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🧵 Thread (87 tweets)
Scientists find high levels of acetaminophen glutathione in the urine of people who have high levels of chronic pain. Suggest reducing glutathione as a way of treating chronic pain disorders.https://t.co/gsLctilIlB(this is what half of Alzheimer's research sounds like to me)
Is serine good? https://t.co/HodHYSA77dIs serine bad? https://t.co/8DZFq91bnNScientists don't know, but they suggest reducing it since PHGDH is involved somehow for some reason.
PHGDH is a red herring?"While PHGDH is often overexpressed in cancer cells, how it is regulated has been unclear." https://t.co/2ADYssPVkD
Linkin Parkin to mitochondrial function and oxidative stress.https://t.co/f2yJm7lmC4
"I tried so hard and got so farBut in the end, it doesn't even matter" 🎶for reasons that have nothing to do with a suspicion of gut inflammation driving ROS. Nope. not at all. I'm sure its L-serine. https://t.co/Vk4VxJmTa6
"Is the MTHFR C677T variant a genetic risk factor in the etiology of autism spectrum disorder? Is it alone or by combined with rare variants of the PHGDH gene?" [april 2022]https://t.co/t1gHcwy8Y3MUST BE THE GENETICS DERP. https://t.co/KHH4982kkv
M(o)TH(er) F(ucke)R's be DERPing.https://t.co/YEA2IQcl9F
I am as Diogenes, shining a lamp on a featherless biped.Is this your genetic cause of autism?https://t.co/gSBNcOmZXu https://t.co/XnXJhULWy0
@realjdburnett @eigenrobot We focus on genes like some kind of scientific fetish. I think it's massively oversimplifying the complex nature of adaptation and responses to resources in the environment. Missing the population forest for the gene trees.https://t.co/4JcsUrG1yn
Maybe. My mom's immune system is pretty fucked.https://t.co/9i7BgdBvaz
Parkinson's cause by smelling farts? Learn more about this new intriguing finding in tonight's broadcast, and learn about one autistic man's quest to reframe all of western disease as a hibernation syndrome stemming from one's butt.https://t.co/qUZeYJlOKIhttps://t.co/coPAA4MeKz https://t.co/pDb2SeWjg7
Would be a shame if there as some complex cellular mechanic where bile function has a secondary impact on mitochondrial heal via calcium associated pathways that correlate with GLUT1 mutations in autism.https://t.co/fge5p4n2y2
Have you ever wondered if a poor sense of smell means poor self-medication?Have you ever wondered what healthy soil bacteria smell like?Do you think ants taste good?https://t.co/P5JRhs8xNp
ITS FUCKING RAWhttps://t.co/ZQq1Af1f0f
The real joke is if you take too many anti-inflammatory drugs, you kill your gut and destroy your body's endocannabinoid system via impaired lipid function. So it's the COX2 inhibitor that is the problem. GSH is good actually.https://t.co/8yEI2IH3X8 https://t.co/idIhaZP0lF
I bet Tylenol causes Alzheimer's and Parkinson's given that I already suspect Tylenol can induce autism.https://t.co/TZEJ71fdVR
"Common medications such as Advil, Tylenol, Benadryl, Sominex and many others may increase the risk of cognitive decline and Alzheimer’s disease, according to a study published this fall in the journal Neurology." https://t.co/U6aLwk8Vd4
If I'm right, all these people DERPing over Alzheimer's genetics and autism genetics are really finding what genes predispose people toward being poisoned by modern pharma.This is a religious belief, not a medical claim, FYI. https://t.co/q537xBGTTs
Source? I saw god in a dream. https://t.co/8GK7F5PzjD
I also was told by god how to heal my gut inflammation.https://t.co/QBe8D4lBqU
Of course this is because I steelmanned how Albert Einstein spoke to a farmer in a dream. But I'm calling it god because I think it's funny.https://t.co/rpJbd9gbZm
I'm not even joking, although that would be funny too.https://t.co/TMQDBV1TbI
Some of the sleep meds we give people also are a risk factor for alzhiemers. I don't take those.My epiphanies come from ice-cream having tons of glycine in it.https://t.co/BWnMR9aT4N
I read a paper in my dream describing how overlap between garlic's impacts on gut bacteria and its impacts on nerve regrowth related to an IRL finding aroud THC+Akkermansia muciniphila.I keep going to search for tweets I wrote about it. I keep forgetting it was in a dream.
Reject Modernity, Return to Tradition.https://t.co/75jVNy4WUr https://t.co/Hjvmg97li5
Woof. 🐶💘"Rosa canina L. (Rosaceae), known as dog rose, is widely distributed in and around Europe. The fruit of this plant, rosehip, has been used as a diuretic, laxative, anti-gout, and anti-rheumatic remedy"https://t.co/E5sBDYqa2rhttps://t.co/CYpOZYwmcV
Blood markers are good."showed a consistent increase in PHGDH expression among Alzheimer’s patients and asymptomatic individuals in all four cohorts compared to the healthy controls. Moreover, expression levels were higher the more advanced the disease." https://t.co/w9xIkmsz6C
You fucking what?"Laboratory experiments have shown that something called parabiosis – surgically combining an old and a young rat together, for example – is enough to improve muscle strength, the proper functioning of the liver and reverse obesity." https://t.co/McGvY0ijdH
What happens if you give an old mouse a bunch of antibiotics and surgery as a control?https://t.co/Aq0eApGuHT https://t.co/QZHJIpUuSq
Do mice experience placebo? Or do we just have the model wrong.https://t.co/ZqXYXq8EMB
"The weight loss that was induced by [Roux-en-Y Gastric Bypass Weight-Loss Surgery] alters the mTOR signaling pathway and specifically the mTOR complex 2 subunit."https://t.co/BdWPa4PVdUMust be the weight loss /shttps://t.co/5cuelWFrDC
Lmao. For me to be right, Theil's health investments have to be operating under false pretense and based on assumptions on biology. Biology models that I literally ate dog shit to prove were wrong.https://t.co/Jl53phGi0Z
( also steelmanned "young blood" in history, fwiw. Right for the wrong reasons... can still get results https://t.co/rQfb3oZu8n )
I am a monkey who climbs the lamppost and tries to see in the dark while everyone runs around looking in the light.Let darkness be thy friend.https://t.co/lXEoXtM8OL
"Examples of how the streetlight effect sends studies off track are ubiquitous. In many cases it is painfully obvious that scientists are stuck with surrogate measures in place of what they really want to quantify."Oh hey, I know this one...https://t.co/YlaeKm1kqL
Have you tried to see in the dark? The CIA is afraid of it.https://t.co/t4GT3KhWIL
@pee_zombie That guy who hacked his eyes to see in the dark was on the CIA's radar AFAICT. Night-vision goggles are controlled exports for a reason. Even tho tech like it could help people with poor vision drive at night (like me). Same applies to listening devices.https://t.co/uASDSMTWHG
Apple-a-day keeps the doctors away.Ice-cream-at-night makes the demons play.https://t.co/sxktFVh3Yi
"mTOR is a highly conserved serine/threonine protein kinase [...] cell growth, proliferation, motility and survival, protein and lipid synthesis, glucose metabolism, mitochondrial function and transcription, in response to nutrient and hormonal signals" https://t.co/UdPxhW9dzJ
Loss of sense of smell and gut dysbiosis? Weak grip strength, motor control issues, memory impairments & problem with hallucinations while awake? Sleep problems and sleep terrors? Fecal eating and fecal smearing?Autism: Childhood Alzheimer's Disease.https://t.co/xCUoWJDAHm
Serine glows gold. It's why mTor came to me in a dream about Alzheimer's.https://t.co/Y6wKCDTHwi
When terms light up part of my brain around the idea that i'm interested in, the colors of text shimmer and transition. For a moment I see gold, blue, yellow, orange. Years of excitment over a rare drop in a video game training my emotions. Now it's running in reverse.
What's your star sign?Cancer? Naw. I'm mTorus.https://t.co/edLH6BfUJY
*Sniff*Can you smell it?https://t.co/rMdnb2NdhH
"Previous studies have suggested that the serine/threonine kinase mTOR — a known mediator of growth and proliferation, particularly as part of the mTOR complex 1 (mTORC1) — may be important in intestinal tumorigenesis."https://t.co/jBkqauuhID*sniffs*https://t.co/bl98Lo9YeO
It smells like a prediction.https://t.co/buDothMIuN
Learn to predict the future via scent."Researchers discovered this after a woman amazed doctors with her ability to detect Parkinson's through smell. [...] a blinded test of her odour-detecting skills found she was 100% accurate."https://t.co/sP6xgmrmSehttps://t.co/1LyYjHkYYM
Learn to smell the future.https://t.co/Mcu3meL2CHhttps://t.co/1LyYjHkYYM
@WeftOfSoul @TEP_Lurking I have tweets predicting that parkinson's might be an immune/gut related problem from years ago because of this mental model.https://t.co/hPOUv55f1nhttps://t.co/EdrGZY7A4Obecause a super smeller was able to smell it on people.https://t.co/vouwgZDYzp
Gonna go lay in the sun in hopes of being able to work on healing my eyes. I wanna see better in the dark.https://t.co/rqccvQPuz5
@theolearns @DrJackKruse I'm assuming that I'm perhaps a rarity who's actually supposed to be crepuscular - able to shift my sleep around in response to the seasons. exploring vision via https://t.co/rVDCqDF6dT blindsight, and stuff like this https://t.co/GNtMgIHPfp is what helped.
In before FGF17 is manipulated by bile function and gut microbiota and impact neruogensis indirectly via insulin and IGF-1.Oh wait. It is.https://t.co/AO5l7cyXKz https://t.co/qneSpvDKIG
Hippocampus.A school full of hippos.https://t.co/DrfwHF1fCW
If we're going to be sensationalist over some findings in mice. Check out this finding on a gut bacteria modulating antibiotic and it's impact on Alzheimer's (in mice)https://t.co/IpV5kjemRA
Everything I say about Alzheimer's applies to autism."clioquinol, an antibiotic used to increase zinc absorption, on the mice displaying autistic behavior and found that they began behaving in a way almost identical to that of the unchanged mice" https://t.co/ZKLMp3kqiT
Lol. LMAO."Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway" https://t.co/kfGWvW3zO6
I have no idea what I'm doing. But it would appear I can learn more about the truth by making joke about the quality of my farts than modern scientific fields of study.https://t.co/fvb59UwNlG
Did you hear the one about the amyloid beta? It's a real head scratcher.https://t.co/L892melFJu
"immediate, obvious damage is wasted NIH funding and wasted thinking in the field because people are using these results as a starting point for their own experiments."https://t.co/3Xe8OsEQzBI'm a big fan of @MicrobiomDigest BTW.https://t.co/RfFcbCcv1L https://t.co/T3zYglllDj
Have you tried getting stronger?"Furthermore, the upstream and downstream components of mTOR signaling are involved in the pathogenesis and progression of AD. Hence, inhibiting the activation of mTOR may be an important therapeutic target for AD." https://t.co/Z9Ib7lFgia
Glutathione should improve grip strength.Tylenol should reduce grip strength."Future research should focus on the effects of GSH redox signaling in ASD and should explore new therapeutic approaches by targeting the GSH system."https://t.co/ZCJHg3fS8ehttps://t.co/w8D4eB7QSs
Glutathione suspcted to improves limb strength in a neurological disease that I previously linked to disruptions in gut microbiota.https://t.co/JtqaPq9bkqThey cited a study on Glutathione in autism...
Suggests supplementation *will* get Glutathione in the system. No mention of grip strength tho?https://t.co/R9lQlQWhm4
Some studies on knockout mice suggests that Glutathione is involved in pathways associated with ALShttps://t.co/hTi1k6Xwe8
Huh. Neat Hypothesis.https://t.co/AA5dmxvudN
Oh look, Glutathione (and by proxy, cystine supplementation) does improve "Isometric Strength"They used same style hand dynamometer I did.> "Maximal isometric strength and fatigue index were also assessed using an electronic handgrip dynamometer."https://t.co/liJbPfflJG
The things I learn by following down hunches on people's descriptions of the smell of their fart.https://t.co/PIaHASQvtz
What is NAC? It is a source of cystine... https://t.co/nfox1SIxWF
So... can we please please please get studies done on the impact of garlic on Covid, or at least on the disease that have higher rates of Covid related complications and notable grip strength problems?https://t.co/3RwMAMaWDO
Garlic seem really important.https://t.co/k7eWBTkAM5
Sure wish we had someone looking for evidence that garlic would impact pathways associated with Long Covid or ME/CFS, by way of glutathione.https://t.co/8Lpcff5aC6
What could he have meant by this?https://t.co/vWjUz1bWvA
"It is gratifying to see new thinking about this age-old disease. Dementia currently affects more than 50 million people worldwide, with a new diagnosis being made every three seconds."https://t.co/exGwCmKlLHhttps://t.co/pSpfFEHAiu
@The_Lagrangian Every risk factor for Alzheimer's I find is also a risk factor for sz and asd. What if they are different expressions of same disease?I'm probably wrong here in some fundamental way. but the predictive power is phenomenal. https://t.co/V2SrnDQt0h
Once you realize that like 95% of ancient medical models of disease have mapped and modeled infectious pathogens as 'demons', and were using herbal compounds for self medication... A lot of strange thoughts unfold.https://t.co/EskvkEDFJL
Sure is funny how many things impact it.https://t.co/74I72UTllU
Fun to research how gut bacteria manipulate serine metabolism."Gut microbiota-derived metabolites play important roles in health and disease. D-amino acids and their L-forms are metabolites of gut microbiota with distinct functions." https://t.co/nFUYLeOUsw
Some commensal gut bacteria ('Eubacterium sireaum') seem to even make something called Siropins, which are "novel serine protease inhibitors"https://t.co/Z01Sj2qV56
People are trying to manufacture gut bacteria that produce these serine protease inhibitors to treat colitis too.https://t.co/pbRibmbnEZ
It is funny to me that we have all this research on natural products and commensal gut bacteria, but what we are doing with this is trying to manufacture synesthetic versions and gene modified strains instead of fixing our diets.https://t.co/yskKdcteJW
"In summary, these experimental results provide new insight into the understanding of the neuroprotective effects of garlic components in promoting brain resiliency for health benefits." [2020]https://t.co/6huaVc5XPF
"If we simply increased the number of microglial cells, we also would increase the amount of nitric oxide in the brain. Excessive production of nitric oxide leads to brain cell damage and promotes neurodegenerative diseases [...]However" https://t.co/I4CZxwfGsa
"The researchers later found that aged garlic extract, an odourless product widely available in Australian pharmacies and even some convenience stores, can completely prevent the breakdown of blood-brain barrier." https://t.co/OYN5kypcnG
It's amazing how many genetic studies are based on an assumption about statistics. Trying to spot when the current scientific gestalt is based on dependent vs independent variables is really fruitful.https://t.co/KT7WK3JKUQ
I had this insights a long time ago.https://t.co/BdUL35vboS
It's amazing how many processes are assumed to be entirely random and not weighted random / chaotic.https://t.co/6mZ1deUjJI
Wanna hear a funny joke? Learning that most of the assumptions around GWAS depend on naïve models of random chance.https://t.co/YOBcRVIhZx