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🧵 Thread (11 tweets)

UltimApe@ultimape• about 4 years ago

When a termite colony decides to start eating each other to neutralize an infection... What gets them to stop?Ought to be parallels with T cell related processes that drive autoimmunity, if it's based on an underlying game theoretic risk/reward process. https://t.co/rw1d8319DS

UltimApe@ultimape• almost 7 years ago

@ballofgame In termites, getting sick often means the other termites eat you so their gut bacteria can learn to immunize the rest of the colony and/or destroy the infection.

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7/11/2021

UltimApe@ultimape• about 4 years ago

Replying to @ultimape

Cytokine storms? An ant gyre; but its termites cannibalizing each other until there are none left.

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7/11/2021

UltimApe@ultimape• about 4 years ago

Replying to @ultimape

So what happens if a body is full of white adipose tissue that fuels the continuous action of Killer T cells going amuck, and nothing is there to tell them to calm the fuck down?https://t.co/MgeCHvi0hM

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7/11/2021

UltimApe@ultimape• about 4 years ago

Replying to @ultimape

Boiling ourselves alive.https://t.co/qbb3379zwk

UltimApe@ultimape• about 7 years ago

Why do we fever?https://t.co/8ISGktgHlh

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7/11/2021

UltimApe@ultimape• about 4 years ago

Replying to @ultimape

> 'Look on my works, ye Mighty, and despair!'> Nothing beside remains.https://t.co/11MasdZSXm

UltimApe@ultimape• almost 9 years ago

To stand upon giants is to build upon what came before. As civilization is built upon the backs of landfills of ruins, so too are our genes.

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7/11/2021

UltimApe@ultimape• about 4 years ago

Replying to @ultimape

Fever related viruses => mTORC1 + IL6"To further elucidate the metabolic effects of rapamycin in vivo, we examined its influence on the induction of beige adipocytes and thermogenic gene expression in white adipose tissue (WAT)."https://t.co/9Bpza98i51https://t.co/1YYUe3Ps3t

UltimApe@ultimape• about 4 years ago

"These results place mTOR in a complex immunoregulatory context by controlling innate and adaptive immune responses."https://t.co/5gI5lEgBUshttps://t.co/WT39e0VzSq

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7/11/2021

UltimApe@ultimape• about 4 years ago

Replying to @ultimape

Re:generative.https://t.co/Dmx9vz3Wdj

UltimApe@ultimape• over 5 years ago

Fevers let me sit at the edge of chaos and listen to the streams of thought, plucking delicious fish out and cook them a bit to smell the aroma of an idea.Sometimes the fish is rotten, sometimes it is delectable.https://t.co/QM4cRru0Jh

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7/11/2021

UltimApe@ultimape• about 4 years ago

Replying to @ultimape

"It has been observed that termites are often eaten when “moribund but not yet dead”4, but no study to date has attempted to identify the stage of infection at which the risk of cannibalism first begins to increase."https://t.co/JacjSAiH6bhttps://t.co/yFkfemEkhq

UltimApe@ultimape• almost 5 years ago

study the anthttps://t.co/Bs6rDDLJ2V

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7/11/2021

UltimApe@ultimape• about 4 years ago

Replying to @ultimape

"understanding of ant foraging gained from experiments and models to provide insight into T cell search processes. We find that there are significant parallels between how ants forage for food and how T cells search for pathogens."https://t.co/baIjetSSqGhttps://t.co/dOM74XSmT9

UltimApe@ultimape• almost 6 years ago

Talk to be about ants as a model of human's immune system.https://t.co/aJMIY242oh

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7/11/2021

UltimApe@ultimape• about 4 years ago

Replying to @ultimape

"Researchers have found that when some members of an ant colony are exposed to a pathogen for the first time, all members of that colony—even the ones that were not initially infected—build resistance to the pathogen. How this happens was never clear." https://t.co/q9Kdc6G6qS

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7/11/2021

UltimApe@ultimape• almost 4 years ago

Replying to @ultimape

Learning how the calm the ants in my brain.https://t.co/9oZfpdkeP2

UltimApe@ultimape• almost 4 years ago

I also noted that mTORC1 is a direct player in regulating this space. https://t.co/QeHEtQnZtrI haven't translated this into how this might impact neurons yet, dumping fatty acids in via adrenaline does seem to impact muscle activity quite profoundly.https://t.co/IgWC9HW3gR https://t.co/NkEYKAKFRR

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11/29/2021