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🧵 Thread (19 tweets)

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UltimApe@ultimape• over 4 years ago

Say someone had a poor vegan diet that didn't have enough Tuarine, and their generation of it via methionine & cysteine via "cysteinesulfinic acid decarboxylase" is impaired, and they started getting Taurine deficit associated heart failure and nerve problems, is it reversible?

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1/22/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

I wonder how often humans have problems with bile that is actually driven by mutations and gut microbiota problems that impact all of this.Dysfunction in bile->gall stones->heart problems show up all the time in humans https://t.co/WuYyh8by4Lhttps://t.co/NrNRL73Qix

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1/22/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

If bile acid construction pathways itself (not just pool size) is mediated by gut microbiota, & your bacteria aren't signaling to make enough... wouldn't that lead to stones as the calcium fall out of solution?https://t.co/GsosCWhdpghttps://t.co/CrgG7OQe0t

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UltimApe@ultimape• almost 6 years ago

@PLT_cheater @The_Lagrangian @JimmyRis yes, good thing my liver can produce bile acid on demand on top of having a well functioning gallbladder. I specifically taylor my diet to promote Lactobacilli colonies (what ferments saurkraut?) that trigger FXR antagonism to increase bile acid pool size https://t.co/GsosCWhdpg

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1/22/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

I don't actually know if microbes play a role in this. Low taurine might also be indirect symptom of kidney problems.https://t.co/NYa6zHVRAQIf so, taurine regulation itself may be downstream of glutathione, and smooth muscle blood flow issues. (at least in rats)

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1/22/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

Complex systems are weird to get a handle on, its like a bucket with a thousand tiny holes that all could be leaking, but you can't tell which one necessarily.

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1/22/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

But Taurine seems important"New areas of research should extend these studies to include applications to clinical problems such as autoimmune diseases and inflammation. "https://t.co/55qyqk8g8y

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1/22/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

I know an old lady' whos ate an egg to increase her bile, to heal her gut, to enhance absorption, to fix immune function, all to solve the proximate cause of why kidneys were failing...Perhaps she'll die? 😭

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1/22/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

It's amazing how I wander around streams of information and eddies of utility function like some kind of ant solving gradient descent style info-foraging problems.Does this idea smell right? I think so.https://t.co/UtDmYNmx3C

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UltimApe@ultimape• almost 5 years ago

"The Kidney Vitamin" - Vitamin Dhttps://t.co/lD7WULe14W

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5 0
1/23/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

Watching ants run around and figuring out how they do it.Realizing the reason I am better at this exploration game is I don't hold these myths in my head.https://t.co/doezxogTMU

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UltimApe@ultimape• over 9 years ago

Ant Myths in the Ant Colony Optimization method:1) Ants have no sight (they do!)2) Ants behave with a correlated random walk (they don't!)

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1/23/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

Kidney failure as symptom. Kidney damage acceleration as symptom. Leads to heart problems.In diabetics. Must be the stress /shttps://t.co/lHttBf9ZrL

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UltimApe@ultimape• almost 5 years ago

Heart problems you say?"Several studies have now shown that roughly 10 to 30 percent of hospitalized COVID-19 patients had high levels of troponin—a protein released into the blood when the heart’s muscle cells are damaged."https://t.co/8G2NUEh8LFhttps://t.co/2NUN2xLfa0

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1/23/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

I know a lot about ants.https://t.co/mCMoR0v6OJ

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1/23/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

I need to figure out how to test what kind of bile acid I have. I need to find a place I can send my vomit to so I can confirm if cysteinesulfinic acid decarboxylase process is impaired.https://t.co/m1omEJ51kH

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UltimApe@ultimape• over 4 years ago

Flexing about my models of TSH being right.https://t.co/bNQvodeK6a

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1/29/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

"Is it really possible that half of the population older than 70 has chronic kidney disease?"https://t.co/AYNUWbm6Xv

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1/31/2021
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UltimApe@ultimape• about 4 years ago
Replying to @ultimape

Sonic Hedgehog activation can improve heart attack outcomes from diabetes?https://t.co/4MnwXh0LaX

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7/29/2021
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UltimApe@ultimape• about 4 years ago
Replying to @ultimape

"in this review, we will summarize important literature about the involvement of SIRT3 in cardiac remodeling/repair following MI and its potential underlying mechanisms."https://t.co/PvI5m6GKL6

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7/29/2021
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UltimApe@ultimape• about 4 years ago
Replying to @ultimape

Ya'll got any of them SIRTins?https://t.co/ZfFrTSCZwQhttps://t.co/vgFBnqh4sB https://t.co/yEmDcVT2Dp

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UltimApe@ultimape• almost 5 years ago

Ya'll ever look up SIRT-1 and realize you've been exploring those pathways indirectly while trying to fix age-related diseases tied intimately to the gut and immune function?No? Just me? Well then.https://t.co/UfzoVUBahS

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7/29/2021
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UltimApe@ultimape• about 4 years ago
Replying to @ultimape

He's the fastest thing alive."Resveratrol as a calorie restriction mimetic: therapeutic implications"https://t.co/DjUu6jtYynhttps://t.co/SSZyGVsyDc

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UltimApe@ultimape• about 4 years ago

GOTTA GO FAST"In lean animals there was a significant increase in both Shh and Gli1 expression in the hypothalamus after an overnight fast" [June 10, 2021] [print]https://t.co/HeW8CJ31bg

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7/29/2021
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UltimApe@ultimape• about 4 years ago
Replying to @ultimape

Did you know that sonic can only go fast if he has his speed shoes?https://t.co/0BygS31Mwghttps://t.co/W92Q5XQf1U https://t.co/dXfemjN8yt

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UltimApe@ultimape• about 4 years ago

@Grimhood @LucVareilles Resveratrol is also mediated by piperine https://t.co/hFzXesRIptMost fasting-mimicking things act on that pathway.https://t.co/gCUVzEHFHbmay be a bunch of alternatives.

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7/29/2021
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active resonator@loopholekid• over 2 years ago
Replying to @ultimape

@ultimape @sonikudzu uh oh, you plugged a hole and now there are more holes

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5/31/2023