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I don't seem to have the GLUT1 deficiency, but I researched all of this too. Wondering why so many degenerative neural disorders manifest with Sweet Tooths is what lead me to https://t.co/DMxZGreo0s andran down this rabbit hole: https://t.co/z4t5YRQpAT https://t.co/DtwvgNvFhy
Odd that cannabidiol directly activates 5-HT1A serotonin receptor.People who smoke pot seem to have a better insulin profile despite higher intake of carbs... maybe its metabolic impacts on mitochondria via insulin effects via the pancreas? Just saying.https://t.co/tzeYPDrVXe
Huh, if you research all of the neural degenerative diseases that manifest in sweet tooths... they all seem to respond favorably to serotonin manipulating stuff. You'd think it's having an impact on their microbiome or something.
Non-alcoholic fatty acid liver disease. Whats that?https://t.co/EgKyici5fB
What a weird result. its almost like this stuff is related. And that nobody is looking for it.https://t.co/GSkw4UimOa
An common anti-seizure medication causes non-alcoholic fatty liver disease? I wonder how this stuff is related...https://t.co/7VYKTBC3yl
Oh, of course it does. VPA acts on Serotonin Receptors. Funny that."VPA exposure is not due to a general effect of VPA on this signaling cascade, but due to the up-regulation of 5-HT2A receptor number."https://t.co/km15RIIeDx
I could do this all day.https://t.co/RBx8Qz00j3
What is a complex system? asking for a friend.https://t.co/bQpLJehrE5
What is homeostasis even?https://t.co/goPIyVBwRN
Models, they have great predictive power when honed well.https://t.co/AFZ05bXsfB
How well do RCTs perform when measuring a complex system?Is there a better way to get at what is going on than by guess and check?What is Bayesian search theory, and how does exploring novelty work?https://t.co/K5jaSwUSsJ
Dysgeusia is fascinating. Why do taste sensors seem to show up in parts of the body that deal w/ chemical concentrations, microbial management, or have a high need to maintain homeostatic / immune responses?We have taste receptors in our brain, ovaries/testes, pancreas, & anus.
Hypothesis: early in growth, pancreas sets up centrifugal governor-like system that mirrors and help simulates + respond to larger homeostatic systems in body.It develops like light organ in bobtail squid & Type 1 diabetes is when it fails to bootstrap.https://t.co/Zh9Dhb8YIx
The bobtail squid's light organ doens't develop if the bacteria is not present. I think this is partly why stuff like allergic reactions and autism seem to be associated with soil bacteria and interactions with farm animals in childhood. Also why Type 1 is linked with C-sections.
Type 1 is linked w/ C-sections, and Type 2 is linked with C-sections, and Autism is linked with C-sections. All are linked with stress and diet in the parent. Stress/diet manifests with microbial changes via the gut/brain axis and impacts vaginal bacteria during pregnancy.
This is also related to schizophrenia, all the way back in 1880s https://t.co/Lo5GwK8qXg https://t.co/FdbbY2UdRF
and it also answers why I could predict that female bears have pseudo-penises and why some lionesses have manes.Regulatory networks in response to the environment, weather, or predator.Acclimation, Acclimatization and Adaptation.https://t.co/tBzAft7R1C
I drank 3 liters of wine and then didn't eat for 3 days to bring you this delicious insight about bear dicks and poop networks.https://t.co/t7UZeN0VIe
Serendipity - a random internet search on gay bears caught my attention because I learned that bears make their own buttplugs to overwinter. Hilariously absurd:https://t.co/Z6ftB67QaO
Just so happens, I wanted to fix my sleep schedule. I was reading about a rare theory on human hibernation, and it reminded me about the serotonin/micochondrial metabolic stuff I learned about w/ my autism studies.Maybe we can do it via our microbiome?https://t.co/uS2COYNNjv
I'm just putting this stuff here to remind future me how fucking weird bears are.https://t.co/CdrSCjh0W7
Also because I think its funny to point out how I turned a random spam response to one of my comments into a meaningful exposition. I had to set this joke up for it to make sense.https://t.co/4oNWrmgUO3
How to deal with brands?1) pretend you are drunk2) pretend they are markov bots3) shitpost about bear shithttps://t.co/V5zh0B57oR
Divinations performed as an interaction of human and machine.Social media, internet search, and the self analyzing meme.https://t.co/Nu0XvcLERy
It makes sense to me that long-term cultural norms around disease would affect the variation in immune system genetics. There's tons of strange papers on the ways religions have basically been at the core a way for society to deal with disease ala ritual https://t.co/LpayfvNsPM
Some studies were written about this week that fit my understanding of the disease model.Diabetes, High Blood Pressurehttps://t.co/oEbfMVwm49And Microbiomehttps://t.co/UzQ5WMNzBm
This keeps happening.https://t.co/fvQXeONL8S
Surprisingly well researched article in Frontiers in Sociology is making a similar argument as my socially mediated genetic interaction / immune system theory of autism. Even explicitly mentions many of the same genes.https://t.co/uPwsjpzhQc https://t.co/OHTGNcHD5K
By modulating my insulin / serotonin / microbiome profile, I seem to have developed a stronger innate immune response. Both the people i'm living with are sick with a nasty head cold, and yet I am fine. This is rare for me.My mucus is doing it's job!https://t.co/F1E4yIhmXW
@vgr They tested against opossum kidney cells (a common set of cells for research at the time) and it seemed to shut off Adenylyl cyclase by how it acts on serotonin receptors. Finding suggest it's an agonist for that receptor (which I think is how it makes my nose run/produce mucus).
I am also not having strong reactions to things I was previously allergic to.https://t.co/ovYFDCw0Gl
Detecting autism via a bloodtest + machine learning.https://t.co/sigLlE0ahIhttps://t.co/EdlPwksRb3
Currently exploring taste receptors / seeing if they talk to the CNS somehow. related:https://t.co/GNAQ54gypAhttps://t.co/7GEHCTYcj3and curiosity:https://t.co/MvTqN8Y2MB https://t.co/hdbFisDJqZ https://t.co/y6qlyNMfZqhttps://t.co/tYLRtCnJQEhttps://t.co/9ptxQ9OBNG
Insulin regulation genes => Metformin => longevity 1) intermittent fasting => longevity (note: BDNF) https://t.co/KoBfP82ogi2) Fasting => improves Diabetes type II https://t.co/wQ1sST4pbm3) metformin + Type II => BDNFhttps://t.co/IByPYc8iV1https://t.co/xMKN8fXL3L
Strange: "Our results suggest that BDNF may be associated with lipid metabolism and that increased production of BDNF may be related to metformin treatment."oh neat, BDNF 'regulates cholesterol metabolism' https://t.co/DRFgoFe7LfI wonder...
"BDNF expression was found to be reduced in the hippocampus and cortex of germ-free “gnotobiotic” mice, and the reduction in the expression of BDNF was found to specifically associate with increased anxiety and progressive cognitive dysfunction"https://t.co/eztAbDnjZdOH SNAP
BDNF just got real interesting to me.https://t.co/aPV1omadMt
"activation of the CB2 receptor is a potential therapeutic strategy for the treatment of inflammation, pain, atherosclerosis, and osteoporosis."So... like the same thing bears are doing - low bone loss, and non harding heart!https://t.co/sEhtZ6JHvU
A study on the communication between marmots and bears via poop."Gas chromatograms (GC) of the anal gland secretion from a typical female (a) and male (b)brown bear (Ursus arctos) [...][Beta-caryophyllene] were only found in females." 👀https://t.co/9PCBsIitS0
(notable: female bears tend to hibernate longer, especially if they have children)https://t.co/FA0b3sV2i9
Snoots loudly.https://t.co/zGoJz25pfH
oh neat, using https://t.co/uGLbngW57s I can find out when studies are being funded and predict what they find.I predict that https://t.co/Lx9KQ7Z7KV will find positive results for long term weight loss as I am both upregulating oxytocin + BAT and have has sustained success.
Oxytocin Research is weird.Mixed results on Picotin from different studies done roughly the same timeframe.https://t.co/iVEMyCsz3uhttps://t.co/CRNs9Uqm6VOft No benefits foundhttps://t.co/GHl4J4jkXOBut I take it all with grain of salt.https://t.co/b0OE049LqJ
"Valstad et al. conclude that “blood plasma may not efficiently index central oxytocin concentrations under baseline conditions.” This, they note, is a problem for the many studies which have looked for behavioral correlates of baseline plasma oxytocin"https://t.co/FWemtR8B0d
So i'm looking at oxytocin with a bit of a side-eye.https://t.co/fP4e5c0Ywr
I think something else is going on related to thermogenesis and heat-shock proteins as part of the process of how our bodies regulate our gut bacteria, with all of these hit-or-miss studies seeing localized flashes of a complex etiology.https://t.co/N9Gg0ixuAZ
Hypothesis: early in growth, pancreas sets up centrifugal governor-like system that mirrors and help simulates + respond to larger homeostatic systems in body.It develops like light organ in bobtail squid & Type 1 diabetes is when it fails to bootstrap.https://t.co/Zh9Dhb8YIx
and I mean complex etiology. There's some really weird shit our skin (and by proxy, our GI tract lining) does to protect itself from disease. https://t.co/jdxJK3E0NM
Viewing our immune system (of which our skin is one facet), as a massive constantly shifting microbial ant colony battlefield is fun. You start researching curious adipose tissue responses in diabetes like this:https://t.co/vfwaaBwCrJhttps://t.co/7n7xWU0oR0
And then scientists find out that yes, white adipose tissue is in fact a mobile larder conscripted to feed the troops on the front line.https://t.co/puVhyrTPjz
There's weird stuff involving cancer cells moving in the body: https://t.co/fvXtkPyc6O and brain/gut permeability in autism https://t.co/GVo3mnijae that have been buzzing in my head for a while now. So the idea that our immune system (including fat cells) wander? of course!
Glutamate Receptors, in MY anus?It's more likely than you think... https://t.co/u9XnXqAWrP https://t.co/SvzHuo3xft
Dysgeusia is fascinating. Why do taste sensors seem to show up in parts of the body that deal w/ chemical concentrations, microbial management, or have a high need to maintain homeostatic / immune responses?We have taste receptors in our brain, ovaries/testes, pancreas, & anus.
Vagal Nerve. Taste receptors. Serotonin Signaling. Who could have guessed.https://t.co/eb8LecjKqhhttps://t.co/CXwXn1qYqk
Spending so much time trying to figure out what was wrong with my head. Turns out I was looking at the entirely wrong end.https://t.co/QQVtEKxgow
Fucking Chemosensors, How do they work?"Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing" [2010]https://t.co/bEHoGkfI0Q
THE ANSWER CAME SCREAMING OUT OF MY ASS:"into the colons of mice and waited for the enteroendocrine cells and their partners to light up. Those partners turned out to be to vagal neurons, the researchers report today in Science." BACK & FORTH, FOREVER!https://t.co/W03rocW8Gi
Did you know that the animal with the most amount of external taste buds is a fish?Their body is basically one giant tongue. I found it while researching the development of the vagal nerve / neural crest among chordates.https://t.co/3XKNnMhZIP
Why was I researching Neural Crests? Well, my fascination with dogs and domestication made this catch my eye: https://t.co/13pT7FCvIw
Then it came up again on @The_Lagrangian's feed, which I reshared within that context. https://t.co/PqNBIaVVpD
Then I started thinking about the behavioral syndromes of anxiety and dog butts... like one does.https://t.co/bWF5NYT5le
My fascination with genetics -> autism being associated with doggos was triggered by this:https://t.co/yl9IXdaHNz
And it mingled in my head with a funny theory I was playing with about social system.https://t.co/Siu6Fcsqd0
Specifically, I made a joke about human colonization via @hankgreen's fantastic video on the way human poop tunnels form ass first.https://t.co/Pd4wDpX2MJ
Which itself was the origin of this weird joke I made on behalf of @literalbanana's musings on politics.https://t.co/vSXYLlfJNu
As you can see, I referenced it here as well: https://t.co/gdA6OEBuM2
And all of that ties back to a concepts of the origin of eusociality as explored in wasps, (which are cousins to ants).https://t.co/X8vNYAbj25
And really is just an extension of me trying to explore what it means to be autistic and how neurochemistry plays a role in my particular etiology.https://t.co/TQKbVrrc35
Which I subsequently became obsessedhttps://t.co/OsqbOhcRrg
Now, there are tons of other influences in this space, all evident in my twitter feed. But that was the critical path of the idea.https://t.co/57Q7bDisFJ
Most of what you see in my feed (or more specifically, most of what people seem to RT) is a sort of sublimation of insight porn. Aspects of my exploration process. Weaving narratives about interesting things to remember better.In public. For future me.https://t.co/pxyRj0PwbE
Even my bad poetry, and the occasional essay, are all a result of trying to explore myself, and hone my meaning making skills.https://t.co/Ed8ur3T84M
Remember that time that I said I was losing weight and gaining muscle mass just sitting here on on my ass? I was specifically targeting bile-acid associated microbes as part of my diet change.https://t.co/ZX2qh9L277
Well, it happened again. A study came out explicitly confirming my model of adipose tissue and inflammation regulation.https://t.co/Rhs0yJgr5z
On a hunch I found from investigating the intersection of Crohn's disease and macrophages. https://t.co/YkHBIOSZeghttps://t.co/bHUStIsOMA
Eating real Allspice and Clove (as part of Genuine "Pumpkin Spice") could play a role in modulating your gut bacteria via action from terpenes. Happy Halloween!https://t.co/Kjjn1xJupJhttps://t.co/IXEmH5ug7a
Inflammation! 👻"Bile acids, initially discovered as lipid solubilizers, are now recognized as signaling molecules with an anti-inflammatory action."https://t.co/phZc19JXAU
I'm trying to convert fat into muscle by using diet to tweak signals my body uses to induce muscle destruction to counter aspects of autism. https://t.co/hLsxrXTMYPI'm slowly becoming an Übermensch, growing muscle via diet alone.https://t.co/vYU8cZyn9Qhttps://t.co/fTIEG1y0Kn
TL;DR: I am way weaker than I should be for my body size, and it is a common issue among many autistic types. I have not been exercising, but have increased my grip strength quite a bit (I'm using it as a metric). https://t.co/YzRG1WLKt1
Certain kinds of cancer linked to glucose metabolism changes in the gut, pancreas, leading to diabetic like insulin resistance.https://t.co/xkn0CnMeFOMentions Leukemia, and by induction perhaps also pancreatic cancer.https://t.co/J5eJ3a8NJT
@MimeticValue Black pepper has bunch of fun stuff in it. Apparently have types of terpenes are similar to that found in cannabis, cloves, and certain kinds of cinnamon. It and play a role in serotonin regulation. Terpenes are how plants communicate with bacteria...https://t.co/FJwRUTKBTd
A quick google search nets this gem:"The truth of the matter is cancer is caused by microbes. The microbes are inside of the cancer cells."You were so close! https://t.co/ILWwkCBl9k
A chemical in Allspice has been shown to play role in down-regulating prostate cancer proliferation. https://t.co/QF6J9VkW9Hand Allspice is one of a number of plants that inhibit α-amylase and useful for diabetics. https://t.co/CzVoHPWtd3Happy Halloween!https://t.co/D2rEadcN66
Note: Not all cancers are fueled by glucose. Some are fueled by Ketogenesis.Be sure you have your cancer genotyped so your doctor can know better what kind of mutation is fueling it. If your doctor has no idea what I'm talking about, get a better doctor.https://t.co/ryMIly2ZBU
Be-careful with spices.Nutmeg can kill you in teaspoons.https://t.co/epVLNs4dftAnd the spice 'Mace' (not the pepper spray), is from the same plant.https://t.co/tHRGFnA1a3
I basically don't exercise, and yet I was able to run the distance of a peewee football field (~300ft) and keep pace with the house's pupper (beagle). A year ago I couldn't do 50ft without lungs burning.How does one actually measure these things? Think pooch is out of shape.
Ah yes, our old friend H Pylori does neat things to BDNF associated with the gut brain axis.https://t.co/JVysAqJucN https://t.co/6fjgrtG2RC
I know someone with low iron; It fixed itself spontaneously, unrelated to menstruation. Docs had no idea why.I'm almost certain its an H Pylori infection.Now to convince them to get an H pylori test.Why are doctors so clueless?https://t.co/XdCOM2ys0Ehttps://t.co/O626KCPvX5
Sweet tooth.https://t.co/sHFMg7aww1https://t.co/J7i7CiaZ6f
Now, to encode sweet tooth effect into my memory palace.Dog butt theory of autism + sweet tooth = Toot Sweetshttps://t.co/lohto1Er0x
Ahh yes, toot sweets, made in the willy wonka chocolate factory wing exploring dog candy in "the inventing room".https://t.co/hhBFoa2wNv
Ahh perfect, I can tie all three of my thoughts together today.Mean ol' slugworth is trying to sell candy using probiotics.https://t.co/6If6OFdZi8Sugar... Its what probiotics crave.https://t.co/Wq3f2aE583https://t.co/ahyrlu00va
MOJO, a strong brand (in Australia)... is being bought by coca-cola.https://t.co/e6wbjnN2TT
I haven't gotten sick yet!https://t.co/TRNXrU35C0
Friendly reminder that if you are feeling sad this winter that you might be under the effects of low vitamin D. Vitamin D + Omega 3s + Tryptophan has been shown to be effective at boosting serotonin: https://t.co/e7eL2OoFnQhttps://t.co/zIZG2KvfaX https://t.co/flvSdnkD76
In addition, there is the possibility that those 3 nutrients play a role in helping to avoid non-alcoholic fatty liver disease thru action on the microbiome. https://t.co/6o4tfFSbgI
Randomized controlled trials have shown vitamin D supplementation improves symptoms of autism.https://t.co/trv0aleGMcand may help with schizophrenia https://t.co/ntpYZn2UtgTake care of yourself(s) https://t.co/F0cboDajyB
Vagal nerve stimulation directly affects appetite.https://t.co/kWP7MzGoKFhttps://t.co/hWSpjIe7mWhttps://t.co/v0vMDRvqNi (h/t reddit)Maybe there is a link?https://t.co/rmFby6LINA
Maybe there is a link?https://t.co/TbbFPDzaxe
What could that link be?https://t.co/3jBBb1lFyu
Nah, its not linked at all. It's culture and society. /shttps://t.co/V34zEGgbHN https://t.co/qT2AmLmriq
Updating my governor hypothesis to include cytochrome / liver as immune related. Ties oddness around early childhood gender/immune system together with the same timeframe as when type 1 sets in. Suggest type 2 more likely puberty?https://t.co/AiFqGwfq7Thttps://t.co/QDYR7tBgpr
Hypothesis: early in growth, pancreas sets up centrifugal governor-like system that mirrors and help simulates + respond to larger homeostatic systems in body.It develops like light organ in bobtail squid & Type 1 diabetes is when it fails to bootstrap.https://t.co/Zh9Dhb8YIx
Is this why children can't ever get enough sweet things? Neat.https://t.co/ZrhO3Y23r4 https://t.co/fWrGdyC5U2
A scent, a scent. Or lack thereof.https://t.co/J8kw32OKr2 https://t.co/I1arlbF6Sh
Lack thereofhttps://t.co/07tNPEPsgm
@literalbanana @Tipsycaek I suspect that our sense of smell is modulatable. I have gained mine back since changing my diet and microbiome to create more serotonin (and by proxy, mucus). I can smell things better than before. I basically had anosmia previously.
Why do we have taste sensors in our anus?https://t.co/oIs88WmuwG
Sweet tooth.https://t.co/SvzHuo3xft
Dysgeusia is fascinating. Why do taste sensors seem to show up in parts of the body that deal w/ chemical concentrations, microbial management, or have a high need to maintain homeostatic / immune responses?We have taste receptors in our brain, ovaries/testes, pancreas, & anus.
Is anyone researching this? I found a case report on Diabetes Type II manifesting with a taste change... [2014]https://t.co/4qIGIPoJma
Cytochrome enzyme causes taste changes when elevated. Cytochrome enymes elivated in both Diabetes."Increased expression of CYP2E1 mRNA in peripheral blood mononuclear cells was found in both types of diabetes mellitus." [2003]https://t.co/BDj5tDAFSs
A powerful model of disease? Or am I just bullshiting myself? Something smells funny.https://t.co/i8wOZrrX4D
Updating my governor hypothesis to include cytochrome / liver as immune related. Ties oddness around early childhood gender/immune system together with the same timeframe as when type 1 sets in. Suggest type 2 more likely puberty?https://t.co/AiFqGwfq7Thttps://t.co/QDYR7tBgpr
Being sick changes your sense of smell... and other people can smell you too?We are fucking ants... Grumpy ants who can smell when others are sick, and change foraging habits when ill. https://t.co/FNtYuTOQS8
Isoprene, you smell like a terpene when your insulin spikes.https://t.co/ltVc6qt1qVhttps://t.co/EJIpEpnIFK
" and it might be a hell of a lot more common than we originally thought."https://t.co/v80JAiINax
"But why would sick people smell differently in the first place? The key is that our bodies are constantly launching volatile substances into the air." (Like an ant.)https://t.co/Pmdy7Ksu9c https://t.co/OPMyyi6oWO
Question: I wonder if human's have a 'death scent' unrelated to the normal course of decay.Enahancement: who would be fucked out of their gord enough to actually research sniffing dead people so I could find out?I wonder if there is a mammalian proxy?https://t.co/i4MpASX6W2
Hmm. If humans can smell fear....https://t.co/leZ34oD8dN
And cows can smell fear...https://t.co/QnR4qbs49b
The herd can controlled by fear, and leans toward novelty seeking behavior. Also can smell fear in each other's piss. http://t.co/Bt3b3yJqtQ