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With long term impacts when this is paired with antibiotics or endocrine disruption of some kind like how Tylenol impact on liver function. Due to B/T celll abnormalities and enhanced microglia neuron pruning when mTOR signaling is impaired. https://t.co/Uk40EE6rD8
Vaccines work better if your body can mount an immune defense and train it's T/B cells instead of having impaired immune cell differentiation.Funny.https://t.co/JEMlmxIQCV
It would also happen spontaneously upon vaccination related immune response / fever / allergen in such cases where the mother's gut bacteria is already impaired due to gestational infection of some kind and proper transfaunation hasn't taken place.
Did you know breast milk contains butyrate and melatonin on top of the prebiotic colostrum? It varies thru the day too.Works well to feed bacteria & calm the child's immune system during the first few months of their life when their natural antibody system hasn't bootstrapped.
I'm pulling this out of my ass. When you stare this space long enough, I can just bullshit my way thru it.Like I never read up on this before, but I can accurately predict that Tylenol impacts NAFLD via mTOR because for me to be right, it has to. https://t.co/MipyUUn3ol
Does it feel weird that I can just shitpost about this space of ideas for fun?I made a joke about dog butts once. and this has all fallen out of it.https://t.co/XY7qPlj8el
I have some short term goals that i have to meet, but one of the long term ones if find out if I can make autistic squirrels**chipmunks are a kind of squirrel.I think my theory is testable, but it would take some serious automation to do it at scale.
Death is coming.https://t.co/O7HKT1TyHw
I will gamble with death and win.https://t.co/250y4WGcb2
"Besides ruling the Moon, it was believed that Khonsu ruled over the evil spirits and protected humanity from death, decay, and disease."https://t.co/FA2l48diqEhttps://t.co/DC4xcgrxKF
Why doesn't everybody try to out do the gods? Is there anything in our collective mythos that would inspire more greatness that to want to be peers with the divine?https://t.co/y2W0ZRrcOk
The well actually of a lifetime.https://t.co/V2SrnE83RP
why do some autistics seem to get Aβ Plaques? https://t.co/zJ1VyoQWwRI believe my model has an answer for this. Did you even know that was a thing?
its always been the same hunch. Way back when I was working on curing my major depression, I had found a drug that treats Alzheimer's that just so happened to work on treatment resistant major depression.If I didn't have Alzheimer's...https://t.co/C9BbIqCnWw
Ah yes. "Notch" signaling.https://t.co/l5kbGnRQxl
funny looking opioid signaling molecule.https://t.co/khXhatwXme
I miss my witch. She was right about her model of psoriasis being treatable by targeting TRP receptor pathways. I had the answer in my tweets and she shows up talking to me about itch and pain as it relates to autism.https://t.co/riMIw7ufOE
Everything about this model of gut dysbiosis instigated BDNF function and Aβ Plaque clearance can be translated to autism.https://t.co/GglU6qXaj7 https://t.co/Zsn6IGJZhu
It has to.https://t.co/sHh54iQlZy
You mean Diabetes type II, a disease w/ noted lipid metabolism problems, is risk factor for schizophrenia, autism, alzheimers? Might somehow drive bile problems on same pathway that impact neurons ala calcium pathways? Possibly upstream of BDNF function? https://t.co/buIJpYsotj
Because it's the same fucking system. Biology doesn't spontaneously differentiate itself when you are labeled as autistic or Alzheimer's. https://t.co/DgnDQMI766
You can pin this down by just not calling it autism.https://t.co/nCiDuBm2hn
Inb4: "it can't be Alzheimer's, that something only old people get"https://t.co/ydbq94QArw
One of the reasons I learned all this is because I'm butt hurt. Are you butt hurt too? Are you also suffering from GI conditions that our society hides with "shame and guilt" instead of addressing the immune system problems that drive poor gut motility?https://t.co/bBDODaw1b7
If I had discovered Substance P, I would have called it Substance PeePeePooPoo. https://t.co/NdVlX1yW0JBecause it relates to Freud's ideas of anal retentiveness, but under a lens of it being partially tied to immune function and associations with intestinal motility.
Listen. I have the documents that say *everyone is wrong*. And I don't need to quote a bad study to prove it.https://t.co/GxfDn5ZS1W
I can pull them out of thin air. Here's one from 2013."The bacteria that live in the human gut may play an important role in immune response to vaccines and infection by wild-type enteric organisms, according to two recent studies." https://t.co/xTLJ1WEzjD
Another one, from APRIL 27, 2022 https://t.co/tnP9jOhOmS
What happens if you give your kid children's tylenol because of the fever they got from the vaccine they were given?Nobody knows. And everyone is screaming about vaccines because no one understand about liver's role in immune function tied to immune cell differentiation.
"To our knowledge, this is the first demonstration of the effects of broad-spectrum antibiotics on the immune response in humans — in this case, our response to vaccination — directly induced through the disturbance of our gut bacteria" [2019]https://t.co/sp8Ys0psel
"broad spectrum antibiotics cocktail to induce gut dysbiosis and monitored its impact on the generation of long-lasting memory T cells and thereby BCG vaccine efficacy. [...] significantly decreased the activation of CD4+ T cells and CD8+ T cells" [2020] https://t.co/T1seffTzYq
Tired: vaccines cause autismWired: antibiotics cause autism.Inspired: actually what matters is if the delicate balance of the gut ecosystem can recover after the immune system is perturbed, and in some cases antibiotics help prevent autism while sometimes causing it.
#eatshit"The intestinal microbiota and improving the efficacy of COVID-19 vaccinations" [2021] https://t.co/zsfit7ORiW
Letter to editor: You're all fucking wrong."Therefore, during vaccination, rectifying gut microbiome dysbiosis with prebiotic and probiotic oral supplementation might be a solution for the management of Covid-19 vaccine induced adverse reactions." https://t.co/35TkQ5YQzj
"Our study establishes compositional and functional alterations of gut microbiome in AIH and suggests the potential for using gut microbiota as non-invasive biomarkers to assess disease activity." [2020] https://t.co/nBEgb7rSlf
Am I putting you to sleep yet?https://t.co/z9WrpitMiR
Cuz like a broken record i'ma repeat myself.https://t.co/baq6qWQMln
Two groups of people with higher rates of problems associated with heart complications from Covid...Autism and Alzheimer's.The question is, how much of this is from living situation (group home), and how much is biological underpinning? https://t.co/lAJqBNMrRf
I'm so tired of this shit." Sleep problems are twice as common among children with autism as they are among typical children or those with other developmental conditions." https://t.co/sq7FPEcW0O
"Sleep disorders are common in patients with Alzheimer’s disease, and can even occur in patients with amnestic mild cognitive impairment, which appears before Alzheimer’s disease." https://t.co/jWPgmY5alu
"In summary, the present results indicated that APOE hypermethylation in peripheral blood DNA may be used as a diagnostic biomarker for ASD." https://t.co/G9GtBp0KUL
"These data suggest that the APOE CGI is differentially methylated in AD brain in a tissue- and APOE-genotype-specific manner." https://t.co/SYvOL375oY
"Genes that control synaptic molecules also show epigenetic regulation. Among them, SHANK3 gene is subjected to a specific epigenetic control mechanism [27]. Indeed, DNA methylation regulates the tissue-specific expression of SHANK3 gene [28]." https://t.co/jbGZawZrwf
"Taken together, the differential Shank3 expression among brain structures/regions indicates the varied local density of the excitatory synapses. [...] decline of its expression in aged and AD brains may relate to the degeneration of excitatory synapses." https://t.co/DtwqLSUSzV
Stabbing this issue with a shank3 until it's dead.https://t.co/21EID8jUUq
"Shank, Shank, Shank, Señora, Shank your body lineTwerk, Twerk, Twerk, Señora, Twerk it all the time[...] OK, I believe you." 🎶https://t.co/U9vYFaCfvC
Does your butt hurt because of impacts of the Shank3 mutation on the expression pain receptors such as TRPV1? https://t.co/e54iuJA6Bd
*Ring ring*Them: Hello?Me: Is your butt running?Them: Huh?Me: Then You better go catch it then.Them: ... how rude.https://t.co/eDJtjVATOS https://t.co/qA6osUsoh3
"The PI3K [...] has been enriched [...] support the hypothesis that SHANKs mutation serves to cross-link further disease related signaling cascades (mTOR/PI3K). [...] indicate that SHANK3 has a previously unappreciated role in early neuronal development" https://t.co/m09ZD2cfzh
I love playing clue.PI3K/Akt/mTOR with the Shank3 in the twitter thread.https://t.co/ogOYYjqaAU
"In this Review, we summarize the experimental evidence from recent peer-reviewed studies and provide a brief overview of the causal relationship between [probiotics etc] on the components of PI3K/Akt/mTOR signaling pathways and human disease."https://t.co/WiUqnctne6
I wish more people had a clue.https://t.co/Js7iCq5NXH
I'm good at clue.I can guess things accurately without having the complete picture. For example here's a study suggesting the method of action for gut bacteria impact H Pylori is via butyrate fermentation.https://t.co/Q7epO1UY4Rhttps://t.co/EW5Zx27Iq8
Blues clues all day.https://t.co/cCZDgc8gPk https://t.co/KrTSeZ8ebV
Guessing another's models of their own guessing of the clues, and then modeling how their guesses would be changed if they are modeling your model of them. A meta model about model models used to model another's models of their own guessing of the clues.https://t.co/U81tA1WZPJ https://t.co/94WVAPahmT
Answerhttps://t.co/smnVQynuit
@krzhang @Plinz @ricard_sole "we propose a view of the adaptive immune system as a dynamic Bayesian machinery that updates its memory repertoire by balancing evidence from new pathogen encounters against past experience of infection to predict and prepare for future threats." 🥳https://t.co/f66LL8ZWP5
I like predicting things."Not all of the skills of successful forecasters are innate; many can be learned." https://t.co/N4mtSdXsjShttps://t.co/uIjudCpzAj https://t.co/rp4ohhQVke
But I repeat myself.https://t.co/WlH7sPTBIU
EVERY FUCKING THING I'VE READ FOR FOLK CURES FOR ALZHIMERS AND AUTISM SYMPTOMS INDIRECTLY KILL H PYLORI.EVERY FUCKING THING I'VE READ FOR FOLK CURES FOR ALZHIMERS AND AUTISM SYMPTOMS INDIRECTLY KILL H PYLORI.EVERY FUCKING THING I'VE READ FOR FOLK CURES FOR ALZHIMERS AND AUTISM
The autistic squirrels will be giant, and anxious (seek hugs), and seek out warmth too, so they will make good pets. This is how I intend to fund my empire.They like to eat brains tho.https://t.co/GanL81BTYK
Gestational function impact T cells? What do you mean we can pass on immune function challenges to our children via gut dysbiosis?https://t.co/4Yqq2GOaZ6
Do you ever listen to old songs about the birth of Jesus and intuit that the Magi were bringing ways of improving T cell function because you piss yourself during Christmas?No one? Ok then.https://t.co/PsReCtthng
Must be the Serine. Pay no attention to the complex gut bacterial interplay with mitochondrial function and ROS induction via Parkin genes.https://t.co/5yujT2PGM5
Serine? Serine? Anyone?"Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature [...]There is a paucity of studies on body fluid levels of d-serine in ASD." [2017]https://t.co/H5OF2EFEya https://t.co/Z4y6JKja8m
"Several studies have investigated mTOR signaling in developmental and neuronal processes that, when dysregulated, could contribute to the development of ASD." [2018]https://t.co/J6lzZmRRcShttps://t.co/MHVmr4C0r5
"mTOR is a highly conserved serine/threonine protein kinase [...] cell growth, proliferation, motility and survival, protein and lipid synthesis, glucose metabolism, mitochondrial function and transcription, in response to nutrient and hormonal signals" https://t.co/UdPxhW9dzJ
"Our findings causally link mTOR-related synaptic pathology to large-scale network aberrations, revealing a unifying multi-scale framework that mechanistically reconciles developmental synaptopathy and functional hyperconnectivity in autism." [2021]https://t.co/6gnoDTUf2h
That was published in October.I wrote this in earlier... April.https://t.co/tDpPgNG86k
@Queen_Levan @MeFromBefore @eigenrobot @selentelechia The dog shit I wanna eat should boost mTOR which directly impacts mitochondria function. But I think EDS has more going on along different pathways around vitamin C and collagen synthesis that might be caused elsewhere.THC's action on mast cells might be why it helps glaucoma.
Gut bacteria => Lipid function => mTORhttps://t.co/Qk2FVWOjnw
Of course I've been working on this for a while, but the connection I made w/ lipid function occurred right here.Gut bacteria => Serotonin => Liver health => Bile => fats => eventually connecting it to SCFAs for production of endocannabinoidshttps://t.co/CrgG7OQe0t
@PLT_cheater @The_Lagrangian @JimmyRis yes, good thing my liver can produce bile acid on demand on top of having a well functioning gallbladder. I specifically taylor my diet to promote Lactobacilli colonies (what ferments saurkraut?) that trigger FXR antagonism to increase bile acid pool size https://t.co/GsosCWhdpg
I got stronger."The literature suggests that sarcopenia and cognitive decline share pathophysiological pathways. Ageing plays a role in both skeletal muscle deterioration and cognitive decline." https://t.co/2CfVzD3bQihttps://t.co/Wz37hekfzV
Eggs."Many foods contain L-serine, and some foods have higher concentrations. High-protein foods, including eggs, milk, cheese, a wide variety of seeds, pork, beef, chicken, fish and some spices, provide the highest concentration of L-serine in foods."https://t.co/XVG6YO9gLC
Prediction machine is going to predict.A diarrhea medication that is in clinical trials to help Alzheimer's also has been shown to improve autism (in mice).https://t.co/9nhono1c3G
Everything I say about Alzheimer's applies to autism."clioquinol, an antibiotic used to increase zinc absorption, on the mice displaying autistic behavior and found that they began behaving in a way almost identical to that of the unchanged mice" https://t.co/ZKLMp3kqiT
"the virgin "NOOOOOoooo the symptoms are totally different and in fact contradictory!!!1" vs. the chad ultimape"yeshttps://t.co/cN6E4xaxyE
Sure wish there was some explanation for why tweaking mTORC1 and regulating metabolic pathways has an impact on age related disease.https://t.co/wqChBNAl2Khttps://t.co/VBkSw5d3v5 https://t.co/Zvcm8GQ8ps
Lipids, lipids everywhere.https://t.co/dwJI6oehTq
*stab stab*Is the AKT pathway impacted enough to survive metabolic decline associated with poor blood and low oxygen state we see in covid. The situation mimics hedgehog's aestivation trigger.https://t.co/QwsYUXuFDu
"Lamotrigine, which is sold under the brand name Lamictal, among others, is a medication used to treat epilepsy and stabilize mood in those who suffer from bipolar disorder."https://t.co/mxd0Z3iSQ1Who did this? 🤣 https://t.co/jEujbZMpIp
mTORC1 you say?"Except for ketogenic diet, none of commonly used AEDs showed an effect on mTORC1 activity. Vigabatrin and ketogenic diet treatment were able to significantly delay seizure onset. In contrast, survival was shortened by lamotrigine." [2019]https://t.co/Jq4wQVvh2d https://t.co/5BgYheh1qR
I made the same conclusions as this person. One of the leading microbiota researchers in the country.https://t.co/knz7M81Oep
I think vaccines can cause autism in some cases due to it's impacts on gut microbiota and the resulting shift in epigenetic expression due to metabolic changes driven by loss of SCFAs and impacts on gut inflammation.https://t.co/Lbl5Lh9I8B
I have dedicated my life to solving my own fucking autism, because I see people trying to remove genes from the gene pool to get rid of us. I think it's monstrous.https://t.co/Wv39orrdy2
I wasn't anti-vax. In fact I was trying to figure out why vaccines never seemed to work for me and my family.It was because of our autoimmune disease impacting B and T cell differentiation. My immune system wasn't learning to identify viruses.https://t.co/fbE1RIuasD
You better bet I'm antivax now.https://t.co/JZoHi5WSXJ
Tired: vaccines cause autismWired: antibiotics cause autism.Inspired: actually what matters is if the delicate balance of the gut ecosystem can recover after the immune system is perturbed, and in some cases antibiotics help prevent autism while sometimes causing it.
Fighting covid with gut bacteria made sense back before we had a vaccine.https://t.co/dGUyPpRKhp
@jelani9 @ekverstania It's been a year and six months since I wrote about using gut bacteria to fight covid symptoms.We are only just now starting clinical trials on FMT.ideas that I've directly operationalized to heal my body still only hypothesis in medical literature.https://t.co/mMWQXLJmeG
Made a lot of sense.https://t.co/w0c7IuRXBV
How's that vaccine working out for you? How about herd immunity? https://t.co/eyxi7VraV8
The idea of accidentally an entire bacteriophage thru mRNA replicating in a gut bacteria / fungus? Should scare the piss out of you.https://t.co/ucGx3gCTHH
"It’s an attractively simple idea: Use a virus to infect the bacteria that are infecting a person. And it’s by no means new. Bacteriophages were discovered in the early 20th century and were even used to treat bacterial infections in the 1920s and 1930s" https://t.co/stHdSddae5
Would be funny if you can simulate the effect with some rabbits.Did you know they are viable as an animal model of microbiota studies?https://t.co/qcnpekITVdhttps://t.co/uopYKW6GxY https://t.co/XeuMQU0TFS
A vaccine that doesn't work well for immune compromised people with high rates of breakout infections among that population? Great idea.https://t.co/P0h60MR6Z0
Is it a smart idea to give vaccines to people who are more likely to be immune compromised?Knowing someone will likely have a lower response to infection, also means knowing they will act as a host to incubate the virus in a way to promotes more chance of mutations.
Wish we had studies showing that improving gut bacteria changes diseases (and vaccine efficacy) outcomes.Shame we don't have any.https://t.co/B3KW1lAdFM
Nothing to suggest that a disruption of gut bacteria could be occurring. Nope. https://t.co/64MMQTbxmk
"a paucity of data on the gastrointestinal sequelae of SARS-CoV-2 infection. Since COVID-19 can directly or indirectly affect the gut physiology in different ways, it is plausible that functional bowel diseases may occur after the recovery" [Nov 2021]https://t.co/y314Bdomco
You can take your vaccine if you want, but maybe fixing the gut could make it work EVEN BETTER?https://t.co/Qqa23pjlr1
> We’re on the cusp of meaningfully communicating with animals.Bruh. I wanna talk with their gut.https://t.co/bTkfDseXh6
"Bifidobacteria: A probable missing puzzle piece in the pathogenesis of multiple sclerosis" [2019] https://t.co/CLUpup8rY9
Bifido? whats that?https://t.co/4HqjCJyQ9h
"co-cultivation [...] Bacteroides adolescensis was able to promote the growth of F. prausnitzii. [...] Bifidobacteria [main producers of acetate] in the colon and [studies report] low levels of Bifidobacteria have been associated with several diseases "https://t.co/w9EAAefq44
Bifido, increased in my anus? You bet your ass.In fact if you look at my viome results, it went from 9 strains, to 34 strains. many of which seem to be from probiotic strains I never ate.https://t.co/08gpecAZFU
Garlic => Bifidobacteria? Could that be useful?"reported that when mice with an autism-like condition had lower levels of Bifidobacterium and Blautia gut bacteria, their guts made less tryptophan and bile acid — compounds needed to produce serotonin"https://t.co/8a2mgVrLjr
Have you tried magnesium, anon?https://t.co/Oo0XGe3iGQ
@dlx5dlx6 @JBianco215 @LocalRachel @Grimhood "Changes in Intestinal Bifidobacteria Levels Are Associated with the Inflammatory Response in Magnesium-Deficient Mice"https://t.co/xrOKvuawz2(this is one of the anti-inflammatory species that are also problematic in autism etc)
Have you tried to fix your homocysteine function?"homocysteine levels may be a potentially useful marker for predicting the risk of unfavorable progression in patients with COVID-19." https://t.co/hnGlNF4ELrhttps://t.co/VV03YBRt5y
@Apex_Evolution "probiotics increased the prevalence of bifidobacteria in the gut microbiota, as well as folate, and B12 levels, and decreased plasma homocysteine [suggests] a close relationship between gut microbiome composition and the methionine-homocysteine cycle." https://t.co/PFK5UmbanW
Before you were even worried about the trump vaccine, I decided to become resistant to covid.https://t.co/0va1y8PCgI
I am worried this thing is going to hit us fast. No one seems to have been preparing or distancing themselves. I'm worried that the speed of it will mean overwhelming medical systems.I'm sad there is nothing I can do but make memes & shitpost while hole'd up in self-isolation.
Are you familiar with the myths of vaccination?"In fact, vaccine literacy and misconceptions regarding the safety of childhood vaccination and their involvement in long-term adverse effects is the major cause for vaccination refusal"https://t.co/ZGJrzQAmt2
Oh boy, how illiterate am I?https://t.co/HfUcPCKc65
Vaccine literacy? Is that like documents? I have the documents.https://t.co/mSRrAACBMj
I am not an expert. I have no formal training. I am only passionately curious.I know how to make vaccines. I have notes on everything I would need to run a BSL-3 certified medical research facility. I even know market rate cost of most of the machines. https://t.co/5ux8wLj0xA
I know more than your doctor.https://t.co/Y21M8EL9Ix
@zeynep My GF's 60+ mother got what appears to be autoimmune thrombocytopenia from vaccine. The doctors that were prescribing her medication for RA that neutralizes antibody response to the vaccines didn't modify her dose at all when asked. She eventually had a breakthrough infection.
Before I thought the spike proteins was going to cause autism, I thought covid itself was going to cause autism adjacent phenomena. https://t.co/sqUXXRVJQn https://t.co/itNF0x71km
What are the chances a disease that disrupts gut microbes & changes immune cytokine profiles is going to cause an uptick of autism in a few years?And I don't mean the kind that makes you smart & socially awkward. I mean the one makes your whole lived experience a sensory hell.
I legitimately cited the CDC when people were telling me to get the vax.https://t.co/KIbc9NMCv0
"People should be counseled about the unknown vaccine safety profile and effectiveness in immunocompromised populations, the potential for reduced immune responses, and the need to continue to follow current guidance to protect themselves against COVID-19"https://t.co/94vKSIpyiV
I legitimately cited John Hopkin's research when discussing viral shedding in immune compromised people.https://t.co/atgB1KZVDVhttps://t.co/QDvkCllK9Y
Have you tried not being retarded?https://t.co/A2suK43Q9A
Drug that impacts gut microbiota positively in Crohn's disease ends up making Covid less deadly."Immune modulator drugs improved survival for people hospitalized with COVID-19" https://t.co/wsyzkSSwDZhttps://t.co/h2NYB5aQik https://t.co/HLhLFMv0fF
"Revitalizing myocarditis treatment through gut microbiota modulation: unveiling a promising therapeutic avenue" [16 May 2023]https://t.co/9OOmeaVmxyConversely, destroying them, might make it worse...https://t.co/VKkbZfNOlA
To resist disease, I promoted ones that help fight bacterial infection."One of the most important types is called Bifidobacteria. These beneficial bacteria digest dietary fiber, help prevent infection and produce vitamins and other important chemicals."https://t.co/B8GwK7rSSZ
F. prausnitzii, Bifidiobacteria, and Akkermansia muciniphila. https://t.co/skLOLJ2eRr
"F. prausnitzii and its metabolites exerted protective effects against colitis in mice, which ameliorated gut dysbiosis, with an increase in bacterial diversity and the abundance of short-chain fatty acid (SCFA)-producing bacteria" https://t.co/zkkvFHKsJH
"Consistent findings from both preclinical and clinical research have revealed declined abundance of A. muciniphila in obesity and metabolic syndromes."https://t.co/xnoISNsSoP https://t.co/uGBRNl7kkg
"A. muciniphila has been reported to convert dietary fiber into acetate, propionate, and butyrate; these metabolites can have effects on glucose and lipid homeostasis"https://t.co/2BI8USErFG