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Doritos are a great proxy for a body seeking lactic acid bacteria related metabolites and butyrate producing strains of cheese-smelling anti-inflammatory bacteria and related SCFAs and proteins.Terpenes, phytochemicals, metabolites? Bacterial and fungal manipulators. https://t.co/ii2Jc4pd8C
Why, I wondered, does flavor have such a hold over us? And why do so many scientists carry on as though nutrition starts from the neck down, that what truly matters in food is carbs, protein and fat, and flavor is just some meaningless and frivolous indulgence?
Its amazing how understudied gut microbiota's impact on taste receptors is.https://t.co/9kLjzV8Yxy
I can tell you if I'm low on sodium and zinc by what something tastes like.I learned this by reading up on how geologists taste test rocks.https://t.co/HSfekmLdl6
When I get them, I'll eat 4 cans of smoked oysters a whack. Apparently that's 260gThen they start tasting bad for some reason and I go back down to 1 can (65g) every 2-3 days. That means my body seems to self regulate around an average 100% DV of zinc?https://t.co/y8FRMVHXRD
Taste receptor expression is interesting to study."This review summarizes how ion channels work during the transduction of multiple tastes, as well as the recent progressions in the epigenetic regulation of ion channels." https://t.co/01Un0ZtpfW
There is so much we don't understand. https://t.co/Rqlgm0GVOb
But if you reject modern nutritional wisdom parroted by 1900's nutritional science, you can start to reframe things in terms of... something else.https://t.co/3kSV2oZPvf
Dysgeusia is fascinating. Why do taste sensors seem to show up in parts of the body that deal w/ chemical concentrations, microbial management, or have a high need to maintain homeostatic / immune responses?We have taste receptors in our brain, ovaries/testes, pancreas, & anus.
I can smell gold in the soil. So can you. If you only knew how powerful you really are.https://t.co/zzUVYWRoWO
I would bet money this is via synesthesia driven by yet unstudied gut-brain axis phenomena impacting memory & sensory related parts of the brain tied to socially mediated disgust responses as a learning phenomena.https://t.co/Yad155aAeC
Why do severely autistic kids seek out salt and feces? Because indole and sodium tend to be things high in lactic acid bacteria?I hope we can pose these questions better soon. https://t.co/aoBgC6cumq
@Grimhood @dlx5dlx6 @marinagamba1909 @ResilientDad @PnkCadyCourtney There are some miserable stories about how parents need to lock the fridge/cuppboard up at night because the kid's pica drives them to excessively eat. Often ends up being malnutrition via gut disorders driving hunger.Salt is a big one that poisons autistic children.
*sniffs*https://t.co/jGyfyIR9Uv
Fun fact, I've never had Covid and my sense of smell is fine AFAICT. Dog shit does smell like fruity rancid wet hay and eggs.What you're smelling is a *lack of* skatol & indole sensitivity.“Poo now smelled better than coffee.”https://t.co/Y8SCaljfQC https://t.co/lPdAg88jRH
"How Gut Bacteria Tell Their Hosts What to Eat"https://t.co/YtPX4cAUs5
"In our venture to decode the language of fungi, we first uncover if all species of fungi exhibit similar characteristics of electrical spiking activity." https://t.co/iJDmAtbCGZBacterial and fungal farts.https://t.co/uBZnVPRqEa
@WeftOfSoul @TEP_Lurking At a fundamental level, we can reframe scent as a latent form of communication, reformulated as game theoretic reputation system under lenses of Axelrod.I now wonder if deep learning algorithms can translate terpenes as a sort of basic grammar.https://t.co/L8rbnqGgyT
Linalool smells like lavender. Lavender makes me calm.https://t.co/sVRnItq6qc
Whats really fun is finding someone who's already 3-5 years ahead of me in exploring TRP function and finding out that all my hunches on terpenes and endocannaboids are mostly correct.Linalool consistently resolves a pain/itch sensation from Flow State.https://t.co/19yDZ6lwIo
"Against fungi the citral and geraniol oils were the most effective (inhibiting all twelve fungi), followed by linalool (inhibiting ten fungi), cineole and menthol (each of which inhibited seven fungi) compounds."https://t.co/yLlgSwBPflhttps://t.co/Jtvua02GxD
@debasis52 @Dominic_Valente @DoctorAjayita Thats fascinating.Many of the terpenes that plants make seem to be fundamentally insecticidal in nature. Other chemicals we see as 'drugs' are also insecticides in some way. I wonder what strains of cannabis they were using.https://t.co/zoWXd89CFP
Smell and taste are under-rated.https://t.co/rysbtXGFfV
Because we are a society who's cultural learnings are based on studies done on poorly fed orphans during an era endemic with pellegra.https://t.co/H7DVHbA91A
What else have we overlooked? https://t.co/cx87NZBLgg
Have you tried to see the world thru the lens of a dog?https://t.co/QBZP63yBKs
We are nose-blind.https://t.co/Dij0EIXCdJ
@QueenOfTheWilis Studies on terpenes are all largely "if we we use this chemical, these bio markers go up" but there is very little in the way of causal modeling going on when I read up on this stuff.Its all "number go up" and then everyone scratching their heads as to why.
I've been washing my hair with pine-tar to fight dandruff driven by fungal species. It smells like pinene. I like pinene.https://t.co/Vt0FNXXBmJ
Did you know mucus impact sense of smell?"Our data showed that the α-pinene exhibited significant antiulcerogenic activity and a great correlation between concentration of α-pinene and gastroprotective effect of Hyptis species was also observed." https://t.co/RG4i1CPRIk
Anosmia."CONCEPT-SHAPED HOLES CAN BE IMPOSSIBLE TO NOTICE" https://t.co/ZibJy2H8qshttps://t.co/UlxxPuQaJR
What happens if I'm right?https://t.co/TlV0iOY6iT
A concept shaped whole so big you could drive an entire bus full of shit thru it and no one would notice.https://t.co/8E9VnNXRJM
I'm planning for 10 years in the future where we start shipping feces via medical drones.https://t.co/vJ4a64vala
"It seems surprising that such a large percentage of our genome is dedicated to the olfactory system, [...] other mammals, like dog s and rats, live or die by their sense of smell." https://t.co/SFLRPBaeHn
"We are the first to demonstrate that when humans describe the 'metallic' odor of iron metal, there are no iron atoms in the odors, [...] The odors humans perceive as metallic are really a body odor produced by metals reacting with skin." https://t.co/ZEcpFRm0S4
“how does the nose do it? [...] How can it possibly detect something that isn’t even a detectable peak on a gas chromatography-mass spectrometry instrument? This paper solves it in a big way.” https://t.co/7MPOXs3Ipd
Imagine thinking we can't see the color purple because scientists can't find the purple receptor in the eye.That's you right now.https://t.co/zztFN7Fbwy
Humans are dumb. We make sensors that are tuned to only give a reading under one set of circumstances. We should be thinking about the sensors as multidimensional ranges & fields; engineering overlapping fields that cancel out using computation.That's how TRP receptors work?
Tired: a musician's musician.Wired: a scientist's scientist.What kind of lab coat would I need to inspire other scientists to try?"it's only because the nice people in the white coats ask them to try."https://t.co/1Utl1xLqKm
Sufficiently advanced magic is indistinguishable from meta-science.https://t.co/N6IXX01Jqw
"fluoxetine (Prozac) causes nerve growth in the olfactory bulb after a few weeks. [...] more likely they work by [a cascading system of effects involving] causing nerve growth more generally, and the olfactory bulb benefits along with everything else." https://t.co/5wXju9PaYR
Smell ya later, losers.https://t.co/x1EorCZvJh
"mood stabiliser lithium and the antidepressant fluoxetine, influenced the composition and richness of the gut microbiota. Although some [...] drugs have been previously investigated in in vitro settings, this is the first evidence in an animal" [2019]https://t.co/z6crEpCft1 https://t.co/mKN2FwQwZa
*SNIFFS*"To our knowledge, we are the first to study the associations of the oral microbiota with olfactory function in humans." [2021]https://t.co/gM4bxq7EZp
Wish we knew more about interactions between naturally produced antibiotic peptides in the gut and the role of fluoxetine as an antibiofilm agent against candida.https://t.co/TetwzT3WB3
"The association of fluoxetine with gentamicin and erythromycin P. aeruginosa and E. coli presented synergistic effects, demonstrating that this drug can selectively modulate the activity of antibiotics of clinical use"https://t.co/890RJODd0Mhttps://t.co/BUtCx22YG2
Sure smells like an overlooked insight."These results reinforce the potential interest of SSRIs as anti-biofilm agents to be study to counteract resistance phenomena on candidosis." https://t.co/xNO6y7t7Py
"A topical application directly in the vagina can be assumed to be a desirable therapeutic approach, as it would allow direct introduction of drug quantities that can result in high drug concentrations in this milieu."https://t.co/QZDktH6WSe
A scent of things to come.https://t.co/lP2kBEq0Gz
It really is amazing how many papers talk about being able to smell sickness and disease.https://t.co/seTjF5f0No
"This chemosensory detection of the early innate immune response in humans represents the first experimental evidence that disease smells and supports the notion of a “behavioural immune response” that protects healthy individuals from sick ones" https://t.co/ZxTr0nAz2x
This is also true of all of the work being done to use gut health to fix food addiction. https://t.co/d75xIi4iS5
There is a war on your body. The food industry does not care about the consequences of poisoning you, or exploiting addictive behaviors, as long as they can maximize your consumption. They do not care what they have to do, or what it does to you, as long as you keep eating.
Just say no to turboslop. https://t.co/rSANEhwVF7
Throw in all the preservatives and synthetic garbage that destabilizes gut health and you also get food cravings tied to the body trying to fix the gut. Many of the flavors that are 'added' can loosely described as similar to the metabolites the body would need to restore them.