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Something interesting tied to this is that many people in the last 50 years have been on some kind of SSRI that directly impacts the metabolism of caffine thru liver enzyme interactions.For some people this doesn't matter https://t.co/FHJ2EVdZPO https://t.co/haeWKxjrwl
The sleep -> sex relationship might be bidirectional.Having good sleep lets you have more sex, which can help improve your sleep. https://t.co/MLkrEudgrpI... keep track of this.https://t.co/gqztaP50oF
One of the reasons why I wanna track my erection and sexual arousal is because of weird ties between M.S. and immune function. https://t.co/NHINWvPFWjI noticed that my arousal levels vary fairly consistently with immune factors related to M.S. Symptoms.https://t.co/5QtowzwdQR
I'm in the middle of experimenting with alcohol's impact on sleep under a weird hunch. This month I am avoiding excessive amounts to see if I sleep better.Next month I plan to get captain Morgan.https://t.co/uVOhPGj8PL
I'm thinking if I can get extra butyrate in my gut at the right time of day, I may be able to enhance alcohol's impact on sleep.https://t.co/DDFEtFZ3e4
I've been experimenting lately to see if I can harbor acetate making microbes in my gut. Neutralizing small amounts of alcohol & turning it into acetate & eventually butryate should super-power my gut health. Butryate producers need lactate as well. https://t.co/cNUkQscgWg
That's right, I'm exploring coffee, alcohol, and tobacco... And using it for health reasons.https://t.co/S8hs5RWk18
@MineralChief Interestingly, one of the things that coffee can do is increase lactate. But in people who drink a lot, that effect goes away.It's important to consider your own body's regulation of lactic acid and aspects of tolerance when accounting for impacts here.https://t.co/yEobpRZ9pz
It's funny to me that I can see the days where my resting heart rate is lower -> the ones that I drink coffee in the morning and the right kind of alcohol a few hours before bed.What am I doing different? https://t.co/H0oHSqCHfb
My sleep score is litterally higher on those nights too, its funny. https://t.co/WpbQ23W5dn
Too much alcohol can be problematic. I limit myself to no more than a bottle of wine (750ml) or an equivalent amount of ABV. E.g. half of one of thsese: https://t.co/2nS6wYedsD
E.g. I can do the whole 1L Winterliebe Glühwein from Aldi's but it's also lower ABV and the spices help me sleep better. https://t.co/xeXOkHwL0M
An interesting correlation I found after the FMT I did fixed my nitric oxide signaling is that the erection turgidity and the impact of alcohol on my sleep seem to loosely correlate. If I drink so much that I can't get hard anymore, my sleep is bad. https://t.co/FVwanmUakd
But If I get that Balmer Peak...https://t.co/ZrY8tWrTsd
Your mileage may vary here. I may have a unique response to all of this stuff.https://t.co/lVTUAMsjKa
Like the coffee factor, the alcohol thing may also vary significantly with genetics (and gut health factors). https://t.co/RqyDxKP1Ps
There may be huge genetic underpinnings for how our bodies handle alcohol. https://t.co/E0MqI6vZlM
@Stew_Fraser @rickmorty1324 @Evolving_Moloch also a neat video"significantly: the percentage of teetotal monkey matches the percentage in the human population [...] This similarity between us shows that a liking for alcohol is determined mainly by our genes"https://t.co/KqUx5BofMN
When I drink, sometimes I have a spreadsheet up on my screen and use a stopwatch to time how long it is between shots. Been doing this kind of experiment since college (I was not a social drinker). Which means I have 20+ years of experience.https://t.co/VRGa6I5A6p
I don't actually recommend this unless you are intimately familar with your gut health and response to alcohol.I have the timing down so I can drink an entire bottle of 151 in a night and not black out, I also know my genes tied to alcohol tolerance https://t.co/XDg81rVXRO
I also can quickly figure out which wine or cider is full of sulfur because they make me quite ill the next day. I avoid those like the plague.https://t.co/b7vyrP4jKY
Caffeine's role as an adjunct for antidepressant is fascinating. We've seen it increase the 'swim test' effect of SSRIs.(a question: does this mean caffeine helps mice swim longer? no shit...)https://t.co/c1Us3BxBGS
But this effect of coffee interacting with drugs is somethign that everyone in america should be aware of. Given how much coffee we drink as a nation.Could your Dunkin Donut habit be a sign you're self-medicating for improperly dosed antidepressants?https://t.co/qQwEABeYxy
Serotonin Syndrome!"Excessive coffee intake triggers serotonin syndrome by promoting 5-hydroxytryptamine (serotonin) secretion. Patients with psychiatric diseases that necessitate treatment with SSRIs should be educated regarding caffeine consumption." https://t.co/VUKh8sN7Wn
Sorry. "Adjuvant" as in "Adjuvant Therapy"Not realizing caffeine messes with bog standard SSRI drugs like fluvoxamine is a blindspot in most of the west AFAICT.https://t.co/eRS8JfuHAJHuge implications.https://t.co/NaALIqNh1c https://t.co/Tm8yHzDBxo
@kkmaggiepie @trikomes You may like this study."Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19"https://t.co/T8lS28AhRoHighlight an interesting case below that may be also counteracting the increased caffeine load. https://t.co/cvazKEWEdx https://t.co/z0YfXbfqsA
This was particularly impactful on me. I have all sorts of weird mutations that make SSRIs last longer in my system, and get thru my blood-brain-barrier in much higher concentrations. https://t.co/WJgkLkY0la
I think a lot of the problems I was having with citalopram was due to coffee + liver mutations interacting.https://t.co/zbRSmTjJEk
Studies on these CYP* genes and how they impact drugs like citalopram & the liver have been dropping almost every year since I had issues with it. Here's one from 2021 exploring it in some detail. https://t.co/X6xKrEIHqp https://t.co/qbYSmsmEVo
Probably the worst drug to put someone on if they have high risk of NAFLD due to crohn's disease and gut health issues.The side effects were so bad... It's partly why I'm so interested in sexual health at this point.https://t.co/dh8JRc2D3a
America runs on dunkinâ„¢ and SSRIshttps://t.co/A6QVflSsj4And we wonder why we are so fucked.https://t.co/PIZGvgT4Qi
Or rather, why we can't fuck.I've had no problems with sexual wellness since fixing my gut.https://t.co/PWWQisj5ha
So we should be able to do a gene test for SSRI associated sexual dysfunctions and perhaps modulate gut microbiota to counter it."Chronic administration of selective serotonin reuptake inhibitors can be used 'off label' to treat premature ejaculation."https://t.co/p2wphvZAwt
But what do I know. I'm just some idiot autistic retard who likes shitposting about dog shit.https://t.co/MlwMauucx2
Please don't kill yourself. Please be careful with SSRIs.https://t.co/PpHKsxoeyv
Banned from modern society for wanting to die (for "community safety") and told to call 988.Motherfucker, when I was suicidal, it was because I couldn't handle talking on the phone with strangers to get help.And they all fucking suck. https://t.co/i0VhI9LoNw https://t.co/J4eG9QTW0X
Gotta get that Honk Mimimihttps://t.co/DQGwHpszN0
Having suffered with jet lag for most of my life due to non-24-hour disorder, this makes me laugh. Fast during the flight and drink a little alcohol to put the gut bacteria into a dormant state, then eat breakfast in the new timezone's AM. https://t.co/FMt51laiJy
Idk why I trust John McAfee's autism more than Bryan Johnson's.https://t.co/RYfJHaMfBF
Loss of bile production is one of the longer term side effects of drinking lots of alcohol. I wonder if that would work.Looks like he also avoided processed meats and had a low fat selection diet. That would avoid issues from poor bile function. https://t.co/ZJ6XYoU2WP