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Neat, all of these also seem to coincide w/ gut bacteria. What if its not the sleep, but the impacts of gut bacteria we're seeing?Lots of fun studies suggest insomina may be due to gut bacteria. I with some antibiotics even having it as a side effect https://t.co/a0NtLg0lzh https://t.co/Dzw93r5o1m
The FDA even put out a warning on that particular class of antibiotics.https://t.co/649y3Zgd2VImagine thinking that being suicidal is because you're not getting enough sleep, and ignoring the impact of antibiotics.
> Some fluoroquinolones can intensify the effects of caffeine (a stimulant found in coffee, tea and cola), which can make you feel irritable, restless and cause problems falling asleep (insomnia).https://t.co/rJcTtd1gihNah, you just need a good nights rest brah. /s
"Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice" [NOV 2020]https://t.co/mSei50gHrC
"Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms"https://t.co/3RNqmoV0HwHuh.
Boy, I sure do hope there aren't a lot of really important bacteria that help regulate oxidative stress in the gut using chemicals like melatonin.https://t.co/SqcGSkf1fL
Wait, you mean melatonin seems to help protect the gut from oxidative stress, and is on a pathway tied to sleep function in animal models?https://t.co/XIWQNxiWk8
Oh boy. Oxidative stress is one of the ways many antibiotics seem to function?"These findings underscore the complex nature of antibiotic action and suggest practical approaches to enhancing our current antibiotic arsenal."https://t.co/BeklOVKHH4
And we already have studies that tie these spaces together in human sleep function?https://t.co/5momNSIe6b
And oxidative stress might be one of the things that seem to drive health issues from sleep loss?https://t.co/XoZN4XayVz
Sure wish there was some explanation for all the sleep issues and weird GI problems that show up in Alzheimer's.https://t.co/xZxwpDSFuN
Don't mind me. I'm jus trying to figure out my family's chronic and persistent non-24-hour sleep wake disorder.https://t.co/zAfjLjkQFO
It's so fascinating how many bile acids are transformed via gut bacteria into antioxidants. https://t.co/wNmIRXcKv1
I wonder if liver problems show up in Alzheimer's...https://t.co/GmBqCINdtV
Maybe glutathione might help?https://t.co/xKTzINl164
We should test this maybe? like in rabbits? maybe in 1998.https://t.co/Vde2hAXyoJ
You'd expect something interesting here if gut bacteria impact sleep.Like maybe they'd modulate antioxidants like glutathione... kinda like this 2015 study.https://t.co/FpT0ekNcVS
Maybe there's some kind of diet that impacts bile acid production and helps to boost gut bacteria, while also reducing oxidative stress? You'd expect it to help my sleep disorder.Oh wait, it did.https://t.co/qGRRdUo7vL
Wait, and there's even a key peptide that operates on gut inflammation that seems to enhance sleep, and it's made by gut bacteria? And it also helped me sleep?https://t.co/eE6kGu4tM2
Maybe this bacterially produced fermentation byproduct also does something neat to oxidative stress.Oh, it does? huh. Imagine that.https://t.co/sUbCoQpCZo
You'd think that if your bile was impaired you'd have these weird sleep disturbances.https://t.co/EtkpPwl7qU
Maybe there is some kind of fix for liver problems being experimented in this space https://t.co/EgkIvgYo2i
Could there be some underlying factor that ties all these together? https://t.co/dWbMXu2KCi
Lol get wrecked.https://t.co/sLN1z0EjPG
Everytime I read anything in sleep science I just got apeshit. https://t.co/7H5w3nDcSO
If you pay really close attention to this, you'll see why I think I might be able to go without sleep."Moreover, reducing oxidative stress in the neurons of wild-type flies by overexpression of antioxidant genes reduces the amount of sleep."https://t.co/FYdcM40ujH
Sonic says oxidative stress causes neurodegeneration.https://t.co/BnJE5Vst2i
"Our findings demonstrate that activation of [Sonic Hedgehog] signaling protects cortical neurons against oxidative stress and suggest a potential role of [Sonic Hedgehog] for the clinic treatments of brain ischemia and neurodegenerative disorders."https://t.co/UQEzjs0TXR
"Our study revealed the causal effect of gut microbiota on sleep and identified causal risk and protective taxa for chronotype, sleep duration, snoring and insomnia" [2023]https://t.co/H3iebBiGqI
Since bluesky is now publicly viewable, check out my thread on the links between gut health and sleep, and how oxidative stress / DNA repair relate.https://t.co/0rCR7Xi8hs
@bradstradamus @spryte106 @fillefoux I'm mostly here because @AlexJournal2019 keeps linking to things on my discord that make me angry haha.I've written more about this dna repair thing on BlueSky. It is also tied into sleep disruption seen in autism/adhd/alzheimers. https://t.co/znnMWBbg3O