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UltimApe@ultimape• 10 months ago

My first success in treating my Treatment Resistant Major Depression was in doing a gut intervention. https://t.co/mwbCbqL29N

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

I reasoned thru that the cause of sleep deprivation being a possible cure Treatment Resistant Major Depression was it acts to distort gut environment and allow it to recover differently.https://t.co/uvw4XKRlIb

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

So I decided to leverage an alcohol based gut clearing regimine and fasting as a way to more acutely targeting gut health shifts. The fasting was meant to mirror studies looking at fasting for Multiple Sclerosis. I also reasoned that was gut based...

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

On top of the fasting, I had also gone KETO and focused on using Kefir and Kombucha to create the right environment for my gut to recover. I had been Major Depression Free since that experiment (2018).

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

This worked, but it didn't fully restore my gut as I was struggling w/ poverty diet and issues tied to years and years of Crohn's disease symptoms. You can't restore gut bacteria that aren't there to begin with.So... thats what made me decide to do FMT.https://t.co/6emD8tNzHU

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UltimApe@ultimape• 12 months ago

"Human studies indicated clinical benefits of FMT (from healthy donors) in people with MS including: improved intestinal motility and motor ability which lasted at least for the duration of the studies, ranging from 2 to 15 years." [AUG 2023]https://t.co/yi2xLv7g7s

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

There's a lot of moving parts going on in this space. The M.S. was making my vagus nerve demylinate so the gut signals weren't working well.https://t.co/bd3pBQcV7r

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UltimApe@ultimape• over 4 years ago

Nor how radically 'gut-brain-axis' is in upending our models."Critically, blocking vagal signaling from gut to brain, via subdiaphragmatic vagotomy, abolished the antidepressive effects of oral SSRI treatment as determined by the tail suspension test."https://t.co/pWFLb97oRE

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

It's possible the reason the SSRIs I tried caused me so many problems was because of the vagus nerve not working well and my gut already being in a challenged state. That and a ton of liver/blood brain barrier mutations that impact metabolism of it.

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Did you know coffee can trigger serotonin syndrome when combined with SSRIs? not many people do.I was drinking tons of coffee to counter the Crohn's fatigue. Whoops.https://t.co/QUS53Z5iGT

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UltimApe@ultimape• 10 months ago

Serotonin Syndrome!"Excessive coffee intake triggers serotonin syndrome by promoting 5-hydroxytryptamine (serotonin) secretion. Patients with psychiatric diseases that necessitate treatment with SSRIs should be educated regarding caffeine consumption." https://t.co/VUKh8sN7Wn

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

This whole space is absolutely fucked.https://t.co/cqq50sBIPY

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UltimApe@ultimape• over 1 year ago

@bradstradamus @thom_ivy_1 @DogIsABot All the anti-seed oil peaters are currently demonizing serotonin. They are wrong. They should specifically demonizing SSRIs. Serotonin is fine if your body can make Progesterone properly. But if your lipid function is screwed up due to bad gut...https://t.co/k86SEyfsL9

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Everyone is modeling it wrong.https://t.co/IEVjAaAUIL

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UltimApe@ultimape• 11 months ago

@CO2Ascension @haidut The kynurenine build up thing is the real reason why too much serotonin is bad, the body stop making serotonin and instead turns it's precursors into the inflammatory chemcial instead. https://t.co/IpMTcxu5CX

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

There's more than one way to fix your gut.https://t.co/FlDwGbWBBd

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UltimApe@ultimape• 11 months ago

@marknadal Ayahuasca => gut bacteria modulation.https://t.co/XV3kLZ2w6a

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Some outcomes of shifting my gut was I got stronger. I could suddenly run again and didn't suffer from my lung issues and my allergies seemed to abate somewhat.Trying to figure out why I felt so much better so I could get sustainable remission was my focus from 2018 to 2022.

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Did you know that your gut health can impact Telomeres? Its really fascinating to explore how many different conditions have weird telomere expression and a distorted gut environment. https://t.co/kqu6RX9cJv

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UltimApe@ultimape• over 3 years ago

Got my after @MyViome sample.Now up at https://t.co/wYtHF5Zvxu It worked! I went from 37 years old to 27 years old according to measure of IGF-1, mTOR, sirtuins, and AMPK.How bout them apples.https://t.co/0OKR4zKAn4 https://t.co/LYUqmtuu7X

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

Sure wish someone knew what was going on with this..."telomeres were significantly shorter in patients with mood disorders overall, and in patients with major depressive disorders" https://t.co/UvNWK0lQVR

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UltimApe@ultimape• 10 months ago
Replying to @ultimape

But what I know. I'm not a doctor. I'm not qualified.https://t.co/6zkAJ23k4X

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UltimApe@ultimape• about 4 years ago

You can invalidate Bret Weinstein's theories on telomere length being pleotropic by finding creatures that violate haystack limit and undermine Horvath's clock. And it becomes trivial to do from my model of hibernation.https://t.co/WsZXbzL1qc

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