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For all my new followers: Guys, you remember how anesthesia was discovered and then _not used_ for about 50 years? Yeah, for 50 years it was known that nitrous oxide, ether, and chloroform could abolish the pain of surgery and yet _nothing was done about it_. Well, it turns out right now there is a disease that's far more painful that surgery without anesthesia called cluster headaches. Standard medicine isn't very effective against it. It's 10/10 pain for 1-3 hours 1-3 times a day 3 to 12 months per year. Huge suicide baserate in sufferers (nicknamed "suicide headaches"). Pain is literally worse than receiving a gunshot. It's certainly much more painful that surgery without anesthesia. And guess what? DMT can be used to abort it in seconds, even at sub hallucinogenic doses for some patients. This is, I argue, literally one of the absolute most important EA cause areas right now, and almost nobody is working on it. If we get our act together, we could literally abolish this hell in the span of years. Will we?

See my TEDx Miami talk about this and other low-hanging fruit for drastically reducing extreme suffering in the world. https://t.co/PeRTsDPrHh

At my last "real" job I had a coworker who suffered from migraine headaches. I was trying to work up the nerve to talk to him about psilocybin's efficacy in treating migraines but we never got there. I chatted quite openly with a patient there with MS who was using psilocybin to treat depression and death anxiety. But couldn't bring myself to discuss it with my coworker. Healthcare tends to lean conservative around these topics IME. It can be a little daunting to face the fact that, as a whole, our species is quite regressive and reluctant to actually treat pain and disease because of our attitudes around pain and disease itself (believing that suffering is good and necessary, constituting an attitude I would characterize as nonconsensual internalized obligatory societal latent sadomasochism) and around certain forms of medicine and their validity. It's part of the reason I got my tattoo, the rod of Asclepius, symbolizing my connection to plant medicine. These tools are very old but humanity has this resistance to understanding that they can be safe and effective forms of medicine. Championing their use requires a lot of bravery. So I will always support you in this.

@jbfly46 Yes absolutely. DMT is more versatile and cost effective. Many sufferers only need one 5 minute trip every 3 weeks and they stop having clusters forever. It also works within seconds to abort. LSD takes half an hour, which is a big deal with this utility monster.

@diegocaleiro Thanks. Yes, I do have a bucket of social capital on Mexico I could pull anytime for e.g. a couple high profile interviews in national newspapers. But in waiting for the right time and framing. Perhaps I should just go for it.

@algekalipso Oh no, here we go again. Have you heard of Emgality or Nurtec? Theyâre protein inhibitors. Or Botox? From someone who suffered from migraines that could not be cured with tryptophans. And who has experience with hallucinations, including during migraines.

@BorisBartlog Where are you getting your facts from? I read this whole thing last year: https://t.co/N911MJ1mkL..

@algekalipso I get icepick headaches a few times a year but they're gone in about 10 seconds. No clue what I'd do if they lasted an hour. I'd still like to never experience them again. Once they came with an migraine aura and I thought I was dying or something as my vision flickered.

@algekalipso DMT is unlikely to be patentable without some kind of stupid adminstration device. Best option is trying to raise funds for a proper clinical trial. Also what kind of dosages are we talking here? Sub-psychedelic? Anything over 10mg is going to be a hard sell to the FDA.

@dip4fish I don't know how well it works. But af Eulosina in Mexico I was told several neuropathic pain patients benefitted a lot from high dose psilocybin https://t.co/FZAQDBiRjI

@algekalipso Korzybskiâs thought created new possibilities in quantum mechanics. This book will alter your perception of reality. https://t.co/Db7TwTae2Z


@algekalipso My headaches brought me to the floor of the fast food joint I was working at some years back. Don't wish that hell on anyone. Apparently, you're supposed to go to the hospital when they affect your vision... I'd have a lot of bills if I did. Yeesh