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🧵 Thread (94 tweets)
" Functional metagenomic analysis suggests that B. animalis mediates the anti-influenza effect via several specific metabolic molecules. In vivo tests confirm valine and coenzyme A produce an anti-influenza effect." [APR 2020]https://t.co/HSOuAEN03F https://t.co/UJH6VAoFmR
"Coenzyme A is naturally synthesized from pantothenate (vitamin B5), which is found in food such as meat, vegetables, cereal grains, legumes, eggs, and milk.[10] In humans and most living organisms, pantothenate is an essential vitamin" https://t.co/FGDsYUQgme
"Pantothenic acid status is not routinely measured in healthy people. [...] urinary concentrations are the most reliable indicators because of their close relationship with dietary intake" https://t.co/qbM6fchy3k
"Deficiency can cause neurological problems and a burning sensation in the feet (both of which are also common in diabetics)[...] What doctors recommend: 150mg"https://t.co/WvKwpVjopD
inb4 microbiome mediate effect of this:"In some open studies, pantethine seems to lower levels of cholesterol and triglycerides in people with diabetes. But not all studies agree. Larger studies are needed to see whether pantethine has any real benefit." https://t.co/SNL6nqDz6Q
"Pantethine is a dimeric form of pantetheine, which is produced from pantothenic acid by the addition of cysteamine" https://t.co/7EFuk5qgoV
B5 + cystine derived Pantethine, a chemical that is a sister to Coenzyme A, maybe an alternative to statin therapy.https://t.co/p2IaKuSbtL
So what I learned possiby. That cholesterol function problems and heightened cold & flu issues may be downstream of a chemical that may be missing in diabetics, possibly partly mediated by gut bacteria associated transformations of B5 w/ Cysteine.
What the fuck is Bifidobacterium animalis doing to treat cancer via jiaogulan (Gynostemma pentaphyllum)? https://t.co/mlAemf6krP
Viral gastroenteritis?!"These results suggest that L. acidophilus and B. animalis subsp. lactis may exert a potent anti-inflammatory effect through modulating TLR2-mediated NF-κB and MAPK signaling pathways in inflammatory [intestinal epithelial cells]." https://t.co/tAUSeMgVAO
Review of evidence:"The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials" [2018] https://t.co/PyJkn8MaVu
Review refers to L reueri for helping with gut inflammation. https://t.co/hADtw3IJmB
also cites a paper"Consumption of dairy yogurt containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and heat-treated Lactobacillus plantarum improves immune function including natural killer cell activity." https://t.co/uE6aT5ml8yAnimalis! https://t.co/IHsDnViFLr
*Checks botttle*These are in my kefir. I drink this to help keep Crohn's at bay. Diabetic type II GF does too, it helps her control blood sugar.https://t.co/EGpnhLxymvhttps://t.co/3z8txl8rU5 https://t.co/W46nGLWyaM
So I need to confirm that Lactobacillus paracasei ssp. paracasei acts like L. Casei, and if Bifidobacterium animalis ssp. lactis does the same thing as the one studied as protective against influenza in mice, or acts like longum/breve
"Bifidobacterium animalis and Bifidobacterium lactis were previously described as two distinct species. Presently, both are considered B. animalis with the subspecies Bifidobacterium animalis subsp. animalis and Bifidobacterium animalis subsp. lactis." https://t.co/PrUyJ8bLfe
Does anyone know if H5N1 is also killing via ACE pathways in lungs/gut? If it is, then curing my crohn's disease may have made me generally resistant to flu."Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury"https://t.co/KY7juwvEAx
Kefir is great, The L Reuteri in mine theoretically can protect my intestinal cell walls from dying.https://t.co/9BHD5NZmvU
Kefir is great, With the right strains in play it can promote lipid digestion via bile acid secretion stimulation.https://t.co/OttVxwt377
Kefir is great, if you believe that the dairy type matters because of caseins and that playing a role in infection then the right strain might help mitigate that.https://t.co/eBEuAvGQDn
@keller_via @embryosophy @DesidErratum A quick look suggests Lactobacillus paracasei and Lactobacillus helveticus might be doing something interesting. And that the goat milk helping is the casin type!The "L. casei" sub species all seem to do thing to dairy. https://t.co/XAT10ecagc
Kefir is great, certain strains in kefir can help the body maintain tight junctions from being dysrupted from other pathogens. This means it can may possibly reduce the impact of certain flu associated damage.https://t.co/IBHpbrxw0S
@Vorvayne "Lactobacillus rhamnosus GG and Lactobacillus casei DN-114-001 protected epithelial barrier function against Escherichia coli-induced redistribution of the tight-junction proteins [22, 23]."https://t.co/RbsE1y5hf5Kombucha and kefir are nifty things.
"In this review, we discuss the pathophysiologic mechanisms leading to disruption of [apical junctional complexes] and the potential ensuing ramifications." [FEB 2021]https://t.co/V72xgjFTqh https://t.co/uM6izo6MbH
Older people with poor gut health (mirroring antibiotics) end up getting bad response to flu vaccine due to gut bacteria depletion it seems.https://t.co/sp8Ys0H3CVhttps://t.co/kzJ6r66LD7 https://t.co/TbC4bZQXWz
1) Flu vaccine effectiveness mediated by gut bacteria.https://t.co/sp8Ys0psel2) Maternal gut regulate RSV infection risk in children via bacterial strain Lactobacillus johnsonii.https://t.co/Nfh8Ptlnja3) Gut Bacteria disrupted due to covid.https://t.co/rijnuu9AaH4) Ergo: https://t.co/7RsTVWtgTZ
Secondary bile acid => "lithocholic acid" drops 1000x?"molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms" [2014] https://t.co/a95aOCpFIX
Using chatGPT to check terms I am unsure about. https://t.co/YishKudRBJ
Asked chatGPT to give me progressively more complex answers about secondary bile acids. Just double checking that I understand what this implies.My hunch here is that secondary bile acids dropping after antibiotics means something weird going on here. https://t.co/hiQ6U2Jsbk
Gut makes many secondary bile acids? Confirmed. chat wasn't pulling my leg."The Role of the Gut Microbiota in Bile Acid Metabolism" [2017]https://t.co/KZMRUqLIrO https://t.co/t6gYzigiPt
Here's the paper that found associations between secondary bile acids and antibiotics while testing vaccine + gut . https://t.co/PfxUfOTUPi
Here's a paper from April 2020 discussing how the loss of secondary bile acids seems to be a driver behind gut-dysbiosis associated inflammation. Further they found restoring it can treat ulcerative-colitis, a form of IBD.https://t.co/wLffDIU60d
This gut dysbiosis effect we see in IBD is likely why I have had poor response to vaccines all my life FYI. I just made the connection here more explicit. https://t.co/Wve07JjBtT
Of course I knew all this stuff about bile acids and immunity before I wrote this thread.https://t.co/8QA1vZbPGg
Fixing these secondary bile acid pathways was one of the core facets for why I believed that eating dog feces pills as a cross species FMT would treat my Crohn's disease.https://t.co/UxL4TW9FE6
@garyvee My right hook? I ate dog feces in a pill for 30 days. I got younger as a result. Have a blood test showing it.My model of thinking aligns w/ findings from gut microbiome studies in people who live 100+ and it's impact on bile.Aging like a fine wine :)https://t.co/UK0bnWxmOg
We have a myopia around anti-aging and fetishizes plant based fibers, and then ignore the underlying bile function that the metabolites elicit. https://t.co/m0hFNspYCc
@Grimhood These studies keep coming out linking gut bacteria to aging. https://t.co/sEtbKTE4Hz but every time they ignore that fiber to a gut bacterium, is a source of nitrogen. They ignore protein's role in aiding gut diversity and bile function acidity.Its madness.
I happened to be looking at the bile more directly cuz I wanted to know what bear farts smell like.https://t.co/hSMlLxtnLk
Why would bile have anything to do with viral resistance?https://t.co/SKfHEXTxml
Dog shit in a pill taste like bile by the way.https://t.co/OMA7c6OkC4
We're going to see the synthetic stuff on the market soon enough. But probably not for covid.https://t.co/GbQr3xYIrP
I like learning about bear farts.https://t.co/PqqslHoPzT
Synthetic bile might mean we don't have to kill the bears to get it. Bears are fren, not medicine.https://t.co/MpDrOlpXXo
@Tazzie1986 @PatriciaJean00 @angryangryalice @BBCIncorporated @Catnixidy @blessedbyV @polo_man404 Some good news is that because of interest in bile for fighting covid, there are now promising synthetic bear bile hitting the market. Hopefully the barbaric practice becomes a thing of the past.
Theoretically, as most of the impacts of bear bile is via secondary bile acids, we may see that people who take NAC and SAC and various other bile acid supplements end up not getting the results they want without also improving their gut health.https://t.co/eQdwb81t8D
@TweetAxxount1 @bowtiedkobra This is why stuff like NAC have a spread of outcomes. https://t.co/UCpjmvDtlrSo we get people that just take NAC every day, mirroring how in the history we would kill bears to harvest bear bile & use that as a supplement. Just dumping it in without thinking about how it acts.
One of those ancient recipes tested that had an impact against MRSA was a bile acid fermentation method. It was likely making secondary bile acids externally.Fermented bile! I bet it smells like death.https://t.co/per4Ybb4yH
"instructs the reader to crush garlic and a second Allium species (whose translation into modern English is ambiguous), combine these with wine and oxgall (bovine bile), and leave the mixture to stand in a brass or bronze vessel for 9 days and nights."https://t.co/m9aghNFfFr https://t.co/guT0cpIRQh
Imagine someone trying to write a story about how I have figured out making myself resistant to flu because of a weird anime about lesbian bears.https://t.co/zuRN8ZaITfhttps://t.co/gYf1x3bJnz
Fix your shirikodama.https://t.co/Ty3aXLqyMK
@strnglft Lots of demons are making themselves known.The kappa demon "are often accused of assaulting humans in water and removing a mythical organ called the shirikodama from their victim's anus."https://t.co/Rvh50OaW4OWhat is a microbiome anyway?https://t.co/pHAUmZ8Wds
"Investigating what can modulate this interferon signaling and affect how well our body fights back in the earliest stages of a flu infection, the researchers discovered an antibiotic treatment of just two to four weeks directly inhibits this process."https://t.co/kQbJ5w4kwm
If H5N1 becomes the net big pandemic, you're going to wanna have a functional gut health, fren.https://t.co/TcqFMwXcRC
"In the present article, we discuss current insights into the regulation of viral infection by the commensal microbiota. We also draw attention to the disruption of microbiota homeostasis by several viruses." [2019] https://t.co/NUOVEaif7w https://t.co/B7DdLJumOH
CDC says not to worry about H5N1https://t.co/Zo6lztNm1G
But my threads on flu is about the current strain going around. This flu season is one of the worst we've had in a while. https://t.co/5oW7hQwPwh
I am now interested in sanitization. On inanimate surfaces, there is possibly a divergence between infectious vs PCR viable. This says it takes about two weeks until various H1N1 strains becomes uninfectious, despite showing positive with PCR for seven. https://t.co/d1DIb2hRSg
"ethanol-based disinfectants might not be as useful as previously thought has to do with the mucus that surrounds droplets of the influenza A virus. The mucus acts as a hydrogel and protects the virus from the ethanol, the investigators reported." https://t.co/tFi2G3alLV
I hope we see studies like this on flu vaccines. Knowing what gut bacteria and metabolites are specifically driving impaired immune responses would be quite useful.https://t.co/GKE51eWuG6
Thinking about Flu again, and how gut health impacts this space.Did you know homocysteine levels correlate with outcomes from flu, and as such improving cystine may help.https://t.co/PGyR6J22yahttps://t.co/k0AYqM7Q00 https://t.co/dpK5qN9nym
What if a healthy gut is causing resistance to secondary bacterial infections?"If confirmed in humans, fighting serious respiratory infections could become as simple as supplementing one’s diet with the requisite gut flora." [JAN 2024]https://t.co/cXZuacGC77
anti-pneumonia could help fight a #H5N1BadSoonScenario"pneumonia was caused when bacteria that normally inhabit the nose and throat invaded the lungs along a pathway created when the virus destroyed the cells that line the bronchial tubes and lungs"https://t.co/IwacR1NieP
There may be profound changes we could get if we focused on improving innate and adaptive immunity via gut health.https://t.co/kY66intnqs
@ign76 @muellship1 @my_ueg @geteccu @aeg @NTNUikom I focused on fixing my bile health & liver function via gut bacteria. The more I did this, the less Crohn's flairs I had. Then I did the FMT and it VANISHED."Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells"https://t.co/JhwTWU7rFe https://t.co/aU7DwgHaAS
"robust evidence to support a role for [bile acids activated receptors] in tuning [...] innate immunity, suggesting a potential role [...] treatment of clinical disorders contributed by metabolic and immune dysfunctions" [AUG 2018] https://t.co/jQ186Huyl4https://t.co/0ol3hc31pR
@imrane @CaloriesProper All the pharmaceutical solutions to treat crohn's fixes the inflammation, but tit doesn't cure the underlying problem. Seems to be roughly same thing we see in related gut health factors tied to aging. Improving lipid function and tertiary bile acids. https://t.co/HTC32ImPUo
One of the most annoying things I see happening right now is that @Lifeway is being replaced with inferior store brands that don't have the same species in them. I'm looking at you @Hannaford and now @AldiUSA.This is bullshit. Your kefir is now garbage.https://t.co/YZsPDqxfiq
Can't wait to watch the FDA slow everything down if Flu tips into pandemic mode.One of the most annoying things I saw early during the pandemic was at-home flu test kits were pulled off the market. I wonder if that was FDA's doing too.https://t.co/5Sqh8gBdAy
I will have to figure out why they were missing when I went to order them.https://t.co/rLCwFKC0MV
@I_Am_JohnCullen @ScottAdamsSays @DoomMetalMachi1 @JFGariepy @WHO One of the most annoying things I saw happening during the early pandemic is that the at-home flu test kits were taken off the market. I was going to buy a bunch of kits. https://t.co/3G4w6kO6uG
Does anyone else remember back in February 2020 when Fauci said don't wear masks and the risk of covid was minisqule?https://t.co/1GoZ8rwhjBhttps://t.co/IpNUKqxrlN
it's really funny to me that he was downplaying the risk of coronavirus hitting the U.S. literally while I was busy packing up to visit my immune compromised mother.https://t.co/UCUeFdwWb9
Oh, and if you're hoping for a universal flu vaccine, don't hold your breath.https://t.co/k6xl1sP1q4
If any one is curious. I have been continuing my thread on flu over on bluesky https://t.co/gnQ6R1eOPn
I need a place to live where I can raise my own cattle.https://t.co/Yfl2VUoNGT
"preparations for the next pandemic should focus on more than preventing and treating infections with a novel influenza strain alone."https://t.co/tyK7pt9WaO https://t.co/6FZhpC064P
"Bacteriologic and histopathologic results from published autopsy series clearly and consistently implicated secondary bacterial pneumonia caused by common upper respiratory-tract bacteria in most influenza fatalities."https://t.co/IHV4ztdiZ9 https://t.co/WquydlzjYG
"The pneumonia was caused when bacteria that normally inhabit the nose and throat invaded the lungs along a pathway created when the virus destroyed the cells that line the bronchial tubes and lungs."https://t.co/IwacR1NieP https://t.co/Bp5DAOc46O
"With increased antibiotic resistance and vaccine evasion it is important to monitor the epidemiology of pathogens in circulation to inform clinical treatment and development, particularly in the setting of an influenza epidemic/pandemic."https://t.co/3jhLbJYi68 https://t.co/aMFq1Ufisk
> "A better understanding of how natural infection induces broad and long-lived immune responses will be key to developing next-generation influenza virus vaccines." [2019] https://t.co/LGILFQLyNUhttps://t.co/oPCdCyiw99
1) Flu vaccine effectiveness mediated by gut bacteria.https://t.co/sp8Ys0psel2) Maternal gut regulate RSV infection risk in children via bacterial strain Lactobacillus johnsonii.https://t.co/Nfh8Ptlnja3) Gut Bacteria disrupted due to covid.https://t.co/rijnuu9AaH4) Ergo: https://t.co/7RsTVWtgTZ
> "He notes that butyrate, one of these metabolites, has been found to suppress inflammation and that gut bacterial species that produce butyrate metabolites, such as F prausnitzii, are less abundant in people with covid and long covid." [may 2024]https://t.co/XzK2eAu8jj https://t.co/kUGHwMSG6F
> "Here we show that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II. High serum levels of angiotensin II appear to be linked to the severity and lethality of infection" [MAY 2014] https://t.co/x00bZDxNgn
Kefir is good!https://t.co/s4FMPuP8Mjhttps://t.co/gVBapb4QO0
> "The literature reviewed here demonstrates that there is a growing demand for kefir as a functional food owing to a number of health-promoting properties." [May 2021]https://t.co/ix8R3DBZA4 https://t.co/wF8ZfHzruc
"rosemary essential oil reduced disease severity and tissue damage in the rats at all dose levels."https://t.co/rkq1AoWeDzThis fits what I would expect to find if it's active in this space. It treats IBD like my crohn's which has elevated ace activity!https://t.co/M5u6L4VCi1
It's fascinating how often bio-active compounds are found in old songs about herbal remedies.https://t.co/6b6EGgICqK
"Please see for me that her hair is hanging lowfor that's the way I remember her best" 🎶https://t.co/4EjvgD461bhttps://t.co/ycgT7c7Dso
I shit you not, I just came home from buying a book from 1964 about how herbal remedies and the like have been turned into pharmaceuticals for profit. https://t.co/JL001hshdjhttps://t.co/6aMjl5W36o https://t.co/33RdI6YdXG
Shot: > "By studying a monozygotic twin cohort, we found that although prior exposure is a factor, host genetics are a stronger driver of subtype bias to influenza viral strains."https://t.co/NSQsQOOmXZ
Chaser: > "mong those household sharing and aging are likely the most crucial determinants of fecal microbial dynamics in twins while H. pylori is the key factor in defining the stomach microbiota composition." https://t.co/HgoBiOVOcL
Aperitif: > "H. pylori on the upper respiratory tract are inconsistent. Whether or not H. pylori is located in the upper respiratory tract and whether or not it plays a role in the pathogenesis of upper respiratory tract diseases remain unresolved." https://t.co/cycnoRRNbc
Hangover:"So far, there is no clear evidence of a causal association between H. pylori infection and respiratory diseases, and larger studies with appropriate epidemiological design are required." https://t.co/m0NMXKUr3j
Afterparty:> "The microbial burdens of H . pylori and influenza virus are variable in singly infected C57BL/6 mice but show a strong positive correlation in coinfected" [2012] https://t.co/2teMaJfxns
"If the result shows H. pylori positive, H. pylori eradication therapy must be tried in every [Immune Thrombocytopenic Purpura] case, or the conventional ITP therapies won’t have an effective treating result on the patients" https://t.co/MVeFLCXTPy
inb4 H pylori causes ITP via gut disruption, causing influenza vaccine side effects depending on the extent.We may be able to mitigate this if we understood it better. Correlations b/w H pylori and upper respiratory infections need to take into acout Gut-lung axis! They don't.
Make vaccines safer!> "Although vaccine-related [Immune thrombocytopenia] is rare, in patients with systemic symptoms, primary care physicians should perform systematic physical examinations to detect any hemorrhage, as ITP is a possibility." [2022] https://t.co/3htiZdI1J0
If you want better vaccine adoption, don't shit on and shame anti-vaxers. Listen to them when they talk about side effects that they are worried about and study the gut to fix it. Don't be a dick.https://t.co/oPCdCyiw99
1) Flu vaccine effectiveness mediated by gut bacteria.https://t.co/sp8Ys0psel2) Maternal gut regulate RSV infection risk in children via bacterial strain Lactobacillus johnsonii.https://t.co/Nfh8Ptlnja3) Gut Bacteria disrupted due to covid.https://t.co/rijnuu9AaH4) Ergo: https://t.co/7RsTVWtgTZ
Protip: garlic has been studied as a way to resist influenza infection.https://t.co/VkypiPL6eC
I was reading that H1 and H2 can give some cross-resistance to H5. So while its not great to have flu in general, there is a bit of silver lining if H1 is spreading again. https://t.co/ilFNcVomUZhttps://t.co/eJ9pA64xW0
Last year a strain of H1 overtook H3 toward the end of the flu season. If we're lucky those who have successful immune responses to these will create some resistance if H5N1 ends up human-to-human. https://t.co/dPdGhXwPJq https://t.co/y3b3BsRKsK
This seems so freaking stupid, we could have dumped that money into scaling the existing and mature flu vaccine tech that we already have.https://t.co/FdrdEkuZ7Uhttps://t.co/Ctd0ZYTPtA
Instead we're gambling on a vaccine that isn't even out of phase 2 trials? We've already spent more on it than what we spent on getting existing stockpiles. https://t.co/UFYHH58oML
Does seem that way. https://t.co/GqyJlbAmg1
Who are the reckless advisers telling influential people like Gates and Ellison that mRNA is a viable technology? For the vast majority of intended uses, it simply isn’t, and experienced researchers in the field will tell you this. It’s only investors trying to sell this.