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Should I start talking about the market for bull semen?https://t.co/klQOlrk0vB
Or maybe explore intersections between human semen quality, effects of nutrition and stress, and bees?https://t.co/3AKftp96cH
Western decline in semen count and quality is fascinating as it seems to correlate with a number of metabolic diseases and tracks roughly the decline in various nutrients + antibiotic use.https://t.co/2u3DY8w2qg
My suspicion is the decline in IQ that we seem to see correlated with semen quality is actually an artifact of nitrates in meat stemming from Victorian Era. Is perhaps upstream of multifacted microbiome / brain function issues correlated w/ heat disease.https://t.co/IZ7hfwVod2
What's up with the trend of using celery seeds as away to boost semen volume anyway? There's something weird here.https://t.co/uJuNQMziW4
Is this lies? Can we sue?"For Oscar Mayer hot dogs, the packages now list ingredients like celery juice that has been treated with bacterial culture. That turns the naturally occurring nitrates in celery juice into nitrites that serve a similar purpose."https://t.co/Z7eFxrhDzG
I should read mroe about celery. It seems there is a bit of a fad about it stemming from "Goop" and other purveyors of fine snake oil.https://t.co/aeGDlbiory
Without looking closer at the actual studies, there does seem be a trend: that it reduces uric acid? Now they say you can "just drink some water", but does that help if you're diabetic?https://t.co/dfWvbKKevG
IIRC many problems we see in Diabetes is caused by uric acid crystals building up... Flushing it might help. But why is it there to begin with? Maybe celery is acting on gut microbes in similar way as why it makes nitrates for meat preservation? Hmmhttps://t.co/QoZOL5f1oB
"Just drink more water"https://t.co/VhhknykFOV
Whelp.jpg"uric acid may induce adverse effects to sperm function, at least in part, by reducing the activity of vital enzymes [...] further research, mainly clinical, is still required to fully explore the role/effect of uric acid in semen" [July 2018]https://t.co/tXagGzOGvH
This is... fairly easy to test? Just eat more celery for a month and see if your gut microbiome changes? The "time lapse" ubiome ones would be fairly strong evidence. https://t.co/MH18QS9Rqjhttps://t.co/JUymDIwxfK
There's already a ton of blogs talking about links between gout and diabetes ala microbiome. Some science pubs harvested from themhttps://t.co/WUO4gIGLBUhttps://t.co/oLlkWMzo5Hhttps://t.co/H7dh1T7zQv
That last one:"Screening and Characterization of Purine Nucleoside Degrading Lactic Acid Bacteria Isolated from Chinese Sauerkraut and Evaluation of the Serum Uric Acid Lowering Effect in Hyperuricemic Rats"https://t.co/OZMKivD7URhas many citations.https://t.co/meKNuLVLfF
So.. sugar bad?https://t.co/igGGMcwtZmAnd if you remember that recent study tying health and sugar signaling to microbes there may be direct ties to human health. https://t.co/ZFmpwauFxv
Some neat stuff being done with animal models of this. I find the 7-14 day effect time to be suspiciously correlated with my personal model of bacteria growth cycles in the body.https://t.co/00er1tESzS
The questions that tie this all together:1) Do Hyperuricemic Rats have reduced semen quality/volume? 2) Do Hyperuricemic Rats have reduced measure of Intelligence?3) Has anyone been studying this?4) Can it be translated into human models?https://t.co/IsaecX9yAC
I'm... Done looking this up for the time being.I got grossed out at reading about squeezing sperm out of Rat balls.https://t.co/5N8HS0cWhm https://t.co/JNySLnsw0M
I found some neat associations between oxidative stress + uric acid reduction and some studies reviewing "ancient Chinese" / Tibetan herbal medicine that I had previously noted as having diabetes adjacent virility cures. I'll have to branch down that path later.
Given the taboo of talking about this kind of thing even with medical professionals, what would be a sufficient proxy for researching cases of "when I ejaculate it is painful and the semen is yellow/brownish?" to explore uric acid issues? https://t.co/ZC1YzntTC2
So could this effect be due to the immune system changes that happen during puberty as a result of hormones?https://t.co/KH6m8UR0bj
huh, familiar."pituitary gland is involved in the release of growth hormone (GH), prolactin, vasopressin, adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH, luteinizing hormone (LH), and oxytocin."https://t.co/ZrfnDHzGWg
It seems you can pick up on a lot of health signals by voice. A change to a strangely quiet voice can indicate virus infections. An a couple of immune disorders directly impact the vocal cords too.Acromegaly (excessive growth hormone) can cause deep voice too.
Maybe growth hormones are the link to the deep voices in apes? Competing on muscle mass etc, but a side effect of low sperm... Sounds like the kind of shit tradeoff nature often ends up in.https://t.co/SbMoSUnqd5
"Exploring Interactions Between Growth Hormone and the Microbiome": Not yet recruiting. Damn.https://t.co/T8grX7UEEk
(Bellows in triumphant rage)"levels of growth-related hormones were significantly higher in the boys with autism even after the researchers compensated for the fact that higher levels of these hormones would be expected in children with a greater BMI."https://t.co/EEZnnWLJ4u
I'm not even going to bother correlating Growth Hormone and conditions that have higher rates of Gut Dysbiosis. https://t.co/YXodmhZSQphttps://t.co/NWg8Q2U1jR
Whats really funny on a meta-level is the naive reader may be thinking I am researching this because I want to improve my virility.https://t.co/py41B2olp5
Where I actually want to decrease it somewhat. I think part of my metabolic issues associated with autism may stem from T overproduction due to liver issues and possibly associated Growth Hormone weirdness. I was always +90th percentile in height.https://t.co/4qtzbIkiB8
@form_break Every ad you hear on the TV for testosterone enhancement pills will say it makes you gain muscle. No one ever mentions how too much tesosterone messes with immune system leading to stuff like zits, & can actually destabilize insulin regulation due to estrogen balance in liver.
Honestly though at this point I'm just pretending that JBP is my mimetic rival to steal your attention. The excitement of IQ signaling as I one-up his theories helps me learn faster.https://t.co/2dHSgBpttJ
Concept of boringness is interesting.Why do I find so many popular thinkers 'boring'?Ideas that bore me the most: ones I can recreate from scratch.Here, Peterson references Schrodinger's theory of life: https://t.co/tXrn8zuFg7I didn't learn anything.https://t.co/5Ovbc5hz9I
That, and everybody love throwing poop at false prophets.It me:https://t.co/IPVPbddz6f
So yeah... I was actually waiting for that study on NSAIDs and Semen quality to come out. It s another angle that I think western society has been impinging on our gut microbes. See also: https://t.co/OJmTvq6r3xhttps://t.co/djAsjJyZi2
Do we know why "Prenatal use of NSAIDs and aspirin increased the risk of miscarriage. These findings need confirmation in studies designed specifically to examine the apparent association."?https://t.co/XARBGyo2SB
Or the result of a complex system of gut bacteria and homeostatic feedback loops that would average out to be 50%?https://t.co/qhd7n1GSZA https://t.co/Jyy2DNR1zK
That meta review was from 2005.We've started exploring mice models of NSAID use now.https://t.co/8GsxMHjQrL
Which... ties together nicely with another study from roughly the same timeframe.https://t.co/I6QJw5qDRA
Alzheimer's may be a result of a biological function that makes your semen rely on to work well.https://t.co/GYy8oET0xX(study? https://t.co/aSx1wqELvS )
Oh hey, does that tie suspicion of aluminum's impact in fertility with Alzheimer's?https://t.co/UFEfF8lvpmI find it strange how often fertility related metals are implicated in the condition, but its always 'inconclusive'.https://t.co/lxyO6hTVyK https://t.co/O8wp1e3xyP
ZincIn the Guthttps://t.co/cekn0R4sx1In the Headhttps://t.co/RDO9GEpKZXand in the Dickhttps://t.co/b58z0QBX8mlol
Oh what a complex web we weave."In conclusion, we have demonstrated for the first time that a single oral dose of Cu(II) and Zn(II)-bound Indo-like compounds have marked anti-inflammatory effects in an acute model of vascular inflammation in vivo."https://t.co/Rcl3pXaC5W
"Our study shows decreased zinc, copper and ferritin levels with respect to decreased cognitive abilities in children." (and note that they excluded ADHD kids)https://t.co/qqbpGfMmek
There's a subgenre of incomplete models of metal disorders as possible cause of autism (see: mercury/vaccine fears). Dr Bill Wash seems to be at center of it with his theories on metallothioneins. https://t.co/TGoYe8k1SeIts not vaccines but gut microbes? https://t.co/LHMur9KjGg
Insert joke about randomly controlled trials of jumping out of plane without parachutes.https://t.co/REmHtA09Yk
I find it funny that the butter coffee guy talks about techniques to improve your IQ. I wonder if he bothered to measure his semen quality too.What you don't think its possible to raise your IQ? That it's some inherent quality of a person?https://t.co/m0ne1mMxml
@TeubenRoald @MimeticValue I just found out that a large number of Olympic Sprinters use Modafinil - enough that its a sort of conspiracy that many of them "get diagnosed with Narcolepsy". Not sure about that being true, but found many examples of doping scandals. https://t.co/ABOovbo4uh
Could semen be used as a signal of disease and metabolic health, possibly as a proxy for intelligence and performance associated measures?https://t.co/bCfWrhmpqx
Oh and of course that whole "Metabolically Dominant Soldier" thing they're doing is basically what I am researching to fix my self. Did you know the US Patriot act had restrictions on research that could be construed as bio-weapons?https://t.co/Cuxu9Bq0cl https://t.co/lU93LXaM9U
There was a thing they were doing on (unconfirmed?) collecting semen as part of their ADEPT program: https://t.co/0UumxNV0gjBut its hard to tell which place got their funding for this particular aspecthttps://t.co/csliTSq85u
It seems Tufts University managed to find a way to stabilize various organic materials using Silk, and they have the patent. But this doesn't seem to be directly funded by their ADEPT grant. https://t.co/WiEdgiRwHM
I can't find out if anyone actually managed to pull off the mobile 'biospecimen' detection thing. Though I did find out that David Walt from Tufts (scientific founder of illumina) is working at Wyss/Harvard now, used to be chair of Darpa's Advisory council. That's neat.
But... I did find this... "A man's semen count is a marker of his general health, according to the largest study to date evaluating semen quality, reproductive function and metabolic risk in men referred for fertility evaluation."https://t.co/R8WRReMghA https://t.co/VopgSDDw0b
Found A bootleg of the presentation...about half of the cause is 'idiopathic' (another way to say "we don't know").Only 5-10% is known genetic; Klinefelter Syndrome (XXY), & random mutations.Goes on to show its hypogonadism, manifesting in sperm count.https://t.co/SmLYm8GyiM https://t.co/7guZad62m3
An Inherited form of Hypogonadism is common enough that they have a term for when it manifests with anosmia: "Kallmann syndrome". Neat.https://t.co/b4F6nPv3nr
Ah damnit. Another dead end where they haven't even begun the research on this. stuff."Examine the effect of altered gut microbiome and metabolome of the microbiome on hypothalamic neuroendocrine function, i.e. GnRH, TRH and CRH secretion."https://t.co/te709lzAfC
Huh, GnRH agonists are used to treat Hyperandrogenism. This all happens via the hypothalamus.(note: Hyperandrogenism is associated with PCOS + type II diabetes https://t.co/nqRza6K6GA )
I wonder if anyone's investigated sense of smell during pregnancy as an offshoot of hypothalamic transcription changes. Further, does it coincide with insomnia / sleep walking ala changes to melatonin signaling?Melatonin modulates fetus gonad growth.https://t.co/HPdnUa4bUo
I'm just going to leave out all the weird results of bacterial responses to melatonin and share this:https://t.co/6wNw4a0zUM https://t.co/Ty33hRCQDz
My guess? No.Given that we see changes in puberty onset among breastfed/formula girls https://t.co/IiLTsJPiyiand seen in boys + girls in a different study: https://t.co/DGH32C0UiL
Oddly, adding extra melatonin to help children sleep can delay puberty (disturbing: a common remedy parents give to autistic children). This suggests some strange interplay between receptors and normal development of how hormone associated regulatory cycles are set up.
As tangent. Given that chronic fatigue syndrome becomes evident at around the same time as puberty, and the HPA axis plays a role (https://t.co/BsI1KZBBeg), what we are seeing is partially modulated by breast feeding. Of course melatonin plays a role: https://t.co/fiLXBZwg3F
Melatonin is wild!"support the idea of melatonin as an immune buffer, acting as a stimulant under basal or immunosuppressive conditions or as an anti-inflammatory compound in the presence of exacerbated immune responses, such as acute inflammation." https://t.co/ZKBCsT84YS
"Melatonin in seminal plasma is positively correlated with damaged sperm DNA of infertile patients. The mechanism of this phenomenon needs further study."https://t.co/1jvHd1d6Zh
Some other interesting studies on IQ that associate it with maternal microbiome. I can't find it, but I think I associated this with same inflammation associated systems that increase autism risk if your dad's semen is old.https://t.co/mTExHh69QJ
Thinking about IQ as a group level phenomena and not an innate quality leads to looking at epigenetic, transcription oriented, and horizontal transfer patterns among IQ associated phenomena.https://t.co/zdBdoDYSa5
That line of thinking is what gave me a prediction that I had particular genes associated with MS and Crohn's as they are interrelated with testosterone imbalances and cholesterol processing. The melatonin->HPA->gonad hormones thing ties in interestingly. https://t.co/DVdilTt9Ot
@37point78 Been focusing on skin, tendons, brain. All seem to involve fatty acids + cholesterol. Seems related to cholesterol-calcium / testosterone regulatory trouble.People w/ PCOS have high rate of skin tags and cholesterol deposits and is a curious / is a risk factor for autistic kids.
I have a mini thread on mastodon about Vitamin A where I associated chemosensing and sense of smell with it.https://t.co/oIs88WmuwG
Earlier in this thread you're reading, I mention how anosmia seems related to semen quality.I had a thought... What if they're related? https://t.co/XzjHlX3yKp
Huh, I wonder what vitamins are in Semen...Sure enough. ~3% Zinc?Oh and Zinc seems to play a role in smell/taste issues.https://t.co/e5FkW05uhv
My thirst for knowledge knows no bounds."But you'd actually have to drink nearly 4 oz (a half cup) of semen to match the protein of one egg white."https://t.co/rr74os5ja1
Low Vitamin A *can* cause night-blindness, but it actually operates via Zinc? Cool!https://t.co/dOkS3f98Dd https://t.co/CYYmYWR1iA
Zinc supplementation alone is enough to lower blood triglycerides & help people lose weight (mirroring results found in rat trials)?"randomized, double- blind clinical trial was carried out on 60 obese participants in the 18-45 age range for one month"https://t.co/7rRGtHjOmz
So if we assume the blood triglycerides is an inflammation associated symptom, we should be able to see Zinc and Vitamin A having an impact on microbiome, particular targeting those that show up between healthy/obese mice+people?Association ala: https://t.co/9CUkFDEh2x
Note that this prediction is subtly different from the original research where Microbes use Vitamin A to affect host immune system.https://t.co/AsP4muBEpbBut is a more specific on *which* bacteria are selected for in an ecosystem when this zinc/vitamin A action breaks down.
I'm at a point in my research where I need to figure out ways to measure semen in mice without needing to cut off their nards (so you can see semen changes over time when supplimenting with zinc / bacteria) and so I'm stopping again.https://t.co/96k3ufIOhG
(note to self: begin cataloging all bacteria across obesity related microbiome research. Cross reference with diseases I am familiar with. Further, explore effects of antibiotics on gut health in farm animals https://t.co/AsBZ7KOQRH and boar taint within this cross section )
"archaeological evidence that humans had figured out how to make cheese 7000 years ago. It just does not seem probable that this long association with fermentation microbes, many of which are Lactobacillus strains, is contributing to our obesity epidemic in the 21st century."
Talking with a friend on how best to detect hormones in mice excretions effluvia.I feel like this is the kind of thing that would be overlooked due to medical research taboos. But maybe not so much among livestock and animal husbandry?https://t.co/noCsHTehXP
I am reminded how during early chemistry research, people would just taste things to see what they were. These days we have nanotechnology.https://t.co/7SNjbL0PoJ
Thinking about the oral microbiome and how it influences a number of gustatory factors like saliva production and I am stricken with a realization. The vice article had an oversight: https://t.co/RSaHoe10aO
Another realization has me wondering if you could ferment beer with semen based amylase.https://t.co/EUbvUetxnQ
Of course studies on alcohol use show mixed results on impacts upon semen quality -> some say it is bad, some say it is good. This is exactly what I would expect if the effect is actually due to impacts on the microbiome that no one realized it was happening.
I need to learn more about glucose genes. It seems they may play a different role in sperm ala glucose metabolism factors unrelated to gonadal issues. https://t.co/IXaSI96v8W
Of course, if the sugar feeding the sperm isn't being used correctly, this could attract microbes who produce uric acid and amylase. Which suggests there is a gonadal microbiome?Yeps. Yeps there is.https://t.co/td5clQGasA
heh, I knew this implicitly;"We have taste receptors in [...] ovaries/testes"https://t.co/SvzHuo3xft
Dysgeusia is fascinating. Why do taste sensors seem to show up in parts of the body that deal w/ chemical concentrations, microbial management, or have a high need to maintain homeostatic / immune responses?We have taste receptors in our brain, ovaries/testes, pancreas, & anus.
Whut"One study—known, in some circles, as the “Great Balls of Fire”—claimed that probiotic yogurt imbued male mice with bigger balls and a behavior the researchers called swagger."https://t.co/L4iYJGuiAO
Heh, That study was on L. Reuteri.https://t.co/w4g7djASrdhttps://t.co/6v0CIlfJWr
Now Playing: a band of mice rocking out to AC.DC."And my balls are always bouncingMy ballroom always fullAnd everybody comes and comes againIf your name is on the guest listNo one can take you higherEverybody says I've gotGreat balls of fire"https://t.co/JhJ6T6x31W
I think I'm going to start a separate thread on biological aspects of female fertility.I just saw https://t.co/7mjI5HTxPL and it reminded me of this weirdness earlier in the thread. https://t.co/mdtvcgLIlt
I am attracted to women with interestingly pitched voices. I wonder how universal that voice tone competition thing is.related: https://t.co/oI9jsZjCsG
If I am attracted to those with PCOS genes at some more fundamental level, and health is correlated with voice pitch lowering problems, does that explain why I find higher pitched voices more alluring? Cowbird theory of human associative mating.https://t.co/aQ3CHRgSdW
heh. I wonder if the PCOS voice thing is an artifact of hormone changes associated with changes that affect gut microbes. This suggests voice pitch is correlated with fertility signals: https://t.co/G8lDDKEe46
I wonder if mice squeeks can be affected by microbiome profiles.Apparently babies and seven year olds sound unique enough that voice pitch can be partially predicted later in life.https://t.co/WaOQq7xyiP
Oh neat, someone might be close to researching that."DeepSqueek" is exploring emotional affect and mice phenomes.https://t.co/DEXablgFNf
So, my understanding of the way that this stuff happens suggests to me that this might be a semi-adaptive phenomena? In bird calls there is a sense that emotions are adapting to norms. Shouldn't we expect similar phenomena in mice/maiting sounds?https://t.co/JUgh95owwp
Birds learning to scream."This acoustic-acoustic association mechanism of social learning could result in the rapid spread of alarm-call recognition in natural communities, even when callers or predators are difficult to observe."https://t.co/S2t6x3Xmda https://t.co/vFGQ5Ru7Jq
Stop looking for normal. Why do they always look for normal?If you assume normal is 'best', you overlook the cowbird and the maned lioness.https://t.co/XcJHfsP5RB
Bouba/Kiki is a synchronization primitive among language encoded in genes, but it isn't arbitrary. Everybody basing these highfalutin theories on it are ignoring entire swaths of experience, wiped under the rug because we're 'diseased' and don't count.https://t.co/rQpqW2AsoH
Water fireflies.https://t.co/5OejfmH9hr
Bird fireflieshttps://t.co/huZfkb5y6Z
Firefly eating fireflys."Called Photuris, it is a firefly that eats other fireflies."https://t.co/hu7dOVu658
Why do male lions kill the cubs?https://t.co/fDxexQ2g4k
Cannibalism among fruit flies. Posted a minute ago.Syncopation.https://t.co/Xn3JxD9oRL
Always asking "why". But never "when""But why, scientists ask, do animals and humans abuse and slay their young? "https://t.co/CUvIA3gAoH https://t.co/FVNU0ARM1B
When is having a pesudopenis a viable sexual selection and maiting strategy?When does R or k selection tip into being the dominate child rearing among a species?https://t.co/z204IWGV00
How can we simulate this behavior among mouse colonies in such a away that we don't actually need to subject mice to killing each other?https://t.co/9uuebMKvZ0
All my ideas are related.https://t.co/QJ01D8r0DV
I see it as: complex system w/ emergent group strucures.Creation/Destruction:Collaboration, Coordination, Cooperation, Clusterfuck, Collusion, Cheating, Catastrophe.Symbiois:Commensialism, Mutalism, Parasitism, (Competition, Predation, Neutralism)https://t.co/Se45qyHSdC
Why is entropy never considered among biological systems.And how does it scale to groups?When will we see it?https://t.co/6bgR11CLjQ
OH: "The earth is fat"/"Thicc Earth Theory"What if this is true?Because its infested with simians.All the toxins they produce end up causing dysbiosis in the ecosystem.Alas, this too may be necessary for us to escape entropy?https://t.co/aZ8UebXZDK https://t.co/V35ZCB0aXM
Apparently MDMA can cause testosterone profile changes thru gene expression modulation? In rats at least.https://t.co/bzTGK6x2w0
And I just realized that "smooth muscle" has direct associations with girth, intestinal issues, and brain blood flow.Interestingly, a calcium antagonist used to improve heart issues also improves testosterone. In rats at least.https://t.co/tglZHJX03L
Unlike semen quality, you can apparently test this in rats without cutting them open.https://t.co/Qpdqqiwi9p
"Compared to ephedrine, Oberlin observed that it had similar effects on vascular smooth muscle tissue, stronger effects at the uterus, and no "local effect at the eye". MDMA was also found to have effects on blood sugar levels"https://t.co/88HB8I5EEp
"large amounts of serotonin, MDMA causes the brain to become significantly depleted of this important neurotransmitter""Research in rodents and primates has shown that moderate to high doses of MDMA, [...] damages nerve cells that contain serotonin."https://t.co/lApmet3st7
"MDMA Increases Cooperation and Recruitment of Social Brain Areas When Playing Trustworthy Players in an Iterated Prisoner's Dilemma"https://t.co/1GyPiRiIBa
Please tell me someone's giving MDMA to ants?https://t.co/vyC5n09Nsd
They're rolling octopuses."But as in humans, when the octopuses receive a dose of MDMA, also known as the party drug ecstasy, they begin to become very social indeed."https://t.co/eaxkeGNX9R
Now a tangent is a similar drug found from frogs."In the 80s researchers found one of the constituents of Sapo venom in the urine of autistic children, and developed an entire theory of autism around it."This mentions abortion.(cw: seizure warning) https://t.co/nsktQkImdO
Which I think ties that drug to smooth muscle tissue ala the Myometrium, aka 'Uterine smooth muscle'.https://t.co/lvJJKBa0fW https://t.co/mydlGsqgA5
Could that be related to semen damage causing premature abortions somehow?Semen damage = abortions is correlated.https://t.co/o06KIM0i2bhttps://t.co/CdDsEeM0qthttps://t.co/GquXmq26avSome research coming out this year even.https://t.co/Ai4BPk9bSzhttps://t.co/rYWKw1v5Rr