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"This review discusses published evidence for viruses that cause obesity, focusing first on animal viruses in animal models, then on human viruses in animal models and in humans." https://t.co/zFhwqspPqohuh https://t.co/0khMHUezWQ
Listen, I have spent past 5 or so years of my life exploring autoimmune triggers, including viruses and microbes related to weight gain.ππππ© ππ ππ© ππ¨ ππ€π£π©ππππ€πͺπ¨?Who the fuck is Ben Shapiro? does he do science? Is he qualified?https://t.co/fQfiAiUDYF
Do you know that fat cells contribute to the immune system and are quite literally part of the way our body fuels various immune cells?https://t.co/puVhyrTPjz
"Here we review the modulation of immune cell populations in adipose tissue and discuss regulatory processes implicated in controlling the interface between metabolism and immunologic function."https://t.co/3TB5y34eOQhttps://t.co/6rCAookBQx
Obesity spreads like a contagion?"Network phenomena appear to be relevant to the biologic and behavioral trait of obesity, and obesity appears to spread through social ties. These findings have implications for clinical and public health interventions."https://t.co/iAKbADbod6
If I'm reading this right, obesity is kinda a big deal in terms of overwhelming intensive care units.Do we trust this source? Am I reading this wrong?https://t.co/SkHbGaiDti
Ya'll ever wonder if we're working on an obesity vaccine?https://t.co/mWNBbwDHDd
"H. pylori bacteria may be passed from person to person through direct contact with saliva, vomit or fecal matter. H. pylori may also be spread through contaminated food or water."https://t.co/encg7PWwDMhttps://t.co/CqYfvCj8qS
"the pooled analysis revealed that participants infected by H. pylori had a higher risk of obesity than non-infected participants with an odds ratio of 1.01 (95%CI: 1.01, 1.02)."https://t.co/eJDq0DLiPj
"It is increasingly clear, several experts say, that viruses might play a role in some obesity cases. There are 49 known human adenoviruses. They cause everything from the common cold to gastrointestinal problems"https://t.co/GrSfv1QxOS
"The Adv36 infection should therefore be considered as a possible risk factor for obesity and could be a potential new therapeutic target in addition to an original way to understand the worldwide rise of the epidemic of obesity." [2015]https://t.co/er5iB4eLDx
"[Adenovirus-36] Ab positivity was significantly higher in the obese/overweight PCOS patients. Obesity can be prevented in patients with PCOS by treating [Adenovirus-36]." [2021]https://t.co/WXqsy6Fa5T
"The control group showed 17% greater body weight and 20% more epididymal fats compared with the vaccinated group." [2014]https://t.co/FWvACScqmE
"In this review, we have discussed the known facts and what requires to be understood regarding Ad36-induced obesity. [...] the cellular mechanism of Ad36-induced obesity, as well as the genetic and immunological factors affected by Ad36 infection." [2020]https://t.co/MdZYcHCJgW
Can we... uh... try to replicate this finding?https://t.co/dzJ12U93ue https://t.co/itAwcRZKNm
"The association of microbes with obesity, namely, adenovirus infection and metabolic endotoxaemia, is reviewed."https://t.co/zxeZz79E0Y
Can we explain this yet?https://t.co/rVjxu4jFvk
Strange."There are reports of new-onset diabetes that occur after someone's been infected with the SARS-CoV-2 virus"https://t.co/upl75cUPJf
Unexpected?"Researchers donβt understand exactly how the disease might trigger Type 1 or Type 2 diabetes, or whether the cases are temporary or permanent. But 14 percent of those with severe covid-19 developed a form of the disorder, one analysis found."https://t.co/EdanWL6rsy
"How so? Itβs believed that the virus damages certain kinds of cells β known as beta cells β that are found in the pancreas. They are found within another kind of cell known as an islet cell (more on islet cells below)."https://t.co/dXfMtakuJ5
"A growing body of findings suggests that insulin contributes to normal brain functioning and that peripheral insulin abnormalities increase the risk for memory loss and neurodegenerative disorders such as Alzheimer's disease."https://t.co/HUkreBj39t https://t.co/us03ndurRC
Could this be connected somehow?https://t.co/a0YzDnA6zq
Do you ever wonder what MHV (mouse coronavirus) does to trigger EAE (experimental autoimmune encephalomyelitis)? And if we may be overlooking ties between diseases such as Multiple Sclerosis and Diabetes? https://t.co/d2q5Z4utvP https://t.co/e1Im3IDg3W
"Type 1 diabetes (T1D), an autoimmune disease once thought to be mediated exclusively by beta cell-specific CD4+ T cells, is now recognized as one in which autoreactive CD8+ T cells play a fundamental role."https://t.co/577GgujOdD
"Although the importance of B cells in [Type 1 diabetes] is increasingly apparent, exactly how these cells contribute to disease and its comorbidities, such as [diabetic kidney disease], is not well understood."https://t.co/e4LSjzdxnV
I make funny joke about electroconvulsive therapy impacting Depression, Multiple Sclersosis, and Schizophrenia by way of shifting insulin profile (and immune function?) by impacting the brain. Based on studies from 30 years ago. https://t.co/iJCOG4RWIfhttps://t.co/J7i7CiaZ6f
Dump Moar SSRIs into your brain, what could go wrong?https://t.co/rUVwZ8K51k
Oh."Given that SSRIs promote insulin resistance while inhibiting insulin secretion, these drugs might accelerate the transition from an insulin-resistant state to overt diabetes."https://t.co/nfwRJpStgI
Remember that time Citalopram was giving me weird seizures? That was fun. Maybe it's because of the way insulin in the brain is regulated per this 1974 study?https://t.co/mx1Ra9l37n
Viruses causes risk of type 1 diabetes.. news at 11https://t.co/9FyecZLs92https://t.co/EHjQ5BCcj3
"As genetic predisposition cannot be changed, research needs to identify the biological agents that may have an etiologic role in diabetes mellitus, and to envisage curative and preventive ways to limit the diabetes pandemic." https://t.co/h0ECQMRIcI
"respiratory tract infections occurring in both age intervals [...] Having respiratory tract infections in both age intervals was associated with an increased T1D risk compared with having infections in only 1 age interval or having no infections" https://t.co/2EilATtWIy
"Recent clinical data have suggested a correlation between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19." https://t.co/YuHg2pL4ay
"does not appear to be a clear increase in type 1 diabetes incidence during the pandemic. Because type 1 diabetes develops months to years after the initiation of autoimmune Ξ² cell destruction, longer-term follow-up studies of COVID-19 patients are needed" https://t.co/FYl8AqHmRt
"Saydah and her colleagues did not distinguish between types of diabetes, including both Type 1 and Type 2 in their analysis. The increases were seen both among those who had been ill with Covid and those who were asymptomatic but tested positive."https://t.co/8OMQ9s8SVm
"Why are people developing diabetes after having COVID-19?"https://t.co/z51q5Uwu17
"[creatine kinase] was elevated in 27% of COVID-19 and in 28% of influenza patients. [...] higher in severe COVID-19 as were markers of inflammation.https://t.co/pwrsnoysczhttps://t.co/b2cvirscxV
Whelp, Twitter search is failing me once again. I'm still recovering from a head-cold, so I'm frustrated.Note to self: PDE5, 5-Alpha Reductase, Acytlecholine, Parsley, Diabetes, PCOS, Asthma, Smooth Muscle Tissue, Cytochrome/liver genesMuscles, what?https://t.co/W3RrtW2INb
"In this patient, the creatine kinase level decreased to normal after hemodialysis therapy was begun, and we suspected that fluid retention had..." [1 May 1987]https://t.co/eonOTNxToM
"Conclusions: Exertional muscle damage produced by eccentric exercise in healthy individuals can cause profound CK and Mb elevations without renal impairment." https://t.co/ifSZ2a45BxSo... what happens if you can't clear out CK?
Sure wish there was a known mechanism that could drive heightened inflammation that could contributing to beta-cell destruction in the pancreas.https://t.co/71pAqlyoFk
"In the current review, we summarize PDE5 inhibitors' utility in disease states and clinical conditions related to kidney disease [...] and discuss the mechanisms explaining possible kidney protective roles" https://t.co/Yu774Z3y1n
Sure is some kind of MIStery. https://t.co/zT4hnddD2I https://t.co/AGHoRfrtaM
"objective was to systematically review the current understanding of kidney involvement in children suffering from MIS-C. Based on our systemic literature search, 19 studies have either partially or fully discussed kidney involvement in MIS-C patients."https://t.co/HlVyWe3bKn
"In patients with [Kawasaki Disease], both prerenal and renal [Acute Kidney Injury] have been reported." [2013]https://t.co/LZkrU1wnCNhttps://t.co/ggwODUOrT7 https://t.co/nbWhAhEk1l
Equilibrium."consider the physiological constraints operating in the intact cell is emphasized throughout. The aim is to provide a coherent pathway through an extensive, complex, and sometimes bewildering literature, particularly for those unfamiliar"https://t.co/zZ7XI0rEBv https://t.co/HvVulKtw2x
"In addition [...] the intestinal flora can also regulate the immune system, increasing the risk of CVDs. For instance, interleukin 17, a key regulator of the mucosal interface, was reported to couple gut microbes with the body's immune system."https://t.co/PxCyISlYfy https://t.co/Qw6fGRsGPc
"In conclusion, analyzing the gut microbiome in the context of COVID-19, and exploring its modulation through diet, prebiotics, probiotics, or fecal transplants warrants further investigation. [Dec 2020] https://t.co/xQOuLRc0TD
"A population-wide caseβcontrol study performed in Scandinavia illustrated a strong association between antibiotic exposure and the development of subsequent T2DM. [...] Further detailed work is required to establish association or causation." [AUG 2021] https://t.co/X335CJDlN1
"lot of evidence from animal studies linking antibiotics with increased weight, and antibiotics have been used as growth promoters in meat production for decades. The possible link between antibiotics and obesity in humans is an area of intense interest." https://t.co/uO0n1LbHXh
"the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria" https://t.co/s8S8Xx83e4 [JUL 2021]https://t.co/9A9JW3rHjh
"provides evidence of gut microbiome dysbiosis in recovered [healthcare workers] three months after discharge and its association with persistent symptoms after discharge. [...] gut microbiota may play an important role in the recovery of patients"https://t.co/cVM6FwkBUl https://t.co/LKF3ePL2yy https://t.co/STO4bMdqXF
"While the impacts of the gut microbiota have been reported mainly on chronic kidney disease, acute kidney injury (AKI) is also affected by the intestinal environment. In this review, we" [JUN 2021] https://t.co/bGylBQpQNv
Bad idea of the day."Consuming cholera toxin counteracts age-associated obesity"https://t.co/NYTzgvXegp"Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans"https://t.co/W29walvyBXhttps://t.co/pluF2w7CnX
"aloin A which was isolated from Aloe harlana Reynolds also showed activity against E. coli, S. typhi Ty2, Shigella and V. cholera bacterial strains."https://t.co/fDt2oSFNcHhttps://t.co/LSruQyuSO7
Nice."Low aloin concentrations showed minor perturbations to intestinal bacteria, whereas high concentration increased Lactobacillus sp. counts. Aloin also decreased butyrate-production in fecal microbiota in a dose-dependent manner after 24 h exposure."https://t.co/ivhxZ7jpxP
The Father of Epidemiology and The Father of Toxocology walk into a barr.It's Epstein Barr and it's laughing a them for being fools for not understanding epidemology of genotoxins.https://t.co/xLsfdBgBP0
Fear my rhein of terror.https://t.co/Kd7xdK3CoD
Imagine believing eggs are bad because of a bunch of studies showing TMAO from choline is problematic for the heart and not even knowing this is gut microbe related and only just barely being understood in mice.https://t.co/ZSc0Twqw8Uhttps://t.co/vL3OLXaGJP
It's almost like if you sample a large population of people with heart disease, you end up inevitable also sampling people with gut dysbiosis and end up finding TMAO levels are high. https://t.co/vlGk3rvUsV
Wait, you mean FMO3, a major component of obesity and heart disease somehow has a direct tie to gut microbiota and TMAO?https://t.co/OrQ358ctqtWhat ever could be happening. /shttps://t.co/YVmiP7lHDw
Must be the meat.https://t.co/VlsCCy23yg
"This is perplexing, given the β¦ clear evidence for harm associated with high red meat intake,"https://t.co/Asuz5kEptrWhat evidence? Are they talking about some shit surveys and an implication raised by TMAO that conflicts with research on fish consumption?
Sure wish there was tons of evidence showcasing that gut dysbiosis was tied to lipid processing problems associated with stuff that predispose risk of heart disease.Oh wait.https://t.co/YNadXLL7Nb
What *are* bile acids? https://t.co/x44aOVNedW https://t.co/96b9QMrsSX
@dlx5dlx6 @MMMalign That's actually the root of the original discussion from a few days earlier.The connection between mTOR/Fasting and bile regulation/gut bacteria and the resulting impact on p-glycoprotein are at the core of what I've been spiraling around it seems. π https://t.co/g6o6ywphFs
"Everything you know is wrong"πΆhttps://t.co/NoO3shLKgn
Ideas rhyme."reducing the activity of a plant to its measurable ingredients could be compared to trying to understand the contents of a book by analyzing the quality of the paper it is printed on, without reading it."https://t.co/o3FUMCLwb6https://t.co/sK7Y1okR57 https://t.co/vod5MlzMh2
I meditate about toilets while sitting on the toilet. But also while musing about complex nonlinear interactions of the dynamics of biofilm formation (at the colony level) in response to antibacterials+fungalcides and applications of combination therapy. https://t.co/GHC6CGCRm3
"Warum soll sie nit ebenso gut sein wie eine alte? Wenn ihr jedes Gift recht auslegen wollt, was ist, das nit Gift ist? Alle Dinge sind Gift, und nichts ist ohne Gift; allein die dosis machts, daΓ ein Ding kein Gift sei." https://t.co/pHAMuEcuQa
Rhyme, motherfucker, Rhyme.https://t.co/th6QWVdBVS
inb4 adenovirus vaccine that helps fight contagious obesity ends up operating by gut bacteria... like everything else.https://t.co/oPCdCyhYjB
1) Flu vaccine effectiveness mediated by gut bacteria.https://t.co/sp8Ys0psel2) Maternal gut regulate RSV infection risk in children via bacterial strain Lactobacillus johnsonii.https://t.co/Nfh8Ptlnja3) Gut Bacteria disrupted due to covid.https://t.co/rijnuu9AaH4) Ergo: https://t.co/7RsTVWtgTZ
inb4 part of how kefir helped me cure my GF's type II was it fights off... obesity causing VIRUSES.Many such cases.https://t.co/JcNVYlXubyhttps://t.co/QVo1u0HFtw https://t.co/kDl7NUD68B
Something that always bothered me: If we found that obesity was contagious across social network ties, what was the underlying mechanism? Everyone makes assumptions, but no one has a smoking gun?I think often about @NAChristakis's ted talk on epidemics https://t.co/B46cWRPTSR
If obesity can spread due to a literal adenovirus virus is impacting gut health and driving obesity via dysregulated metabolism... Does that explain part of the effect seen in is his paper? https://t.co/bg2tMJsxwR
Obesity spreads like a contagion?"Network phenomena appear to be relevant to the biologic and behavioral trait of obesity, and obesity appears to spread through social ties. These findings have implications for clinical and public health interventions."https://t.co/iAKbADbod6
There are so many interesting phenomena that seem to be wired to spread in ways that act like memes. Given I've cured a treatment resistant depression in myself, I often wonder how much of emotion is social, vs how much is gut.https://t.co/cB24ICjD6shttps://t.co/1PhpxT0Kul
Are emotions as a viral like phenomena, and some of us are immune to spreading it?https://t.co/vt9kiPaUqX
