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I fingered that gene a while back while exploring connections between liver function and cholesterol that may have been impacting my M.S.I suspected my gut was making alcohol due to high rates of NAFLD among those with crohn's disease. https://t.co/VWrDYUdFDT https://t.co/DP3wIrFcNv
That PCSK9 gene is a major player in autoimmune diseases. They are playing with fire if they are mutating that gene. https://t.co/uYcthabrAb
This is also on the same pathway that makes excessive alcohol cause cholesterol and heart health problems.it may Litterally be that you can treat PCSK9 mutations with gut bacteria via gut/liver axis. No gene editing required.https://t.co/LSMrWg1eQx
Remember that time I got a gene test so I could figure out if it was safe to drink red wine for 3 days straight as a gut cleanse, fasted, and it cured my treatment resistant major depressions? Me either.anyway, you can see that gene in your 23andMe https://t.co/rRUW7LAs93
My GF is getting off statins now. My own cholesterol has never been better.The doctors are modeling this space wrong.https://t.co/74xe4Ey0ep
@J_Killa_ @ResilientDad @TheRootCauseCo My cholesterol went from broken to perfect after realizing I could eat eggs and cheese to fix my family's genetic predisposition to high cholesterol. Did exactly the opposite of what the doctor told me to do.I've read books on statins https://t.co/CQxGoSeaJy
Drug didn't work, lets try a gene edit instead. Measure outcomes not interms of QALY or overall death.. but by lowering cholesterol.https://t.co/FWC6RTPtp2
"When a measure becomes a target, it ceases to be a good measure"https://t.co/qApxX7xFYy
A useful exploration on the topic of Goodhart's law"The dynamics highlighted are hopefully useful to explain many situations of interest in policy design, in machine learning, and in specific questions about AI alignment."https://t.co/Ka60eX7ra6 https://t.co/cymqBtsDxm
Something something definition of insanity."We tried a solution, it did not help the patient, so now we will edit their genes to do the same solution that the medication did, which didnt help." — Paraphrased by @AlexJournal2019 https://t.co/6g0R5ir0Oc https://t.co/R8muozR1iG
