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Meta-Metacognition -> when you learn about how Richard Branson learns and find he is also interested in learning about learning.“If I’m not interested in something, I just don’t grasp it,” https://t.co/hTwBqwZEDDThe trick, I think, is to learn to make everything interesting. https://t.co/8s7Te5lZ02
I disagree with the HBR article's focus on sleep. But I also think my pineal gland is compensating for sleep problems and allowing me to encode memory while I'm awake.https://t.co/Br9tGPbbwl
Tryptamine (& DMT) in the pineal gland causing synesthesia due to brain wave changes?"Updated View on the Relation of the Pineal Gland to Autism Spectrum Disorders" [2019]https://t.co/usf2lcrC7vhttps://t.co/UiHUIB6SNAhttps://t.co/SV8va4tXzL https://t.co/lyhyKrcmjR
I'm learning as we speak."Thus, the strikingly high prevalence of [pineal calcification] in MS provides indirect support for an association between MS and abnormalities of the pineal gland."https://t.co/TeFzUQ3dIVhttps://t.co/KecfmnAVTA
Why the heck would Diabetes Type II and Periodontal Disease be correlated with Pineal gland Calcification and Melatonin issues?https://t.co/kOcqCXz48Chttps://t.co/hI7Y6dDmGa
If schizo, autism, & multiple sclerosis are related via white matter/myelin issues due to widespread brain inflammation... we should expect Diabetes Mellitus to exhibit demyelination symptoms?What is diabetic neuropathy?https://t.co/wdQF3mGwlVhttps://t.co/Ni4skuzQTo
"Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s disease patients." https://t.co/kOcqCXz48C
"This coordinated shift of the source of melatonin driven by NF-ÎşB is called the immune-pineal axis. Finally, we discuss how this concept might be relevant to a better understanding of pathological conditions with impaired melatonin rhythms "https://t.co/tsx44okWEH
"[pineal gland calcification] occurrence is primarily associated with pathological conditions and aging. The exact mechanisms of how it occurs are currently unknown; however, several theories have been proposed to explain calcium deposit in the gland."https://t.co/XndfUrHnkL
This suggests smoking might be a self medication to prevent Porphyromonas gingivalis infection. Huhhttps://t.co/hEX3JGbve9
Going to need to dig these to get to the root of the study designs."Industry-affiliated studies indicated that smoking protects against the development of AD, while independent studies showed that smoking increased the risk of developing the disease."https://t.co/ER4WhKxRyc
Plausible that the studies were doing statistical analysis of populations and didn't take into account that people who smoke more might already be predisposed to an immune disorder, but that fact got overlooked. But it's complex.https://t.co/7Ch2VUMV2uI never find controls.
"These data suggest that ChoKα inhibition could be an effective strategy in inflammatory arthritis. "https://t.co/RGY7tok9Y4"New treatments that inhibit ChoKα expression or activity in patients with lung cancer should be studied further"https://t.co/gQytcYq2XOFascinating.
Choline kinase directly related to Phospholipid Metabolism. Low levels of choline seen in ASD cases https://t.co/oZ5diHEBYU , and even some rare mutations manifesting in symptoms https://t.co/sPjmXmSAUI (already know about choline+nictotine receptors weirdness ala schizophrenia)
I wonder if smoking impacts lipid metabolism associated with white matter.You what?"Results from recent studies suggest that chronic cigarette smoking is associated with increased white matter volume in the brain as determined by in vivo neuroimaging"https://t.co/scOaYQr2YX
And yet"More observational and mechanistic research is needed, but the available evidence supports cigarette smoking as an independent risk factor for MS susceptibility"https://t.co/L52qu7jI6pI keep drawing up "hmmm..." results.
Does lung function and smoking impact autism?We just don't know.https://t.co/G7o6CTrwYdBut MS and COPD correlate.Don't know why.https://t.co/73Z1KaECgThttps://t.co/uugZcO56gY
My mom has x-rays on file; Fibrosis went away."In particular, pulmonary fibrosis is an irreversible alteration and a primary cause of mortality in patients with pulmonary diseases such as chronic asthma and chronic obstructive pulmonary disease (COPD)" https://t.co/2Y0wUMlATK
Seems there is already an exploration underway tying an MS med to fibrosis by a researcher who 'focuses on understanding how normal repair responses “go awry” in aging'https://t.co/aLYGZdVHCp
My mom doesn't have an MS diagnosis; hasn't been treated for it. Accidental?"explorers can be perceived as boundary walkers reflecting limitations within the conventional health care system and as initiators regarding what MS patients find useful in CAM"https://t.co/vBkPALff2O
"Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes"https://t.co/w0u4oXpeZM
"But recent findings have shown that — depending on interactions with other factors, as well as the interactions’ timing and context — CXCL12 could also be anti-inflammatory and immunomodulating, and promote re-myelination." https://t.co/MwVns8HOwh
"the results of the present study suggested that autocrine CXCR4/CXCL12 axis is an important mechanism underlying the pathogenesis of idiopathic pulmonary fibrosis" https://t.co/xWKLIDWdlU
"CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling."https://t.co/MU33b1AMCaFancy way to say that the molecules fuck with each other.
I'm out of my depths now. I have no idea what a Chemokine actually is. https://t.co/1RmgcXpCM0And my knowledge of heterodimerization is still in infancy.https://t.co/yLenmkOjgm
Weird ideashttps://t.co/Br9tGPbbwl
Tryptamine (& DMT) in the pineal gland causing synesthesia due to brain wave changes?"Updated View on the Relation of the Pineal Gland to Autism Spectrum Disorders" [2019]https://t.co/usf2lcrC7vhttps://t.co/UiHUIB6SNAhttps://t.co/SV8va4tXzL https://t.co/lyhyKrcmjR
As a joke.https://t.co/XOJKFOvHFs
"The chemicals are telling me Imust perish like a dog!"Ape whispers to himself in a half daze—succumbing to maniacal laughter—as insomniatic delirium allows elder memes to enter his dreams once again.With brain waves like these, who needs chemicals.https://t.co/ZnDst1ANKl