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"Oxidative cleavage of the side chain of cholesterol generates pregnenolone, the common precursor to all other steroid hormones."https://t.co/Hzge6ZrJuaWeird. https://t.co/RykhcWbhIK
@raypeatfan I focused on fixing cholesterol function as M.S. seems to be problems with myelin (which is made from that). I believe the excess estrogen we see is a response to poor lipid digestion.My modeling is based on ideas about ground squirrels becoming estrogenic during hibernation.
Have you tried not being in a constant energy deficit, anon? https://t.co/0016E1rM6L
Thyroid-Gut Axis again and again until the idea sticks in the zeitgeist.https://t.co/8ayHu3djD2
Thyroid Gut Hypothalamus pituitary adrenal gonadal axis & it's role in hibernation via mitochondrial health. "data indicate that in the hyperthyroid state, increased feeding is associated with thyroid hormone-induced up-regulation of mTOR signalling." https://t.co/8KlePpqw9v
"Metabolic changes in patients with hyperthyroidism mainly result from increased insulin resistance, because excess thyroid hormone increases endogenous glucose production and insulin requirements and reduces hepatic insulin sensitivity" https://t.co/5jns068XeN
We fetish the genes and ignore that wild bears and captive bears can get diabetes when they eat human garbage."Bears don’t get diabetes. Understanding why could some day revolutionize treating the disease in humans" https://t.co/FpL37SapMH
We are down to 8 potential genes. But we have a long way to go until figuring out how the gut shifts tied to thyroid function changes their epigenetic expression.https://t.co/eBYUvGAxvd
Fix the fucky-wucky thyroid by fucking with the gut's impacts on mTOR ala lipid function via bile and liver.Its all a big regulatory loop that trips into states of torpor and we're all tripping.https://t.co/GhrD3T0xkS