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Penis rejuvenation baseline measurements: 1. Nighttime erection: Mean: 2 hr, 12 min (age 49) Goal 3 hr, 30 min (age 18) 2. Questionnaires EHS: 4/4 IIEF: 25/25 Come along... + details soon on getting nighttime device + score ur self EHS & IIEF + will share rejuv protocol https://t.co/wW6l1CwW4q
@bryan_johnson Are you taking any pharma to artificially boost nitric oxide–cGMP pathway, or is this being used to track natural NO signaling function?I've had good luck turkey hearts for l-arginine, tho normally it's garlic and fermented beats.
@bryan_johnson I've been using garlic to treat problems in my brain & gut by leveraging it's action on ACE. Its fascinating how much brain blood flow and penis turgidity correlate.Nighttime thing is good proxy for toxin clearance from the brain via (g)lymphatic system.https://t.co/7z5R3oCWEF
@bryan_johnson Treating my gut with stuff that enhances nighttime erections seemed to help a ton for my Crohn's symptoms. Many of the herbal stuff that aids in kidney stones seems to improve blood flow via smooth muscle regulation. https://t.co/X0jIJCVg0p
@bryan_johnson Biggest shift in urethra-corpora cavernosa reflex was in fixing anandamide/endocananbinoid function via gut health. It seems not being able to absorb fatty acids to produce them was making my dick not sensitive to NO. https://t.co/FooFxOLl45
@bryan_johnson I figured out this is also like at the core of impotence among diabetics. So testing your endocannabinoid function would be a good way to enhance this.https://t.co/MECS3JAGaL
@bryan_johnson it is intimately tied to aging as well."Poor nutrition status and low nutrient intakes observed with many elderly are reasons to examine the role of dietary PUFA actions on the [endocannabinoid system] to improve health." https://t.co/uJnzGpQ870
@bryan_johnson Fun fact: this is also directly associated with female orgasm problems (clit sensitivity is the same sort of bloodflow problem), and directly on a pathway involved with PCOS & female fertility / menstrual pain.I wrote about this on bluesky a bit: https://t.co/rsCgHUJ7VV
@bryan_johnson Highly recommend exploring penis stuff in more depth from the perspective of woman's health if you can, its quite a rabbit hole.https://t.co/HpMRJN2rxO
GF no longer has PCOSGF no longer has Type II diabetesGF no longer has chronic pain and inflammation that impairs her movement.She's getting strongerShe's starting to get feeling back in her fingers and heal her dry cracked skin.Fix. your. gut.https://t.co/kiTZceIMRF
@bryan_johnson The only thing I found to measure this stuff in women is sonography. Tho it supposedly correlates with REM sleep like in men, there isn't as much of a sign of this like we see in men to test if there is a similar diabetic complication.https://t.co/5KLHmWUTo3
@bryan_johnson Could help a lot of people if we had better dick/clit measuring devices.https://t.co/R4avbeOpIp
I found my thread on dicks and diabetes.Viagra works afaict because it fixes blood pressure weirdness associated with smooth muscle tissue and vascular contraction. IIRC it operates on nitric oxide associated pathways. https://t.co/B3F5763hJdhttps://t.co/X0jIJCVg0p
@bryan_johnson Congratulations, you have discovered smooth muscle tissue's impact on penis turgidity via acetylcholine."botulinum toxin directly inhibits smooth muscle contractility as evidenced by the decreased contractile response to ACh."https://t.co/jcf7kCXuduhttps://t.co/jHmDU15p6h
I injected Botox into my penis. It increases penis length by 1 cm. It also improves: + erection hardness + peak systolic velocity + end diastolic velocity + sexual health satisfaction Therapy was built on a double-blind randomized placebo-controlled prospective comparative study conducted involving 70 patients with ED refractory to PDE5Is. My penile function is optimal (EHS 4/4 and IIEF 25/25). We are testing whether an intervention that showed positive outcomes with ED will enhance performance. This therapy is normally reserved for those that do not respond to PDE5is and shockwave. However there is some theoretical basis that it may enhance the tissue rejuvenation effects of shockwave therapy, otherwise by itself it has unclear long term safety or efficacy. Process: + A tourniquet was applied at the base of the penis, the treatment dose (100 units of BoNT-A in 2 ml of saline) was distributed along 4 points, right and left distal and proximal shaft using a 23G insulin syringe. + The solution was injected into 4 different injection sites 1 inch proximal to corona and 1 inch distal to pubo-penile junction at right and left cavernosa, respectively. Following injection, a fine massage was applied to the injection sites for 5 min and the band was removed after 20 min.
@bryan_johnson Spending time figuring out what makes my gut's smooth muscle tissue contract and expand is why I tracked my penis size during my FMT.Do you think the length is due to the sphincter contracting harder, or relaxation in the cavernosum? https://t.co/HXfhAv1CuT
@bigmastertroll @frogstoyevsky @meta_nomad I get mixed findings on if it's a vasodilator or a constrictor. I think it may be acting in concert with actylecholine.I found a clinical trial where they stuck it up people's butts to see what happened. Small sample size, but it was a pilot.https://t.co/U0LNvsyL5P
@bryan_johnson The acetylcholine receptors is why Brazilian Wandering Spider toxin give people erections for hours before they die. https://t.co/8btHBAivut
@bryan_johnson FYI, I was always transparent about taking [Dog Shit]. When I first started talking about my [Dog Shit] protocol, I explicitly mentioned I was taking [Dog Shit] (YouTube: “Dogshit N-of-1 (Taste Test?!), July 2022 [1]).[1] https://t.co/xTLxeDi5kThttps://t.co/BlmX2McJqw
In my video about smelling and tasting the dog shit pill, I also talk about erection turgidity aspects.I woke up this morning feeling shame about it and thought maybe I should edit it out. But the topic is directly relevant to my thinking on this space.Should I leave it in?