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I have heard enough grapevine reports of Methylene Blue having an impact on health factors related to infection that it has greatly attracted my interest.https://t.co/TROrxCB4mu https://t.co/3UIcypaMSk
This in particular is interesting to me. How is it doing this? Why would light make it act this way? https://t.co/5hiHyzKvLI
Also, there are some very strange reports of Methylene Blue impacting gut bacteria that seem to suggest it's preventing immune system from destroying the gut after a head injury. https://t.co/4QIT92mbKG
Sure enough, there are even findings that it seems to hit SIRT1https://t.co/oiI7GUXpZmWhich may explain action against progeria?https://t.co/R9Qa0XcRUz
So the cool thing is that I was able to extrapolate out from this and guess that it would be improving Multiple Sclerosis in exactly the same pathways as me eating dog shit.https://t.co/CfM9ITHov3
This is a strong indication to me that it is doing something fairly significant. But what exactly is it doing? and why does light mediate it effects?If it is acting as an electron donor, does that mean that my gut bacteria are now doing the same? https://t.co/j5whrFu5i8
Reading about potential antifungal action of Methylene Blue and now I'm thinking if there are other stains that have potent abiotic action against bacteria & fungi.https://t.co/HgKxaGVPCE
Shoutout to @observing_hades for reaching out to talk to me about this stuff. They saw my arena entry on it [https://t.co/fSDMjhB9ha] and mentioned about a bunch of people doing research on it.Sounds very experimental, but fascinating.https://t.co/shc4gBOfkO
I think it would be fun to die my hair green with turmeric and methylene blue. Stuff seems very potent.https://t.co/bSAaPWsBM4
I remember using iodine to stain some kind of plant while learning about microscopes in 4th grade. I need to learn about the space of dyes and their action on cells, so it was good timing!https://t.co/EARmK3zMaj
Staining seems to be a subset of pigment work, so I think these things have a long history.https://t.co/vOBYjpvCSu
"Methylene blue was the first synthetic drug ever used in medicine, having been used to treat clinical pain syndromes, malaria, and psychotic disorders more than one century ago." https://t.co/Q6unRWV5eQ
"Long-term use of methylene blue in bipolar disorder led to a better stabilization and a reduction in residual symptoms of the illness. It is usually well tolerated, but caution is needed in the light of its inhibitory effect on monoamine oxidase A." https://t.co/ezm5zt0urb
I need to figure out why it can cause serotonin syndrome. As 90% of the body's serotonin is made by gut bacteria, there may be something more going on here besides just direct MAOI activity.https://t.co/9vj8cdN1wE
That it also has an impact on depression is also fascinating to me. I don't think that is actually via serotonin in this case tho. (I suspect immune system effects being primary driver here)https://t.co/nw84XQo7sj
Ooh, it looks like I made a reply thread on methylene blue a while back exploring how it might be acting to shunt electrons in the mitochondria. https://t.co/no05jHuG73
My anti-covid era is largely about preventing fungal infection.https://t.co/W6krJW9tJv
"idiopathic pulmonary fibrosis" -> why Bryan hasn't had great lung function?"COVID-19 vaccination may cause acute IPF exacerbation"https://t.co/uGA9NKbl1dhttps://t.co/SCxt5ZLkN7
@bryan_johnson This is predictable."provides evidence for the induction of liver fibrosis by multiple factors during acute COVID-19. Findings also indicate possible liver fibrosis in about 5% of the post-COVID group." [2021]https://t.co/3ZWELZEbecSystemic fibrosis. https://t.co/gWorXnIiAH
"Some study investigates the causal relationship between gut microbiota and idiopathic pulmonary fibrosis (IPF) as well as lung function using a two-sample Mendelian randomization approach"https://t.co/U0YXU8IgNl
Breathe my pasty friend.https://t.co/OsMPGiPiiH
"Microbes may be recognized by host immune cells, resulting in systemic cytokine release. Or in some cases, "the bugs make drugs," such that bioactive compounds are secreted by microbes, absorbed into circulation and directly alter lung function." https://t.co/PrkXQJCrSi
I have a thread on bluesky talking about how gut health might impact factors associated with progeria ala SERPINE1 and IBD. https://t.co/9WmHlRGzRc https://t.co/bNA0o6uMLL https://t.co/siF92N2Lwv
"Significant decrease in malondialdehyde (MDA) and inducible nitric oxide synthase (iNOS) levels as well as significant increase in superoxide dismutase (SOD) and mitochondrial cytochrome c oxidase levels were observed with MB" https://t.co/kHjtnY0vFu 😇https://t.co/7e68UDHqzz https://t.co/NF8rc6ZMSa
> "[...] the molecular mechanisms causing accelerated aging in progeric patients also occur in healthy cells of older individuals. [...] may also help explain some of the cellular changes that accompany normal aging." https://t.co/2hhGIdUpE2https://t.co/4IRz3vKUCS https://t.co/dJow2BNHBv
ATP? Oxidative Stress? Modulated by my anus?https://t.co/15tJtyml9q
It's more likely than you think.Also, the reason why Bryan is so impacted by lack of sleep is he can't handle the oxidative stress of a little extra melatonin in his system.https://t.co/TDNr1Fc3L6
Fix your NADs Bryan.> "MB can reroute electrons in the mitochondrial electron transfer chain directly from NADH to cytochrome c, increasing the activity of complex IV and effectively promoting mitochondrial activity while mitigating oxidative stress."https://t.co/uviZp51Nh3
A swift kick.https://t.co/FaJm2qQRKU
You can... just fix your circadian cycle Bryan.https://t.co/OMasoH7dWE
@seconds_0 @Outdoctrination That is likely because with those other drugs the serotonin is being metabolized into melatonin. So the levels of serotonin actually drop akin to what happens in sleep states. https://t.co/j2Fq2MzSztThis is just messing with their circadian rhythm.https://t.co/N66FpI94YH https://t.co/CUMO2pZkQy
Have you considered your body isn't able to metabolize alcohol properly because your gut and liver is weak due to excess aldehydes as a fallout of long-covid, Bryan?https://t.co/DQGwHpt7Cy
Having suffered with jet lag for most of my life due to non-24-hour disorder, this makes me laugh. Fast during the flight and drink a little alcohol to put the gut bacteria into a dormant state, then eat breakfast in the new timezone's AM. https://t.co/FMt51laiJy
Sure would be a shame if you're trying to optimize an indirect measure of performance, Bryan.https://t.co/5fi7oSWFW8
Kinda fun how lab mice with lab guts shows MB don't have any significant impact on aging. I wonder if this is b/c they weren't accounting for pathogens / impacts on gut health. Other studies show MB has an impact on mice guts, so... https://t.co/OpQwSbxCVJhttps://t.co/O0t2U7WEwD
Some evidence that Methylene Blue will infact be the right color of green to dye my hair with.https://t.co/apLhw3FhZd
One of the precursors of methylene blue is a potent pesticide. Methylene Blue itself seems to fight malaria too, which is fascinating. https://t.co/uOy6PtkMn0
Phenothiazine itself is a precursor for a lot of antipsychotic drugs, so it's useful to know about if you want to understand how those drugs work.https://t.co/xj8qcu6tVy