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🧵 Thread (203 tweets)
"... different variants of the [...] COMT, gene affected people’s multitasking performances"https://t.co/xWOzzCCxJ3 https://t.co/K76eIEo9z2
"fit a model in which dopamine activity needs [in range] for optimal prefrontal functioning"https://t.co/ohPazJpIPE https://t.co/M4u2mO0cTV
Autism, rigidity in thinking, dopamine, and our friendly adversarial Stroop test.https://t.co/LthtJGQ2p7 https://t.co/K9t1bBYIPD
"dopamine-antagonist antipsychotics [.] to significantly improve repetitive behavior, aggression, and mood symptoms"https://t.co/0tr4zIJ8LT
Link between COMT gene and pain sensitivity in fibromyalgia(my mom has this DX! COMT thing is blowing my mind.)https://t.co/BqVBhWW0wf
Shout out to @CTZN5 - pointed out COMT gene and https://t.co/I9ybZWvX4vThe genetic link with dopamine fills a big piece of my ASD puzzle.
Population dynamics"the disorders were more likely to have suspect variation at the same four chromosomal sites."https://t.co/9jjXlcVvBK
~4500 words on why you probably misunderstand Oxytocin. https://t.co/TAqONVTzAd
Genetics are also commonly misunderstood - especially in regards to mental 'disabilities' due to research trends.https://t.co/IAjIfxWzwC
And now to tie this chain back to my favorite theory on autism:https://t.co/G8HpPB3nel https://t.co/utjHvN5dMy
Another article pointing out the more positive traits associated with these 'genetic defects'https://t.co/hAb3GBAdpr
"Kanner had been as wrong about autism being rare as he had been about parents causing it."https://t.co/gcHhUdCHll https://t.co/2fgY2pMnTv
"... starts with being honest about the addictive behaviors that increase stress and misery"https://t.co/hyH7GeBYGg https://t.co/cUiKlOh0Ra
On the prevalence of autism and overlap with other syndromes:https://t.co/TQeJBwlLf7
"neurobiological way to differentiate personality disorders from putative molecular markers"https://t.co/EFCbieDwy2 https://t.co/tBFgQ2zs9U
But Nick, why are you posting all these things about genetics?This: https://t.co/pG7NVEUkfm
"... is mechanistic in a way that the DSM-5, ICD-10 and biopsychosocial model can never be"https://t.co/1q8f6F6tXa https://t.co/ah8iasKzaD
Posting this paper twice for posterity:https://t.co/1q8f6F6tXa https://t.co/0WmwaADnA6
I wonder how it manifests if one has this gene & the COMT variation associated with autism?https://t.co/W3KYVQ3wGg https://t.co/lA1MCsTnc5
"most of us don’t even understand our own software, how it works, or why it works that way"https://t.co/F1oN8QI2ky https://t.co/orxfiNBowr
( If you aren't up for 21000 words, here's a 10 minute video someone posted in the comments: https://t.co/yWZcYLY0XF )
Bird brainshttps://t.co/nD4v7XpWYI https://t.co/3p5SF4tfEn
People brainshttps://t.co/tjtIvLMng8 https://t.co/uRJTrakZhG
Addiction; it is what makes the world go round: https://t.co/DewTe6jkXp
Bees like caffeine. It inspires their waggle dance!https://t.co/YTHP257kvm https://t.co/8YRrNIATv1
"Much like flooding a car engine with too much gasoline, prefrontal-cortex function melts down" https://t.co/7LX537pYgI
"The trade-off seems to be rooted in how each task is affected differently by dopamine metabolism level" https://t.co/1py4C69O7P
"Darwin's conundrum: how selection could favour individually costly behaviours" #ants #beeshttps://t.co/3SqW4RJTd2 https://t.co/q8pbrs74xS
We're just one node in a fractals of networks.https://t.co/zRW7usOBLU
"modulating, and in some cases enhancing, cognitive processes by exciting brain regions" - https://t.co/wnnZxmWLHV (.. like done w/ birds?)
The genes assoc w/ altruism seem to encode for the nuerochemicals that @simonsinek talks about here: https://t.co/ptbI0waVpP amazing!
How do drug like Psilocybin make you more creative? Brain chemistry, Duh.https://t.co/A4CHmJm2fl
Want to naturally get more creative? Get sleep deprivation (due to depression?) may be the biological way: https://t.co/vBcmkCPqEY
"Handwriting and spelling errors were found in 89% of suicide notes left by adolescents" https://t.co/IHyCVTFzae
Maybe there is a campaign, I just never saw it that way."Different... Not Less" https://t.co/7bXZul3Ko3https://t.co/evlPiEo4eP
"an umbrella over all of my phenotypes. I thought: This has to be the unifying principle."https://t.co/fQHbmwofJN https://t.co/buo50l55Lz
"fit a model in which dopamine activity needs to be neither too low nor too high for optimal prefrontal functioning" https://t.co/ohPazJpIPE
"This is the first study to link altruism to a specific gene."https://t.co/aOr9yQvHC3 https://t.co/3USoEFV6sX
Undoing Freud: "... help us move toward classification that will be more faithful to nature"https://t.co/9jjXlcVvBK https://t.co/ZfyOtWw55e
"we can measure, to millisecond accuracy, how good they are at switching from one task to another" https://t.co/1qqGQfv0Lm
"transfer of videogame training to untrained tasks is modulated by preexisting neuro-developmental factors" #COMT https://t.co/QDso6wBNAW
"these same brain chemicals prove essential in permitting brain plasticity and thus learning" https://t.co/4vpCZ2z3E6
"first published demonstration of a link between those genes and the animals’ behaviour." https://t.co/ON6a6bBrUk
"…accurately quantify reward responsiveness and motivational tendencies in ASD are lacking" https://t.co/ydkX6UWORD https://t.co/4ybvt2Nm6f
"This population of dopamine neurons thus selectively promotes learning and retention of habitual behavior." https://t.co/zijwdL8mRO
"an exciting finding that shows a brain mechanism whereby anxious personality affects social competitiveness" https://t.co/aszDDTVFyM
"CBT is basically being mindful of your crappy neural connections, and gaining skills to retrain those connections." https://t.co/T2MF0ljTMO
Some days, I just needs a hug. Why?https://t.co/Gjno41uSwX
"the etiological and the functional significance of these areas of overlap are uncertain"https://t.co/x1k0tHJP32 https://t.co/yS61dHP7xI
"Sensorimotor gating reflects the ability of an organism to filter out irrelevant stimuli."https://t.co/g45rngC2cm https://t.co/jwG8ukwIT0
"these disorders are remarkably consistent with a theory of area-restricted cognition"https://t.co/6CbzFt2RUl https://t.co/BgkSev1f6a
"their cerebellum start to look more like the same size as the typical normal kids and it would explain why..."https://t.co/ecx7h1is0Z
61 results on Cerebellum and it's association with Autism (and more): https://t.co/0TjTu0avsT(this is going to take a while...)
127 on depression. I wonder what the rate of overlap is...https://t.co/wRD2qvKZFa
First person to find a chart like this one wins a cookie: https://t.co/syCj8z800E
"I have an easier time planning a 20 aircraft fleet, than I do paying my light bill." https://t.co/T5jowNAKvx
"... this view of chemical imbalances in the brain as if the brain were some kind of bag of chemical soup"https://t.co/mBgF5yKhTa
"like trying to change your engine oil by opening a can and pouring it all over the engine block" https://t.co/WsNWmTZia5
"first to measure the synchronization between the brain areas that make up the Theory of Mind (ToM) network" https://t.co/xRf7hBrC9Y (n=24)
Shooting in the dark, listening for the pings. Why don't we find a lightswitch?Shocking study, but not unexpected:https://t.co/gHoT9BrA5h
"paradigm-shifting book proves that dyslexia doesn’t have to be a detriment, but can often become an asset" https://t.co/jQYwGPIuQs
"and the important part is that it's a variation on normal"https://t.co/ZQOICERpY4
“uncontrollable, threaten physical integrity, or involve trauma tend to have a high, flat diurnal profile” #cortisolhttps://t.co/6MNqTyvHWp
Hehe, why stress makes you not want sex: "hypothalamic-pituitary-gonadal axis"https://t.co/jm04xHEFxb
"To understand the neural mechanisms supporting social information seeking behavior requires..." https://t.co/75zyBEBwEh
"A behaviorally distinct subcaste known as “pathfinder” foragers can relocate long-lived pheromone trails." https://t.co/4ULgYjRG8B
Genetic variant as possible causal link with social withdrawal (shame?) w/ experiencing other people's anger? https://t.co/HUIj2kWhFq
Pain tolerance associated with dopamine, opioid, and comt gene: https://t.co/WFntw1rQGE
Anxiety modulation in the amygdala associated with Kappa Opioid Receptors: https://t.co/PDXgCqDSPs
"visual and olfactory perception, sensory–motor programming, motivation, memory, emotion, and endocrine regulations" https://t.co/7ahdDGQB5E
COMT gene mutation associated w/ caffeine metabolism.Beneficial for someone on spectrum.https://t.co/yPrDkBK2nC https://t.co/cOxpN18RMr
Cortisol... Emotional states as a way the brain shifts priorities and attention:https://t.co/a4CjodNfri https://t.co/DgCLlYMkzK
Would love to see Caffeine study done with an eye toward genetic variation of COMT genes.https://t.co/YhhpYtU5pZ https://t.co/HmLjrdVaiP
If N=96, but assoc. gene mutations are < 10% of population, what does this say about the significance? How Bayesian.https://t.co/CtW5zlASty
For ref, the cortisol caffine test studied cortisol in morning. but... odd in autism (N=44):https://t.co/yqdbTEpeNC https://t.co/xmuqZquTS5
AFAICT, caffeine (and alcohol) seem to be high on list of 'self medication' for those on spectrum, or schizophrenia.https://t.co/VzAr24EJJl
Depression, anxiety, autism, alzheimer's seen as being helped by https://t.co/irrF73SV8B So maybe OPRK1 mutations are also common factor.
I'm predicting stuff like https://t.co/DvmHiL4LaD but more directly for research within adhd, bipolar, schizophrenia, and autism.
Possible link: psoriasis, chron's, Infliximab, oprk1, cannabinoid, keratin, (dandruff?) in P Kupczyk, A Reich's work https://t.co/yuL5mL8Vek
also, why the fuck is this even patent-able: https://t.co/f0hTvFlHva
“risk for autism lies mostly in variations of common genes, and not specific mutations.” n=400 (demographic: sweden) https://t.co/CuKpY82OpB
"...will also clear the way for a more precise scientific understanding of the overlap of these two disorders." https://t.co/rrYL2eTr79
Saw strange correlation in PCOS across ethnicities. seems to follow COMT mutation... BAM:https://t.co/KPRnyj3Ntyhttps://t.co/2M18ZUl0yF
Oh hey, PCOS is assoc w/ depression, drugs that help also relieve oxidative stress in Alzheimer's? [duh?: https://t.co/Iav93YZYVK ]
Parkinson's Disease study also helped by PCOS drug, mentions Apoptosis: https://t.co/V2iOPu87Gf (link?:PCOS risk of endometrial cancer)
Parkinson's manifests in basal ganglia. Basal Ganglia is associated with memory https://t.co/1dJdcns6Gm and emotion: https://t.co/TucKf44zXe
COMT mutation associated with Endometrial/ovarian cancer: https://t.co/PIzG7NKAI1So is PCOShttps://t.co/eSIKL8gY7z
It's really hard to find information on women or minority groups and autism.This is why: https://t.co/p6vhuqKjb4 https://t.co/tcX7IHez6D
I wonder how many women have autistic traits, but laughed off as PMS, framed as "bitchiness" or simply ignored: https://t.co/4zagojwIdJ
I blame everything on traditions going back to Freud. I hate Freud and his ego.https://t.co/UAHfjVYOQy https://t.co/TgEZT6E3AJ
"If it doesn’t work on the chip, how can we expect it to work on the brain?"https://t.co/ovUoodqxgb https://t.co/1ZZDrO4yHJ
"study of these concordances may shed additional light on the nature of both disorders."https://t.co/x1k0tHJP32 https://t.co/aXSUbJlRfG
"examined the relationships between COMT, early life stress, and personality in a healthy adult sample"https://t.co/nvSrGks1Ht
Different, not less. A variance in trait.Weaknesses are strengths? What do you thrive in?https://t.co/VkilkdxoVd https://t.co/8OpAOiKGLw
Outgroup not worth thinking about?"mPFC activates less to members of extreme outgroups that elicit disgust" https://t.co/alOjpdPzPr
"elimination of caffeine may vary across the menstrual cycle, with elimination being about 25 percent longer in..." https://t.co/aYlSYnryyX
Yep, just another $230 science book on memory and attention going into my wishlist.https://t.co/0zFTdIMnfE https://t.co/MTEj3wWtI3
Interesting parallels in disgust pathways when looking at autism and depression.https://t.co/LEvSxQ4N1D https://t.co/7ebYlDYHCU
Disgust is an interesting topic. Is this why I don't have a severe dislike of the outgroup?https://t.co/2Ez8W2bPaK
Is a lack of sensitivity to disgust why I find I am mostly immune to normal political rhetoric? https://t.co/v6YwkmOh6U
More than that, it's spooky that I find parallels with social motivation/learning and disgust training: https://t.co/P9R4rmhp7v
Diseases and abnormalities in the Basal Ganglia and Prefrontal Cortex are all interesting similar in their effects.https://t.co/YbT3TuykgO https://t.co/6D1AQ379TC
"this should be studied in a broader context, including the neighboring regions that are in genetic linkage." https://t.co/uQ4nemjD8H https://t.co/fZ0sj1BLUJ
Possible angle of ligament issues (flat feet, loose joints, congenital hip dislocation, scoliosis) and autism?https://t.co/QtpHGeaf5K https://t.co/Od1qLFEObs
Everytime I look up issues that seem to correlate with autism, I find MTHFR (folate, b12) being implicated.https://t.co/qyaXeSAd4C
I hate MTHFR thing; it crops up in food conspiracy theories. But it also interests me b/c of ants & epigenetics: https://t.co/kX9R6Whtxj
"...To diagnose and treat a brain disorder accurately, it would be necessary to look at the brain directly." https://t.co/3coCXapfA1