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🧵 Thread (84 tweets)
"in the 1960s [...] studying a group of young men in Egypt who had not grown to normal heights and remained underdeveloped in other ways, too. [...]When Prasad gave them zinc supplements, the men grew significantly taller."https://t.co/Tx16F62CQN
@strnglft The fun ones are seeing people buying homeopathic cold relievers when the main non-diluted ingredient is zinc. There's a lot of people that are so afraid of western medicine that the don't even realize they are taking something derived from insights there https://t.co/OKOMzOU6pJ
"Her boyfriend's tall and he plays ball, so how am I gonna compete with that?'Cause when it comes to playing basketballI'm always last to be picked and in some cases never picked at allSo I just lean up on the wall"🎶 https://t.co/3fHr4JF7iE
"Children with [Crohn's Disease] continue to suffer from short stature and slow growth, and several studies have indicated that children with IBD may fail to achieve optimal bone mass" https://t.co/XZQCe8w61X
I wish I were taller. https://t.co/y4ZwNZdtxS
Hello, computer gods? can I take an order?Vitamin A, Vitamin D, Some zinc, and a side of Sumerian Anunnaki .https://t.co/hvPDIQMWLe
"the risk of neurodegenerative disorders, affecting neurogenesis and increasing neuronal apoptosis, which can cause deficiency in learning and memory. This links Zn deficiency to cerebral aging, depression, Parkinson's disease, and Alzheimer's disease" https://t.co/QbrPdpeFyv https://t.co/LuxmYA3AIq
"Research on the immune defenses' decline with age has focused new attention on a pinkish-gray two-lobed organ called the thymus gland. Mysteriously, the thymus begins its own decline when many organs are still growing." [1982] https://t.co/wbfvukmBd5
I already figured out how to do what @LifespanIO just published... by using gut bacteria's regulation of mTORC1 via sertonin and lipid metabolism. https://t.co/wXMWmdUgW8https://t.co/k5jPfe8Obs
mTOR -> Thymus -> T Cell Developmentlol dog butts"The present study also implies that long-term usage of [rapamycin] might increase the risk of autoimmunity by impairing thymic epithelial cell] maturation and function." https://t.co/6NqYFh2ltIhttps://t.co/cQfTp64zCk https://t.co/rd2vS8Gx2O
By undermining mouse studies"Although it is accepted that many factors contribute to age-associated thymic involution, little is known about the mechanisms involved in the process." https://t.co/P2HR5guB0D https://t.co/gD77N3PC0z
The trade off is an illusion driven by gut and diet factors. "By contraries, GH deficiency is favorable for the longer lifespan, as hypo-pituitary dwarf mice such as Ames and Snell dwarf mice exhibit longer lifespan than control."https://t.co/RwpRvWupGY
I wish I were joking.https://t.co/yo7vMikQQQ
Well. I am joking. But it's funny because it's true.https://t.co/cQfTp6matS
I'm not going to even bother to read these.I can extrapolate their results by inference to what I already know about age related disease and T-cell function in Multiple Sclerosis.https://t.co/4CRMid69urGotta go fast.https://t.co/0KAS0SJXuU
Jump around and find out."I got more rhymes than the Bible's got PsalmsAnd just like the Prodigal Son I've returnedAnyone stepping to me, you'll get burned'Cause I got lyrics, but you ain't got none" 🎶https://t.co/Wib6a5XYJAhttps://t.co/rPpO6zqi7s https://t.co/vsTXzD8cDU
mTOR does WHAT?"The present study also implies that long-term usage of [rapamycin] might increase the risk of autoimmunity by impairing TEC maturation and function." https://t.co/zubzVJ6ZfD
This shits a lyrical TRP.https://t.co/XvBc1egopD
@37point78 The chart in the lower right is particularly interesting.The link to this with mTOR is"TRPV1 caused an increase in intracellular calcium concentrations ([Ca2+]i) and that this activated mammalian target of rapamycin (mTOR) and promoted muscle hypertrophy" https://t.co/iX4tLDcwr8
Tie'ing up an idea with a thread. Rapping it with rhythm.https://t.co/B7Ylys846c
Let slip the dogs of rawr. :3https://t.co/avGISSHdR2
One miracle at a time.https://t.co/IizAREmNF9
Devourer of Gods.https://t.co/uP0tqYKXtr
Eater of moons."Studies have revealed that garlic is a rich source of essential nutrients and beneficial phytochemicals that can be incorporated in animal feed to enhance gut activity and promote growth in livestock and poultry."https://t.co/538QivyCeUhttps://t.co/MDxNZ2um9v
It's wild to me that people are using Procrustean methods to get taller.https://t.co/UafNJ8c8qg
It also makes me laugh how often these articles get cloned by journalists trying to scoop each other's hot take.https://t.co/pmYWbViulb
GATTACA is a good movie. https://t.co/EeNPCS1vZT
Shame about it being wrong tho.https://t.co/eOjzRIOG6M
Good luck with that my dude."In conclusion, bacteria in the gastrointestinal tract reflect the combinations of medications that people ingest. The bacterial composition of the gut varied with the type of NSAID ingested."https://t.co/Dsb126ifhdhttps://t.co/P4q8UB5vDV
With enough silly ideas in a twitter memex, the jokes write themselves.https://t.co/6BcSuXU7ck
I can touch a ceiling with my knuckle that I couldn't touch with my finger tips a few years ago.https://t.co/YpQFVZW81l
Reducing the crohn's inflammation helps restore some of the height potential. but not all of it. What is missing?https://t.co/kSxLxDoL3S
I bet it's the gut's ability to digest phytate that we've been overloopking, and ultimately is a function of the bioavailibility of zinc from foods.This also has implications for lead and cadmium toxicity. I wrote about it on bluesky recentlyhttps://t.co/P6rTgG7U60
Fixing the inflammation doesn't improve zinc availability, but curing crohn's by fixing the gut microbiome does.Ergo. I am getting taller.https://t.co/Edk2CIryuV
@CodysLab @waitbutwhy Fun fact: royal jelly can induce Pluripotent state in cells, and zinc can promote height development. I even found a study that suggested it works on adults.I'm short for my family at 6'1" (some are 7'5"+) and its apparently due to IBD. https://t.co/PgCnFlV0x4
Ball'nhttps://t.co/VR6ZqHLl0A
@goblinodds @seconds_0 I also saw there's some wild stuff happening around height currently, but in the opposite direction. With some leg-lengthening surgery and even HGH use. Its often parents giving it to their children here too. https://t.co/kETEL85FFUFashion trends are fickle. https://t.co/5n6FHQRkjb
A stack that looks like the main nutrients I promote in my diet is also working to get other people taller. https://t.co/Uq2H0FkGiY
I get EGCG from hard cider, green tea and/or matchaMolybedenum from Stinging NetttleZinc from Oysters, and now from plant digestionB5, B6, and B7 are availile from gut bacteria productionVitamin C from saurkraut/kimchi and hard ciderhttps://t.co/A8PjovHJqE
My approach is to optimize these nutrients and ensure my body has most of the co-factors needed to make good use of them.https://t.co/peYMpjckCk
Have you tried fixing your gut, anon?https://t.co/osqTkZgSp0
Have you tried fixing your autoimmune issues, anon?https://t.co/cJTxORrp21
EGCG (matcha), Zinc, Selenium (Oysters), Lemolene, Yerba Mate, Sapponins (Tereré), Lactic Acid based low lactose diary as source of cholesterol+fats (cheddar cheese)San's yerba mate, this is basically what I'm doing to reverse Multiple Sclerosis. 😇https://t.co/AuC8InPYzM
You can optimize for heavy metal chelation if you want, its not that hard. Just takes a bit o' autism.https://t.co/j4XdykLdnb
@T_R_Heisenberg Also, you may want to look into selenium too. The excess copper can be partly mitigated by having selenium bind to it. You may be able to get more milage out of your stack if heavy metals weren't suppressing the creation of selenoproteins. Often having more in the diet is enough.
When you realize most of the people struggling with Vitamin A may have a zinc deficiency due to problems in their diet, a lot of things fall into place.https://t.co/aYYa7tFyot
@Helios_Movement One of the complications here is copper excess can counter the role of zinc here. This is probably also related to copper toxicity driving some autoimmune disorders. Need zinc to help metal absorption and chelation which sounds like what you're on about? https://t.co/u5y4PBMy65
Think bigger. Nay, Taller.https://t.co/9nNb2YjsnR
Become solar powered today!https://t.co/8H5MADUK4f
Have you tried becoming resistant to plants?https://t.co/SxgKeVHgdi
@eigenrobot One of the more interesting things about authentic fermented ranch dressing is that many of the sulfurous herbs added to it (as well as the kefir/buttermilk itself) can help the body resist the heavy metals that are sometimes in lettuce. https://t.co/zF4KShLr0S https://t.co/Tqu18Ov7KF
2.5 inches too! lmao.https://t.co/3rnoJgVVPT https://t.co/Uf7rwozVmY
This space can be very unintuitive. https://t.co/JlkHyUOBbt https://t.co/S8hF8AJsW3
There's more than one way to generate Taurine in the body. It seems B6 + methionine and cysteine can act as an alternate pathway.If this conversion is microbial in nature, it may explain why some people don't notice not having it in their diet.https://t.co/rSKrbQkNWB
There's more than one way to optimize for genetic expression, methylation, and DNA repair.https://t.co/09cDGE4uHM
@Arciel___Baez @djack_littel @bryan_johnson Has a lot of implications."overall, our study suggests that gut microbiota mediates [Methionine] metabolism in the host and is a prospective target for the treatment of [Methionine] metabolism-related diseases." [2022] https://t.co/46jPhGjdr9
It probably helps that I am also ensuring calcium/magnesium intake is good and the high collagen diet I have probably aids in bone synthesis.Did someone say natto?https://t.co/WkYhqBpJJ4
@TrampolinRocket @Robotbeat Hypothetically hibernation would also enable upregulation of DNA repair.I found your tweet cuz I was looking for a thread of mine on trying to grow taller by inducing pluripotent/stemcell states to enable bone growth.Your models were out of date then.https://t.co/5uOh2aS4Dx
Neat how bone growth works. If you have the right gut bacteria in you, it seems to do magic.https://t.co/6SRpvPyRnk
One of the biggest things I focus on now with my nutrition is preventing copper from building back up and driving my M.S. again.https://t.co/l9JDGaBhPt
"TM has the ability to reduce copper levels and is being researched as a potential treatment for Wilson’s disease, cancer and multiple sclerosis" 2/2https://t.co/9z7PgvRSjcOk, cool. Time to dig into molybdenum sources in my diet and see if it makes me not piss out all the b2.
This is the main reasons why I fixate on feedback & self-tracking. Using gut to extract minerals / produce vitamins from food is an overlooked factor in metal homeostasis. Letting body modulate gut populations makes it easier / not need to be so exact.https://t.co/WQ3vyTgvJj
There's so much we don't understand in this space.https://t.co/MmpXVaudkK
@djinnius @eigenrobot @alth0u @Join_ZOE One of the big ones that we overlook is phytate digestion and how it unlocks zinc from plant sources. That one also require B1 to function well, either thru diet or gut sources.Fixing this is likely why I am getting taller.https://t.co/1sjX2Sn5MW
Get good (guts) lol.https://t.co/gIzWoAVFq5
@AlpacaAurelius A study was just published last night that suggested high levels of B1 driven by gut health may be helpful for treating alzhiemer's. https://t.co/67NOYuk6UoTL;DR: gut dysbiosis driven Beriberi leads lacking B1 to deal with coffee tannins & phtyic acids.https://t.co/DvTXPZqGOk
IF you want to read a cool rabbit hole, def check out the thread on Heisenberg's protocol. Its fascinaging.https://t.co/tImwOOw0M1I can't comment on the forum myself, but @whatisaging has been doing a good job on my behalf. I'm at page 137 now.
You can explore this stuff indirectly by looking at the inflammatory effects of LPS and ways that green tea / garlic can act on that space. They both help with that and also help chelate metals. Have some notes in a thread here:https://t.co/6ubBMrVmPs
Oh hey, I should get my height properly measured and see if I am officially taller than bryan now.https://t.co/6Ul3sjaMMk
Sweet, @whatisaging is able to afford bloodwork and get legit data on that interesting nutrient stack.https://t.co/W9U0V7E0yN
And their grip is going up! https://t.co/I8i59SOPp4
Digging thru notes, it looks like I started doing something similar to heisenberg's during early covid. It wasn't always consistent, but I was doing it fairly regularly (daily?) up until winter 2020, and then again in spring when I moved back w/ my GF's. https://t.co/cJTxORrp21
EGCG (matcha), Zinc, Selenium (Oysters), Lemolene, Yerba Mate, Sapponins (Tereré), Lactic Acid based low lactose diary as source of cholesterol+fats (cheddar cheese)San's yerba mate, this is basically what I'm doing to reverse Multiple Sclerosis. 😇https://t.co/AuC8InPYzM
It's highly likely that while I wasn't able to use it, the stuff I was doing to heal my intestines was also working on my muscle mass over that time even tho my nerves couldn't talk to them well.https://t.co/Py9bjB3UXk
@whatisaging @ToShooLo The entire point of my FMT was to cure my M.S. 😅> "Among these, neuromuscular junction instability and mitochondrial dysfunction are particularly significant. Dysfunction in neuromuscular junction can lead to muscle weakness or paralysis." [2024] https://t.co/A1Y0jXbhsY
I had a weird issue at one point during this where i got very sick. It looked like a bacterial infection, but looking at all of this after the fact makes me think it could have been caused by dumping copper via excess bile? https://t.co/H5Fpiy4N35
@alexeyguzey @dlx5dlx6 @Grimhood @dailectic @The_Lagrangian I guessed it might have been destruction of mucus dwelling bacterialphages somehow, but i'm not certain.I did find that I seem to automatically eat the right dose of zinc if I do oysters.I bet your sense of taste improved https://t.co/WWEul29G70https://t.co/DGA0mkpOnT
Notably this also coincides with a timeline where I was experimenting with modulating my Taurine regimine.Given that bile is one of the ways the body excretes metals, I may have accidentally triggering some side effects here. https://t.co/RTUrSlju85
Specifically, the green poop thing showed up. At the time, this was usually only something i'd seen when I had a gut infection https://t.co/0pAL0Y98P8
@alexeyguzey @dlx5dlx6 @Grimhood @dailectic @The_Lagrangian I was taking a zinc pill a while back that caused me to have some weird GI response. Symptoms of a bacteria infection (green poop unrelated to diet coloring). But also wasn't eating as well as I should to promote the ones I wanted.
I learned when my GF was having trouble that green poop can also be a problem with excreting too much bile.https://t.co/2QZ7wc4mUV
At the time I was eating a lot of sardines in olive oil. I may have accidentally triggered an olive oil flush without knowing what it was. All that extra bile in my gut without good gut bacteria to handle it would have made me feel quite ill.https://t.co/ewx3eSKEwb
TL;DR: While I may not have modeled it correctly at the time, the lesson I learned of "don't take too much zinc supplements, you dummy" helped me figure out I should depend on taste/smell/homeostasis factors instead, so I still walked away wiser.
There may also be a weird tipping point where drinking too much alcohol triggers a bile release? I know that excess alcohol puts stress on the liver. It may be thru dumping bile? I am not certain, but it would fit my dietary profile at the time.
Side effect of experimenting w/ TRP responses to foods is that I learned not to drink so much alcohol at once lol. I'd bet that regulation of bile duct function is in part thru something driven by these receptors. Will need to chase down that hunch later.https://t.co/qtNG7eK2Cg
@market_death The bitter flavors in olive oil also vanish, I found this while eating some sardines in olive oil after 6 hard ciders.Wasabi also stops burning, I think alcohol is preventing TRPA1 activation and its why we see bile shifts in alcoholics. https://t.co/wYskffcBW4
Since that time, I have moved on to fresh (air fried) fish, or canned in water/brine. I also rinse oils from oysters (cottonseed) or let them drip out quite a long time.FWIW, my regular use of oyster was long after I had that problem w/ green poop.https://t.co/HcKK6yNXKL
This phenomena of bile release may be why some people think canned fishes have high amounts of histamines. Dumping bile into the gut triggers inflammatory responses as the intestine is directly damaged (without enough mucus to protect it). Prob pisses off mast cells pretty bad.
Mind you, this space is complex. It is highly likely that alcohol itself is causing problems with histmaine, so people who claim the headaches are from histamine aren't talking out there ass.. More thinking there could be other phenomena adding to it.https://t.co/zReDH1yoY0
"Ethanol may also interfere with enzymatic histamine degradation, but reports on the effects on DAO activity are controversial. [...] also conflicting reports whether disulfiram, an FDA-approved agent in the treatment of alcohol dependence, inhibits DAO."https://t.co/avo6etNmCu
My headaches from alcohol is because sulfites fuck with gut bacteria responsible for anti-inflammatory chemical production. When I switched to 'dry' hard cider, I stopped getting what people told me was a 'histamine' response. Turns out it sometimes isn't.
I don't have a 'sulfite allergy'. It only is a problem if I eat it. I have a "don't fucking kill your gut bacteria off you dumb motherfuckers" allergy. https://t.co/x4TvS6Z8aU
I haven't even had a signle allergy response since my FMT. I used to get it all the time.The one thing that looked like one? wasn't.https://t.co/tLrZHMXUOs
@worlddestroyar @zarathustra5150 @pmarca @hubermanlab I haven't had any real hedaches since my FMT. Used to get really bad cluster ones and occasionally migraine with aura.Tho one time I did get one after drinking a wine with lots of sulfitesTurns out there's some precedent for this.https://t.co/0WkO0rCN4g
Gonna be funny when it turns out that the mixed results of studies on alcohol on longevity and stuff like alzheimer's are because no one controlled for sulfite levels and the variability is due to gut health.https://t.co/aLUiIjN3Ct
B1, motherfucker. Does your gut make it?https://t.co/m6iAnXFkuv
Say sulfite allergy again. I dare you. Double dare you.https://t.co/4idJGVwAoK
Sofa king dumb.https://t.co/ljjPYWcUlI
Oh noes, your wine might smell funny. Better put stuff in it that destroys yeasts.https://t.co/YZ2fJMFuFO"Sulfites inhibit the growth of four species of beneficial gut bacteria at concentrations regarded as safe for food"https://t.co/pQaJAESSnxOhhttps://t.co/xwjdVCZCqz