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🧵 Thread (44 tweets)

UltimApe@ultimape• over 2 years ago

Speak weirdness to your gut. https://t.co/34Am1S6qyz https://t.co/EtLGt8y88T

UltimApe@ultimape• over 5 years ago

"Technically "you're modeling the future" when you process your sensory inputs. You just have to be aware that you can't see the future. You have a probability cloud of expectations." - anon Simulate harder. Divine future. Look seer. Deep pool. And Bet. https://t.co/bQlGhLADZg

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

"Spanning mathematics, psychology, economics and physics, Adam Kucharski reveals the long and tangled history between betting and science, and explains how gambling shaped everything from probability to game theory, and chaos theory to [A.I.]"https://t.co/4Aju3yrupZ

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Fear of losing money.https://t.co/2eQWGVVvgp

UltimApe@ultimape• over 6 years ago

Risk Tolerance and Loss Aversion are linked."Now that we know loss aversion is a key factor that drives risk tolerance, it is important for investors to take steps to reduce their loss averse tendencies."https://t.co/GmWiRsRY4Y

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Gambled with the moon and won.https://t.co/y15gtoeP96

UltimApe@ultimape• over 3 years ago

@stahura @ZPostFacto @sama I used game theory to predict energy balance in gut and figured out how to heal myself by directly operating on lipid function. I wanted to remember the whole chess board again like in my childhood so I could compete with him. I ain't afraid of nothin. https://t.co/GhSuKvhJA4

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Risk tolerance is modifiable.https://t.co/HBb9TNv8Ly

UltimApe@ultimape• over 6 years ago

"Think you can predict your risk tolerance? I bet you can’t."is that a challenge?

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Fear vs Curiosity an the impact of metabolic function (driven by lipid signaling) on the desire to explore vs hunker down.https://t.co/RGl6MdUPjG

UltimApe@ultimape• about 4 years ago

I type [gaba impacts "risk tolerance" -site:pinterest.*] into googleand my tweet shows up:https://t.co/QGWFqTRVyV https://t.co/PCCooyrzpu

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

A little birdy told me to speak to the big yud.https://t.co/Lb4IopHRHGhttps://t.co/4L2CdAo1yA https://t.co/Q4mK0LKHkl

UltimApe@ultimape• almost 3 years ago

@ESYudkowsky You're probably low on bile acid and your body wants to get carbs. The sweet cravings are gherlin being triggered by gut-liver axis https://t.co/R2DfQeDsvrhttps://t.co/D32j8bdZUs

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Moon? What do you mean moon?Ah I mean the important serine/threonine kinase and it's role in mTOR associated risk tolerance changes we see in bipolar disorders.https://t.co/6svMYDZA4D https://t.co/SAQ7veDom1

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

I speak funny. The words don't work right some times. So I realized when I was talking about the moon. I was talking about mTOR. Serine = Selene.https://t.co/LeKrTsrycthttps://t.co/H5OF2EGcnI

UltimApe@ultimape• over 3 years ago

Serine glows gold. It's why mTor came to me in a dream about Alzheimer's.https://t.co/Y6wKCDTHwi

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Quite the gamble."The daily dietary intake of garlic and its derived-products as an adjuvant therapy may improve side effects and toxicity of the main therapeutic drugs with reducing the used dose."https://t.co/J3lwsZhzPAhttps://t.co/hBgwOOQXcr https://t.co/qRY5snXy5R

UltimApe@ultimape• almost 4 years ago

Serine = Selene = Moon = Garlic GoddessA clove of garlic looks like a tiny moon.

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

But I won. It was a good bet.https://t.co/k7eWBTl8BD

UltimApe@ultimape• over 3 years ago

I regret to inform you that there is no evidence that garlic can cure 2019-Ncovhttps://t.co/bm439El65o https://t.co/MJ1EIMlczc

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

I got stronger by fixing cysteine.I got healthier by eating the moon.I got happier by fixing my gut.But because of my dysphasia?You probably think I'm a loon.https://t.co/jL4QeRnDRs

UltimApe@ultimape• almost 3 years ago

Oh look, Glutathione (and by proxy, cystine supplementation) does improve "Isometric Strength"They used same style hand dynamometer I did.> "Maximal isometric strength and fatigue index were also assessed using an electronic handgrip dynamometer."https://t.co/liJbPfflJG

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Look, I get it. We're not birds.But we can learn a lot from learning how metabolic function tied to gut bacteria seems to manipulate how animals decide to take risks. https://t.co/bz2Kb9NdDB

UltimApe@ultimape• over 5 years ago

Please ignore me. I am spreading myths derived from ancient healing traditions based on a fucking chickadee.https://t.co/zQaK6VARZi

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

But you're right. I'm crazy about the moon.I'm not loon-y. I'm a lunatic.Easily confused.https://t.co/2BpdmXbLud

UltimApe@ultimape• about 5 years ago

Hexing the moon just gives me more power.I feed off chaos.

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1/31/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

"Effect of supplemental dietary zinc on the mammalian target of rapamycin (mTOR) signaling pathway in skeletal muscle and liver [...] Zn may contribute to the initiation of protein synthesis as a signaling molecule in vivo."https://t.co/oHiCgDsxWIhttps://t.co/JY8wWXZKM4

UltimApe@ultimape• over 2 years ago

"Spontaneous cleavage of proteins at serine and threonine is facilitated by zinc[...] The presence of zinc may therefore significantly affect the long-term stability of cellular proteins."https://t.co/JNz2bNCov8Zinc is a moon agent, a lunatic.https://t.co/uwYzUMSrj1

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Fix your gut, lmao. I figured out how to hit mTOR back in march 2020.https://t.co/rh6Yw6kr0I

UltimApe@ultimape• over 5 years ago

So while everyone else is dosing up on Malaria drugs and synthetic antibiotics, I'll be drinking Kombucha, and eating zinc heavy foods. https://t.co/wpUPoGh1MQ and helping my gut bacteria produce erythromycin naturally instead of just killing everything off and getting psychosis.

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

And I just kept running.https://t.co/2srJBLw2tB

UltimApe@ultimape• over 2 years ago

Keep masturbating over drugs that are anti-aging. I dare you. Just dump that shit in without heed to how it fucks with the body's natural regulation of metabolic function. What could go wrong?https://t.co/7VO2UexlaM

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

I fixed my gut. My gut diversity is literally maxed out on the Viome test I took. I have to find another way to measure it.https://t.co/F6PVzwmNOt

UltimApe@ultimape• over 2 years ago

I took another Viome test on January 7th. Compared to my first one it's huge!It seems after a year I now have so much microbe diversity that it is 100% compared to low and average before.Similar for my "Biofilm, Chemotaxis, and Virulence Pathways" improved. https://t.co/VLT4ks4HVD

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UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Suck it.https://t.co/r8cD4IWiaZ

UltimApe@ultimape• over 5 years ago

So... Zinc and Vitamin D improve your sperm for the same reason as why a pathologist recommened sucking on zinc. It directly impacts immune regulation related to T Cells;https://t.co/VdAHErjllX1/2

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Figure out how to keep running without exhausting yourself.https://t.co/EsIo0HNLfa

UltimApe@ultimape• over 5 years ago

Zinc, Vitamin D, Calcium, Bile acid precursors / Liver health, Selenium, and L-arginine( https://t.co/VwetMhkVuZ )Any other major immune system boosting nutrients that might help prevent T cell exhaustion?https://t.co/TCbKl6fO4k

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Stop being in a state of suppressed immune function. "An Evolutionary Perspective on Immunometabolism"https://t.co/SVZ1u9z70P https://t.co/fsVV1ez9HM

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

Our western diet makes us eat like a hibernating bear trying to prepare for winter. And our lived environment is one of sedentary torpor.https://t.co/Z95bEvWyX4

UltimApe@ultimape• over 5 years ago

The entirety of western civ is sitting in air conditioned artifical caves, staring at low powered light boxes, and eating carbohydrates. Screaming at each other about how we need cheaper antibiotics. Scratching our heads about why we are sick and stressed.https://t.co/HPLFIDsN05

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

I encoded this idea in a song."Let's be r(evolution)ary"https://t.co/hD80TL6UsF

UltimApe@ultimape• over 5 years ago

"Let's be revolutionaryYeah, we could be so much moreLet's be more than ordinary(What are we waiting for?)Let's be revolutionaryNew history can't ignoreLet's be more than temporary(What are we waiting for?)"🎶https://t.co/P1Pg63nRIb

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

I have no idea what I'm dong.https://t.co/QfGy3USKTQ

UltimApe@ultimape• about 7 years ago

Just so happens, I wanted to fix my sleep schedule. I was reading about a rare theory on human hibernation, and it reminded me about the serotonin/micochondrial metabolic stuff I learned about w/ my autism studies.Maybe we can do it via our microbiome?https://t.co/uS2COYNNjv

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

I'm just obsessed with this stuff, that's all.https://t.co/rWvokBLZRi

UltimApe@ultimape• over 6 years ago

Fixing microbiome improved autism symptoms, even 2 years later. Study size of 18, all children, using FMT. They're going to try it in adults next.The question you have to ask: why does one dose not work like under C Diff? I suspect this is metabolic.https://t.co/TnA2rlmjwj https://t.co/CFOb6PIvCf

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

You can maybe get this without FMT, but it requires diet change and some aggressive fasting to kickstart your liver's metabolic signaling.https://t.co/LVyDF2LZKW

UltimApe@ultimape• over 6 years ago

I fixed my autism symptoms by pretending I had metabolic issues associated with diabetes type II, of which gut microbiome was just one aspect. I suspect you can shortcut around the whole needing to eat poop for 3 months straight if you boostrap your metabolism via fast. But N=1.

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

"Thrombin is a serine protease that plays critical roles in both blood clot formation and anticoagulation."https://t.co/litmKxScRf

UltimApe@ultimape• about 3 years ago

The moon is serine tonight. Shame you are cursed by her.https://t.co/VNIHih3rn3

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2/11/2023

𐫱 arcove 𐫱@dschorno• over 2 years ago

Replying to @ultimape

@ultimape whats your take on this: https://t.co/OhTGMvIsOg it seems like it lines up nicely with some things ive heard from you but it takes the position that things like fiber supplementation is like a bandaid solution maybe? i read it like a week ago so i forget lol

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @dschorno

@dschorno Difference between wolves & bears is wolves keep eating meat & fat over winter, so they don't need to hibernate. I am taking that strat this year."Organ meat is the first to be eaten. Except in rare cases, all significant pieces of muscles are eaten." https://t.co/6YpHIYzsY8

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno Organ meats are an high in animal-based fiber.

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2/6/2023

𐫱 arcove 𐫱@dschorno• over 2 years ago

Replying to @ultimape

@ultimape animal based fiber, interesting i tried liver for the first time recently and it was terrible, maybe because i have the gene for hemachromotosis and the last thing i need is more iron idk

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @dschorno

@dschorno Yep, bones and hide also. Bones are mostly collagen, so is most organ tissue. Liver is a good source of vitamin A and is basically a vitamin-B shot. Can perhaps emulate this with with Nutritional Yeast + plants high in vitamin A, like the one in my header image.

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno If you want to shock the liver into doing things to AhR to control lipids, then look into fasting's impact in this space."Activation of Aryl Hydrocarbon Receptor Dissociates Fatty Liver from Insulin Resistance by Inducing FGF21"https://t.co/IDJUz39iufhttps://t.co/V4nxJTvUH1

UltimApe@ultimape• almost 3 years ago

Fasting helped me do this."FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver"https://t.co/FO1ax2HQSP

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno How bears get out of hibernation has been what I've focused on since I realized what it was.It seems to be managed via FXR / Cystiene (bile shifts) that hit a temperature dependent TRP receptor.

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno I can time when the bears wake up based on my own body's response to weather patterns. The TRP receptors play a role in sensing environment and shift immune state as a result.

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno There's something neat going on in a tightly knit metabolic loop that responds to cold-stress.I haven't' found the smoking gun yet.https://t.co/uG1UUqZEL9 https://t.co/cCvCY0fvsC

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno Does the animal burn fat for warmth, or hibernate?Does the bird fly south for the winter, or does it stay put?https://t.co/4EK8dbmdN0

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno It's a feedback loop. Temperature swings play into how TRPs respond and the internal body's bile acids control if it spins up or ramps down. It's a feedback loop controlled by immune system monitoring fat reserves.

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno This doesn't work well if the liver is impaired for some reason.

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2/6/2023

𐫱 arcove 𐫱@dschorno• over 2 years ago

Replying to @ultimape

@ultimape oh interesting! I have the sense that inflammation issues are related, and there is a lot of chatter about bile supplements being used to treat psoriaisis

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2/6/2023

𐫱 arcove 𐫱@dschorno• over 2 years ago

Replying to @dschorno

@ultimape also psoriasis has a seasonal component to it, come to think of it

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @dschorno

@dschorno https://t.co/rTvGt1FTy6

UltimApe@ultimape• over 3 years ago

I miss my witch. She was right about her model of psoriasis being treatable by targeting TRP receptor pathways. I had the answer in my tweets and she shows up talking to me about itch and pain as it relates to autism.https://t.co/riMIw7ufOE

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno We've got the thing backwards.https://t.co/cvIGzCebAh

UltimApe@ultimape• almost 7 years ago

I've got an itch to scratch.TRPM8 seems to play a role in our response to skin irritation.Cold makes me itch well before any of my skin has a chance to experience dryness. I suspect folk wisdom has the causal chain reversed.https://t.co/BwmDLSWUKU https://t.co/FZQgu8IqN4

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2/6/2023

UltimApe@ultimape• over 2 years ago

Replying to @ultimape

@dschorno The liver is at the center of my family's pain disorder involved with TRP receptor signaling role for chronic pain.Hard to ask a bear how it feels to hibernate, but I bet it's miserable.https://t.co/hbg7qBJ6en

UltimApe@ultimape• over 2 years ago

Would be a damn shame if you can fix itch disorders by treating your liver via gut bacteria associated metabolites. All that R&D money wasted!*scratches*https://t.co/2lJKZ7oHGAhttps://t.co/4s0zNx5iA7

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2/6/2023