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Time to find specific instructions of the preparation of Aloe in Papyrus Ebers https://t.co/puuj3lCnXq
This suggests the Ancient Egyptians used it as part of some preparations, but the "Plant of Immortality" frame may be a more modern Egyptian interpretation.https://t.co/jvyCTyrneZ
What I want to know is what causes it to heal burns / reduce pain faster? It might help w/ Crohn's."The mechanisms that may underlie its action include: anti-inflammation, antimicrobials, wound healing promotion, and biological/immunological modulation."https://t.co/4Q6tTKIEEp
Cool, another ~$170+ book that I'll never be able to afford."Evidence-based validation of herbal medicine"https://t.co/iSrv0tlDunMentions Aloe a lot.https://t.co/Ncmh0huQmC https://t.co/BpiMrpU1NE
Rhein?"isolated from several traditional Chinese medicines, including [Chinese rhubarb. Aloe, Senna, Chinese climbing knotweed ... has] anti-inflammatory, antitumor, antioxidant, antifibrosis, hepatoprotective, and nephroprotective activities."https://t.co/VOrhyCBsrz
Looks like Rhein may be acting on wound healing pathways as part of a medicinal "burn ointment".Rheum palmatum L. is Chinese Rhubarb.'Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway'https://t.co/WDyQe32n6V https://t.co/CWfguyKsYp
Looks like Rhein acting as a plant based selective inhibitor of amoeba?'Anti-amebic effects of Chinese rhubarb (Rheum palmatum) leaves' extract, the anthraquinone rhein and related compounds'https://t.co/PeeEjAcIsh https://t.co/WAgtkbQJAw
Huh."Amoeba have been found to harvest and grow the bacteria implicated in plague. Amoebae can likewise play host to microscopic organisms that are pathogenic to people and help in spreading such microbes."https://t.co/9MK6VGwBfR
"enhance plant defenses by using different molecular targets of specific enemies through a variety of mechanisms of action. Emodin illustrates the wide and often overlooked potential for chemical multifunctionality in plant secondary metabolites."https://t.co/nA42VrLZP8
Good observation."curious whether the aloe referenced by the Egyptians is truly Aloe vera, or if it could possibly be aloeswood/agarwood."https://t.co/HwGXh0Dnlr
Ah, so I'd have to select for species that don't have lots of Aloin, or avoid eating/extracting it from the rind.https://t.co/GzdRajargIBet that does weird things to gut bacteria.https://t.co/gE2YaJIqpR
Looks like some formulations filter Aloin out with charcoal. Makes me wonder of effective ways to test for it.https://t.co/BumkWHJ1Ya
Seem to confirm Emodin is important bit."The present study confirmed that increased wound healing occurs following treatment with aloe emodin,, compared with resveratrol, providing support for the use of Aloe vera plants to improve burn wound healing."https://t.co/GanFwfS77f
Combined with Rhein, it sounds like that might help with motility."improve motor function and colonic electromyography of constipation mice, and reduce expression of AQP3 in the colonic mucosa, thereby relieving the symptoms of constipation effectively."https://t.co/uPdO54Hu8v
Scare peice:"However, as mentioned earlier, aloe can slow down the formation of these blood clots. It does this by decreasing synthesis of prostaglandin, a hormone-like compound, which stops platelets from doing their thing." https://t.co/uOHbiotTi3 https://t.co/3m7q99et8Z
TL;DR: herbal remedies that impact blood clotting shouldn't be taken before surgery. Doctors don't check for this and patients don't realize it's a medicine.Which caused a poor old lady (taking some due to a clinical trial) to bleed a lot.https://t.co/GdjrGkaCRs https://t.co/tOLfviwwHu
Please respect herbal remedies that impact blood like you'd respect a doctor's prescription that impact blood.https://t.co/wKLIW6iSCp https://t.co/UNVPazVZSA
Digoxin is also an interacting med. That is also used to treat heart failure issues. https://t.co/YxgbsSPuteInterestingly, most of the side effects are tied to diarrhea.
"[IBD] reduce the absorption of sodium, chloride and calcium, while they increase potassium secretion. In addition, mild to severe metabolic alkalosis may occur [...] depending on the severity of the disease and the part of the gastrointestinal tract"https://t.co/Ly1ly2uJXR
Oh god. "There are not many studies concerning the prevalence of heart failure among the IBD patients. However, a recent population-based cohort study showed a twofold higher risk of heart failure in IBD patients"https://t.co/Ckkx7pEymi
I wonder how many heart failure patients are taking digoxin and have IBD, and are accidentally causing digoxin toxicity due to variability of potassium due to intermittent symptoms. https://t.co/iEm0akB3ak
Nice."Low aloin concentrations showed minor perturbations to intestinal bacteria, whereas high concentration increased Lactobacillus sp. counts. Aloin also decreased butyrate-production in fecal microbiota in a dose-dependent manner after 24 h exposure."https://t.co/ivhxZ7jpxP
Looks like Rhein is also doing very similar stuff as Aloin."We concluded that, in addition to prostaglandins, diarrhoea induced by rhein anthrone must also involve the calcium channel"https://t.co/XoRHnC8DmmSo hypothetically have similar side effects?https://t.co/X1trxLiHrf
Some interesting stuff this idea drudges up tho."Taken together, our results indicate that modulation of the gut microbiota may play an essential role in the antidiabetic effects of rhein."https://t.co/SyuytShtR0
Purines! this is 🔥"We showed that rhein could modulate gut microbiota, which indirectly changed purine metabolism in the intestine and subsequently alleviated colitis. "https://t.co/1ArYiEpNCmWas Goop was right about celery for diabetes?https://t.co/EhPrOqvToM
"The extracts of Aloe vera collected from colder climatic regions showed good antiplasmodial activity and also showed the presence of higher amount of aloin and aloe-emodin in comparison to collected from warmer climatic sites."https://t.co/I3nZS6t4L0
Senna seems to fight H pylori! Really impressive.https://t.co/UPJCHIjYzB