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🧵 Thread (52 tweets)

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UltimApe@ultimape• over 6 years ago

Exploring links between the microbiome, the heart, and teeth.https://t.co/lpm2bo6aeRbecause bears.

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

"calcium binding of bacteria in an acidic saliva would lead to demineralization. I'm thinking that calcium floruide's anticavity aspects are actually a sort of bandaid for acidic mouth environments."https://t.co/HpcdRZ2XDp

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

Teeth tho.https://t.co/GRtXWEP3N0

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UltimApe@ultimape• about 7 years ago

@Tipsycaek @literalbanana I think its a oral microbiome thing. I'm only recently learning more about how the mouth maintains itself and how calcium deposition and remineralization operate.

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

"Changes to these bacterial communities in newborns have important implications for infection or disease early in life"https://t.co/pzFHJ593vHhttps://t.co/ckZWcdVBmm

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UltimApe@ultimape• about 7 years ago

Ancient Memes"milk was considered a miracle fluid which could cure people and give wisdom. The mythical figure Philosophia-Sapientia, the personification of wisdom, suckled philosophers at her breast and by this way they absorbed wisdom and moral virtue."https://t.co/tVdJxhrdie

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

Candidia Albicans can affect enamelhttps://t.co/FUOC6Fk88uAND we've known about Streptococcus Mutans role in tooth decay since 1986https://t.co/jf5NBWm1tDStrains of L. Reuteri fight Candidia albicans and streptococci mutans.https://t.co/8TPv4meHYH

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

Gerber sells probiotics with a strain of L. Reuteri and Vitamin D.https://t.co/4PZiD2Bz3Zhttps://t.co/v16rRDajkn

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

"As few as one in five formula-fed babies and one in 20 breastfed babies are getting as much vitamin D in their diets as the nation's leading pediatricians' group now calls for, the CDC says."https://t.co/iWgEHm3GYU

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

Find yourself a dentist who reads scientific papers on the microbiome."Oral microbiomes: more and more importance in oral cavity and whole body"https://t.co/IxDwCwjbr3 https://t.co/pVg1sWn7Hj

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

"The effect of periodontal infections on diabetes mellitus is potentially explained by the resulting increase in levels of systemic proinflammatory mediators, which exacerbates insulin resistance"https://t.co/0onOE2i7fr

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

"Most striking changes in uncontrolled diabetes are reduction in defense mechanism and increased susceptibility to infection leading to destructive periodontal disease."https://t.co/hPM5yB9IWV

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

"Enrichment of gut microbiota with L. reuteri increases insulin secretion, possibly due to augmented incretin release, but does not directly affect insulin sensitivity or body fat distribution."https://t.co/Pf6Xw2kwbC

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

"L reuteri was shown to inhibit NO production of macrophages when co-cultured with the other bacteria or when cells were pre-treated with LPS."https://t.co/zMc6IOlL90

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

"These results show that Kefir has a potential to modulate the immune response and activate peritoneal macrophages in diabetic animals, which suggests that it could enhance the immunocompetence of patients affected by diabetes mellitus"https://t.co/y8cjA1fHUL

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

I love reading stuff like this. It goes on and on about how processed foods are bad and how we need more nutrients...But then you look at what it recommends and it's all stuff that boosts healthy bacteria. "replenish nutrients" is a red herring?https://t.co/y5R0jTWDmr

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

The nutrients don't matter if you're destroying your gut microbiome and recreating it with destructive stuff like Strep Mutans. Gotta have both the nutrient profile and the right environment for this stuff to work.https://t.co/kgbZLXGhmD

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UltimApe@ultimape• almost 7 years ago

A quick google search nets this gem:"The truth of the matter is cancer is caused by microbes. The microbes are inside of the cancer cells."You were so close! https://t.co/ILWwkCBl9k

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

The 'organic'+'natural'+'unprocessed' flaunting group are right... but not for the reasons they state. Its a good rule of thumb, but without the full picture they're going to run into edge cases where this stuff breaks down.

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

Toxins destroying teeth, and nutrients restore them.Demons destroying my life energy, and love restores them.https://t.co/JgFsWmzKar

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UltimApe@ultimape• about 7 years ago

@NEETWizardJanus You're talking to someone who suspects that god is a mythic representation and series of rituals meant to coordinate behavior for the sake of the bacteria in our gut. https://t.co/X9Y5xzfkSv

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

When you realize that 'Chi'/'Chakra' 'energy' combined with herbal medicines may be an alternate conception / model about various body axes.Gut brain axisHypothalamic pituitary adrenal/gonadal axishttps://t.co/JgRRpe8CID

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UltimApe@ultimape• over 6 years ago

I found some neat associations between oxidative stress + uric acid reduction and some studies reviewing "ancient Chinese" / Tibetan herbal medicine that I had previously noted as having diabetes adjacent virility cures. I'll have to branch down that path later.

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

Stealmanning history.https://t.co/YqKMzAppRJ

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UltimApe@ultimape• over 10 years ago

If Evil Spirits/Prayer are an ancient explanation of Germs, Sickness and Death.Could Chakrasbe Brain chemistry, Oxytocin and Cortisol?

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

How do you teach a child that if they don't control their stress it will make them poop wrong?https://t.co/nqwEZiCXHv

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UltimApe@ultimape• over 10 years ago

How to Open Your 7 Chakras - As Explained in a Children's Show.https://t.co/IUIBidMisp

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

TFW your culture's notes on ancient dietary habits to avoid disease are turned into a religious belief system. Many such cases.https://t.co/r6CpiM71Pe https://t.co/TuYeeX5y7B

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

"My fire Chakra would like to eat something other than onion banana juice."https://t.co/dsyezThKGr

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UltimApe@ultimape• almost 8 years ago

from 'Bodily Changes in Pain, Hunger, Fear, and Rage' 1916 https://t.co/NFjM2nzT4d

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

Mommy, Why does the sun make my poop hurt?https://t.co/S4pbU23vle

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UltimApe@ultimape• over 9 years ago

Serious question: can sun make my poop hurt?https://t.co/7qaS8i6oxz

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

The tooth fairy is a lie-to-children to distract them from the fact that our freaking teeth regularly fall out and then other ones grow in. https://t.co/xlVeM5s2ED https://t.co/ADnxuWpkaW

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

Rejecting cultural narratives, one tooth at a time.https://t.co/dl7GPHtSfK

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

The best fairy tale? https://t.co/gUG4a9LXHp

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

The tooth fairy is one of the few rituals we have in modern western society that hasn't been invaded by candy. https://t.co/2WuHQgm4M3 https://t.co/kn4Eh9xGHh

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

If toothpaste is a western invention promulgated on the back of advertising, what do other cultures do to maintain their teeth?https://t.co/h1soS9m8j5

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UltimApe@ultimape• almost 8 years ago

It makes sense to me that long-term cultural norms around disease would affect the variation in immune system genetics. There's tons of strange papers on the ways religions have basically been at the core a way for society to deal with disease ala ritual https://t.co/LpayfvNsPM

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

George Washington's teeth didn't rot out of his head as we understand it. He actually used some of his own teeth as part of his dentures (they weren't made of wood)? Maybe he had gum disease?Whoa.https://t.co/QA60oxEnTW

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1/19/2019
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UltimApe@ultimape• over 6 years ago
Replying to @ultimape

The guy ate cornbread pancakes every day for breakfast?https://t.co/0Q3R1nIIwZ

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1/19/2019
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

How much do you not understand, and assume is a fairy tale?https://t.co/j1G36srBIN

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UltimApe@ultimape• about 5 years ago

@loremasterLuigi @SupaMalaman We draw dog faced people on a map. thinking they are figments of inventive minds.https://t.co/Gmoy4gSBj2Meanwhile, in indonesia, somewhere between India and Sumatra there are a people who sharpen their teeth taht could be describd as dog-like. https://t.co/FlW32BlLNX

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1/15/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

How much do you not understand about fairy tales?https://t.co/JyQ6EowNkr

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UltimApe@ultimape• over 4 years ago

Your body is a temple, they said.You are what you eat, they said.Why?https://t.co/5uwEmGisnc

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1/15/2021
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UltimApe@ultimape• about 4 years ago
Replying to @ultimape

Have you tried to Grant the Premise?https://t.co/VqZaOk1R5x

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UltimApe@ultimape• about 4 years ago

There are lessons to be gained from the past. If you are willing to listen.https://t.co/TjJbv6NhGe https://t.co/7hCmm8OqW6

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8/12/2021
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UltimApe@ultimape• about 4 years ago
Replying to @ultimape

Or considered alternate uses of a culturally imbued mythos past on from generation to generation as a learning aid?https://t.co/ymECXPmsDk

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UltimApe@ultimape• over 4 years ago

"Fairytales are in my head,and in my head they startTo tell you bout the deepest thoughtsthat live inside my heart"🎶https://t.co/qZFdT8YSQWhttps://t.co/3ubEwiFAkK

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8/12/2021
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

"No one would have predicted this."huh... https://t.co/m1xe4gymAehttps://t.co/J78bMxjE2I https://t.co/gHqeTy0kfy

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UltimApe@ultimape• over 3 years ago

@chaosprime @deafitist @GENIC0N @rivatez I have hyperthymesia.I saw Streptococcus in that article and my brain pooped out dog rose.Not sure why it happens."Streptococcus mutans"+"Candida Albicans" are probably synergistic, and dog rose fights the biofilm formation.https://t.co/EQCI7Pj7Dw

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

I don't just predict these things, I literally act as if this is the normative model that bacterial/fungal biofilms operate.https://t.co/GaqbHHykeA

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UltimApe@ultimape• about 3 years ago

"Their emergent intelligence and the evolutionary defence strategies are very similar to how organized human communities respond to society-level insults. […] key to our battle against biofilms could lie in understanding how bacterial societies function" https://t.co/NzYHLUPsNu

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

Just keep isolating strains and testing them without looking at how they interact. What could go wrong?https://t.co/ckGORRDnyl

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UltimApe@ultimape• almost 4 years ago

If you isolate a bacteria or a fungus and test the anti-biofilm components of an isolated pharma or plant based product... You're going to miss the complex interactions that take place in the real world.Like Yeast helping Lichen.https://t.co/LmZaiNR3YL

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

Pull the worm from the tooth.https://t.co/kdq9SUp4py

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UltimApe@ultimape• over 3 years ago

May I see past the existing dogma of a society who's ideas rest on the fragile glass of the petri dish and the derangement stemming from divinations out of a clay bed pan?https://t.co/iMjiZNgg3M

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

Can't find what you aren't looking for.

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

What circumstances lead to bacteria and fungus to team up and wander around the tooth landscape? Is it like slimemold shifting to their slug phase to find food?https://t.co/Z53Ubm60fO

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UltimApe@ultimape• over 8 years ago

@monk51295 oh that's interesting I hadn't thought of slug mode as a different foraging strategy! #TMMTO https://t.co/aFp3MIDTyF

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

If you really think about it. Biofilms are kinda like a structure extruded by bacteria and fungus. Like keratin or bone, or shell, or dead skin cells, or silicon, or... This is a primitive body. A Bivouac.https://t.co/gNnXiHsHS3

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UltimApe@ultimape• almost 9 years ago

Ever see a swarm of caterpillars acting as a blobby wheel-like structure to move faster in the under brush? Yep.https://t.co/lcXmXYav3y

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

Like bunch of bees all huddling together to stay warm and then start vomiting some waxy substance to cocoon. Couple generations later and you get a hive.#SymBEEosis and #beehiveiorism

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

These things are everywhere.https://t.co/g4UDwHeuYc

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UltimApe@ultimape• over 4 years ago

@MMMalign @DouglasKeeth "systems, these organizational structures, that allow a lot of autonomy to sensing units — to sense and respond to the environment without constantly going up to a central controller — are ubiquitous in nature. They are the most adaptable kind of systems." https://t.co/tX6bUrtRsO

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

Cleaning teeth by analogizing them to other surfaces prone to collect biofilms.https://t.co/sK7Y1o3fGx

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UltimApe@ultimape• over 3 years ago

I meditate about toilets while sitting on the toilet. But also while musing about complex nonlinear interactions of the dynamics of biofilm formation (at the colony level) in response to antibacterials+fungalcides and applications of combination therapy. https://t.co/GHC6CGCRm3

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

Can't wait until we see what kind of biofilms we are harboring in our gut."Dental biofilms from symptomatic COVID-19 patients harbour SARS-CoV-2 RNA and might be a potential reservoir with an essential role in COVID-19 transmission."https://t.co/Qdtsn6K4UV

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UltimApe@ultimape• over 3 years ago

Would be really funny if all the herbal cures touted early on to treat a common cold ended up having anti-fungal properties in ways we don't really understand either.Maybe its impairing a biofilm based interaction?https://t.co/arboFVS87T

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

So many biofilms, so little time.https://t.co/x6iA8FQZVU

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UltimApe@ultimape• over 3 years ago

the term "biofilm" is a fairly generic word. So just because one quasi anti-fungal drug seems to have action in this space doesn't mean it has action with them all.https://t.co/3rWjnROWCW

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

I wonder what kind of mouth wash I can make to clean my teeth of biofilms awhile preserving health oral microbiota?https://t.co/Al4Ef6mwDR

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UltimApe@ultimape• about 3 years ago

@RahmSJ @TylerAlterman @seconds_0 I'd also be worried about spill over into other species if we are dosing it orally. Many of the ones we want to harbor in our gut for normal digestion of foods use biofilm formation to protect themselves. Hard to only target one species using a pharmaceutical approach.

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

Teamwork makes the dream work.https://t.co/xY9ghoCuae

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

"The mutualism exhibits oscillations because the strain that is more abundant at the beginning of a growth cycle might end up less abundant at the end of that cycle"

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

The bacterial carrying capacity of your oral landscape.https://t.co/CiZXQwvl5G

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UltimApe@ultimape• almost 8 years ago

Finding paths, vacillating between red queens & red kings.Walk the line. Boundaries between the light and darkness.https://t.co/vtfHDiRZMW https://t.co/3sC0hcrlfF

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

"advances that underscore the roles of [bacterial-fungal interactions] across relevant habitats and ecosystems. A particular focus is placed on the understanding [...] within complex microbial communities and in regard of the metaorganism concept." [2018]https://t.co/ZX2Wb7FSh3

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10/16/2022
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UltimApe@ultimape• almost 3 years ago
Replying to @ultimape

"Who does the measuring? What we find depends on what the observer is capable of seeing."https://t.co/weCBvnTPFv

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UltimApe@ultimape• about 4 years ago

25+ years being obsessed with evolutionary theory, and all I got a bad case of disillusionment on what it means to be an individual.https://t.co/QYHGH9Mddx

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10/16/2022