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🧵 Thread (21 tweets)

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UltimApe@ultimape• about 2 years ago

How would you know if you're a chimera if no one ever bothered to look? https://t.co/UKgXN44d95

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UltimApe@ultimape• about 4 years ago

Talking with my mom about the possibility of being a chimera and how we couldn't know easily. And she goes on to tell me how twins run in her side of the family. Fuckhttps://t.co/xpyGqLSd8t

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

Its a really fascinating thing to explore if you're interested in gestational factors that might drive autism.https://t.co/4XtN1aBoFV

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UltimApe@ultimape• over 4 years ago

Did you know that just having twins nets a higher rate of autism due to inter-utero competition for resources and the resulting impact on immune function in the parent.https://t.co/w6a1DOoRs0

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

If twinning is a something that can be genetically predisposed for. Then that suggests that autism could be partly driven by twin genetics. But that raises the question... HOW?Maybe it's the vanishing twin phenomena.https://t.co/M36Rs51OEU

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UltimApe@ultimape• over 3 years ago

@MilitantHobo @dpovey1 @S_Gallienne @Aella_Girl The Vanishin Twin phenomena https://t.co/a0u7zfstxS also seems to not care if the twins are identical or not.

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

IQ is known to be weird in autism. What if interwomb competition for resources lead to fusion of twins because there wasn't enough nutrients?That would explain higher rates of 'mental retardation'. Twinning could make it easier to gestate under scarcity.https://t.co/f6zl5pWx7T

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UltimApe@ultimape• over 3 years ago

@MilitantHobo @dpovey1 @S_Gallienne @Aella_Girl With so much of IQ being driven by early development trajectory important for brain development, it strikes me that these aren't good models for exploring cognitive ability. I haven't found a good explanation for why we think twins ought to. https://t.co/J5G2a3WNVM

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

A partial form of this could also explain why even when twinning is successful, there is often a bias toward one twin having more sever symptoms.https://t.co/7CIcLu1r7J

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UltimApe@ultimape• over 3 years ago

@MilitantHobo @dpovey1 @S_Gallienne @Aella_Girl Older studies on autism in twins didn't account for variation in severity. https://t.co/69833wPIIa

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

Chimerism may be way more common than we realize, but no one bothers to check.https://t.co/O0r35McfGr

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UltimApe@ultimape• over 3 years ago

@healingfear @Alzubair007 @BretWeinstein I'm trying to figure out if I'm a chimera. Apparently this is common in Autism because of weird immune problems that show up in twinning (the evil twin is about a Fetus who's body was absorbed by the other).Not avail on most gene tests sadly.https://t.co/DxYL2QdrOY

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

In most cases, chimerism isn't visible. It takes weird health issues and notable skin distortions to get doctors to even bother to look for it.https://t.co/5DYMlge3dL

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UltimApe@ultimape• about 4 years ago

I don't know how to tell if I'm a chimera.https://t.co/MHiWLr4wd7

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

There are often a lot of weird problems that can stem from having twins. If the gestation isn't healthy (twins are quite stressful on the body), then it can lead to strange gestational autoimmune diseases manifesting.https://t.co/QDjHfrdHZz

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UltimApe@ultimape• over 3 years ago

@The_Lagrangian Someone found what gut bacteria differ in twins where one twin has allergies the other doesn't.https://t.co/IHvPNWt1r0Next step seems to be to isolate them and experiment.

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

THe most obvious way to tell there may be a chimera phenomena is by Blaschko’s lines. However That isn't the only way that chimerism manifests. You can get double-faced kinds just like the chimera cats. Or just the lower body. https://t.co/kvLAoOQL7I https://t.co/GKqZjtT2NI

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

My GF has some weird blushing phenomena that I haven't been able to trace to anything. The only thing I can come up with is that it matches one of those chimera patterns.

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

I found case reports of people with "Lichen Planus" (an autoimmune skin disease) that manifests along Lines of Blaschko. https://t.co/ZcgGghOEoc

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

So it occurred to me, maybe half her body has an autoimmune disease that impacts her mast cell reactions? That's a bit of a stretch from the odd blushing responses she gets, but could explain a lot of her problems.

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

A genetic chimera where half the body has TRP receptors that bias one way, and another half that has calcium deposition proteins that cause skin issues? Not impossible.How this impacts blood flow would explain her healthy feet skin, but diabetic hands.

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

This woudln't show up on 23andMe at all, and I would have no way to tell what part of her body I did genotype if all her blood comes from one half of the twin.

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

Weirder shit has happened."But what makes this man’s case unusual is that some of the cells he obtained from his twin were apparently germline cells, which develop into eggs or sperm"https://t.co/vY2VhgGbkM

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

Anyway, here's a @zefrank video that talks about sharks literally eating each other in the womb.https://t.co/gz51KqH3Kz

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

I think my GF has E type, and I have F type.https://t.co/YgNk24Phfq

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UltimApe@ultimape• about 2 years ago

THe most obvious way to tell there may be a chimera phenomena is by Blaschko’s lines. However That isn't the only way that chimerism manifests. You can get double-faced kinds just like the chimera cats. Or just the lower body. https://t.co/kvLAoOQL7I https://t.co/GKqZjtT2NI

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

Though I could also be C type and just coincidentally happen to not have different colored eye genes. This would explain weird bilaterality in my hearing and vision that seems more extreme than wat I'd expect given lateral development weirdness in autism.

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

It also catches one one-side numbness thing I was getting in my leg.It might not be chimerism, but the left-right weirdness in leg development tied to may explain why some autoimmune stuff like M.S. and Palsy impact one side more than another.

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

I'm thinking this patchworks phenomena that shows up in chimerism would imply there are other forms of "Blaschko's lines" that arise simply due to changes in how early cellular differentia manifest in body plan. So it could be chimerism, or just early developmental quirks.

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UltimApe@ultimape• about 2 years ago
Replying to @ultimape

If it is not chimerism, I'm coining this as "psudochimerism" where gestational quirks change the same genetics to express differently along the same dividing lines.

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