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muh autism."Now we are showing that the same IL-17a in mothers, through changes in the microbiome community, produces co-morbid symptoms such as a primed immune system." [in mice]https://t.co/W6ogFXzjjydog butt theory of autism strikes again. https://t.co/OkhtiYD0Br
Oh look a study published a month ago says they don't have causative theory for it.I came to this conclusion via a causative theory.How do I publish?"Social impairments in autism spectrum disorder are related to maternal immune history profile."https://t.co/CfDkUfWwEE https://t.co/5aWHpcO8da
Why does old semen cause autism?https://t.co/BMtbM1pVxy
CRUSTY SEMEN"Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathway"https://t.co/LezbVPlDMW*farts*https://t.co/MaIHHgB80o
Talking about crusty semen with @nsreed while recording content for podcast. Discovered that old crusty semen (ala advanced paternal age) does infact impact sonic hedgehog signaling pathways "previously implicated in the aetiology of autism".https://t.co/IqtVGLcKED
PCOS as risk factor?PCOS has lots of funny ties better IL-17 and things associated with autism.https://t.co/IWjpadCOyp
"Women with polycystic ovary syndrome more likely to have a child with autism"https://t.co/qQdiln1tUg"it is inevitable that this environment may induce changes in the fetus during pregnancy, leading to an intergenerational risk from maternal PCOS."https://t.co/Dnp7M86wNi 🤷
"The abnormal level of HSP70 is correlated with Treg/Th17 imbalance and corresponding cytokines, which indicates that HSP70 may play an important role in PCOS immunologic pathogenesis."https://t.co/AvSd3ZBmZ9https://t.co/nR6MnTsK8b
Fox goes yip."Furthermore, we now appreciate the importance of Th17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease."https://t.co/ZZMNCl1KJ7https://t.co/uuzbLhsRmt https://t.co/uFg4FvlWeK
Nothing to see here.https://t.co/jithDVdF9j
"By targeting IL-17, which operates ‘upstream’ of both IL-1 and IL-6 and results in a reduction of neutrophil recruitment, several factors known to play major roles in ARDS would be inhibited. Therefore, IL-17 presents itself as a plausible target."https://t.co/xtD5gpfAP5
"The potential pathogenic role of IL-17/Th17 cells in both type 1 and type 2 diabetes mellitus"https://t.co/HyrCpyh4q3"Could IL-17A Be a Novel Therapeutic Target in Diabetic Nephropathy?"https://t.co/zziQuDgMUuhttps://t.co/8IEg1O29ZZ
"Interleukin 17A promotes diabetic kidney injury"https://t.co/AdVIOyJEBchttps://t.co/VjZm4Gd21J
@Cererean @The_Lagrangian Lately I've been looking at weird ties between autism and kidney function that might coincide with Vitamin D and odd hormone levels and also makes ties with schizophrenia and diabetes. Looking at as immune system regulator helps it fall into palace better.https://t.co/JY968g1c07
"Cross-talks between the kidneys and the central nervous system in multiple sclerosis"https://t.co/hvSdMjVC68https://t.co/G6QdZnvF6D
"many neurodegenerative diseases thus far identified have diverse characteristics and etiologies, many contributing factors are likely shared in common, which offers the possibility of identifying novel targets for intervention."https://t.co/HkdeB21gDehttps://t.co/baq6qWzbtP
Two groups of people with higher rates of problems associated with heart complications from Covid...Autism and Alzheimer's.The question is, how much of this is from living situation (group home), and how much is biological underpinning? https://t.co/lAJqBNMrRf
Did you know that Mast cell activation is associated with IL-17? It correlates with all sorts of fun things.https://t.co/tCR6dWRo0Uhttps://t.co/yTBGTb0lMe
IL-17 is kinda weird.https://t.co/pYjUxKp2Ml
My gut hurts sometimes.https://t.co/mD1GMyQOjG
IL-17 thohttps://t.co/0ZfXpIl5eHhttps://t.co/XXMWSwZWLHhttps://t.co/gvkz0JRshNhttps://t.co/2Eif6ogxTWAutism, caused by immune system dysfunction assoc w/ schizophrenia and multiple sclerosis ala whitematter degradation? Muh Corpus callosum hates me.https://t.co/ceOZkSIdCL
All the time really.https://t.co/mxhh0uTHej
Really wish there was some kind of explanation for it."Role of the IL23/IL17 Pathway in Crohn’s Disease"https://t.co/qEdg8lbroqhttps://t.co/soLKlQl8xk
@pmarca @sbaroncohen I have PCOS genes and estrogen resistance genes. And so while I present and was assigned male at birth, I have immune disorders that seem to show up in females in 5:1 ratios.It is said women get IBS more than men, but we ignore autism's GI issue rates.https://t.co/YaaBF9GNIR
"a number of cytokines implicated in other disorders, such as depression and obesity, are yet to be measured in [Anorexia Nervosa]. One example is IL-17"https://t.co/m2Pj8ywdEO¯\_(ツ)_/¯https://t.co/AcsoUzw4dF
Mice poop, lol."IL-17 controls central nervous system autoimmunity through the intestinal microbiome"https://t.co/a1U38WjUwyhttps://t.co/WWpvnKsZak
"Induction of TH17 cells depends on gut microbiota; however, the effect of salt on the gut microbiome is unknown. Here we show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacillus murinus." [2017]https://t.co/onJzGoJvJq
Rubbing salt in the wound to fight biofilm formation.By promoting commensal bacteria that produce acetic acid.https://t.co/QlUFB3geIvhttps://t.co/AMGqVoXSLw
I think it is interesting how many of our commensal gut bacteria are salt-loving varieties. Lots of fermented meats are made via a salt rub. Kimchi/Sauerkraut is made by putting salt on veggies and letting oxalate eating bacteria take over. Etc. Etc.https://t.co/9hrRlKjhbW
Salt Lick."The Gut Microbiota and Associated Metabolites Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders"https://t.co/Bvyr0dW0VIhttps://t.co/jD49HNP0Lz
Why would I call my collection of papers about sleep "Sleep, let me lick you?"https://t.co/qP6YKYjQ0X
"Autism may disrupt the body’s circadian clock"https://t.co/ybmniWZKjlyes. yes it does.https://t.co/yQQh8njBqv
@yuukoposter @leaacta It's fun to explore modern research on gut bacteria's influence on circadian rhythms. On a population of people who have chronic GI issues and weird sensory processing, I'd be surprised if this effect wasn't dominate influence on sleep cycle timing. https://t.co/wnXh8rjOCv
Waiting for those papers to drop.... Like this preprint exploring the polyamine pathways that impact epigenetic expression of TH-17 related genes that promote cytokines over Foxp3https://t.co/7FhSBr2UOvFor reasons.https://t.co/6x6GkPJJW2
And here they are. IL-17 and IL-22 impacted in a mouse model of mycobiome + gut.https://t.co/nN80o1q77N
"the spatial organization of the gut mycobiota is associated with host-protective immunity and epithelial barrier function and might be a driver of the neuroimmune modulation [...] through complementary Type 17 immune mechanisms."https://t.co/NtzFow6cdshttps://t.co/gZ3Wrskqwm https://t.co/spmDpfNzmR
"Interleukin-22 Influences the Th1/Th17 Axis""Interestingly, the IL-22 system has also been linked to a range of T cell driven inflammatory diseases such as rheumatoid arthritis (RA), graft versus host disease (GvHD), and multiple sclerosis (MS)"https://t.co/gAfUSQRJWq
"Serum IL-17A levels were raised in the group with autism, and the levels correlated significantly with the severity of autism. This is the first study to measure levels of IL-17A in relation to the severity of autism, to our knowledge." [2012] https://t.co/0ZfXpIl5eH
"[IL-22] is increased in [M.S.] patients and targets astrocytes""141 MS patients and healthy control (HC) subjects, we found that serum levels of IL-22 were significantly higher in relapsing MS patients [...] also remitting and progressive MS patients."https://t.co/2SjFT6h7Ia
"RNA sequencing revealed a close association between ASDs and the genes related to glial cell activation and genes belonging to immune and inflammatory categories"https://t.co/LBiMQwsaYY
Astrocytes and Glia impact neuronal development you say?https://t.co/XtgZbxuOjd
Why would TRPV1 activation impact my autism symptoms? We may never know. /shttps://t.co/Nb5Yc9vuAZ
Immune system activation driving brain development weirdness, in my neurodegenerative disorder?It's more likely than you think.https://t.co/DM1WuagAjT
"The authors also defined a module of genes upregulated in ASD that was enriched for astrocytes and activated microglia. [...] Several other studies searching for genetic factors of autism and ASD have also found strong connections to the immune system."https://t.co/SRz5B1KCHt
Fox goes yip."Overall, our data suggest that defined gut commensal bacteria with a propensity to induce TH17 cells may increase the risk of neurodevelopmental disorders" https://t.co/2Be5owvLPIhttps://t.co/ZD8Wx9AxHR