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Fight feline depression by giving your cat a ball of twine on a rotating stick with some pretty cutouts.Gonna explore cat depression and FCoV thanks to this #adnoyance https://t.co/EizFbzkt2c https://t.co/lqZ1eTYBs1
Apparently we give fluoxetine to cats? https://t.co/DOvtm0r53pI wonder how we'd measure 'chronic stress' in cats.https://t.co/Ni4nBMs0SZ
Looking at animal models for insight into this:"Our results demonstrate a critical role for IL6ST and NF-kappaB Subunit 1 (NFKB1) in fluoxetine’s ability to act as a potential therapy for hyperinflammatory states such as asthma, sepsis, and COVID-19." https://t.co/K6r3IWx4cJ
One of the early ways we collectively tackled this was existing treatments for FCoV and FIP in cats.E.g. hunches about Mpro inhibitors"that has shown antiviral activity against feline infectious peritonitis (FIP) CoV in experimentally infected cats." https://t.co/YnF0tMagKU
Fluoxetine was one that I thought might increase effectiveness of other SARS-COV-2 targeting drugs.looks like someone actually tried it!https://t.co/NLpmx5fU9o https://t.co/vblrSLJYOh
GS-441524"predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 [...] could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC50 of 0.78 μM."https://t.co/yh9jwNsq5W
There's been some good results around Remdesivir, Some people also figured out ways to avoid problems via combination of monoclonal Ab. https://t.co/PznSPK5Gyz
The space isn't without controversy, however.https://t.co/aLGmoD9gxK
Remdesivir seems to be a common therapeutic treatment for people who need oxygen. Presumably this is for people with breakthrough infections? https://t.co/1rhmCnhiOC
I'm curious about fluoxetine because it may have anti-candida activity, which implies indirect regulation of gut bacteria via mycobiota factors.https://t.co/ss1AZb5ttc
Something that stood out recently with my diabetic type II GF being on mycostatin for thrush, is the rare incidence of rash and allergic response.Reminded me of some of the rare-er side effects of fluoxetine.https://t.co/m7tZTGBGRW
Why would an anti-fungal drug (itraconazole) be a viable treatment for feline coronavirus infection? ¯\_(ツ)_/¯"In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection."https://t.co/2iJs6cyusK
Would be really funny if all the herbal cures touted early on to treat a common cold ended up having anti-fungal properties in ways we don't really understand either.Maybe its impairing a biofilm based interaction?https://t.co/arboFVS87T
How long does a strain last on a surface (or in a sewer) if it is encapsulated in a biofilm?https://t.co/cukmPJXMoG
Oh neat, itraconazole impairs S. aureus associated biofilm. I just guessed."A strong biofilm disaggregation and morphologically different extracellular vesicles (EV) production were observed starting from sublethal [itraconazole] doses." https://t.co/F5kOgggeCn
Ok, so the reversal. If itraconazole impairs biofilm.And we assume that is the same method of action as fluoxetine's impact on fungal/bacterial colonies in gut.So should fluoxetine... https://t.co/y8ZzNFvw7Q
Neat."Fluoxetine and thioridazine inhibit efflux and attenuate crystalline biofilm formation by Proteus mirabilis" [2017]https://t.co/bc1J6eVfDT
cool."Furthermore, in the biofilms, microparticles showed statically significant improvement for all concentrations used. The study revealed that fluoxetine encapsulated in microparticles has the potential to act as an effective antimicrobial agent." https://t.co/3u344he9P3
Wonder if this has been followed up on."Bacteremia with S. aureus is associated with high mortality rates in patients hospitalized with COVID-19. Further investigation is warranted to understand the impact of COVID-19 and secondary S. aureus bacteremia." https://t.co/tGe9Ts5eQk
I wonder if relationship has been followed up on because covid mortality & MRSA ties may be incidentalE.g. Maybe hospitals simply have it more, and the sewer bioflim phenomena could be driven by something else like Candida Auris. https://t.co/zFXC1z9mf5https://t.co/OBflrTRmiI
"bacteria aren’t the only problem: new research suggests that potentially deadly fungal infections are becoming more drug resistant as well. [...] humans are using so many of these antibiotics that they are getting into the environment and affecting it."https://t.co/Dju5IbCLx6
the term "biofilm" is a fairly generic word. So just because one quasi anti-fungal drug seems to have action in this space doesn't mean it has action with them all.https://t.co/3rWjnROWCW
I found a bacteria that eats rocks. Was thinking about what it would take to make them compatible with the human digestion system. As one does. All this really has given me is a better understanding of how to clean my toilet. https://t.co/c7D473RTWh https://t.co/TssNdDE4IK
I meditate about toilets while sitting on the toilet. But also while musing about complex nonlinear interactions of the dynamics of biofilm formation (at the colony level) in response to antibacterials+fungalcides and applications of combination therapy. https://t.co/GHC6CGCRm3
"from 1,000-year-old Anglo-Saxon medical textbook Bald's Leechbook states onion, garlic, wine and cow's bile should be crushed together and left in a bronze vessel for nine days and nights. [...] kills MRSA in the lab faster than the best antibiotic."https://t.co/0w2roKeLnk
At the current time, I don't even give a fuck about cororonavirus TBH. I'm interested in learning about biofilm formation in case the fucking ER gave my GF drugs that drive C. Auris.https://t.co/ZB92mDpgeA
I really really really hope my GF doesn't die because mycostatin doesn't work.https://t.co/8ZzzKDIicj
Ya'll got any of them ancient medical plant derived monoterpene phenols?https://t.co/oV89VuBa8t
I understand these words."This study also showed that carvacrol can inhibit the adherence ability of C. auris. Adhesins or surface glycoproteins are generally responsible for the adherence ability in Candida species" https://t.co/Cif3v55T7J
Hello! @AlexTheChemist, you are into fungus and know a bit about terpenes. per quote tweet: https://t.co/1fPNwhjOIKWhat are some other interesting plant derived terpenes and terpenoids that might aid in selecting for certain states of fungal hyphea?
FYI Caravacrol is a major component of Oil of Oregano."Carvacrol antimicrobial activity is higher than that of other volatile compounds present in essential oils due to the presence of the free hydroxyl group, hydrophobicity, and the phenol moiety."https://t.co/Kgbn2jhEQ1 https://t.co/4VSRN6PDPl
Looks like I'm learning how to extract essential oil in a home kitchen with basic kitchen tools. I already bought some of them based on antifungal efficacy, so its nice to know there is more to it.https://t.co/znA7eoM45V https://t.co/4deSoQEFlN
I wonder what burning catnip smells like.https://t.co/TvTyozRamX
Oh neat, traditional use of catnip for tooth aches may be due to them fighting bacteria and fungus associated with oral infections?This screams antibiofilm to me. https://t.co/pDViiqYsf0
Oooh and Twitter says the last time I was looking at catnip chemistry was thru a lens of anti-fungal. I didn't even know it was used as a tea back then.https://t.co/wVdfCxbHcy
Mad science energy, this.https://t.co/DZE207H8Ia
"The natural antimicrobials isolated from animals and microorganisms have been shown to have good inhibitory effect on a range of pathogens, however the plants remain the most prolific source." https://t.co/8Kwjq8XCiiCombination.https://t.co/PFKqEpqV4u
Can you smell what the rock is cooking? https://t.co/7uBtTzcFmg
Zoa taste of bile. Thank you @TheRock."feeding ChB improved gut immunity, as reflected by increasing the abundance of IL-10 , FXR and mucin2 transcript, while downregulated expression of TLR4 , MyD88 , NF-κBp65 and TNF-α genes in the intestinal mucosa."https://t.co/raRZZbpDPk
Cuz I wanna know what he puts on his food."this review aims to highlight the challenges that need to be addressed so as to determine the true benefits of these foods and the mechanisms of action that underpin their purported efficacy."https://t.co/eGMTjcFsJe
Gonna see if my GF likes the taste of bile.https://t.co/jGyfyIR9Uv
Fun fact, I've never had Covid and my sense of smell is fine AFAICT. Dog shit does smell like fruity rancid wet hay and eggs.What you're smelling is a *lack of* skatol & indole sensitivity.“Poo now smelled better than coffee.”https://t.co/Y8SCaljfQC https://t.co/lPdAg88jRH
I know this pathway already, but hadn't confirmed up until now that the Phenolic Compounds in bitter plants improve bile function!Apigenin etc. potentially explains why authentic olive oil is what to seek out for helping w/ schiz + cholesterol function. https://t.co/wKbciAs5O1
It's not enough to simply eat omega 3 if you don't also promote digestion of it. Bitter aspects to olive oil being filtered out or substituted with stripped & processed seed oil may be why we see variation in studies? Implies bile function may be key. https://t.co/IRDq8Wbjfn
Apigenin is already on my radar as there have been some successes in neurodegenerative disease.https://t.co/KteOwJIRdS
Lots of other interesting compounds in real olive oil. https://t.co/zXQvxoRvaB
Variation in results of fish oil supplementation and it's impact in schizophrenia may also be due to lipid status? With the condition being a risk factor for diabetes, maybe insulin function would be a way to rule this out.https://t.co/kTveOTOWL1
Looking up that Cynar bitters @no_identd recommended to see what herbs to put in a vodka extraction. It seems that even commercial stuff may be adulterated?https://t.co/t87cegXRv5https://t.co/d10yo4uVtx https://t.co/tgrIWCV6IC
The one thing that is probably missing from @ZOAenergy is a source of vitamin A.https://t.co/37tpnwnGsl
Chakra.https://t.co/04rOI85epM
@Grimhood It's a liver at the core which is why so many people have luck with B vitamin megadoses. Seeing magnesium problems -> liver is responsible for adipose tissue production and hormones related to browning (mitochondria). https://t.co/IoTuGhpGPbChakra model has this implicitly.
Found a study suggesting that rinsing people's mouths out with chlorine dioxide might fight candida infections in people with dentures.https://t.co/GTgyLYUu2iSo since mycostatin didn't work to fight my GF's Candia Infection, it seems I have to Steelman how MMS treats autism?😭
I'm cursed. I hate everything.https://t.co/AyTcrHBcpb
Gonna channel Jack Parsons.https://t.co/SVZ1NnFTRk
@jaredpolowick @CaloriesProper Meanwhile I'm trying to figure out if I can breed fungal strains to help feed Anammox bacteria and use their metabolites to create rocket fuel using chlorine. Expecting a natural form will explain N-nitroso* contamination in pharma supply chains. https://t.co/tbBy9MoQNx
Tired: drinking bleachWired: drinking rocket fuelInspired: you forget to look up the MSDS for chlorine dioxide and die in an explosion like Jack Parsons"Delayed explosions such as these are due to the buildup of an intermediate" https://t.co/5dIRvi5Fkkhttps://t.co/UBhAZUlRy5
"The olive oil-based formulation of 4′-DHA-apigenin demonstrated an increase in apigenin bioavailability of 262 %. This study may offer a new therapeutic strategy tailored to improve the treatment of CVDs." [MAR 02 2023]https://t.co/HV9Edq3pxBhttps://t.co/FPP1cg9M5i
I know this pathway already, but hadn't confirmed up until now that the Phenolic Compounds in bitter plants improve bile function!Apigenin etc. potentially explains why authentic olive oil is what to seek out for helping w/ schiz + cholesterol function. https://t.co/wKbciAs5O1