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🧵 Thread (23 tweets)

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Guy HAS FINISHED WRITING THE BOOK (BETA)@nosilverv• over 4 years ago

ok new theory: in anorexia one FIRST experiences one's body as infinitely small AND THEN acts in a way that accords to that expectation

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @nosilverv

@nosilverv Vagus nerve dysfunction would cause thishttps://t.co/ZKdXDiucSr

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UltimApe@ultimape• over 5 years ago

@naval There's a subtype of anorexia nervosa who's anxiety symptoms don't respond to SSRIs, seems to match up with treatment resistant major depression.https://t.co/fJMLu25h5KGut brain axis tho.https://t.co/0Yc6OjQTtU

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv I traced my weird eating behavior to a form of body dysmorphia. Seems to be a sort of alice-in-wonderland style illusion tied to why I can't seem to draw limb for shortening. My brain can't understand it, so I always see body shape wrong.heh.https://t.co/zvq7gkBfFS

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv stopping the vagus nerve from allowing the gut-brain-axis to let gut bacteria talk to the brain can soemtimes reduce anorexia symptoms.https://t.co/YRktp1knlGSo what happens if you just fix the microbes?https://t.co/zfxZ7o9RM8

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UltimApe@ultimape• over 4 years ago

Not enough people understand how fundamental the shift has been in modern research into depression, SSRIs and the microbiome.https://t.co/WV5bsiFJmM

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv ¯\_(ツ)_/¯"Profound differences in the gut microbial composition between people with AN and normal and overweight individuals have been reported; however, further research is required"https://t.co/Gcgl65JMfp

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv You know what another name for anorexia nervous is? Accidentally triggering hibernation associated fasting thru immune perturbation ala gut bacteria.but I am also insane.https://t.co/46XeBX1FP8

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UltimApe@ultimape• over 4 years ago

@VitalikButerin I figured it out and renamed it incomplete human hibernation.

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv I have no idea what I'm doing, but I bet this is related.https://t.co/WXMzoSFZzuhttps://t.co/UZEopdX0mX

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UltimApe@ultimape• over 4 years ago

@MMMalign "Since PEA enhances mood and can readily cross the blood-brain barrier (Irsfeld et al., 2013), our findings imply that inter-individual variability in microbial production of PEA could potentially explain the variable efficacy of MAOIs on depression."https://t.co/pSENZuJVib

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv Why do antidepressants not work in anorexia?https://t.co/ZlQMTT2lzAI bet bile acid dysfunction tied to gut bacteria / FXR and liver function drive poor choline absorption and directly impair vagus nerve signalinghttps://t.co/bzvOjNrtUy

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv You'll never guess what diet fixes certain bile related factors...https://t.co/s7MrOhR4LOWhy can I just pull this shit out of my ass?

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv Find something where this experience would trigger a feedback loop in the gut and you'll find your answer.https://t.co/vWfw25v46r

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Guy HAS FINISHED WRITING THE BOOK (BETA)@nosilverv• over 4 years ago

ok new theory: in anorexia one FIRST experiences one's body as infinitely small AND THEN acts in a way that accords to that expectation

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv You are what you eat. But you are also what your bacteria are able to properly process.https://t.co/OD2CqMVn3p

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UltimApe@ultimape• over 6 years ago

TFW: Reading a science publication that suggests the efficacy of Talk Therapy is on par with taking SSRIs, and then realizing that I could just eat bacteria shit and cure my treatment resistant depression. https://t.co/jN5azdd0ep

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv Did you know Freud had a chowchow that he used as an emotional sensing proxy while talking with his patients.Dogs are really good at smelling gut bacteria and skin bacteria. Chowchows have good sense of smell https://t.co/TbSf7EcIfV

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv I'm going to one-up Freud and get a pet bear.

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv "2-Arachidonoylglycerol as a possible treatment for anorexia nervosa in animal model in mice"https://t.co/V1g2tbZBinmice, fucking mice. It's going to be another 20 years before this stuff is realized.https://t.co/ESyGjROocE

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UltimApe@ultimape• over 5 years ago

Tired: obesity is a risk factor for heart diseaseWired: obesity is a risk factor for gut dysbiosis leading to microbiome induced inflammation that impacts heartInspired: Do bears get heart attacks?Hired: How can we get humans to hibernate?Desired: https://t.co/NJlwfmXpiW

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv Myopic. We're all collectively myopic. Can't see past our own lenses of the world. https://t.co/l9WQjcM4Go

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UltimApe@ultimape• over 5 years ago

Fasting has been shown to improve viral infection outcomes.Cold has been shown to improve viral infection outcomes.Fasting leads to 2-AGTRPM8 activation leads to 2-AG2-AG hits CB1 and CB2, acting to down regulate IL-6IL-6, left unabated? rampant inflammation.

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv People are larping freud beceause it became high status to be a psychologist.No one even realized the dog was important. Freud has no sense of smell because he was snorting cocaine.They all had pellagra! "nervous disorders" was actually just diet. https://t.co/TibJvYP8yd

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv fix your gut https://t.co/IvOf3ffQoH

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UltimApe@ultimape• over 4 years ago

Fix your gut, fix your gut, fix your mother f*cking gut.as a song https://t.co/vSkLWkBobt (nsfw)https://t.co/wAjl8yRY4y

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2/5/2021
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UltimApe@ultimape• over 4 years ago
Replying to @ultimape

@nosilverv Become bear friend."bloodhounds, dogs so famous for their sense of smell that they're used to track missing people, don't smell as well a black bear. It is estimated that black bears' sense of smell is about seven times greater than a bloodhound's."https://t.co/Y5pCAZwDjt

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2/5/2021
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UltimApe@ultimape• almost 4 years ago
Replying to @ultimape

@nosilverv What have I found?https://t.co/ZKdXDiucSr

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UltimApe@ultimape• over 5 years ago

@naval There's a subtype of anorexia nervosa who's anxiety symptoms don't respond to SSRIs, seems to match up with treatment resistant major depression.https://t.co/fJMLu25h5KGut brain axis tho.https://t.co/0Yc6OjQTtU

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9/28/2021
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UltimApe@ultimape• almost 4 years ago
Replying to @ultimape

@nosilverv "Collectively, these results indicate that [Anorexia Nervosa]-specific dysbiosis may contribute to both poor weight gain and mental disorders in patients with Anorexia Nervosa]." [putting human poop in mice]https://t.co/UarHpXoSZv

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9/28/2021
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UltimApe@ultimape• almost 4 years ago
Replying to @ultimape

@nosilverv Freud mistook some earlier thoughts about people eating feces as sublimation to societal desires. Freud was wrong. He as looking at gut microbiota development and dysbiosis.His dog could smell it, lol.https://t.co/K2vRJyVUs5

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UltimApe@ultimape• over 4 years ago

"This is probably not because madness never produced excremental behaviours of this kind. The question then is why did this only result in a meaningful medical category of behaviour from the late nineteenth century onwards?" https://t.co/36aCsUEHrI https://t.co/5B8upkOvyN

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9/28/2021
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UltimApe@ultimape• almost 4 years ago
Replying to @ultimape

@nosilverv Keto + Ketamine for Anorexia Nervosa... Almost like we're seeing the same thing as how Ketamine helps certain forms of treatment resistant major depression.https://t.co/s7MrOhR4LOhttps://t.co/kx9tCl2vqc

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10/28/2021
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UltimApe@ultimape• about 1 year ago
Replying to @ultimape

@nosilverv Whoops, called it.https://t.co/rcQ40uXQjh

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UltimApe@ultimape• about 1 year ago

"Finally, GF mice transplanted with AN stools on an energy-restricted diet initially lose more weight and have slower weight gain over time compared with mice transplanted with stools from healthy individuals." [2023]https://t.co/a8t4GvQ6vcCalled it.https://t.co/fuMndXl1je https://t.co/wT4WUzQsCG

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8/17/2024