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UltimApe@ultimape• 10 months ago

Having suffered with jet lag for most of my life due to non-24-hour disorder, this makes me laugh. Fast during the flight and drink a little alcohol to put the gut bacteria into a dormant state, then eat breakfast in the new timezone's AM. https://t.co/FMt51laiJy

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Bryan Johnson@bryan_johnson• 10 months ago

Some things I’m trying to lessen jet lag: 1) Fast: No food, caffeine, or alcohol before or during. For a flight from LA to Mumbai via Singapore, this means a 33-hour fast. Overeating on flights wrecks sleep quality. 2) Sleep Immediately: Informed the flight crew that I’ll skip meals and sleep right after takeoff. This avoids being disturbed by the flight schedule or service. 3) Blue Light Glasses: to block bright cabin lights and screen exposure. Read instead of using screens to prep your body for sleep. 4) Avoid Alcohol: it disrupts sleep and dehydrates. Skip it completely. 5) Hydrate: Dehydration makes fatigue worse. I consume more water before and during a flight to make up for this. 6) Sensory Control: Use earplugs and an over-ear eye mask to block out light and noise from the cabin. 7) Exercise: I’ll exercise immediately when arriving at my hotel (11 am) to begin aligning my circadian rhythm with the local time and then have my usual breakfast.

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

If you understand how the gut is involved in circadian rhythm, the "disruption" effect of alcohol can be harnessed to reset their rhythm to align it with the local timezone.Exersize probably helps because it's dumping lactate into the gut to do something similar.

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Jet lag, lolhttps://t.co/eryYQeRStq

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Your gut bacteria can be stressed by timezone changes, so by puttting them in a dormant state, they aren't "on" for long periods of time.https://t.co/C4jyfdn5rs

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UltimApe@ultimape• about 5 years ago

@Baalren But eating the same time every day helps a bit. Doing things that impact gut health to fix 'jet lag' helps a lot.https://t.co/61mXpJ5Lbd

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

"The identification of circadian rhythmicity in gut-associated bacteria is intriguing in light of research showing that the gut microbiota exhibits daily oscillations in its composition."https://t.co/1HwU8nRMYt

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

if you want to experiment with this, you can use body temperature tracking to guage how the bacteria are active.With Bryan's body temperature being so low, it's likely that his strategies won't work for you.https://t.co/nCnYdS6m3V

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UltimApe@ultimape• over 3 years ago

@sabbatical It's how I figured out that gut bacteria's serotonin rhythms control body temperature. Their cycles coincide with serotonin levels, and serotonin plays role in wakefulness.https://t.co/1HwU8nSkO1

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

I literally wasn't able to get to my disability lawyer because of my non-24-hour disorder and suffered greatly with struggling with jet lag while trying to force myself in to a 24-hour day.So I took figuring this out pretty seriously.

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Figuring out the alcohol + fasting trick was HUGE game changer.https://t.co/z9jsXRnKST

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UltimApe@ultimape• over 5 years ago

@BillStewart415 @tadethompson There's a protocol for treating jet lag assoc, 'brain fog' that is about fasting https://t.co/w4jim8tFeR (and for some, consuming alcohol) in such a way that it resets them. As someone w/ cortisol weirdness & non-24hr syndrome, learning this has been huge. https://t.co/SnQ0DbIUae

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Honestly, since the FMT fixed my non-24-hour I have a really hard problem, I can't help but wake up at ~10 am no matter what. I can't even shift it to fix daylight savings time.

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

The alcohol thing doesn't work for me anymore. It's like my gut just ignores it. lol.https://t.co/KYx0UlTjRh

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UltimApe@ultimape• 10 months ago

@goblinodds There's some stuff around jet-lag fixes that involve fasting for a while and syncing the first meal with 'morning'. With the non-24, this was what I would have to do for a couple of days if I wanted to get my sleep to line up with an important event. https://t.co/cxuehCideq

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

These insights are brought to you by JƤgermeister being on sale again this month, and the local co-op having full fat organic kefir for cheap.I'm drinking it at 10pm to see if it impacts my sleep. https://t.co/DDFEtFZ3e4

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UltimApe@ultimape• about 1 year ago

I've been experimenting lately to see if I can harbor acetate making microbes in my gut. Neutralizing small amounts of alcohol & turning it into acetate & eventually butryate should super-power my gut health. Butryate producers need lactate as well. https://t.co/cNUkQscgWg

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

I have no idea what I am dong.https://t.co/B0WmKT6JPz

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UltimApe@ultimape• over 2 years ago

I'm losing my mind. an entire 30+ years of non-24-hour disorder and out of the blue I wake up at the same rough time each day for 2 weeks straight?I'd lived on lots of burger before... but maybe the FMT back in January set me up to finally secure a win?

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Gotta get that Honk Shoo.https://t.co/dDbK8TEU6f

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UltimApe@ultimape• 10 months ago

I'm thinking if I can get extra butyrate in my gut at the right time of day, I may be able to enhance alcohol's impact on sleep.https://t.co/DDFEtFZ3e4

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

DAE measure how drunk they are by if they can masturbate to ejaculation?https://t.co/dBJ8eRYhV2

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UltimApe@ultimape• 10 months ago

An interesting correlation I found after the FMT I did fixed my nitric oxide signaling is that the erection turgidity and the impact of alcohol on my sleep seem to loosely correlate. If I drink so much that I can't get hard anymore, my sleep is bad. https://t.co/FVwanmUakd

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12/1/2024
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UltimApe@ultimape• 10 months ago
Replying to @ultimape

I will be as Diogenes, masturbating in the marketplace of ideas.https://t.co/ndrMj4DHl6

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UltimApe@ultimape• over 4 years ago

There was a fashion trend during the renaissance era where statues were depicted as non-erect. Being foolishly drunk and walking around with a raging erection was considered uncouth.https://t.co/wfPylB2u6thttps://t.co/FXu3H3v1eE

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12/1/2024
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

I now know how much JƤgermeister causes me to vomit. Experiment was a success. Woke up at 7am after sleeping for ~4 hours.Going to go out into the sun. Seems like the sun is good enough to get vitamin D today and it's very clear out :3https://t.co/0reiGLilhL

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UltimApe@ultimape• 7 months ago

My dad died of stroke, so I am smoking an drinking to spite him. https://t.co/JJZhnwpm1F

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Its freezing cold out, but the sun is so nice that my body stayed warm. So refreshing.

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

It seems I chewed 2 of those last night given there are two missing from the packet. Thanks past me for documenting. Also how rude! https://t.co/N8FGZZk4ig

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UltimApe@ultimape• 7 months ago

Fuck you, in particular. https://t.co/0c98MYzLvO

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

It seems in my drunken haze I decided that it would be funny to fuck with some bacteria & get them to go into a biofilm state at the same time as I had a bunch of anti-biofilm herbs in my system.🤣https://t.co/8dRbAElUAJ https://t.co/Jaj4DFfSED

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Ah, I had this up in another tab.I was thinking about my GF's health it seems.https://t.co/9VClBAqBjAhttps://t.co/BdBVnGF1ra https://t.co/wHyNlEi5mH

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UltimApe@ultimape• about 1 year ago

@seconds_0 @cynomaxxx Gotta go medival on one's ass."Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients" [2020]https://t.co/23FuKjA8B5

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Well that explains why the vomit smelled strongly of mustard. I thought it was the curry I had eaten earlier in the day cuz it was brightly orange.Sure enough, the bottle of mustard is moved.https://t.co/Ll0Qtjr1n1

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UltimApe@ultimape• about 1 year ago

@seconds_0 @cynomaxxx I learned about mustard being a potential way to fight biofilms by exploring how coca leafs and other plants make cocaine https://t.co/EDNMHpzdHY https://t.co/kISqmKzKDE

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

I bushed my teeth with activated charcoal tooth paste earlier. Now I'm chewing on some mastic gum to clean my teeth.https://t.co/RdOBYn3qXJ

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UltimApe@ultimape• about 1 year ago

@seconds_0 @cynomaxxx It's all connected. šŸ˜‰"Dental biofilm of symptomatic COVID‐19 patients harbours SARS‐CoV‐2" https://t.co/2xJbk2HimYhttps://t.co/z6kOXbttAr

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Gonna fast until tomorrow morning so I can see if I can reset my gut rhythms.Those stressed fucks are gonna need to eat each other if they want to survive.https://t.co/c9AHFOy7yy

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UltimApe@ultimape• over 3 years ago

What if instead of prevent pathogens from gaining antibiotic resistance, we instead tried to get it so commensals were resistant?Then we could have them fight all-out in a battle royal.There can only be one.https://t.co/9er6DAEi5I

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Sorry if I was rude or alarming to anyone last night. I don't think I was, but I may have been belligerent.https://t.co/GUXlLZbHUi

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UltimApe@ultimape• 7 months ago

It's fun that I can treat my drunken states as an alter because I know that my mood is different while drunk, and have a pretty good idea on the feeling of when I'll not have a memory the next day.https://t.co/7mRmDokwzs

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

I never claimed to be sane.https://t.co/hYTeU7eqvn

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UltimApe@ultimape• about 5 years ago

@WoodIsGood6 @Austen You are stumbling upon the journal of a mad scientist detailing his ascent to biohacked godhood, through the power of ants, hibernation, and wine. I'm not settling until I'm immortal. https://t.co/mQJzK47xiL

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Chewed Vigorously for an hour. Ironically its not my jaw that is tired, but my tongue (from moving the gum wad around my mouth continuously).Ladies... get your man some mastic, tell him it's for his jawline ;)

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

The bears are awake :3https://t.co/0128gABZlV

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UltimApe@ultimape• 7 months ago

Awaken.https://t.co/4vk0SrXNky

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3/3/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

GM, woke up at ~8am :3

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3/4/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Everyone trying to look at bacteria under a microscope. What if we listened to them instead?https://t.co/SxtpPUg6zu

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UltimApe@ultimape• 7 months ago

Oh hello there, simple method that would allow me to listen to the scream of dying demons as they drown in the alcoholic ether of my mind. https://t.co/jGql8EiFpA

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3/4/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Woke up at 7am.Today I will drink some kefir w/ jager while sitting in the sun.https://t.co/6fRB9o6B1o

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UltimApe@ultimape• 10 months ago

@Solahmi_ @RogerSeheult "Or does the reality of our seasonal past reveal that our gut microbiome is a shape shifting metabolic organ pulling the strings on our health and well being in a bi- or even tri-annual circadian–like rhythm?" https://t.co/NwtDTA5uTohttps://t.co/FfzWTw1Wih

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3/5/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Time to awaken, gut frens. The bears are out here causing a nuisance, so it's time to rekindle your vital heat.https://t.co/0128gABZlV

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UltimApe@ultimape• 7 months ago

Awaken.https://t.co/4vk0SrXNky

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3/5/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Bet.https://t.co/rSAOp7uJcA

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UltimApe@ultimape• about 4 years ago

I bet starting and cessation of smoking have huge impact on GI environment.

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3/5/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

Bet.https://t.co/Bz6drLPtB0

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UltimApe@ultimape• about 1 year ago

@goblinodds @seconds_0 @bryan_johnson Which is kinda the "evil twin" version of him."An evil twin is defined as somebody who thinks exactly like you in most ways, but differs in just a few critical ways that end up making all the difference." (@vgr)https://t.co/JujvJC88KN

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3/5/2025
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UltimApe@ultimape• 7 months ago
Replying to @ultimape

I only play games with my life that I know I can win."He wore no rings or fancy things, like other gamblers woreHe spread his money far and wide, to help the sick and the poor"šŸŽ¶https://t.co/u4OxwvHatE https://t.co/IQL8TXktew

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UltimApe@ultimape• 10 months ago

@GRITCULT I bet on my life multiple times and now I'm the healthiest I've ever been.I figured out how to 'beat' poker in highschool. But unlike musk, I Don't want money. I grew up in poverty with my mom being sick.Health is everything.https://t.co/lYAHRSZbs3

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3/5/2025
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UltimApe@ultimape• 6 months ago
Replying to @ultimape

What does this mean?https://t.co/7AFzQ4MWw9

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UltimApe@ultimape• about 2 years ago

Have you tried steel manning the germ theory of disease, anon? https://t.co/qbCLkK9Jrk

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3/7/2025
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exfatlossšŸ„›@exfatloss• 2 months ago
Replying to @ultimape

"I have no objections." Oh you had Non-24 too?! I'm not gonna ask how you fixed it lolšŸ˜¬šŸ’© For me it went into remission w/ keto for 7 years. Then after 2 years of aggressively cutting out seed oils, it seems completely gone. I can eat a pure rice diet now and my sleep is stable. Wild that microbiome can do it. Do you have a post where you talk about that?

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7/13/2025
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no@nullbotto• 2 months ago
Replying to @exfatloss

@exfatloss @ultimape First time I made the trip back to the US(~12.5 hour flight), I watched movies the whole time, didn't drink at all. Luckily we ate at a steakhouse in NY and there were endless pitchers of water and salty steak.

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7/13/2025