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Wish I was an investor because I would have shorted this stock when my GF's psych doctor prescribed Wellbutrin and she gained wait. I figured out it was interacting with her Ozempic to cause this. lmao. https://t.co/llkxwheG1x
It's triggering mast cell shifts identical to what we see in hibernation.https://t.co/pQcUuxWnXT
We're never going to learn, are we?https://t.co/YL6BNnQ8xJ
Endocrine Specialist Doctor is flummoxed by how a medication that directly impacts insulin and hormone balance causes weight gain in a diabetic type II patient when combined with other drugs.What the fuck is wrong with our medical system?https://t.co/dh2wMFpKZW
Naltrexone + Bupropion interact with this. bupropion is Wellbutrin. I wonder how many people are having adverse reactions because they are on antidepressants and GLP-1 RAs. https://t.co/8pPeDMtYW5
Naltrexone is acting on HPA-axis and it's role in weight gain / loss makes more sense if you look at this thru the lens of hibernation response. https://t.co/pCp7wQSH1d
Eating more, graining weight, then eating less? It's all opioid system that naltrexone acts on. In hibernating ground squirrels this is the a delta opioid peptide. https://t.co/fn9JTHETWoIMHO we're prob seeing effect varying genetics and/or gut bacteria. https://t.co/lvXgQFYheC
@Rahmeljackson Some coffees trigger the delta-opioid receptors more than others AFAICT, so it may be personalized depending on mutations that impact that process. https://t.co/VcyEOw3pRxMay also involve TRP receptors, which complicates further, but coffee is easy lever to experiment with.
This is all the same systems that shift when an animal enters hibernation. GLP-1 and interacting meds are modulating the immune system because this is all tied to how mammals respond to starvation. Not everyone is going to respond the same way. https://t.co/LYHLW86Aa4
Even the idea that GLP-1 is going to curb addiciton ends up falling into this pattern, with paradoxical effects https://t.co/48B8gbLDLESomething is making this tip from binge into torpor.https://t.co/iNVBR3kBvv
@AliceFromQueens Did you know that binge eating disorder is also correlated with alcoholism? It's absolutely fascinating.https://t.co/xyg02eoNYSBecause it suggests that what we are really seeing is the binge eating behaviors shortly before we see animals entering hibernation.
Naltrexone + Bupropion are interacting with Ozempic for the same reason Ozempic treats AUD.They're all pushing levers into the same reward system. https://t.co/t383cK2JYT
Gastroparesis is like when you have Crohn's disease and don't shit for a week.https://t.co/z0j1hC1pqm
I may have cracked how the body regulates GLP-1 and used it to cure my GF's type II diabetes.https://t.co/IF4XbFmeCv
@_Messier_33 @PaulSkallas @bradstradamus I cracked it haha. Cysteine pathways are directly tied to hibernation related hunger. When Cystine availably is high, so is fat digestion and cholesterol conversion function. When it drops, bears get hungry. It's a regulatory feedback loop.https://t.co/EOupYYxISA
One day maybe we'll have the data to back up what I'm doing. https://t.co/lASyJF6iex
@AliceFromQueens if we can figure out what Ozempic is doing that acts on alcoholism we may be able to treat it in a more targeted way, and avoid GLP-1 messing with the TRP receptors that control smooth muscle contractions in the intestine. https://t.co/Aukvppcb30
Is mTOR shifting acting as the metabolic trigger for the change into form hunger to torpor? https://t.co/XI18EehlYp