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Did you know that the genes for autism and major depression overlap with Anorexia Nervosa?It's almost like they are related somehow. https://t.co/uMXOrO6HoS https://t.co/kx9tCl2vqc
Why would endocannabinoid and immune pathways impacts hunger related behaviors? We may never know.🐻https://t.co/nk8lHi0Ulc
Someone here in 06 August 2021 talking about a hypothesis of body temperature regulation being an aspect of Anorexia.https://t.co/bvcSmbJGdiI'm cold. I forget to eat. These are M.S. symptoms, but no one seems to get it.https://t.co/fQfiAiUDYF
"Study in mice links appetite hormone and autoimmune disease." [2002]https://t.co/U2JFXOCMVCWhat's pica, if not an intense desire for food?It's funny how many autistic parents complain about needing to lock refrigerators because the kids won't stop eating.
Gonna go drink a glass of salt water because autism and GI issues correlate with sodium loss via diarrhea. https://t.co/6bJXUuCYoc
"Preliminary findings suggest that EDs may increase the risk of developing IBS."https://t.co/7NVNdXjnRO"These data suggest that relative sodium deficiency may contribute to AN-related osteopenia."https://t.co/AZ68PoPtZqIt's almost like these are all related somehow.
But salt is bad for you? /sOr maybe having a condition that impairs gut function and destroys salt-loving bacteria leads to heart problems?https://t.co/4z4KMf3GAB
" These include diabetes and high blood pressure — which are twice as likely to occur in adults with autism — and heart disease, which is more than twice as common, compared with controls."https://t.co/p3T2NUkzk4Its almost like these are the same problem?
Genetic overlap.Dietary overlap.Gut issue overlap.Health risk overlap.A rose by any other name would call a spade a spade.*pokerface*https://t.co/3zWmftiP3X
Sure would be a shame if there were entire swaths of people with autism being overlooked and being told they have all these weird conditions like bipolar and anorexia to explain things like eating problems and meltdowns, because they have ovaries.https://t.co/ZwyXCICITq
Just one little twist in your perspective and suddenly everything lines up.Paradigm shift.https://t.co/mf1uO1Jb13 https://t.co/BcaoNSSZj1
It would seem to me that a relatively large number of the population are dying like what happens to bears in captivity when we try to get them to hibernate.https://t.co/ESyGjROocE
Tired: obesity is a risk factor for heart diseaseWired: obesity is a risk factor for gut dysbiosis leading to microbiome induced inflammation that impacts heartInspired: Do bears get heart attacks?Hired: How can we get humans to hibernate?Desired: https://t.co/NJlwfmXpiW
"I think giving insulin is making people much sicker, [...] I'm hoping that whatever we find is going to ramp up the insulin sensitivity enough that we don't have to supplement with insulin at all."https://t.co/KX5CQhtFze
"focus on [...] the IGF-1/Akt/FOXO pathway. [...] If Dwyer is right, difficult-to-treat anorexic patients may need drugs to get their metabolisms back on track, much as diabetic patients have to take insulin shots."https://t.co/tt4iGuDl5Z
MOAR DRUGS. that's the answer.or you know, we could just fix the thing impacting the IGF-1/Akt/FOXO pathway.https://t.co/u6gkp71bRK
"Evidence is now growing that AN-induced starvation is associated with profound alterations of the gut microbiome"https://t.co/a5z7VF53w9which largely talk to the... Vagus Nerve.https://t.co/ZXgQ9KATiY
So of course we se the same things we see in autism. Strange results around vagus nerve and gut-brain axis signaling via serotonin/oxytocin.So keto + L reuteri?I bet goat milk kefir taste pretty good, along with some salty cheese to help reinvigorate bile acids.
"Hypercholesterolemia in anorexia nervosa may reflect diminished cholesterol and bile acid turnover which may result from reduced caloric intake." [1974]https://t.co/pDT8keaddJ
High cholesterol in blood plasma from the body not getting enough, being seen as heart disease risk?Do you:1) eat less cholesterol?2) eat more cholesterol?3) optimize cholesterol absorption pathways to let the body regulate better by improving bile salts and liver function?
Oh neat, they've already been trialing the same strain of L Reuteri tested on autistics, in female children with constipation and Anorexia Nervosa. With some interesting results. I hope they scale this up.https://t.co/j2vDFELHqo
in mice, the high fat diet impairs L reuteri and seems to cause an autism-like syndrome.https://t.co/eJZsg1wSY8 https://t.co/n3Z7EEuedM
L reuteri seems to be fixing it by impacting gut barrier function.https://t.co/EiSR84zxhMI wonder if I can find any local goat milk kefir.
"increased colonic permeability and histological alterations found in [activity-based anorexia] mice suggest that intestinal barrier dysfunction may also occur in anorexia nervosa." [2014] https://t.co/hWGIm1Wxr5
So. What is ketamine doing to gut barrier function? Is it acting via gut bacteria? Could this be enhanced thru diet?"in this review... we discuss" [june 2021]https://t.co/l6in6Xbxzg
*laughs in autism*https://t.co/V2SrnDQt0h https://t.co/DL828kZRqC
You mean a disease that mimics issues associated with M.S. is a risk factor for M.S.?https://t.co/vKRZny35JChttps://t.co/J8t4eDQ3tYhttps://t.co/ACVPJTrz5uIts almost like these things are related. https://t.co/ASLL3iOt0R
Wat do anorexic people smell like?"Unlike some of the more common symptoms of the disorder, this isn't something that is likely to be picked up on or reported [...] [maybe] aren't comfortable talking about it with their doctors."https://t.co/tRvKZj11Wlhttps://t.co/ipaYmOQpNM
I wonder what Alpha-synuclein smells like."Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders" [2008]https://t.co/4ETgOMDz5k
Say Anorexia, Say Anorexia again, mother fucker."Significant Changes in Plasma Alpha-Synuclein and Beta-Synuclein Levels in Male Children with Autism Spectrum Disorder" https://t.co/Y4UP5Jl6bM https://t.co/MR9UuOdjkP
Medical shibbōleths all the way down.https://t.co/HDJ1fIm0mu https://t.co/szOaO0a4k7
I regret to inform Asperger's isn't real. You actually mean to say Asperger's monster. Or rather Eugen Bleuler's "childhood schizophrenia", or Leo Kanner's "Autistic disturbances of affective contact" but viewed thru lens of medical billing and eugenics https://t.co/nZwyLsIA4w
Ketamine hits endocannabinoid system (in mice)"Here we discovered that ketamine significantly remodels the endocannabinoid-related lipidome and activates 2-arachidonoylglycerol (2-AG)"https://t.co/QKsgKy7TtH
"These data suggest that ketamine, in the presence of a nociceptive stimulus, induces a selective release of AEA levels and subsequent CB1 cannabinoid activation at the peripheral level."https://t.co/eK42qq1qQOI just guessed, lol.
"PCOS are also much more likely to report symptoms of anxiety and depression and those symptoms are more likely to be severe. Research conducted in 2016 has also shown that PCOS could indeed be linked to eating disorders. "https://t.co/mQTHxfVrzghttps://t.co/gj7eSPwvX1
related?"In this pilot study, a [low-carbohydrate, ketogenic diet]led to significant improvement in weight, percent free testosterone, LH/FSH ratio, and fasting insulin in women with obesity and PCOS over a 24 week period."https://t.co/ApXec0UgJMhttps://t.co/PDrAFMfDcE
Better questions lead to better answers.https://t.co/BcKGxhMuv0
if humans can hibernate, and a subset of humans have a predisposition for it, and it's driven by gut microbes, diet fluxuations, and immune system adaptations...What would it look like in a hypernormalized industrial society driven by forces discussed in the Hygiene hypothesis?
"While scientists still struggle with figuring out which mechanisms underlie the keto diet’s therapeutic benefits, the gut microbiota, epigenetic changes and metabolic reprogramming appear to be involved in the response to diet." https://t.co/SJBgJa6Aq3https://t.co/hAb3GBAdpr
That poor non-verbal kid in Bradford during second grade. He was pissing himself. Was Autistic?"The most important contribution of this study to the literature is that impaired bladder dynamics was determined to be a medical complication of [anorexia]."https://t.co/j2YxEtkO9r
The pee spasms have gone away.https://t.co/Mp4JwgV41Y
"Why do cold temperatures make me pee"Translates in my head to "why does activating TRPM8 lead to urinary smooth muscle tissue to trigger?"https://t.co/8wlNpGvsE7
I wonder if guinea pigs pee everywhere like rats & squirrels.https://t.co/LdUVO3DRLI
I stopped feeling really really cold.https://t.co/kE2FiIttAN
I've occasionally had acid reflux symptoms in the past, but it never bothered me. Only once during a 3 day fast was it really painful.Last night it got in my nose and throat. It was excruciating. Burning real bad followed by intense mucus production.https://t.co/xosrfO8pj5
"We're not saying that altering gut bacteria will be the magic bullet for people with anorexia nervosa, [...] But the gut microbiota is clearly important for a variety of health and brain-related issues in humans." https://t.co/vQhsFVxk09
"The study concludes that anorexia nervosa may need to be thought of as a hybrid 'metabo-psychiatric disorder' and that it will be important to consider both metabolic and psychological risks factors when exploring new avenues for treating" https://t.co/Wg4ohzae7z
"The decrease of butyrate-producing species and the increase of mucine-degrading species may represent hallmarks of the gut microbiota alterations in [Anorexia Nervosa], and therefore potentially interesting therapeutic targets."https://t.co/zIFO4YclOm
Tired: "The extent to which AN and obesity can also be considered to be “microbiome bookends” requires further investigation."https://t.co/Ucn8NvCoG9
Wired: human hibernation gone astray?https://t.co/xJh7pffhjH
"hypothesis offers suggestions for employing heart rate variability as an early diagnostic [...] the ketogenic diet for refeeding patients, attending to omega 3:6 ratio of polyunsaturated fatty acids (PUFAs) in the refeeding diet; and exploring [PEA]" https://t.co/tE7IBp8OuZ
"tools to manage AD are mostly focusing on improve cognition and preserve brain functions, leaving out the problem of gut dysmotility [...] management of bowel dysfunctions associated with AD represents a significant medical need." https://t.co/VEc7mN6uxHhttps://t.co/UZEopdX0mX
@MMMalign "Since PEA enhances mood and can readily cross the blood-brain barrier (Irsfeld et al., 2013), our findings imply that inter-individual variability in microbial production of PEA could potentially explain the variable efficacy of MAOIs on depression."https://t.co/pSENZuJVib
PEA = Palmitoylethanolamide."a normalization of excitatory cholinergic and tachykininergic colonic contractions in SAMP8 mice, [...] experimental demonstration that such pharmacological intervention is able to improve the bowel motor dysfunctions associated with AD."
"Our study reveals that loss of acetylcholine leads to a dopamine imbalance in striatal compartments, thereby promoting habits and vulnerability to maladaptive eating in mice."https://t.co/SfLgqt8WzB
Choline you say? Kinda Sus.https://t.co/DRGv8y8hTl
Dysfunctional Gut? Dysfunctional Choline metabolism?TMAO?Heart Problems?"The role of trimethylamine-N-Oxide in the development of Alzheimer's disease"https://t.co/fZxfK4s4NG
Does this pattern in TMAO and choline levels reflect underlying gut population metabolism pathway shifts driven by inflammatory factors and metabolic+immune driven shits in function? (An = anorexia nervosa, AN-REC = recovered, HC = healthy controls)https://t.co/uC78SBaEJu https://t.co/84alh42rPY
What happens if you fix the choline+tmao flow in the gut. Does this improve autism too?"We conclude that choline and betaine intake is inadequate in a significant subgroup of children with ASDs and is reflected in lower plasma levels." https://t.co/FoK2LX7BVy
"The findings suggest that PEA may augment therapeutic effects of risperidone on autism-related irritability and hyperactivity. Future studies are warranted to investigate whether PEA can serve as a stand-alone treatment for autism." https://t.co/qSGx6CKTiZ
Why would production of an endogenous endocannabinoid help populations of people with known issues in their gut? "mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort"https://t.co/ExKupXwNaThttps://t.co/w8YPeo818N
I've been exploring this space for literally years. Here's a tweet where I lay out the connection with autism to @canna_brain and given PEA helps Anorexia nervosa AND Alzheimer's via gut pathways... maybe I'm onto something? https://t.co/2VTYkErZBy
I just wanna feel better.https://t.co/tPqa9ImyLI
Can I fix my Anhedonia & Avoilition by learning about gender bending cane toads and their lack of drive to fuck snakes? Is my theory an alternate explanation on how fringe 'Wilson's Temperature Syndrome' is a result of microbiome's impact on metabolism/hormones by way of TSH?
My mom has an anorexia nervosa diagnosis.I sometimes can't stop eating. Sometimes I don't eat for days on end. It was weird to me.I make jokes about chipmunks having an oral fixation because I think our psychological models of eating disorders are wrong. https://t.co/smwysu13A5
An eating disorder that mimics hibernation-esque fasting in mammals, in a condition linked to metabolism associated genes, and possibly tied to immune factors that regulate gut motility?Nah, must be refrigerator mothers.https://t.co/8ayHu3djD2
Ignoring everybody's theories because they are wrong, and then doing my own thing.https://t.co/DCYNBPmyit
I wrote a sub-thread talking about the role of PEA in anorexia back in 2021.https://t.co/QV3roGcHrJ
Do you think PEA is involved in dynorphin/cytokine signaling and plausibly associated with Alice-In-Wonderland Syndrome? https://t.co/MdE3Lm8pTH
@nosilverv I traced my weird eating behavior to a form of body dysmorphia. Seems to be a sort of alice-in-wonderland style illusion tied to why I can't seem to draw limb for shortening. My brain can't understand it, so I always see body shape wrong.heh.https://t.co/zvq7gkBfFS
"PEA-pre-treated animals showed diminished levels of pro-inflammatory cytokines and chemokines in spleen 24 h after infection, as well as reduced serum concentrations of arachidonic acid and of one of its metabolites, 20-hydroxyeicosatetraenoic acid." https://t.co/MxarFmmQrt
Spleen, and bone problems? In my metabolic response to low food intake (mimicking mammalian torpor), in my meta-model of human hibernation syndrome? https://t.co/RPCSOIVueU https://t.co/bxZwSWHGUm
More likely than you'd think.https://t.co/DCpqlrMu1x
@QunolOfficial No, but my model of human hibernation made predictions that adolescence would have poor bone development. Ended up being found on fossil records of early humans. It turns out this is a process driven by kidneys & vitamin D. Related:https://t.co/wTxpnMIWEGhttps://t.co/6znEkhM9QX
Eggs.I need to eat eggs? https://t.co/k9Pb4rqTQX
"However, it is less known that 6 clinical trials in a total of nearly 4000 people were performed and published last century, specifically studying PEA as a therapy for influenza and the common cold." [2013]https://t.co/aSwcwItYoNWat.
"During a study that was conducted in 1950, some researchers found that patients, in that case less privileged children, which were subjected to a diet rich of dry chicken and egg yolk did not contract rheumatic fever." [2019]https://t.co/twrmz1OcVgWat.
Why would a chemical that reduces inflammation somehow drive a change in AIWS?https://t.co/1jdAxtNCcB
Why would an aspect of our opioid system respond to cytokines?https://t.co/0K0VwlVpT7
There's something complex going on w/ how my body responds to stress and CO2 that is triggering dynorphin, but happens during sleep apnea, and would be mimicked by immune activation/cytokine's action on dynorphin receptors.https://t.co/rRsAVsvu2yhttps://t.co/7VL9gDYd5j
Sonic and Gaston are now in my extended universe.Do you think Gaston would eat 4 dozen echidna eggs, had he lived in Australia?https://t.co/z2ZuwN5KCb
Gonna call my mixed drink "Astronaut PEA".Then see if my girlfriend wants to drink my PEA drink.https://t.co/fejURYFemu https://t.co/R6MKfnot7C
@darwin_muse @Evolving_Moloch I'm expecting them to happen beacause of the interest in bear microbiomes and it's impact on their saturated fats and heart health + lack of bone loss during hibernation. This all has major impacts for space travel and is why scientists are researching astronaught pee.
Nope, different chemical. Palmitoylenthanolamide. Its a form of Palmitic acid and somehow related to the endocannabinoid system.https://t.co/HzpVdbThFK
I have a hunch Palmitoylenthanolamide is a bacterial metabolite related to the other SCFAs, thus acting similarly to butyrate and propionate etc. https://t.co/m73VLErbuu
"These bacteria produce carbon dioxide and a number of compounds that account for the unique odour: pungent (propionic acid), rotten-egg (hydrogen sulfide), rancid-butter (butyric acid), and vinegary (acetic acid)"https://t.co/kdvacJllKUSounds Delicioushttps://t.co/VGq4IiWZjH
When I was a lad, I ate 3 dozen eggs, and it helped make me poops not be so large. 🎶https://t.co/ygs5kFV8eZ
Healing the gut, so your body stops starving itself due to impaired gut barrier function.https://t.co/jhKtpCehX3
"Intestinal barrier integrity in anorexia nervosa (a pilot study)" [JAN 2022]https://t.co/oeyh3Ur4v1Whelp. ¯\_(ツ)_/¯
Walking around with a giant cluestick.*Bonk*Go Horny Jail. Do not pass go. Do not Collect $200 worth of eggs.https://t.co/ahaHPcSNfi
*BONK*https://t.co/E9hyeyQeVW
@AlpacaAurelius Libido also correlates with seasonal shifts in gut bacteria as far as I can tell. It may be evolutionarily adaptive in colder regions. Amazing how many native American Tribes / Viking clans named months after rabbit mating seasons.https://t.co/2dcP3DqMzA
"PEA was first identified almost five decades ago in lipid extracts of various natural products, and its anti-inflammatory and antinociceptive effects were established later." https://t.co/M4wWulxahW
I wonder if you can make PEA from pea.https://t.co/GCL0tHCSXO
My mind palace right now. Thinking about Rhett & Link taste testing Astronaught Peaness yogurt. https://t.co/YdqktwFpqh
> The anti-inflammatory effects of PEA were first identified by modulation of mast cell activation and degranulation.https://t.co/VvKLC8ZbRoMast cells! https://t.co/n3hYTGUUbF
"Palmitoylethanolamide Protects Against the Amyloid-β25-35-Induced Learning and Memory Impairment in Mice, an Experimental Model of Alzheimer Disease"https://t.co/BTaLFjfTGrWat. https://t.co/UBa60rOnRI
If it impacts Alzheimer's Disease, do you think it would work on another Neurodegenerative disorder associated with inflammation?https://t.co/txXMAygFeq
I woke up dreaming about how I need to cook eggs for my GF so she can have more PEAness in her life.https://t.co/I1viHQEANM
Neurosis driven by diet.https://t.co/nI9PSVmWuj
"This is a really fascinating finding because it suggests that the effects of ketogenic diets on the microbiome are not just about the diet itself, but how the diet alters the body’s metabolism, which then has downstream effects on the microbiome" https://t.co/YvQNaSwDgK
Looks like I need to pay more attention to the exogenous ketone bodies. Perhaps not having an impacts for me was because I was missing the gut bacteria that are upregulated? Looks like I may have been wrong here: https://t.co/JsCNUWCj99
That gut bacteria shift effect happening rapidly may also explain why I would have such a drastic change upon fasting. https://t.co/Z3leKUS56z
After all that wine I went on a 3 day fast.Holy shit, true ketosis state is a night and day difference for my brain fog issues. I feel awake in the morning + haven't had a sensory processing trouble since Sunday.I wrote a diary on the fast on mastodon: https://t.co/9bcHvAafos
"Here, we present an overview of the potential mechanisms of interaction between the gut microbiome, the host and particularly the brain in [Anorexia nervosa] and summarize the initial findings of microbiome research on [Anorexia nervosa]."https://t.co/oNn1X5KN23
"Experiments to test whether changing gut microbes in humans could affect the brain are only just beginning." [2013]https://t.co/eb2Jw9BJbu
If binging and purging make you feel better, please consider eating fermented foods shown to impact anorexia."Possible use of fermented foods in rehabilitation of anorexia nervosa: the gut microbiota as a modulator"https://t.co/WHx6M7Ebwmhttps://t.co/hj5Em7dTBA
If you're struggling with bile acid problems that could be fixed by a keto diet, I'd recommend trying small amounts of garlic to boost metabolism. It might also help promote lead chelation and improve mood. https://t.co/SL0EsUE2HT
Rapid weight loss observed in rats can cause excessive lead and iron due to it not being removed at the same time. This increasing concentration means chelating both while losing weight may be quite important to avoid poor outcomes. https://t.co/7U3BGMHgT5 https://t.co/CrxOlDuA4L
"Finally, GF mice transplanted with AN stools on an energy-restricted diet initially lose more weight and have slower weight gain over time compared with mice transplanted with stools from healthy individuals." [2023]https://t.co/a8t4GvQ6vcCalled it.https://t.co/fuMndXl1je https://t.co/wT4WUzQsCG
You can reframe serotonin as a signaling molecule that gut bacteria produce to tell the body there are fats available to digest. In the case of AN, this molecule is a lie. Other mammalian hibernation microbes needed to convert fat to muscle are missing. https://t.co/3cRrvYNMPi
Getting the Short Chain Fatty Acids back in the system by restoring bile health & gut bacteria, and eating fatty foods ends up making the serotonin molecule no longer a lie. Re-framing this as a failed hibernation syndrome makes it make more sense. https://t.co/gPSF9WV7B1
Fundamentally serotonin is a 'stress' molecule the bacteria put out to defend themselves against fungus. So if you play around with starving to lose weight, suddenly you may trigger a cascade of microbial changes that shift you into a different metabolic state.
We collectively did not pick up on this in the west because of inertia around dietary norms from the turn of the century. https://t.co/JTkcGI0BpB
@mike_lustgarten @Mangan150 We don't see this in humans because we study westerners missing these microbes. most of our modern dietary research norms are informed from stuff stemming from an era rife with pellegra, chronic cocain use, and antibiotics.Missing entire possibilities of microbe/gut interplay.
Remember, I am insane.https://t.co/ojpGpFlg6z
All the best people are.https://t.co/SBVl7HkQM3
@naval @bulletproofexec >"Complete and sustained remission of chronic anorexia nervosa is quite rare, and the novel use of a ketogenic diet and IV ketamine treatment in this potentially lethal condition suggests avenues for further research, and hope"Hibernation model get.https://t.co/k4z1MMCZz1
Sure do wonder what could be going on here.https://t.co/sSavZdC89n
Its the same thing every time.https://t.co/pZUJAURbff
@jack_schroder_ @Vera8568 @AlexTheChemist Serotonin is also hitting the vagus nerve and activating the blood brain barrier to let the brain take in serotonin precursors. This mechanism is understudied, and there may be more going on with how the gut regulates BBB.