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Cube Flipper@cube_flipperover 2 years ago
Replying to @ultimape

@ultimape hey do you think it makes sense that if dog poo can cure autism then cat poo can give you autism https://t.co/kvBMG906L0

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UltimApe@ultimapeover 2 years ago
Replying to @cube_flipper

@cube_flipper Toxo isn't just in cats. It's also in cows. Interestingly @bt57414527 informed me there is a chemcial in some dairy that can turn into an opioid impacting peptide.

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 They shared this in the discord:"When these children were put on a milk-free diet, at least eight out of 10 no longer had symptoms of autism or schizophrenia" https://t.co/nUnWN4rOdk

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 There are some interesting implications here https://t.co/vfyZpCZPLK

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UltimApe@ultimapealmost 8 years ago

Testosterone suppression via Opioid use?https://t.co/Koe52FPl39Opioid use causes large scale bile and microbiome inflammationhttps://t.co/n9kdNonVjIT Gondii seems to affect opioid system indirectly, making mice allergic to gluten and casin?https://t.co/yk0kC8A8D6

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 The connection with cows is fascinating.https://t.co/fbzNoK1l60

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 I keep repeating myself here.https://t.co/RFALaY7EnM

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UltimApe@ultimapealmost 3 years ago

@rivatez Fix gut."This study demonstrates that the gut microbiota plays an important role in T. gondii infection in rats. The data will improve our understanding of the association between T. gondii infection and gut microbiota in rodents." https://t.co/FyRDHKVfeM

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Lots of weird stuff might be happening here in relation to gut health (thread has more). I found out that the casein might be digestible by some gut bacteria and may be able to neutralize the opioid's impact on gut health. https://t.co/eBEuAvGQDn

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UltimApe@ultimapealmost 3 years ago

@keller_via @embryosophy @DesidErratum A quick look suggests Lactobacillus paracasei and Lactobacillus helveticus might be doing something interesting. And that the goat milk helping is the casin type!The "L. casei" sub species all seem to do thing to dairy. https://t.co/XAT10ecagc

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 it sets up a feedback loop that drives immune dysfunction https://t.co/j45olk193d

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UltimApe@ultimapealmost 3 years ago

What happens if your opioid system modulates TRPM8, which in turn modulates TRPV1, which in turn modulates the opioid system?https://t.co/eYwRr2qYzk

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 "These results suggest that endogenous opioids may contribute specifically to the state of hibernation. Moreover, a physiological role may exist for an anti-opioid system in the promotion of arousal from hibernation." https://t.co/sXFsEScWD0🤔https://t.co/VGFizmNsZT

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UltimApe@ultimapealmost 6 years ago

So T gondii prevalence—one of the candidate parasites that I think plays a role in the length of female bear's hibernation— seems to be directly affected by temperature.https://t.co/zwCBWjUQ7M

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 don't mind me, just curing my autism.https://t.co/5BzOxHGip5

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UltimApe@ultimapealmost 3 years ago

If OPRM1 suppresses TRPM8 activity in mice, does that mean that our endogenous opioid system can manipulate our ability to feel hugs?https://t.co/bVCOBkQRSu

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 "we demonstrate that intracellular T. gondii tachyzoites are able to take up Ca2+ from the host cytoplasm during host cell signaling events."https://t.co/5t0HpkBdsoDid you know bears eat dirt? They specifically eat stuff with antiparasitic properties.https://t.co/o4jzgfwI4D

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UltimApe@ultimapealmost 6 years ago

Bears fucking what?https://t.co/Z1gjMvCb17 https://t.co/LC9Ob6lVLI

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 That thread about bears got weird for a bit... almost like I was talking in metaphor about viruses and infectious parasites. Why was Santa there? The one who drinks milk.

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 "The antitoxoplasmic activity of Spiramycin and Myrrh were evaluated in murine models [...]reduced the mean number of tachyzoites present in the peritoneal fluid of experimented mice 4 days after infection"https://t.co/wDnXHflMXJhttps://t.co/9nrsz3RwC0

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UltimApe@ultimapeover 3 years ago

Frankincense and Myrrh?Future me, if you are here because you're sad again during the winter, seek out immune system boosting herbal remedies that are in the songs about joy and happiness. Set fire to the rain.https://t.co/qDK0RO4yu1

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 "frankincense to offer have i" 🎶The three kings is a song about three herbal remedies that literally protect us from contracting parasitic disease during childbirth that changes the brain thru immune dysruption.https://t.co/nXp2VzdnIt

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Perfume! Ancient wisdom encoded in rhyme.https://t.co/Txkt5XDrGt

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UltimApe@ultimapeabout 4 years ago

Akkadians might have had a means to distilling that would have been used in perfumes. That dates back to 2000 BC!https://t.co/GTJhHtOKOE https://t.co/aI6yE2HjZa

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 COMBINE THEM."This study was aimed to explore the efficacy of several Egyptian plant extracts against Toxoplasma gondii"https://t.co/IwvvyzEqCV

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Star of wonder, start of light.Star anise, you shine so bright.Burn the herbal treatment, right?incense infuses the lungs? it might.You put the star on top of the tree to dry.Alchemic healing encoded in astrology songs.Could it really hurt to try?https://t.co/9VPJhryHVw

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UltimApe@ultimapeabout 3 years ago

Naruto heals woundsNaruto is a starStar Anise impacts biofilm formation and as such ought to be able ot help can heal wounds.It's like cinnamon.I can predict things from stories. Because there is a signal in the noise. Error correct.https://t.co/ax6xlxjkNO https://t.co/T2fTLyMIqB

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Yummy dirt."Spiramycin is produced by Streptomyces ambofaciens." https://t.co/zusjQEFDtE"Streptomyces ambofaciens is a bacterium species from the genus Streptomyces which has been isolated from soil from France."https://t.co/oWepaTjPI5Bears... fucking what?

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 I wanna go research biofilms so bad.https://t.co/mPAYpuB1vd

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UltimApe@ultimapealmost 4 years ago

I wonder if he has written on kind of plants he wanted to test in Belize before he started messing with drug production.https://t.co/65QX8C4esR

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 I'm literally named after St. Nicholas, and I drank a lot of milk growing up. I thought it was funny to encode an antiparasitic idea into a thread about spreading my ideas as parasites.victory to the people https://t.co/qURwOY4zfnhttps://t.co/CW9ygueM0T

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UltimApe@ultimapeover 3 years ago

You better not shout, you better not cry.Santa is real. I'm telling you why.https://t.co/lTitXK3aDX https://t.co/fdkZeqrAJI

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 This is a joke about how I couldn't walk to the bathroom.https://t.co/NgvQHT8BnP

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UltimApe@ultimapeover 3 years ago

Just put one foot in front of the other, Winter Warlock. https://t.co/czd4uo3XN8

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 "according to this study, experienced T.gondii infection may be one of the several environmental risk factors for MS." https://t.co/CUeMST8DSC

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 "The available evidence supports the hypothesis that T. gondii infection represents a protective factor against the development of MS." https://t.co/hFgWW8nYRQ

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 None of this make sense makes any sense except in the light of gut bacteria causing variation in response.https://t.co/5Ur2AVr9RX

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UltimApe@ultimapeover 5 years ago

Why would Niacin Improve schizophrenia?Why would Niacin Improve Multiple Sclerosis Syptoms?https://t.co/xFZtUsW9ZC

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 I think it's prostaglandin via that calcium thing tha magnesium intake would help to neutralize."In this study, the intracellular signaling pathway of PGE2 synthesis in macrophages (RAW264.7) induced by Toxoplasma gondii was investigated." https://t.co/PEzdMr8l4x

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 "an endogenous lipid molecule that regulates important physiological functions, including calcium signaling, neuronal plasticity, and immune responses. [...] these findings could have potential implications for neurodevelopmental disorders such as autism." https://t.co/q4jMiHJK3s

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Which means I have direct ties between T Gondii and brain development changes thru wnt signaling ala Prostaglandin production shifts and calcium signaling.https://t.co/jUNLnEdplz

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UltimApe@ultimapeover 3 years ago

Does lithium help with autism because it acts on WNT/β-catenin pathways associated with brain development genes?https://t.co/apeItzccK4

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Which is a very very interesting pathway.https://t.co/97p58nApl6

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UltimApe@ultimapeover 3 years ago

" In this review, we examine the different ways human bacterial pathogens with distinct host cell tropisms and lifestyles exploit Wnt signaling for infection and address the potential of harnessing Wnt-related mechanisms to combat infectious disease."https://t.co/AT1LLDO1yD

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 In other news, hair is growing back on wound sites that I've had since childhood. https://t.co/0gEfHxbpwv

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UltimApe@ultimapealmost 4 years ago

"Exogenous Shh proteins induced hair-related gene expression by stimulating both Shh signaling pathway and Wnt/β-catenin pathway in DP cells, and might therefore be a potential hair promoting agent."https://t.co/OESCJfafoTok, what about endogenous?

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 "Myrrh caused a dose-dependent effect on macrophages to increase the reactive oxygen species (ROS) levels, [...] and consequently induce apoptosis, highlighting its ability to modulate macrophage function" https://t.co/sZTvpV7mtA😇

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 There's a tightly woven ball of brain development signaling pathways tied to opioid's disruption of immune function that are directly downstream of T Gondii's impact on host health. And it weaves it's way into hibernation, autism, schizophrenia, and M.S.

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Fix the gut..."Aljarallah reported that water extract of myrrh plant demonstrates high antimicrobial effect against C. difficile strains, which could support its use as a natural product for the amelioration of C. difficile in autistic patient" https://t.co/dKDAGLYd3R

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 But everyone keeps looking at the genetics behind it.We have papers talking about macrophage genes as risk factors! https://t.co/sZ8Lj9NjFkIts the gene *expression* that is impacted here.

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 No one seems to understand how autism actually works.https://t.co/EClziSXm19

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Doctors surprised because doctors are stuck in an outdated paradigm of disease.https://t.co/mv1dFSeFR6

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UltimApe@ultimapealmost 3 years ago

Haha, they're still trying to do this with genetic production of chemicals instead of modulating gene expression associated metabolic factors with gut bacteria metabolites. https://t.co/wX4bFrsQW0

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 mAyBe OnE DaY We WiLl uNdErStAnD tHe PaThhttps://t.co/4AGdwhOgkU

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UltimApe@ultimapeover 2 years ago

“This [similarity] just provides some kind of additional direction we should look into,” Liu says. “Maybe one day we will understand the pathology better.”https://t.co/MipyJbyx0pAutism & Alzheimer's / Parkinson's share similarities in immune related gene *expression* in brain. https://t.co/qmrSHZbFt8

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Another joke. https://t.co/Sd0WsyNMiI

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UltimApe@ultimapealmost 4 years ago

"yesterday the wisest manholding a lit lanternin daylightwas searching around town saying" https://t.co/tjrCS6AXtV

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 We have to look at genes, but we have to keep going, the genes just tell us where the gene expressions can impact the brain thru epigenetic impacts on immune function / cell remodeling and differentiation. https://t.co/AGcraOWhRS

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UltimApe@ultimapeover 3 years ago

@nimrod_cain @limitlessjest I suspect this is thru microbiota disruption and a lack of a metabolism pathway. Been exploring the genetics around it by way of Sonic Hedgehog gene's role in echidna penises.https://t.co/aSHTZLwTSi

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Alas. I am insane.https://t.co/jn6P2bVoGR

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UltimApe@ultimapealmost 3 years ago

@BioavailableNd Giggling to myself about how I have been looking at glycan production by gut bacteria and yeast as a way to make it so I can eat cholera.https://t.co/Q8MhMQoAd2

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 They're still taking about gaba/glutamate signaling being impaired and scratching their heads about impairing the cysts.I already figured out how to disrupt the biofilms to let the immune system attack and destroy them.https://t.co/J2VEoPD0bz

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Can reverse engineer ancient remedies that would fight t gondii cysts and biofilm disruption by correlating disease spreading events with traditional herbal remedies. Hence this: https://t.co/2jn0IoQY1L

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UltimApe@ultimapeover 2 years ago

@cube_flipper @bt57414527 COMBINE THEM."This study was aimed to explore the efficacy of several Egyptian plant extracts against Toxoplasma gondii"https://t.co/IwvvyzEqCV

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 We can fix this.https://t.co/IpgJjiBAd4

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UltimApe@ultimapeover 4 years ago

Do you ever study gut bacteria's role in GABA production to study why anxiety shows up so often in gut dysbiosis associated disorders?https://t.co/HjOaAXaPkT

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 So I troll people who focus on genetic scanning tech about how to fix glutamate signaling with gut bacteria instead.https://t.co/FTeQfAebr6

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UltimApe@ultimapeabout 4 years ago

@noor_siddiqui_ @OrchidInc I see you scan for schizophrenia. There's also some fun research in that space that suspect glutamate production problems driven by gut bacteria might be plausible. https://t.co/GAMB2Hy2UU

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 "we have lived with Toxo for 100s of years." Is really funny to me.https://t.co/oidfPAMFzh

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 I used an ancient story about a snake spirit and it's professed symptoms to correctly identify that snakes would be carriers of T Gondii.Spirits are a model of disease.https://t.co/nPYFnKtC3y

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UltimApe@ultimapeover 4 years ago

Ok, What is Vetala?"Hindu [...] an evil spirit who haunts cemeteries and takes demonic possession of corpses. They make their displeasure known by troubling humans. They can drive people mad, kill children, and cause miscarriages, but also guard villages"https://t.co/AGLFH1Iq4U

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Been trying to find Ancient Sumerian demonae that cause miscarriages and blindness in children, because there's a good chance whatever herbs they used to banish the evil spirit back to the underworld would also work to cure T gondii.https://t.co/WCA1dmz9Tg

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Scholars and historians will have misread the practice as a ritual meant to worship the 'god' that fights the demonic spirit and nothing more. Good chance it's a perfume associated with one of the Sumerian/Akkadian Anunnaki. https://t.co/fYTKPv0Mc5

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UltimApe@ultimapeover 2 years ago

@cube_flipper @bt57414527 Perfume! Ancient wisdom encoded in rhyme.https://t.co/Txkt5XDrGt

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@simplifybot

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 COMBINE THEM. fight the biofilm.https://t.co/moxJZG6Mzw

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UltimApe@ultimapeover 3 years ago

"highlights the need to explore not only single compounds but also mixtures of natural products for treating biofilm infections and underlines the importance of working with biofilm models when exploring natural products" [2020]https://t.co/4dpHAox7EXhttps://t.co/iebfYbsBjs

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UltimApe@ultimapeover 2 years ago
Replying to @ultimape

@cube_flipper @bt57414527 Scientists test individual chemicals for minimum inhibitory concentration and don't realize that you should be COMBINING THEM.Then conclude that because one drug/chemical doesn't do anything on it's own, it must be useless.

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