seem to affect growth.https://t.co/r24sOohNvl

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What is convergent evolution? Why would game theory imply similar successful strategies within a similar environment and similar demands on two different organisms.https://t.co/9iZfRJHyIj

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UltimApe@ultimapeover 6 years ago

@visakanv what's really fascinating to me is that my model for mapping all of this stuff also holds true for insulin processing in ants and reflects similar evolution in how they organize around famine and drought.

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Do you ever wonder if you can milk crickets?https://t.co/I6M5q5LDnvhttps://t.co/9Jkewk88m9

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UltimApe@ultimapealmost 6 years ago

Did you know that when a female cricket eats a male cricket's "nuptual gift" it makers her less horny. But only if she eats it. This suggests it's driven by a microbial process.https://t.co/earil0Z6yq

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What is glycine doing in that little ball of sex juice that crickets use to impact horniness (...and immune function?) in their mates?

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Literally directly related to circadian rhythm."As a neurotransmitter, glycine both stimulates and inhibits cells in the brain and central nervous system, affecting cognition, mood, appetite and digestion, immune function, pain perception, and sleep."https://t.co/TySXgEAAka

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Hickory dickory dock.This mouse study talks on ciracidan clock.Hydrogen sulfide is fun for mouse's guns.Hickory dickory dock.https://t.co/afbykalBD4

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Here's a youtube video variation on a kids nursery rhyme that shows suicidal mice.https://t.co/mzzGSJ8o6zHere's a study from 2013 on how how hydrogen sulfide ameliorates depression in mice.https://t.co/mTD9qOhzTg

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What is glycine?https://t.co/nJKJy389tj

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What is glycine?https://t.co/kjNWSGtNKk

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

What is Glutathione doing with regards to avoiding celluar damage from hibernation-esque states?https://t.co/j2wg1N7fwP

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"We examined the effect of glutathione on 18 traits, using first ants under normal diet, secondly the same ants consuming glutathione, and after that, 4 more traits using only ants having consumed that product. "https://t.co/FkWfuNMAiC

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Under fluoxetine consumption, ants lost their olfaction and their learning ability, having also lower cognitive ability."https://t.co/VxoIFhdbpxhttps://t.co/7IM0Sye4A7

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UltimApe@ultimapealmost 6 years ago

Don't mind me, just trying to figure out how our gut microbiota may effect social behavior memories via what I suspect is chemically induced brain fog via Synaptic Plasticity ala Fluoxetine (Prozac).https://t.co/3zHkgJCx8Thttps://t.co/hRCIElKkdd

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"If you study the small print on SSRIs, you'll find, close to the end of the list of side effects, references to taste disturbances, taste loss, and taste perversion. The official term is dysgeusia"https://t.co/dF3zdnSajx

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"The notion that humankind and beekind share the same neurotransmitters and similar stress reactions is somehow strangely comforting – c’mon, insects, we’re all in this thing together – we can do it!"https://t.co/YoaMKhrpV9

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Why did Darwin not like the taste of turtle?https://t.co/f2dGaDSLff

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UltimApe@ultimapealmost 6 years ago

@Timber_22 @billy74919063 My suspicion is that his having trouble with his sea-legs perhaps caused issues with his nose and sense of taste. https://t.co/6kvCaUqcDV It's possible his pallet was odd and the taste of tortoise was impacted by serotonin weirdness and loss of appetite.

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Another inhibitory chemical messenger, called gamma-aminobutyric acid (GABA), is already known to be involved in autism. The new study, published 15 September in Molecular Psychiatry, is the first to tease apart glycine’s role in the disorder."https://t.co/5FcQ58YlRH

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Lactobacillus casei reduces CD8+ T cell-mediated skin inflammation."https://t.co/3s4Uyh7Ohs"The Absorption of Glycine and Alanine andTheir Peptides by Lactobacillus casei"https://t.co/3USqq8cvUo"Altered T cell responses in children with autism"https://t.co/Ed25GHPTIa

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics"https://t.co/5c2NC1oj48"Targeted Treatment of Individuals With Psychosis Carrying [...] a Genomic Triplication of the Glycine Decarboxylase Gene"https://t.co/EdV17RgcIg

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis"https://t.co/SKV7UlB925

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"However, the picture is still incredibly murky, and studies produce differing results, finding different types of inflammation and various changes in gut bacteria."https://t.co/dWAbKw5WL3

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"The fecal metabolome indicated that multiple eurotransmitters, such as glutamate, gamma-aminobutyric acid (GABA), and glycine, were differentially altered in female and male mice."https://t.co/A2ivm4XKXZhttps://t.co/2ZKWVWUs4M

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UltimApe@ultimapeover 6 years ago

How is gut signaling the brain re:gaba? Can brain make gaba locally? Why does gaba play a role in intestinal problems. Why does blood brain barrier seem to coincide with intestinal permeability. Why do I have genes that predispose for BBB permeability?https://t.co/6yHLo6NXkH https://t.co/hMlcRg50b6

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"in patients with major depressive disorder, a disease associated with an altered GABA-mediated response, we found that the relative abundance levels of faecal Bacteroides are negatively correlated with brain signatures associated with depression."https://t.co/OIKdPXGYvy

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Newborns born vaginally have a different GI microbiota from newborns born by cesarean section, [...] showing an enrichment of Bacteroides, Bifidobacterium, Parabacteroides, and Escherichia/Shigella species in vaginally born newborns."https://t.co/D46wQKxlBp

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"We need more studies to determine whether exposing Cesarean-delivered newborns to vaginal microbes at birth can reduce their future risk of metabolic disorders such as obesity."https://t.co/YXgfZBeEm8

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Evidence presented in this study should motivate more research. Because experimentation is unsuitable, future studies may focus instead on instrumental variables estimation using large-scale linked hospital and child development administrative records."https://t.co/KebIAUmY5q

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Overall, TNFR2 blockade appears to disrupt commensal bacteria–host immune symbiosis to reveal autoimmune demyelination in genetically susceptible mice. Under this paradigm, microbes likely contribute to an individual’s response to anti-TNF therapy."https://t.co/nE0RluQwB0

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"This review focuses on the TNF-α system, although other cytokines do also contribute to the interaction between the brain and the immune system and, in part, amplify the effects of TNF-α."https://t.co/ZqZkHoShzrhttps://t.co/eEUCqHZdTC https://t.co/kg65bxLvjA

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UltimApe@ultimapealmost 9 years ago

"suggests increased reactivity of the HPA axis to stress and novel stimuli in children with autism." https://t.co/kvNp53G1ba https://t.co/89v78GAYzt

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

So to summarize, circadian rhythm might be oddly affected by a sex hormone dependent bias in gut microbes. Wild.https://t.co/RSjHwn6AS5

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UltimApe@ultimapeover 8 years ago

Another study on sleep rhythms and stress, linking HPA issues with abnormal cortisol.https://t.co/DyrWUqV48h

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

And so there ought to be gender differences in Parkinsons?https://t.co/iKhirkGaMn"changes in the levels of cytokines, neurotrophins, and apoptosis-related proteins in the nigrostriatal regions [may be] involved in [death of] nigrostriatal DA neurons."https://t.co/08QTzeRxM0

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

I have no idea what the heck Parkinson's is... and yet.https://t.co/FrIFcrFZhG

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UltimApe@ultimapeover 6 years ago

@whitequark Not sure if its mutation or just population variations, but its fascinating because it suggests we might be able to tweak it by feeding bacteria that out-compete the ones involved in this process.

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Something smells funny.https://t.co/ZFIHfExWLF

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UltimApe@ultimapeover 6 years ago

My current suspicion is that Parkinsons isn't caused by microbes/bacteria/virus/fungal invaders, but shows all the symptoms of having a disrupted microbiome ecosystem, hence showing up with skin smells acting as a possible early diagnostic.https://t.co/vouwgZDYzp

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"There is now a wealth of data that affirms estrogen regulates various facets of the immune system via complex molecular mechanisms."https://t.co/SwSG2BAI2mhmmhttps://t.co/vPdAmciv20

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UltimApe@ultimapeover 6 years ago

Ok, brain, this says there should be a COMT->Estrogen->Prolactin->TRPV loop somewhere in here? That would explain some gender hormone oddness related to testosterone balance in diabetes/pcos/autism/schizophrenia.Oh, there is? And not many knows about it? https://t.co/T7J649Cp4D https://t.co/DKu3wbwEsQ

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Now I'm thinking about female bear dicks again.https://t.co/SNgL2mWYMn

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UltimApe@ultimapeabout 6 years ago

@The_Lagrangian One of my hypothesis of heart disease and other disorders that lead to low life expectancy in autism etiology is b/c of high estrogen being over compensated with high T production causing immune system problems. It's the idea behind why I have threads on virility. Feeback loops.

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Something is missing in this loop.https://t.co/XGGvgQyXPH

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

And I'm back to the idea that to make any progress on this I need to learn to catheter myself.https://t.co/dfl8HIxXsf

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UltimApe@ultimapealmost 6 years ago

How can I measure hormones levels (like testosterone) 24/7 without learning how to catheter myself while I'm sleeping 18+ hours a day like I did when my symptoms were at their worst?

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Dem bones tho.Bone hurting juice interacts differently based on sex hormones.https://t.co/z1Cvx3Jxzrhttps://t.co/vA4w0zp9lW

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UltimApe@ultimapealmost 6 years ago

@CTZN5 @The_Lagrangian @riyenakshi OH wait, I know. its bone hurting juice. https://t.co/2Nop9FNocRNever mind, I figured it out already. My search didn't work cuz twitter's dumb.https://t.co/SxIPbMblmZ

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it"https://t.co/TDzyEkDeiK

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"Complex three-way interactions between these systems appear to be involved in gender dimorphism of the immune system. This paper reviews the mechanisms involved in interactions between sex steroids and the HPA axis"https://t.co/JuT8muR5o0

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Oh, why hello there t gondii. What are you doing in a system that changes risk tolerance and fear response? You're in there changing Adrenergic signaling by action on cortisol homeostasis and the immune system? Why you doing that?https://t.co/HCRXf6yacIhttps://t.co/VMYzmSa7PO

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UltimApe@ultimapeover 6 years ago

To test a theory that T Gondii is operating on predator fear behaviors https://t.co/4lw40K8Fuc via hormone manipulation is thru Endocannabinoid process https://t.co/AEPdVIGCfM which might be a (socially mediated) risk reward factor dealing with resources? https://t.co/vldXwYOCrF

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

That iss weird. Why would increased tryptophan & cannabinoids signaling lead serotonin modulation. Almost like this causes improved immune response and leads to a reduction in parasites?https://t.co/3hjf99rMfNhttps://t.co/xT6WhJpxZV

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UltimApe@ultimapeabout 6 years ago

Is this why CBD oil helps me sleep and seems to be the only thing that improves my mom's Fibromyalgia Pain? Is it reducing some kind of inflammation factor and impacting skin irritability via TRPV1 pathways?https://t.co/t97UPMf480

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Burn them out. Fever. Boiling. Fucking with parasite's temperature homeostasis so you can kill them. Of course.https://t.co/4bboLWoKUe

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

So T gondii prevalence—one of the candidate parasites that I think plays a role in the length of female bear's hibernation— seems to be directly affected by temperature.https://t.co/zwCBWjUQ7M

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Bees as immune system. Ants as immune system.Memes for the meme god.Complex models of insect homeostasis for the homeostasi. https://t.co/BfT7svz4Bz

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UltimApe@ultimapeover 8 years ago

Bees clump to maintain homeostasis.Bees kill wasp invaders to the "body" by boiling them.Tell me, why do we fever? #beehiveiorism https://t.co/SJU3hwWj8f

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Then. Wonder. What does basil body temperature have to do with immune system priming, odd fertility cycle windows in women with pcos. And vaginal mucosa.All the words I have are vulgar.

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10/16/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Trivial really.https://t.co/zR23uCQ5ML

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UltimApe@ultimapeabout 7 years ago

If we can tell hormone changes in mice by measuring the distance of there genitalia... we could theoretically test my hypothesis on microbial hormonal manipulation by raising mice on a diet of different sets of bear poop. Would be trivial in a good lab.https://t.co/Br33ymEwIW

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10/17/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"We have the wrong idea about males, females and sex"https://t.co/0Rl3GH4CUs

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UltimApe@ultimapeabout 7 years ago

This is haunting my dreams now."According to a 1988 study, between 10 to 20% of female bears have a penis-like structure in place of a vagina. "An intersex female bear actually mates and gives birth through the tip of her 'penis'," says Roughgarden."https://t.co/PxY0DAx66S

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10/17/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"But the problem is that scientific research needs to be sound. We cannot build progress on a rotten foundation."https://t.co/IWNkt0vvEp

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11/3/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Its almost like giving people a bacteria that is normally kept in check by a complex ecology ends up turning into a parasite when the environment isn't stable.https://t.co/EC0hkfqCnS

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UltimApe@ultimapealmost 6 years ago

Let's give people random probiotic strains specifically engineered and selected for survival thru harsh healthy gut micribiome ecology... while they are in a stressful environment with new food and a weakened constitution. What ever could go wrong?https://t.co/4vvlUued6G

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11/8/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Learning to catheter myself will either be the best decision of my life, or the worst."Decisions" n=19https://t.co/98xL0RHntm

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11/20/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

"That very question may be the wrong one to ask, a group of researchers argue in a study published last week in Nature Ecology and Evolution, seeking to flip the underlying assumptions of a whole wing of biology." 🎭https://t.co/xawpa5yMKq

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11/27/2019
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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Laughing at the absurdity of it all. https://t.co/mhwdw4oD7V

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UltimApe@ultimapealmost 6 years ago
Replying to @ultimape

Person I borrowed parts of that meme's language from shared me this interesting article by Ed Yong: An insect where 'males' have 'vaginas' and 'females' have 'penises'.https://t.co/QTp4iOoJtYThis🧸repeating:👏Nature👏don't👏give👏a👏fuck👏https://t.co/3ZKoaFEDQc

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UltimApe@ultimapealmost 6 years ago

What do you mean our view of gender divides is biased by platonic idealism stemming from greek phlosophy's impact on western science and can be undermined by looking at ant sexuality?https://t.co/Cja0ku2lIU

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11/27/2019
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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Have you tried tweaking your immune system via gut microbes?https://t.co/EpEXKlwTrw

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UltimApe@ultimapealmost 6 years ago

Balls of fire."In nutshell: No matter what the researches did, the group that was fed with Lactobacillus reuteri, always had higher testosterone levels and bigger balls than the control group."https://t.co/5vI2EGeW0M

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UltimApe@ultimapeover 5 years ago
Replying to @ultimape

Have you tried tweaking your gender profile via gut microbes?https://t.co/vPdAmciv20

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UltimApe@ultimapeover 6 years ago

Ok, brain, this says there should be a COMT->Estrogen->Prolactin->TRPV loop somewhere in here? That would explain some gender hormone oddness related to testosterone balance in diabetes/pcos/autism/schizophrenia.Oh, there is? And not many knows about it? https://t.co/T7J649Cp4D https://t.co/DKu3wbwEsQ

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6/16/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

"A growing body of evidence has implicated the gut-brain connection in initiating Parkinson’s disease. The researchers were most curious whether the misfolded alpha-synuclein protein could travel along the nerve bundle known as the vagus nerve"https://t.co/uo6O0TLAhM

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6/20/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

"This similarity is interesting. There is an epidemiological correlation between Alzheimer's and diabetes: Alzheimer's patients have a greater risk of contracting diabetes and vice versa,"https://t.co/jBrchxuney

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6/20/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

"Basic research has begun to show that Aβ and α-syn may act synergistically to promote the aggregation and accumulation of each other. While the exact mechanisms by which these proteins interact remain unclear" [2012]https://t.co/vxlK9tHfj7

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6/20/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

https://t.co/J7i7CiaZ6f

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UltimApe@ultimapeover 7 years ago

Alzhiemer's and Parkinson's Disease both manifest with a clinically notable Sweet-Tooth, and Both exercise and Fasting seem to help. This unintuitive reason why will shock you!Hint: https://t.co/3KYkBtpvb4

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6/20/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

How do I immune system?https://t.co/4BcR70Jb8I

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UltimApe@ultimapeabout 7 years ago

I'm hearing disturbing rumors that Alzheimer's might be associated with a viral contagion of some kind, perhaps one that affects insulin regulation thru immune suppression action on the serotonin systems in our body. Funny that.

13 0
1 0
6/20/2020
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UltimApe@ultimapeabout 5 years ago
Replying to @ultimape

Just ordered some Glycine to experiment with.Apparently it gets metabolized into methionine. https://t.co/D3kbXLxvlX

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UltimApe@ultimapealmost 6 years ago

What is glycine doing in that little ball of sex juice that crickets use to impact horniness (...and immune function?) in their mates?

1 0
2 0
7/15/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"Woody plants, like chokecherry, are hard for people to germinate. Nature is better at it. Park staff tries to mimic natural germination by soaking seeds in acid baths, but it doesn’t work nearly as well as a bear’s stomach."https://t.co/fwai5UHoHM https://t.co/Zg74hWvmIE

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UltimApe@ultimapeover 4 years ago

And the elephant goes "toot""Alternatively, nuts are collected from elephant dung; the hard nuts survive intact through the digestive process after the elephant has consumed and digested them."https://t.co/4gzrFQNqQZhttps://t.co/SfDKpJPq0C

0 0
1 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"The researchers say they are now hot on the trail of a chemical in hibernating bear blood that they think may promote new bone growth; they will not discuss the details since they hope to patent their work."https://t.co/ThtrDvlodGlol, losers.

1 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

IL-1, NF-κB, Osteoblast, https://t.co/TxQssXc9Pqbeta cell https://t.co/CIFgbZri6Adiabeteshttps://t.co/kLNluIBfhIGut bacteria?https://t.co/NFInmbK18Ehttps://t.co/ksC2njnJgD

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UltimApe@ultimapealmost 5 years ago

"Therefore, the link between IL-6 and gut microbiome diversity is independent of stress despite the link between stress and IL-6."https://t.co/qyhiQ4yEe9Must be the stre... oh wait.

3 1
1 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

bone printer go beep beep, pc load letterhttps://t.co/VBqqHBfWOh

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UltimApe@ultimapeover 5 years ago

Haha bone repair microbes go brrr.https://t.co/4bfZV0ITBJ

3 0
2 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

IL-6, isn't that some kind of cytokine?https://t.co/AZ5YPMof96

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UltimApe@ultimapeover 5 years ago

Anti-bone hurting juice."These findings provide support for a role of serotonin in bone metabolism by indicating serotonin regulates bone remodelling by mediating an inflammatory cytokine." 😹https://t.co/j4PTTnlZnChttps://t.co/xjOQlrbbcI

1 0
1 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Serotonin estrogen calcium cholesterol collagenVitamin K2?https://t.co/l7SEtGcpO8https://t.co/MKDj24AM7Q

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UltimApe@ultimapeover 5 years ago

Making a joke about wanting to learn how to set my own bones, and then some time shortly later I am learning about a traditional Korean health aid that is suspected to speed bone break recovery.https://t.co/IFWL8xAg29

0 0
1 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

K2? Natto. Fermented soy drives calcium associated chemistryhttps://t.co/AqIRCpSWZZprevents bone losshttps://t.co/55tRZsnx9yIf this is because K2 is acting as a hormone...https://t.co/OfRvmmClLD

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UltimApe@ultimapealmost 5 years ago

@eigenrobot @djmicrobeads @thinkagainer @_djpn Why don't your Microbiota eat Phytoestrogens? Bruh, your Gut is weak. Do you even prebiotic?

5 1
2 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

We're changing the frame.https://t.co/tatzuGzQyh

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UltimApe@ultimapeover 4 years ago

Breaking my own brain by wondering..."do female bears get psudopenises because the increased testosterone is acting as an immune active steroid. Effectively assisting in cholesterol/calcium turn-over in liu of vitamin D production?"https://t.co/z3iKdpN9zk

1 0
2 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"Glutathione is a tripeptide (cysteine, glycine, and glutamic acid) found in surprisingly high levels—5 millimolar—concentrations in most cells. "https://t.co/RlUfq6e452https://t.co/yt1fsBd4xK

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UltimApe@ultimapealmost 5 years ago

Even more interesting then...It seem a form of B12 acts as a cataylist to convert Dehydroascorbic Acid to back to Vitamin C with... Glutathione!https://t.co/rg8IprjOdP

3 0
2 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

How do bears make bone? They must be able to do it without Vitamin D?They must be able to do it without Vitamin C?I think I figured these two out. But still missing the soil/gut microbes that would do it. Getting closer.https://t.co/6khGehgofM

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UltimApe@ultimapeabout 6 years ago

"Bears don't eat, drink, urinate or defecate for six or seven months, [...] They're a closed system. All they need is air, and they can do just fine. They're a metabolic marvel,"https://t.co/aWlfOyazAw

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3 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Did you know that Bacillus subtilis natto produces chitinases."An enzyme that breaks chitin polysaccharide down into smaller pieces, called chitin-oligosaccharides." and might be a way to fight fungus infections as a result?https://t.co/5WJOgxSPF6https://t.co/kF44ftKSnq

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UltimApe@ultimapeover 6 years ago

"emerging evidence that chitinases have additional functions beyond degrading environmental chitin, such as involvement in innate and acquired immune responses, tissue remodeling, fibrosis, and serving as virulence factors of bacterial pathogens."https://t.co/SVk2jjFEes

1 0
4 0
12/17/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"The idea is that these ancient hominins might have been trying to sleep through the colder months, and so their bones show the scars of months of sleeping without enough fat stores, a lack of vitamin D, and - in teenagers - weird seasonal growth spurts."https://t.co/tnac2S55Vo

3 0
12/23/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"Fairytales are in my head,and in my head they startTo tell you bout the deepest thoughtsthat live inside my heart"🎶https://t.co/qZFdT8YSQWhttps://t.co/3ubEwiFAkK

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UltimApe@ultimapealmost 7 years ago

If humans can hibernate, you'd think it'd be embedded in our oral history; acting as instructions. Stories about lotus flowers, sirens, fae feeding parasite ridden food that makes you sleep. Goblins like Midgna who use sleep as a weapon. Sleeping Beauty bewitched by fae adjacent.

8 0
3 0
12/23/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Ya'll got any that vitamin D?

2 0
12/23/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Bone disorders tied to kidney? But why does this trigger fatigue & collagen problem?"Renal osteodystrophy is a bone disease that occurs when your kidneys fail to maintain the proper levels of calcium and phosphorus in your blood."https://t.co/iPADiFluZBhttps://t.co/Dr9VhHMVnS

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UltimApe@ultimapeover 4 years ago

Wandering my web of tweets and an idea bubbles up from April. What was echoing around in the jumble of rhizomatic associations at the time?Microbiota & Kidneys. https://t.co/O8NxHPu05i

2 0
3 0
12/26/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

oh haha."The kidneys are highly dependent on an adequate supply of glutathione (GSH) to maintain normal function."https://t.co/hfRzl8gPbVhttps://t.co/YI5ZxknRLp

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UltimApe@ultimapeover 4 years ago

"Glutathione is a tripeptide (cysteine, glycine, and glutamic acid) found in surprisingly high levels—5 millimolar—concentrations in most cells. "https://t.co/RlUfq6e452https://t.co/yt1fsBd4xK

2 0
2 0
12/26/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"Hypothermia in midwinter revealed a marked increase in GABA and glutamine due to active decarboxylation and amidation of glutamic acid."https://t.co/GjClUuMQ1a"glutamate [maybe] from microbes, replicating at a faster rate in the warmer animals."https://t.co/3k2aRIerY4Cycle

4 0
12/26/2020
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Long Huncheshttps://t.co/fYgjFaaeiE

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UltimApe@ultimapeover 5 years ago

So... if bears are hibernating during the winter, how are they getting an increase in vitamin C?"The high levels of vitamin C may act as a mitochondrial antioxidant and counter the effects of uric acid, thereby aiding the oxidation of fat"https://t.co/worztzU8zJ

4 0
3 0
1/3/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Vitamin C is important? Yes!Do you need to get it from diet? I bet not.https://t.co/d48lv5ukQO

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UltimApe@ultimapeabout 5 years ago

@SimonDeDeo Oh, i'm just doing that for fun. I think I can also avoid needing vitamin C if I can figure out how to harbor a gut bacteria that can do that for me. This is unrelated to megadosing.

2 0
1 0
1/3/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Question assumptions.https://t.co/nfrW8cOJpg

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UltimApe@ultimapeover 4 years ago

Time to look up the immune system of spontaneous gender bending fishes just to piss everyone off.https://t.co/GwehLcvg6T

1 0
1 0
2/10/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

If you cut a gonochorous starfish in half, is it possible for one half to regrow as an egg layer and the other to as a sperminator?if you put a bunch of 'sexed' starfish in a tank, is it possible for one to suddenly become the other? https://t.co/3GbrLK4Gq4

1 0
2/10/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

How do genes work? Bueller?"Their results indicate that all bacteria in chicken intestines have the potential to pick up the genes they need to turn into a dangerous infection, through a process called horizontal gene transfer."https://t.co/LqYEMr5dXFhttps://t.co/bzMQOSq3Re

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UltimApe@ultimapeabout 5 years ago

While investigating skin bacteria a bit, I found a human dwelling bacteria strain that — when infected by a bacteriophage — can end up becoming pathogenic via a horizontal gene transfer effect.https://t.co/HcA1gkSF9P https://t.co/sGpL1B8Y2J

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3 0
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

I have to constantly remind myself that so few people actually understand how evolution works.https://t.co/CtDT7nZidI

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UltimApe@ultimapeover 7 years ago

@primalpoly Or horizontal gene transfer occurring in the gut that is associated with increased antibacterial resistance of certain microbes: https://t.co/NCUDmZWDsC

0 0
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

No one ever looks.https://t.co/pDxkE2FRSv

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UltimApe@ultimapeover 5 years ago

Somewhere there is a dog fed corn all it's life, and has somehow developed an asorbic acid producing gut microbiome profile (thru horizontal gene transfer ala viral communication among gut bacteria).https://t.co/u3zKhBA21JWe simply have to look.https://t.co/EwDtWLxBCO

3 0
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

So frustrating. When we look, we find.It's only rare because we rarely look.https://t.co/9PWzJ0nfss

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UltimApe@ultimapeabout 5 years ago

@SisterSeaweed Thanks! I was going to follow up to make sure you saw.That looks like the same carbohydrate that they think was 'donated' to our gut microbes via horizontal gene transfer!https://t.co/ESQR2fWtQeThats fascinating.

1 0
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Enumerating all the ways that Darwin was wrong.https://t.co/QVBzS239pd

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UltimApe@ultimapeabout 6 years ago

Tired: Descent with modification.Wired: Descent with cross pollination."indicated that horizontal gene transfer is more common than we expected in the human genome. This study provided insight into potential mechanisms of HGT in the human genome."https://t.co/VfUrNxT52v

2 0
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

And all the ways these assumptions spread thru our models and distorted how we look and model the world.https://t.co/CkC2W9hSLC

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UltimApe@ultimapeabout 6 years ago

I wonder how many models of evolution in computer science are riffing off of myths and misunderstandings.Ring species wasn't really even validated until 2012! Allopatric speciation (darwin's finches) might even be a result of collaboration between gut microbes and host!

3 0
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Why do we fetishize genetics as the *ONLY* way for an organism to store information and allow for decent with modification?https://t.co/XbcwznZi3v

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UltimApe@ultimapeover 4 years ago

@djinnius @HundredthIdiot One of the stranger things that hit my radar is that darwin's finches aren't as gentically diverse as we assueme, their beaks are actually an epigenetic effect driven by microbial driven gene epression, allowing them to explore niches more quickly.https://t.co/L3UBOGxzBY

1 0
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

My fucking eyes are going blind because of gut microbes.it shows up in mice.https://t.co/qtuIZmmAoqYou're looking for genes.blind. scientists. leading the blind.https://t.co/lkJpNMDEtL

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UltimApe@ultimapealmost 6 years ago

@realjdburnett @eigenrobot We focus on genes like some kind of scientific fetish. I think it's massively oversimplifying the complex nature of adaptation and responses to resources in the environment. Missing the population forest for the gene trees.https://t.co/4JcsUrG1yn

8 1
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

That study on mice, involving Microbe's role in Multiple Sclerosis, was published August 2020 https://t.co/VE1KpCCpa3I am years ahead of the state of the art *in mice* studies because I simply decided to doubt existing models of evolution.https://t.co/g8AObFEdX3

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UltimApe@ultimapeover 5 years ago

@PeterDiamandis I've been trying to find how to boost IL 4 production using gut bacteria and diet ever since reading about it in multiple sclerosis.https://t.co/gI95EdjhamI find it weird how my vision improved when I improved my metabolic profile.

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0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Host plasticity is a dance between genes and gene expression. Gene expression is complex. More complex than we want to believe.https://t.co/8jhyHDOkCM

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UltimApe@ultimapeabout 7 years ago

It'd be really funny if, in order to fix my sleep issues, I have to destroy the concept of paradigm shifts in science and reformulate the theory of evolution in terms D’Arcy Wentworth Thompson's theories thru a foundation in autopoeisis.

42 2
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

I can modulate my eyes using gut bacteria and immune function. Both are localized adaptations that allow the organism to dance with their environment.https://t.co/wXLkfZH3GW

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UltimApe@ultimapeover 8 years ago

Is there a way to fix bad night vision? If I could see the stars again like I was a kid, I'd probably start crying.

2 0
0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"working to understand just how common these transfers might be as they examine how bacterial genes manage to integrate into the cellular environment of a different and much more complex new host—sometimes even displacing native genes and functions."https://t.co/DcsKz3ED7E

0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"So the question bothering Dr. Coppinger and Dr. Lord was this: How much domestication had gone on before the famous fox experiment began?"https://t.co/sL56XQ85U8https://t.co/8NdOFJQqOm

0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"foxes used in the Farm-Fox Experiment originated from fur farms in eastern Canada and that most traits attributed to the behavioral selection for tameness predated the experiment, undermining a central pillar of support for the domestication syndrome."https://t.co/PyqOwBxRrY

0 0
2/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"In this work, we have made an approximation of the relationship between humans and canids through the study of their diet by analysis of stable isotopes of carbon and nitrogen in bone collagen."https://t.co/u7IytzLwIn

0 0
2/13/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"one of the foxes shows signs of having already been a domestic animal in those times"https://t.co/Y9sboSzY7Mbronze age ~ 3000 BC – 1200 BCaka ~3000 to ~5000 years ago https://t.co/Gyd8rsbqK6

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2/13/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"The message of our paper is that domestication has hidden costs, [...] When plants are selected for a small handful of traits like making a bigger seed or faster growth, you can lose a lot of important traits relating to microbes along the way."https://t.co/sY4Zr6Cu26

0 0
2/13/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

"However, further investigations are required across a wide range of domesticates in order to understand the general trend of microbiome shifts in domestic animals." [FEB 2020]https://t.co/6QhWPcxSi9https://t.co/DNKiHeY9QV

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UltimApe@ultimapeover 5 years ago

What are we?"The researchers claim that their results show that infection by viruses which got incorporated into the genome “considerably transformed the transcriptional landscape during primate evolution”."https://t.co/TWdG0MgbPz

0 0
0 0
2/13/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Made a joke about trying to become a polar bear so I don't have to worry about making Vitamin D from the sun and avoid seasonal depression.Realized I never looked that up.https://t.co/Kznl7IjuhRNow I am awake.https://t.co/C9DB8AxUsl https://t.co/pJSbET2USz

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UltimApe@ultimapeover 4 years ago

How do bears make bone? They must be able to do it without Vitamin D?They must be able to do it without Vitamin C?I think I figured these two out. But still missing the soil/gut microbes that would do it. Getting closer.https://t.co/6khGehgofM

3 0
1 0
3/5/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

If I can avoid needing to eat the sun during the winter by creating Vitamin D another way, that would be fascinating.https://t.co/jYq1wlKOrJ

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UltimApe@ultimapealmost 7 years ago

Randomized controlled trials have shown vitamin D supplementation improves symptoms of autism.https://t.co/trv0aleGMcand may help with schizophrenia https://t.co/ntpYZn2UtgTake care of yourself(s) https://t.co/F0cboDajyB

2 1
1 0
3/5/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Weird how often precursors for serotonin end up showing up as having an impact on autism symptoms and correlate weirdly with irritable bowel symptoms. https://t.co/iSgOV048yFhttps://t.co/4nXWUpYaPM

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UltimApe@ultimapeabout 6 years ago

"A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder"https://t.co/E360Ea2rVmhttps://t.co/T9SEecF0GO

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0 0
3/5/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

It's almost like... Almost like... gut problems exacerbates autism symptoms.https://t.co/8lBCnzrDpZ

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UltimApe@ultimapealmost 8 years ago

PCOS -> Higher rates of IBS?https://t.co/wn3DW54IZfAutism -> Higher rates of IBS?https://t.co/sJYejxkpgW

3 0
0 0
3/5/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Oxytocin from a lover's kiss would perhaps work to reduce brain inflammation and the knock on effects of that might drive a shift in the gut microbiota to fix the problem by reversing the hibernation state.https://t.co/RkKMYNHriThttps://t.co/zerFzCJXa5

1 0
3/16/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

The swamp witch is an echo of baba yaga.It's talking about hydrogen sulfide.https://t.co/yoenvpWv8c https://t.co/QmRNhkCJtR

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UltimApe@ultimapeabout 5 years ago

I was just looking up moonflowers as a Mediterranean area hallucinogen. Going to need to learn more about baba yaga it seems.https://t.co/S80OPBZjRW

1 0
0 0
3/16/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Cursed to wax and wane with the moon, by a witch's fart.https://t.co/ro9pSuzr4e

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UltimApe@ultimapealmost 6 years ago

A science news article was published with a headline about how smelling farts can make you live longer, prevent cancer, cure disease. They were talking about hydrogen sulfide. They were talking about hibernation.https://t.co/IobEzdo8CJ

1 0
0 0
3/16/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Cursed by the moon.https://t.co/L0xkoyurct

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UltimApe@ultimapeover 4 years ago

MOON STRUCK"Our data suggest that moonlight likely stimulated nocturnal activity and inhibited sleep in preindustrial communities and that access to artificial light may emulate the ancestral effect of early-night moonlight."https://t.co/0Du5QV6LeThttps://t.co/8tvUD2IT1b

0 0
0 0
3/16/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

Good morning. Sleep well?"Metabolic depression in hibernation and major depression: An explanatory theory and an animal model of depression" https://t.co/D3cxIrJNNthttps://t.co/JkQVzPg0Rr https://t.co/H6jL6HIrA6

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UltimApe@ultimapealmost 6 years ago

What if Multiple Sclerosis isn't a disease, but a disorder caused by a failure in an overlooked human hibernation syndrome related to immune + white matter deposition in the brain.Is there an #ActuallyMultipleSclerotic community that would attack me for trying to "solve" it?

8 0
2 0
4/12/2021
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UltimApe@ultimapeover 4 years ago
Replying to @ultimape

I have no idea what I'm doing.https://t.co/nGnwdJWWS7

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UltimApe@ultimapealmost 5 years ago

@literalbanana @GrumplessGrinch The Thydroid-Gut-Axis is still relatively new idea. https://t.co/v7UIJ1temIIt's plausible thyroid related 'TSH' is being directly hit via cannabis https://t.co/M0nMRJMtea might be part of why it helps so quickly.Many links to M.S. & other autoimmune.https://t.co/CE8pwKYkzV

5 0
1 0
4/12/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

I think I'm going to accidentally recreate a Anunnaki by figuring out how to reverse human neoteny.https://t.co/yMtjC5BmE3

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UltimApe@ultimapeabout 4 years ago

Would be funny if Baculum are like Darwin's finch beaks, and actually vary because they're driven party via their diet + gut bacteria's impact on gene expression.So what gut bacteria would reverse human neoteny?https://t.co/XQqNoPN4bd

1 0
1 1
8/22/2021
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UltimApe@ultimapeabout 4 years ago
Replying to @ultimape

That, or figure out how to achieve my childhood dream of having an extra set of thumbs. https://t.co/LVCPnKTunn

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UltimApe@ultimapeabout 5 years ago

@GBtablereads @HoldenDCat @NealRajpat @WBurner2000 @SwipeWright @ghost1522 @Timcast Did you know the reason why some frogs end up growing multiple limbs is because some pesticides in the water are likely impacting important gut bacteria energy pathways that change the epigenetics expression of tadpoles associated with their growth & diet? Its so neat.

0 0
0 0
8/22/2021
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UltimApe@ultimapealmost 4 years ago
Replying to @ultimape

"The association between specific UVB wavelengths and vitamin D production was determined more than thirty years ago [...] there have been doubts about its accuracy. These doubts compromise risk/benefit calculations for optimal solar exposure."https://t.co/uviCWHrjvv

1 0
10/1/2021
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UltimApe@ultimapealmost 4 years ago
Replying to @ultimape

I knew fish could change their gender, but never thought about how sharks are just funny looking fish.https://t.co/pC11j3Fa2z

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UltimApe@ultimapealmost 4 years ago

Sharks might store sperm, or do that whole fish gender change thing."Understanding these mechanisms—and how they impact genetic diversity—could be vital for the future of shark conservation."https://t.co/HoCWv9sDbf

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12/3/2021
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"The findings of the present study may be suggestive of potential ASD subtypes based on ASD severity and gut microbiome composition that may facilitate the prediction of the therapeutic responses of [oxytocin] among those with ASD." https://t.co/aHak84dKpBhttps://t.co/wSwnFhkYEN

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UltimApe@ultimapeabout 4 years ago

If I'm right about autism severity being driven by lipid signaling and immune function via impacts on oxytocin (via gut-brain pathway) and anandamide/serotonin production/signaling... I necessarily butt heads with placebo research.https://t.co/dRQCwc68qg

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12/28/2021
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Learning about how to manipulate gender expression with sonic hedgehog.https://t.co/WOnkMaZTOa

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3/7/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

*looks up citation on cryptorchid and azoospermia* https://t.co/5ZWbCJJUEXHuh.https://t.co/2pafJcFo4v

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UltimApe@ultimapealmost 4 years ago

Have you ever tried to steelman Alex jones so hard that you start ranting about how low dose pesticides impact frog gender expression via sonic hedgehog... then suddenly realizing they have cloaca.https://t.co/ODykT8xUZc

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3/7/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Shitposting about sonic and gender because autism. Like one does.https://t.co/dYNeTA0Gjb

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UltimApe@ultimapeover 3 years ago

Don't mind me. Nothing to see here. Not undermining the entire field of genetics to solve my autism.https://t.co/AtnPi4K3oj

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3/7/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Gotta go fast.https://t.co/0aDFUmWdSR

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UltimApe@ultimapeover 3 years ago

"Some scientists say the condition, known as diprospus, is a variant of the change in embryonic development that leads to two-headed animals.Others argue it is due to an increase in expression of the sonic hedgehog (SHH) gene" https://t.co/F8LCI6C4ic😘

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4/20/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

On chromatin causing a situation analogous to giraffe necks impacting offspring. "A lot of work remains to be done, but the doors to a world of Lamarckian inheritance are flung wide open"https://t.co/OjUAchGh2MWe don't look for this. Streetlight bias.https://t.co/g7MTo3Xh22 https://t.co/xm0btzX8zz

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4 + T cells" [JAN 2022]https://t.co/0z4X89V2QZJawsome.https://t.co/FXaQabVeVE

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UltimApe@ultimapealmost 6 years ago

I'm half expecting we find that bacteria can influence a giraffe's neck growth in response to food and can be passed on to offspring via immune stress or horizontally transferred. Lamarck+Darwin both wrong. Darwin was more right.https://t.co/7gv0nEAj4Vhttps://t.co/dpWvRVmjeq

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"In this review, we offer insights about the physiology of host–microbiota relationships gained by studying host gene expression jointly with the microbiome, specifically in the gut." [2021]https://t.co/uMRIWFQH8cCorrect horse.https://t.co/rQQoZcqWni

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UltimApe@ultimapealmost 8 years ago

@AmandaChimera Hunch: Microbiomes seems to be a novel thing in science literature. Paradigm assumes genes are only heritable thing... But we also pass on our microbiome. If they're framing the problem wrong it explains why there is low level noise about epigenetics many scientists discount.

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Did you know scientists make giant ants by reprogramming their gene expression using epigentic factors?"Essentially, the researchers found that the more methylated the gene, the larger the size of the ants."https://t.co/LSsJrynrAdhttps://t.co/sQyTA0ljHR https://t.co/pbJW20qpol

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UltimApe@ultimapealmost 9 years ago

I hate MTHFR thing; it crops up in food conspiracy theories. But it also interests me b/c of ants & epigenetics: https://t.co/kX9R6Whtxj

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Prodigious Growthhttps://t.co/6ShoLk9h9e

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UltimApe@ultimapeabout 5 years ago

Happy List #6:The Caption on the MTG card "Prodigious Growth""Look how cute it is now!"—Vivien ReidRelated: https://t.co/rX0pqUGsKS

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

I have strange ideas.https://t.co/BaiVpNoPTI

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UltimApe@ultimapeover 3 years ago

I was ranting about paleontologists misgendering extinct giant plausibly lesbian bears in a nsfw discord channel tonight.Now I'm wondering if they jousted.https://t.co/Llhpxl10qdhttps://t.co/iiuPbNrsyK

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Can you imagine a squirrel the size of a hippopotamus?https://t.co/y3iBBmJvEQ

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UltimApe@ultimapealmost 4 years ago

@goblinodds @MMMalign "In effect, it is the discovery of the mechanism through which the environment interacts with specific genes, revealing environmental factors as an equal partner in determining complex traits."https://t.co/nEjZqGG4SKI want giant squirrels damnit.https://t.co/OAADjoJrDh

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"The investigators found that the boys with autism had higher levels of two hormones that directly regulate growth (insulin-like growth factors 1 and 2). These growth-related hormones stimulate cellular growth."https://t.co/kOJ70ypNznBaller

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

"This review covers current research on the GH/IGF-1 axis and the gut microbiome and its influence on overall host growth, metabolism, and intestinal health, proposing a bidirectional relationship between GH and the gut microbiome." [2020]https://t.co/GgCxxWzGq3

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Yeshttps://t.co/jIwLnFeXqu

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UltimApe@ultimapeover 3 years ago

@mattparlmer Fun fact: height isn't as heritable as you'd think. We keep finding more and more genes that supposedly impact this space https://t.co/87apLJb0gk while neglecting the role of the immune system and gut bacteria's impact on epigenetics.

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Yeshttps://t.co/OqumZlELtr

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UltimApe@ultimapeover 3 years ago

If people shrink as they age, then I want to grow taller.

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Would be neat if this temperature dependent chromatin/methylation phenomena is also what drives gender divergence among amphibians and reptiles. https://t.co/UkdoQU9H33https://t.co/C0PbLX9tLP https://t.co/CZvI6Cm4rX

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UltimApe@ultimapeover 3 years ago

On chromatin causing a situation analogous to giraffe necks impacting offspring. "A lot of work remains to be done, but the doors to a world of Lamarckian inheritance are flung wide open"https://t.co/OjUAchGh2MWe don't look for this. Streetlight bias.https://t.co/g7MTo3Xh22 https://t.co/xm0btzX8zz

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

If this chromatin remodeling is more widespread than we realize, that would have some weird implications about warm-blooded animals. IIRC most of our body heat is regulated by immune related functions.https://t.co/ccr2bQdKMv

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UltimApe@ultimapealmost 6 years ago

What do you mean female lions can have manes. What do you mean stress from competition+food scarcity can change the expression of gender related hormones even if associated gene isn't passed on. https://t.co/MhJB3No0Kh

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5/9/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

If scientists can manipulate the size of ants via epigenetic signaling, do you think that giant ants who dig gold up from the ground were actually real? Wonder what kind of soil bacteria they were smelling. https://t.co/ru5CSooyW9

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UltimApe@ultimapeover 9 years ago

“ants about the size of dogs, living in the Indian deserts and guarding giant piles of gold” https://t.co/q0a3AnxkBI https://t.co/u0DGlMsOXy

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5/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

I wonder what happens to an ant's gut bacteria during their colony's weird 'hibernation' phase.https://t.co/6VQgtG5JcL

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UltimApe@ultimapeabout 4 years ago

Why marmots are great:Cute animal.Fat.Can Hibernate.https://t.co/g7XdCAmuWr

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5/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Thinking about a giant orb-like ant now. :3https://t.co/yVwdGXf1Pr

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UltimApe@ultimapeover 3 years ago

"The physical and chemical principles that rule the transfer of energy and materials within and among organisms generate order in the riotous, and sometimes seemingly overwhelming, complexity of ecological systems." https://t.co/rvWnNvccp0https://t.co/SQ0lYFEnPp

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5/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

For future me.https://t.co/9KnAoG3DCx

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UltimApe@ultimapeover 3 years ago

@__ice9 @CTZN5 megakaryocytes> "demonstrated that MKs are essential for skeletal homeostasis, due to the expression and production of the bone-related proteins osteocalcin, osteonectin, bone morphogenetic protein, osteopontin, bone sialoprotein, and osteoprotegerin." https://t.co/KWXxy6DUql

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6/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Think about bears more."Our findings represent the first descriptive study on platelet function in brown bears and may contribute to explain how bears can endure denning without obvious thrombus building"https://t.co/xe6iM9eTCKhttps://t.co/ebtGjCsK2u

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UltimApe@ultimapeabout 7 years ago

I can't stop thinking about female bears with penises.Why do they exist? What does this mean?How do bears lose weight and gain muscle while hibernating, and not succumb to bone loss in the process?Also this government website talking about bear poop.https://t.co/Pr4SanHNSI

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6/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

We may be able to figure this out.https://t.co/rFJs0CXBOB

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UltimApe@ultimapeover 4 years ago

@KBULTRA0 Literal body horror is my inspiration. I wanna be able to enter hypersleep and survive space associated bone loss.Might have to eat bear gut microbes. https://t.co/M0SpyOBADu

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6/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

My ideas are weird.https://t.co/W4fsUdwYvW

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UltimApe@ultimapeabout 7 years ago

Two things plague astronauts and possibly colonization of mars.1) bone loss2) muscle lossTL;DR: I imagine a future where astronauts injct themselves w/ bear poop to endure the harshness of space, and possibly endure sex changes as a result of microbial impact on sex hormones.

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6/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

How do I fix my bones?https://t.co/3ilk3jDkMY

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UltimApe@ultimapealmost 5 years ago

"Among the MS population, a whopping 27.2 percent of patients report having low bone density—either osteoporosis or osteopenia [...] study published in the medical journal Neurology, only half of MS patients are being screened for bone disease."https://t.co/H4xuvHH8uJ

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6/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Things are going to get weird soon :3https://t.co/RHPQzVvo2j

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UltimApe@ultimapeabout 5 years ago

@bcminister @VitalikButerin That bone loss is a 'problem of aging' that can be explored via space research. It might help astronauts not pee out their bones, and may have interesting impacts on heart disease. https://t.co/WzSliS7FwZCan be directly translated to help heart problems among impoverished.

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6/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Felt cute, might stop my heart for fun."IL-33 and sST2 levels differ between CVD patients and controls. Higher levels of sST2 are associated with increased mortality in individuals with CVD."https://t.co/u3VsFOeufFhttps://t.co/ESyGjROW2c https://t.co/c0h2edq4bW

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UltimApe@ultimapeover 5 years ago

Tired: obesity is a risk factor for heart diseaseWired: obesity is a risk factor for gut dysbiosis leading to microbiome induced inflammation that impacts heartInspired: Do bears get heart attacks?Hired: How can we get humans to hibernate?Desired: https://t.co/NJlwfmXpiW

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6/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

off and onhttps://t.co/3GbPCSNPQU

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UltimApe@ultimapealmost 4 years ago

Reset the state. Regrow the organ.Have you tried turning the spikey rodent signaling pathway off and on again?https://t.co/g8ISZaJQYy https://t.co/sjbVh7Prhv

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6/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

off and onhttps://t.co/BoeU3UP7Nz

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UltimApe@ultimapeover 4 years ago

What is dual-use of remotely turning on and off genes using Ultrasound?"there is a lack of general methods to remotely and noninvasively regulate genetics in live mammalian cells and animals for cancer immunotherapy within confined local tissue space"https://t.co/QPjf1eYaKh https://t.co/Fr1waKdjsv

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6/10/2022
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UltimApe@ultimapeover 3 years ago
Replying to @ultimape

Have you tried turning your human off and on again?https://t.co/Eauai0fnke

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UltimApe@ultimapeover 4 years ago

My human hibernation theory in a nutshell:What if we just turn the human off and on again?https://t.co/puxuNZVqCN

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6/10/2022
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UltimApe@ultimapeover 1 year ago
Replying to @ultimape

"The fusion of two sisters into a single woman suggests that human identity is not in our DNA" https://t.co/XKR4Vh8FnHJawsome. I need a book that talks about autopoiesis and emergence of cells. Book sale this weekend too!https://t.co/xtRPyD47Hk https://t.co/1vROtUdCYD

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UltimApe@ultimapealmost 4 years ago

Who's going to win? Some autistic guy who DGAF so is out here making jokes about sonic hedgehog to reference a children's cartoon about evolution and gene splicing, or some curmudgeon who like to bash religion because it gives him high status?Jawsome.https://t.co/s8oerEBV7S https://t.co/cefZkXGI0c

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5/9/2024
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UltimApe@ultimape6 months ago
Replying to @ultimape

Society is sleepwalking on myths and misthinking.My life-long 24-hour sleep wake disorder vanished in fall 2022 after eating dog feces pills.Turns out what you eat CAN impact your phenotypical expression. Darwin can eat my ass. https://t.co/Wwv2Ofoxqq

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UltimApe@ultimapeabout 7 years ago

It'd be really funny if, in order to fix my sleep issues, I have to destroy the concept of paradigm shifts in science and reformulate the theory of evolution in terms D’Arcy Wentworth Thompson's theories thru a foundation in autopoeisis.

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3/21/2025
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UltimApe@ultimape6 months ago
Replying to @ultimape

What's bacteria, precious?> "Autopoiesis provides the conceptual and systematic framework within which any living system may be identified. In examining living systems, then, autopoiesis gives us a literally "meta-physical" view of life." [1986]https://t.co/h9yR8Y2oSl

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3/21/2025
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UltimApe@ultimape6 months ago
Replying to @ultimape

What if everything you think you know about biology is wrong?ʕノ•ᴥ•ʔノ ︵ ┻━┻https://t.co/aMNK4myaIO

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UltimApe@ultimapeabout 1 year ago

@Grimhood When you throw away the dogma, it all becomes clear https://t.co/AJmhUuhJEf

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3/21/2025
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UltimApe@ultimape6 months ago
Replying to @ultimape

It's dark in here, I think I shall open another.https://t.co/0g0ncSPDPf

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UltimApe@ultimape6 months ago

I don't want to just heal my eyes. I want to see better than every other human on the planet.https://t.co/GNmiqpktAT

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3/21/2025
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UltimApe@ultimape6 months ago
Replying to @ultimape

One does not simply grow new organs.https://t.co/rDby9QRsPm

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UltimApe@ultimape7 months ago

There's more than one way to optimize for genetic expression, methylation, and DNA repair.https://t.co/09cDGE4uHM

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3/21/2025
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UltimApe@ultimapeover 6 years ago
Replying to @ultimape

"Nevertheless, the question is not definitively settled. The problem is connected to an even larger question, the evolution of evolvability."https://t.co/oDL8163qzN

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6/11/2019