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One possible reason we think that genes predisposing for intelligence also encode for depression is because the smarter rats learn quicker that if they stop squirming when hung by their tails they are let out of the torture chamber faster by their care takers.
A weird take on the rat drowning depression experiment is that they might be measuring extent which a rat's intestine generates gas; Could rats float like tiny manatees or sloths? What we're actually measuring is inflammation associated with fat deposition and fart generation.
The real reason we encourage people to eat more fiber is it'll turn everyone into witches. It'll help you float.How does one measure buoyancy? I have lost a lot of weight, but I think I might be able to float b/c of an adaptation: crohn's disease's impact on gut microbes. https://t.co/9yyXfppWMt
... I'm looking up if ants can float on an individual basis (if they are large enough).I found the answer in the image pun on 'gender-fluid'. https://t.co/KDZewS6fdN https://t.co/PCuccZzUmV
I am now investigating if crohn's disease is gender-neutral phenomena, on suspicion that IBS in women is a misdiagnosis in women.I was talking to my gram about her crohn's. Her pain was ignored as 'woman issues' until point that she almost had to have her intestines removed.
After a quick look at bunch of surveys: I still have a non-zero weight it might be a misdiagnosis: women are more likely to get diagnosed as they age.Might be caused by assuming it's period cramps?https://t.co/MznQGMh3Rshttps://t.co/5ZGRPsBz79https://t.co/l4teU08qryNot sure.
A guy with a cyborg intestinal tract mused how the larger chamber caused him to float."in the bath would function as a buoyancy aid that drew my hips up to the surface of the water."https://t.co/oV1BAf29Nv
"stretching 20ft from mouth to anus, air and light at each end, an ingenious pipework that incorporated oesophagus, stomach, small intestine, ileum, colon and rectum, and contained 100m nerve cells or neurons, more than in the spinal cord, as well as 95% of the body’s serotonin."
Remember that time I predicted that I had crohn's after a lot of research stemming from being inspried by shitposting about bananas? https://t.co/c61RFDAnVQ
The aquatic ape theory suggest our immune system evolved to help us float. 😂https://t.co/sV9Ny20WEF
"The immune system was not evolved to protect us? This seems counter-intuitive. We see that the immune system is absolutely essential to survival in a world of infectious agents, and we conclude that it was selected to prevent disease."https://t.co/JcKYQyiSrK https://t.co/IsoF0zqubD
If you were a sloth who's main way of cruising for chicks was floating down river, you'd also want to protect your flotation giving poop and avoid excreting it as long as possible.https://t.co/eIcXdIa9if
Some say sloth's pooping rituals are an evolutionary mystery.https://t.co/tohtmWRIi4
You aren't supposed to talk about sloth fight club guys, come on!"To know that he can interact with other sloths he’s never met—and then fight them and win—is amazing."https://t.co/Fff3KvQLrq
A female sloth screams when she smells the musky sent of a male's piss.https://t.co/ve119fP4xQHAHAHhttps://t.co/skBXKlET0E
We rethought serotonin signaling once. From "turning mice gay" to "this is just aggression & dominance behavior playing out". Just take it a step further."more mice will [be tortured] before scientists figure out exactly what role serotonin plays." https://t.co/fRh9F4Jq6t
How many status moats will I need to destroy before the games we play over serotonin's role in depression is undermined? This suggest that there are many.https://t.co/8OxR4gYfdm
Rethinking the foundations to fell the ivory towers. A house of cards if I've ever seen one.https://t.co/I3WuS3OPQT
I added "Stories masked in a cocoon of insight porn and body horror." to my bio here a while back b/c fundamentally I see what I am doing is finding + inventing alternative narratives on how we view the world. An attempt model as many minds as possible. https://t.co/3Lo0tAPEX8
Building scientific castles on sand and wondering why the ideas are falling into the encroaching ocean's wavefront.https://t.co/onIurRhZbU
You ever say something interesting and someone goes and writes a paper on it?https://t.co/7gzOBLZuw1
What is really interesting is the method I used to find people who write about my ideas for me.https://t.co/MQ4DlgzuOm
"Years of general scientific consensus on how living and extinct sloths evolved and are related may be inaccurate, according to new research." (That also might explain why some sloths float, and others don't)https://t.co/ifUI9k50vn
"Scientists have long speculated that humans killed and devoured ground sloths—but, for many years, there was no physical evidence to support this idea. Then, in 2008, incriminating scars were found on the femur of an Ohio Megalonyx."2008!https://t.co/JR5dDtk8r7
I basically doubt everything we know about history that comes from museums.I even doubt Darwin himself, tho he did seem to move the discussion forward.https://t.co/f2B0byOmHt
Studying Darwin's early childhood and collegiate career, you quickly see how Museums influenced his early habits of collecting and identifying species of plants. A cultural interest in fossils and working in museums influenced how he was able to reach conclusions that he made.
The trick is that I don't call them fairy tales to demean their utility; I actually think fairy tales are more powerful as a way to impart meaning and reason than most people give credit.https://t.co/HiIVfc1Mbv
I wash my hands [in] this weirdness:https://t.co/VfpCK4gGNj
All these questions, no answers.https://t.co/TJRnRmtXtY
I wonder how many models of evolution in computer science are riffing off of myths and misunderstandings.Ring species wasn't really even validated until 2012! Allopatric speciation (darwin's finches) might even be a result of collaboration between gut microbes and host!
Thinking about torturing mice by trying to see if I can breed ones that float better. Wondering if drug trails that test depression in rats might be flawed if the rat has a lot of gas.https://t.co/HM5LIgLrqO
"It is not clear whether mice stop swimming because they are despondent or because they have learnt that a lab technician will scoop them out of the tank when they stop moving." [July 2019]https://t.co/vkiKZmv74jhttps://t.co/4JcsUrG1yn
One possible reason we think that genes predisposing for intelligence also encode for depression is because the smarter rats learn quicker that if they stop squirming when hung by their tails they are let out of the torture chamber faster by their care takers.
I need to make more jokes, they all come true.https://t.co/uw4hurXn0z
In going thru her medical history, it seems my GF didn't start gaining weight until the doctors put her on an SSRI. That was also the time she struggled with motivation.Would be really funny if gut microbiota impact reward pathways or something.https://t.co/r4DwNvYcl0
Looks like I am going to single handedly take down the entirety of the western medical institution in my quest to cure autism and stop my GF of dying from kidney failure.Sorry.https://t.co/3mZxhd0ROi
SSRI use might be partly causal factor for alzheimershttps://t.co/Z2RZrJeimxWith noted population level risk increasehttps://t.co/WWwicXWhR7
known gut bacteria disrupting chemicals change brain in surprising ways https://t.co/myHWLxKi1nIt's almost like something interesting is going on.
Sertraline apparently causes brain fog issues similar to what we would expect if making the rats dumb make them swim longer, and might also trigger mania, which would make them swim longer.https://t.co/l6xGg5gwwr
"It is not clear whether mice stop swimming because they are despondent or because they have learnt that a lab technician will scoop them out of the tank when they stop moving. Factors such as water temperature also seem to affect the results."https://t.co/vkiKZmv74j
Wanna bet stressed rats enter ketosis state and swim longer because they were generating more heat and se oxygen more efficiently during a semi-starved state?https://t.co/op0AGGMdLb
"Brief periods of food manipulation, in combination with multiple other stressors, are used in the chronic mild stress (CMS) model of depression.4,6,9,16,19,21,23"https://t.co/womSvnpXx1So...https://t.co/ZKmIkoDjGo
"show that, [...] taxonomic composition and functions of mouse gut microbiota converge in independent high‐altitude environments and propose the intriguing hypothesis that some of these functional convergences might be beneficial to their host." [2019]https://t.co/vYynb9I9iQ
"Hypobaric hypoxia exposure therefore induces depression-like behavior in female rats, but not in males."https://t.co/R7vXPbKKXC
Oh ok, so you use food stress to cause changes in the animal to mimic stress situation because it impacts stress hormones. Do we have an accurate model of rat's fasting biology & thermal regulation?Turns out we probably don't.https://t.co/bF8eGyQxWE https://t.co/IO6TPodNfK
Good summary of brain fog. I say this having suffered with it for years and having family who have the same.https://t.co/By3WWSZehl
Tired: kids takin Adderall for adhd are on meth.Wired: kids on Wellbutrin for depression are on bath salts.Inspired: Most major pharmacological remedies might be accidentally directly treating gut problems and this may show up in mice studies. https://t.co/xstGR2qjCX
All my brain can say right now is "Freudian butt pucker".https://t.co/HBTqLI2iT4
Is cocaine a cathione? Would that make mice swim longer and so show up as a viable 'treatment' for depression? @OhMalG https://t.co/vPoRSbuHAD
I love that I realized my intrusive thoughts are a form of Hyperthymesia applied to language, cuz now when words like "Freudian butt pucker" echo thru my head I am not as bothered by them.It's an idea I wrote in my tweets!https://t.co/LaB4o90457
inb4 "the subconscious" is just autistic infodumping behavior that happens when you are around trusted psychologists long enough to feel safe (oxytocin).https://t.co/zVBoR2L6Uk
I was getting that state from Crohn's Disease related anxiety. https://t.co/hFBZZQ0VZO
I went to bed shortly after that last tweet, then woke up 7 hours later with scary idea in my head.I wonder if this is 'automatic writing'? I know I was clanging pretty hard, so it's probably nonsense to everyone else until I can back fill the thoughts.https://t.co/d3kc2UMhaG
Diarrhea of the mouth, lol.What is displacement behavior? for $1000 alex.https://t.co/wOefJPFVW0
Something I think a lot about is how MDMA was first described as "a years worth of psychotherapy in 6 hours"...Oxytocin boosting chemical that changes neuroplasticity?https://t.co/DaTe5JBsxm
Its really fun to me to undermine basic axioms of an entire field of thought. https://t.co/OD2CqMVn3p
By pretending I'm Freud's dog smelling his bullshit.https://t.co/HoQHOxSukW
Infodumping about taking a dump.Literal figurative shitposts about Lacanian psychoanalysis.https://t.co/tX8ctzqqCW
Looking for a reference about druggies being really good at finding medicinal plants and other psychotropics... but can't find it.Instead, here's an idea that fascinates me.https://t.co/TxFqSQ4Ejv
Low serotonin in mice, monkeys, & humans all correlate with being an abusive bully.https://t.co/K51kTJQLJuinb4 gut bacteria's production of serotonin is responsible for intergenerational social defeat stress and related epigenetic changes impact mood.https://t.co/sphPcVZYiX
I'm going to prove I'm right that impacting gut bacteria with SSRIs drives anger and aggression and people gonna be really mad at me when it turns out to cause school shootings.https://t.co/Di847HNuQl
"revealed that low brain serotonin made communications between specific brain regions of the emotional limbic system of the brain (a structure called the amygdala) and the frontal lobes weaker compared to those present under normal levels of serotonin."https://t.co/oW1RaelmlR
I bet this effect is driven by gut bacteria impacting the way mice smell and modulating aggression via a kinship pheromone tied to serotonin processes in the gut.https://t.co/bHc8RcAPqo
Trying to figure out how to make people spontaneously shit themselves, for reason.https://t.co/CAEbXt0G5O
*sniffs*Smells like gut immune interplay.https://t.co/nQdpZWRpmn
Gonna make a better mouse trap by making the mice happy.https://t.co/Cysanx1z4E
Smell and taste shifts thru social contact with shared microbiota in a mouse colony?https://t.co/aPXfWIedq7
@SuezLab "As another example, germ-free mice—which have no gut microbes—have altered taste receptors on their tongues. When they are given a microbiota, those receptors change, and the mice change their food preferences." https://t.co/JaM6e2h3zpTaste and smell changes.
What if it's a fear response. if the mouse gets afraid of things that are foreign to it... and then decides to attack instead of flee?https://t.co/Rz8VvrdCE6
And they get stuck there, unable to not fixate on the fear. Like some kind of rumination. https://t.co/3njh7KpHRt
"[…] discontinued the shocks, the ordinary mice gradually learned not to fear the sound. But [those] with depleted or nonexistent microbiomes, the fear persisted — they remained more likely to freeze at the sound of the tone than the untreated mice did"https://t.co/t4AqXKcxd5
Aggression driven by parasite thru gut dysbiosis?https://t.co/C8p1VT7qh8
There's a bunch of studies exploring aggression & bullying behavior in lab mice. People go as far as to trace it to dopamine+ testosterone (with ties to fear/scent via T Gondii), but neglect to explore dopamine in the gut, nor Testosterone's impact on the mice's immune system.
What happens to mice piss when they are infected with T Gondii... Or is it that they can't smell it and get lost, so wander in the open?https://t.co/SBu6f4O5wt
"But that was not the case: the mice remained as unperturbed by cat odour as they had been at three weeks. “Long after we lose the ability to see it in the brain, we still see its behavioural effect,” says geneticist Michael Eisen, also at Berkeley." https://t.co/VMGrJvN8VA
I'm just running my model of this space in reverse. How do I undo what I did? https://t.co/19yDZ6D7zW
Trying to figure out how to decondition myself from fear & anxiety.Everybody's doing this whole sensory acclimation thing using stimulus pairing and neurofeedback. But it was taking too long for me.So I ate some bacteria poop to enhance learning.https://t.co/ZRzOHRm9h8
The freeze response we see in mice is a gut bacteria modulatable response, fite me.https://t.co/WhYIROPVjK
I wonder how regular cannibalism is among captive scientific mice, and if we assume it's normal and don't realize it is because we feed them poorly.https://t.co/nNVkTZTX8l
ah. AHHHHH. no."in laboratory mouse breeding colonies, the loss of pups due to cannibalism is a common issue—so common, in fact, that it is often overlooked or accepted as normal." https://t.co/eSGvIY4XPJI already knew that.https://t.co/yyvSBxWvWT
*squeeks and runs away*https://t.co/mtAjxl8hLy
I'm sure the mice are fine.https://t.co/4Xbia2DNqb
Watching gene edited mice lick themselves like they are the anxious 'pretty ones' in Calhoun's experiments. But they're gene edited/specially breed BALB/c mice whos immune systems don't support right kind of gut microbes to act as viable proxy for real world gut-immune interplay. https://t.co/QKjdM6Oh8t
Don't mind me, just completing the work.https://t.co/UKxJqEaEtk
@MereMirabel "Nicodemus was an Uplifted Rat, one of the NIMH Escapees and the original leader of the Rosebush Colony. In the beginning, Nicodemus was a street rat, no different from other rats, aside from a higher-than-average sensitivity to the Power." https://t.co/Ow4duZAcEL https://t.co/3yzBJrI80z
Why are mice eating each other in labs? Must be climate change.https://t.co/g65L53ICyX
@GRITCULT There are also some strange things that occur due to pollution and noise that may also have epigenetics effects. I don't think it's all just about density induced stress. Calhoun's rat parks are actually a good example of reversing this problem. But myth.https://t.co/83agfBfnDe
Kicking at the load bearing studies until all the mice fall out.https://t.co/i1IgLWnXUV
I don't know why all these scientists are trying to figure out how to solve mazes. I wonder if they're lost and confused.https://t.co/mPoQkITXTv
I wonder how many scientifically induced myths about mice have crept their way into computer science. https://t.co/6jkBR3s0Yvhttps://t.co/0Jnn3CYoPR
"Shannon’s wry humor surfaces at the end of the Theseus film. He looks directly into the camera and notes that the method the mouse uses is mathematically guaranteed to “solve any possible maze.” And then, playfully, he traps the mouse in a single square."https://t.co/B4Akxgzq82 https://t.co/O6C1m9wo48
Pray to the gods of status."symbolism and importance of shrews and mice in the beliefs of the ancient Egyptians is well documented from later periods of Egyptian history, when they were often mummified and placed in little coffins" https://t.co/vlhovnnDzFhttps://t.co/hlSmiNe0nR
I don't float anymore.https://t.co/FSQhn0X8R5
"Fecal microbiome transplant from infants exposed to antibiotics in early life (and sampled one month later) into mice led to increased aggression compared to mice receiving transplants from unexposed infants."https://t.co/wbWADU1U24https://t.co/wqph697hBA
Funniest thing on this I heard was a person doing a F-to-M transition; complained about how it made them feel like they wanted to kill or fuck everything.What if this personalty effect is gut driven? https://t.co/sgV5fJDP3A
Inb4 gut health impacts impulsivity https://t.co/M1aCJtBjzd
My fucking role models growing up is Mr Rodgers and Bob Ross. And my dad. A gentle giant.https://t.co/GLhdFveL8F
The one thing I haven't been able to get control of is my aggression when i'm frustrated. I don't hurt anyone and I don't destroy my things anymore in my autistic 'retard rages', but I get scary. I need to learn to tame that beast within me.https://t.co/HrwIGoPVGw
*it's just society bruh*Society? my asshttps://t.co/iehNXuYO8P
@AndySwan @fwiles @pmarca I think I solved how FMT caused people's hair to regrow.Not sure what kind of hair loss Jada had, but Alopecia Universalis might be gut bacteria's impact on notch signaling. I've also got hunches on Androgenetic Alopecia and Alopecia Areata.https://t.co/xR6qL0xM0Z
Humanized mice improperly process serotonin after antibiotics impact the donor's gut.https://t.co/EJ1k6dMe7p https://t.co/eQ2IiFtVjb
"The authors linked gut-derived serotonin to the creation of tolerance against allergens, suggesting that the pathway may play a role in the development of conditions such as asthma and food allergies." https://t.co/mnqtOYusjf
A natural experiment."The findings highlighted gut health benefits for 'pandemic babies' arising from the unique environment of lockdown including lower rates of infection and consequent antibiotic use, and increased duration of breastfeeding." https://t.co/jskDM8uRDi
haha, oh wow.> "The situation of these rats scarcely seems one demanding fight or flight — it is rather one of hopelessness… the rats are in a situation against which they have no defense… they seem literally to ‘give up.’"https://t.co/z1huXo6Hkphttps://t.co/w3VkoBRUq0
What if the scientist are wrong, and actually the act of drowning and recovery changes their gut health thru a sort of gauntlet of stress?https://t.co/I4dzAXzJoo
What is a normal rat?https://t.co/pElNeEHc1N
I'm Post Rat. In fact I'm into squirrels now. I figured out how to make them (and chipmunks) not afraid of me."One study used these scent markings to help overcome neophobia with lures by mixing grease, dust, hair and scent marks within urinary pillars."https://t.co/xzeIEgS2yJ https://t.co/GHoX8rSYYm