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🧵 Thread (13 tweets)

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UltimApe@ultimape• almost 2 years ago

Most of the people who have astigmatism are 70+What if there are a lot of underdiagnosed autistic people because we attribute their dementia is actually late-onset autism.https://t.co/2w3vm6Wu4j https://t.co/jVOJuQ3F7f

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UltimApe@ultimape• about 2 years ago

@95thoughts @blankxuQ Autism is what happens when the mechanism that impact neurogenesis failure in Alzheimer's happens in utero and early childhood. Quite broadly. https://t.co/9RSTlpldix

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

Do you know the cause of autism?Do you know how many people are misdiagnosed, undiagnosed, or not impaired enough to be diagnosed?How certain are you about your statistics?https://t.co/2w3vm6Wu4j

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UltimApe@ultimape• about 2 years ago

@95thoughts @blankxuQ Autism is what happens when the mechanism that impact neurogenesis failure in Alzheimer's happens in utero and early childhood. Quite broadly. https://t.co/9RSTlpldix

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

Gotta go fast."To identify the genetic etiology of an autosomal dominant constellation of pediatric cortical cataract, asymmetric myopia with astigmatism, familial exudative vitreoretinopathy, and primary open-angle glaucoma phenotypes"https://t.co/SzpAUCizhu https://t.co/80UPS9qdR3

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

Call be a seer cuz I see things the world is blind to> "Sonic hedgehog (Shh) is a morphogen that is crucial for normal development of a variety of organ systems, including the brain and spinal cord, the eye, craniofacial structures, and the limbs."https://t.co/e7xxKSLYeA

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

Oh, tell me more about how you know what causes astigmatism my dude. Everyone knows astigmatism isn't correlated with a trait that is heavily associated wit autism /s(this is speaking to the community note)https://t.co/YzdXVukIPx https://t.co/Ktjfy6GSYE

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

Have you tried to connect brain development to eye diseases by way of DNA repair pathways tied to differentially expressed microglia epigenetics, anon?https://t.co/ZEF1FFxKlo

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UltimApe@ultimape• over 2 years ago

Yell at scientists about how their 'genetic' myopia can be cured by impacting DNA repair via chromatin and copper related methylation pathways to improve collagen metabolism.https://t.co/wW2JIQ73UC

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

have you considered we don't know the cause of many of these problems? If we did, we might have cures."Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?" [2021]https://t.co/U4qw2KgpPDhttps://t.co/kk6rOSFMsI

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UltimApe@ultimape• almost 2 years ago

haha. Eat shit. > Rats that had microbiome transplants from Alzheimer's patients showed impaired memory behaviors, particularly those that rely on a process called adult hippocampal neurogenesis.https://t.co/eKFX080oaCWriting about this on bluesky:https://t.co/owRkAbzX5S

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

"Establishing proof of a link between autism and neurodegeneration could take decades, but in the meantime, the work could offer another benefit: understanding what autism looks like in the elderly and how best to support them." [2021]https://t.co/jczk96DxwE

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

"The prevalence of dementia was lowest in individuals with no ASD and no intellectual disability (0.97%), and highest in individuals who only had an intellectual disability (7.1%)."https://t.co/5mRb8W2zFf

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

"Seventy-seven percent of subjects with intellectual disability, and 42.4% of controls, had ocular findings. The children with intellectual disability had significantly more nystagmus, strabismus, astigmatism, and hypermetropia than controls."https://t.co/LWLFmouODe

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

"these studies indicate that refractive errors are more common in ASD [...] This agrees with literature on other childhood genetic disorders, as higher prevalences of refractive errors and astigmatism have been reported" [2018]https://t.co/EdZQ81A36E

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

What if this is a valid signal of developmental shifts that impacts brain and eye?But everyone shits on it because everyone knows there is no such thing as late-stage autism, and gestational Alzheimer's isn't a thing.Your models of the world blind you.https://t.co/V2SrnDQt0h

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UltimApe@ultimape• about 5 years ago

Autism? Do you mean childhood Alzheimer's Disease?

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UltimApe@ultimape• almost 2 years ago
Replying to @ultimape

Ported this to bluessky.https://t.co/hwjPIkfkwF

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