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š§µ Thread (120 tweets)
1) Flu vaccine effectiveness mediated by gut bacteria.https://t.co/sp8Ys0psel2) Maternal gut regulate RSV infection risk in children via bacterial strain Lactobacillus johnsonii.https://t.co/Nfh8Ptlnja3) Gut Bacteria disrupted due to covid.https://t.co/rijnuu9AaH4) Ergo: https://t.co/7RsTVWtgTZ
"Although the underlying mechanisms by which the gut symbionts influence systemic immune responses remain poorly understood, there is evidence for both direct and indirect effects." https://t.co/1ZlRX9aYRl
āItās interesting to see that these microbes are having an immune effect beyond where they live in the gut. Theyāre affecting places like your blood, spleen, and bone marrow ā places where there shouldnāt be any bacteria.ā https://t.co/jKC7VZYzPS
"We found that lung immunity more closely reflects lung bacteria than it does bacteria in the upper or lower GI tract." https://t.co/fqVEc4ZSHw
"To date there is no direct evidence from human or animal studies on the role of lung microbiome in modifying COVID-19 disease; however" [AUG 2020]https://t.co/M0GRpedjJD
Wonder what else can migrate?"First evidence drug resistant bacteria can travel from gut to lung, increasing infection risks" [NOV 22 2022]https://t.co/rEiAhtmuxg
"Here, we provide a comprehensive overview of microbial products active in the airways, describe the immunological mechanisms they trigger, and discuss their clinical advantages and pitfalls." [May 2022]https://t.co/w1vQVxGj8C
"impact [...] viral respiratory infections on the gut microbiota and discuss [...] imbalance on disease outcomes, including gastrointestinal disorders and secondary bacterial infections. [...] potential role of the lungāgut axis in [covid]" [Jan 2021]https://t.co/m7xXWDUJiV
"Microbes may be recognized by host immune cells, resulting in systemic cytokine release. Or in some cases, "the bugs make drugs," such that bioactive compounds are secreted by microbes, absorbed into circulation and directly alter lung function." https://t.co/PrkXQJCrSi
"Kefir: A protective dietary supplementation against viral infection" [Jan 2021]https://t.co/5Phma1Pioj https://t.co/vLIcRRajuh
Milk brings wisdom.https://t.co/2YwyDQcaiL
"review in Nature Reviews Immunology concludes that evidence is mounting in clinical trials and other studies that the composition and function of individuals' gut microbiota are "crucial factors" in affecting immune responses to vaccinations" https://t.co/Y4j5IEu16d
"We also provide an overview of current microbiota-based approaches to enhance vaccine outcomes, and describe novel microbe-derived components that could lead to safer, more effective vaccines and vaccine adjuvants." https://t.co/NCCCvSHZA9
"A major implication of our findings for global public health is the possibility that the microbiota plays a role in immune responses to vaccines. The status of the host microbiota may be a critical determinant of vaccine efficacy" https://t.co/xCWPaqZbkX
Fix your gut.https://t.co/9htsQ0AUi4
"Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells" [2021]https://t.co/c7Y1iCr9zP
"(ACE) and ACE2 are involved in several pathologies such as cardiovascular functions, renal disease, and acute lung injury. In the current study, we report that ACE2 could mediate the severe acute lung injury induced by influenza A (H7N9) virus" https://t.co/KY7juwwcq5
š§š„š¦ https://t.co/ZhmTLq3LT6
I'm not qualified.https://t.co/XxXiouieEF
I am not a doctor.ĪĪ± ĻĻĪ·ĻĪ¹Ī¼ĪæĻĪæĪ¹Ī®ĻĻ Ī±Ļ ĻĪ¬ ĻĪ± Ī“Ī¹Ī±Ī¹ĻĪ·ĻĪ¹ĪŗĪ¬ ĻĻĪ®Ī¼Ī±ĻĪ± ĻĪæĻ ĪøĪ± ĻĻĪµĪ»Ī®ĻĪæĻ Ī½ ĻĪæĻ Ļ Ī±ĻĪøĪµĪ½ĪµĪÆĻ Ī¼ĪæĻ ĻĻĪ¼ĻĻĪ½Ī± Ī¼Īµ ĻĪ· Ī¼ĪµĪ³Ī±Ī»ĻĻĪµĻĪ· Ī“Ļ Ī½Ī±ĻĪ® Ī¹ĪŗĪ±Ī½ĻĻĪ·ĻĪ± ĪŗĪ±Ī¹ ĪŗĻĪÆĻĪ· Ī¼ĪæĻ , ĪŗĪ±Ī¹ Ī“ĪµĪ½ ĪøĪ± ĪŗĪ¬Ī½Ļ ĪŗĪ±ĪŗĻ Ī® Ī±Ī“Ī¹ĪŗĪÆĪ± ĻĪµ Ī±Ļ ĻĪæĻĻ. https://t.co/ZfECEeILPW
"A new preclinical study by Weill Cornell Medicine investigators found that certain bacteria in the gut may reduce susceptibility to SARS-CoV-2 infection" [Aug 2022] https://t.co/x3TLv0BU3Vhttps://t.co/jdXAyfbrkC
@Joinmich @mohitvirmani11 @pmarca @lorakolodny @balajis We are looking at sick people. We should be looking at what is keeping the asymptomatic healthy, and then trying the microbes they have out on mice inoculated with gut microbiome ala personalized medicine approaches.
I want to engineer my oral, skin, and lung microbes to kill viruses on contact.I plan on becoming immortal.https://t.co/mLnLHQTM0o
I doubled my grip strength without a lick of exercise by fixing my gut bacteria.https://t.co/VxdXYhEFfR
I can't wait to see someone talking about how stupid people were for putting honey, garlic, and dirt in their wounds. Then laying into them w/ about how some dirt has commensal bacteria that promote literal wound healing properties.Well... actually... https://t.co/y0L0uGbZSN
I healed my left eye of near blindness, likely by way of inhibiting inflammatory responses tied to diabetic retinopathy that we also see in M.S and R.A. along the RAGE pathway.https://t.co/H7JL3Sdvc0
Fasting and vitamin A + minerals cured my night vision.https://t.co/A7Yl9zogAh
I'm fairly certain that I know what kind of bacteria you need to get this effect to reverse and it shows up in this guy's latest research on epigenetic modulation of aging factors.https://t.co/kPnG4PpxmF
I ate literal dog shit to fix my gut. meanwhile the FDA only this month approved the first FMT treatment for C-DIFF.https://t.co/JEMlmy0ZR3
Be more aware of the bugs that love you.https://t.co/397APLl8ON
"There was a 1,000-fold reduction in serum levels of secondary bile acids after antibiotic treatment, which was highly correlated with transcriptional signatures of inflammation, suggesting a role for secondary bile acids in suppressing inflammation." https://t.co/9plFXlVT8o
Did you know that "Angiotensin II subtype 1 receptor blockade inhibits Clostridium difficile toxin A" in rabbits?https://t.co/oNs3NoKhvC
"Therefore, the development of drugs based on RAS blockers, such as angiotensin II receptor blockers (ARBs), that inhibit the damaging axis of the RAS cascade may become one of the most promising approaches for the treatment of COVID-19 in the near future" https://t.co/EMa7ob7jtY
How, uh... How long until we can test other.. uh.. other FMT cures against disease?took > 9 years for that C diff thing.https://t.co/PUNST2Lkjo
What happens if you fix your gut to avoid this?"Gut microbiota facilitate AngII-induced vascular dysfunction and hypertension, at least in part, by supporting an MCP-1/IL-17 driven vascular immune cell infiltration and inflammation." https://t.co/5sG9mwuoaF
There's a reason why I'm talking about C Diff infection. It highlights another problem that is a fallout of how we have been treating covid w/ antibiotics and immune modulating therapies. This destroys the gut (hence why FMT is needed). https://t.co/tXWHiAib3B https://t.co/NPBgnkzeJS
There's another thing surging right now too, strep A https://t.co/CKtfVlqk4B
A bacterial infection... https://t.co/T5HNpYO2OtAfter couple years of a disease that drives gut dysbiosis.Color me surprised.
BRB, reading thru every paper who's cited"Emerging insights on intestinal dysbiosis during bacterial infections" from 'Current Opinion in Microbiology' in 2014https://t.co/E4diarwrF2
Don't mind me, just curing wide swaths of disease in a self obsessed quest to solve my autism.https://t.co/7WpGKKyLrN
"To our knowledge, this is the first demonstration of the effects of broad-spectrum antibiotics on the immune response in humans ā in this case, our response to vaccination ā directly induced through the disturbance of our gut bacteria" [2019]https://t.co/sp8Ys0psel
"evidence is beginning to suggest a COVID infection could affect the balance of bacteria in the gut, which might go some way to explaining why some people have persistent symptoms after a COVID infection." š¤Ŗhttps://t.co/a6B1vmqmYbhttps://t.co/jdXAyfaTv4
@Joinmich @mohitvirmani11 @pmarca @lorakolodny @balajis We are looking at sick people. We should be looking at what is keeping the asymptomatic healthy, and then trying the microbes they have out on mice inoculated with gut microbiome ala personalized medicine approaches.
Have you tried eating shit?https://t.co/Qqa23pjTgz
Sure is weird how many people have *checks notes* C-difficile infections https://t.co/HMjuILM4D1
"In this article, a new potential treatment for COVID-19 by fecal microbiota transplantation (FMT) is described." [2021] https://t.co/ZWkmF6gTuwWe must go faster.https://t.co/RsQ1HlIUQD
"The study data confirmed that immunocompromised individuals show varying serological responses to COVID-19 vaccines under the influence of the gut microbiota."https://t.co/X8xnxfty7Z https://t.co/7gLTgcv4Rl
Immune compromised and your gut bacteria is disrupted? Better jab more times just to be sure they work. Don't bother fixing the underlying T and B cell disruption and missing gut bacteria that promote immune system learning. That'd be silly.https://t.co/URW2OZv40C
"Further evidence has shown that the gut microbiota influences the adaptive immune response of the host, the arm of the immune system necessary for Plasmodium clearance, sustained Plasmodium immunity, and vaccine efficacy." [2020]https://t.co/WiyDinxNVl
Jab jab jab. Right hook.https://t.co/GVixvciYvV
Atopic dermatitis, in my mast cell activation syndrome driven by poor gut health, potentially enhancing malaria parasite infection strategies, and treatable via F. Prausnitzii (missing in long covid)? Imagine that.https://t.co/IGQY6C1IsT https://t.co/uUdUHEmk8U
"Human gut bacterial metabolism drives Th17 activation and colitis" https://t.co/1QxAuWg64T"GF mice were also observed to have a Th1/Th2 imbalance: their immune response is biased toward the Th2 response"https://t.co/rE0LIiwt8O
"The microbiome and the immune system are critically intertwined, [...] Whatās present in the gut determines what education immune cells get." https://t.co/A27e3k2ZmI
Vaccine efficacy, in my gut bacteria mediated immune function?What can we conclude from this:"HIV-specific Th2 and Th17 responses predict HIV vaccine protection efficacy"https://t.co/Pw1jCQ3yKL
Talking (ab)out my ass here. clearly.https://t.co/W7uzHP2V7b
SCFAs level up."In this Review, we synthesize this evidence, discuss the immunological mechanisms that potentially mediate these effects and consider the potential of microbiota-targeted interventions to optimize vaccine effectiveness." [may 2021] https://t.co/9plFXmduwY https://t.co/SXNDiT3Avv
Nothing to see here, move along folks. https://t.co/RKT0G1Fut3
"Our recent studies show that microorganisms in the human gastrointestinal tract affect the severity of COVID-19 and for the first time provide indications that the virus might replicate in gut bacteria." [APR 2022]https://t.co/ocUO4wEliBš±https://t.co/na1qukGjok https://t.co/03Oq1qRCyA
Gotta get that dog shit energy.https://t.co/5ykAjAbBRj
Mad scientist energy.https://t.co/tuZefxEkt3
"These findings advance our understanding of the contribution of immune and microbial factors to inter-individual variations in vaccine-induced adaptive immunity." [APR 2023](BNT162b2 = BioNTech/Pfizer's mRNA based covid shot "Tozinameran"/"Comirnaty")https://t.co/JUAM9aeOgl
That study on covid vaccine response seems to be talking about how "Activator protein 1 (AP-1)" makes the vaccine not work as well.Guess what bacteria makes a thing that inhibits AP-1? This is found in my Kefir.https://t.co/YGssXIju0ghttps://t.co/XZfynG18zd https://t.co/vH6dNOXUUF
Hey look, An infection that drives Scarlet Fever that shows up in the throat is spread via throat. Who could have guessed."Bacteria discreetly dwelling in throat revealed to be primary source of Strep A transmission" [JUL 2023]https://t.co/N87Sa90nWE https://t.co/y4sMGz3iP2
Respiratory droplets lmao."Group A strep bacteria often live in the nose and throat." https://t.co/82XQulXdkK
Oh boy. If this paper from 1929 is right, it means killing viruses that target bacteria might make you more susceptible to bacteria infections."The Resistance of Scarlet Fever Streptococci to the Action of Bacteriophage" [1929]https://t.co/x7CSaIHdb5
I did that, wasn't fun.https://t.co/xboXfEPLXM
@alexeyguzey @dlx5dlx6 @Grimhood @dailectic @The_Lagrangian I was taking a zinc pill a while back that caused me to have some weird GI response. Symptoms of a bacteria infection (green poop unrelated to diet coloring). But also wasn't eating as well as I should to promote the ones I wanted.
Would be neat if the problem here is that we are missing some commensal strains of Streptococcus that out compete Strep A. But 'more research needed'. ĀÆ\_(ć)_/ĀÆhttps://t.co/qzcbXTM1eh https://t.co/CuQxDa9GXW
It seems that coming out of lockdown has reversed the reduced spread of Strep A strains (and meningococcal meningitis)."COVID-19 measures reduced life-threatening invasive bacterial infections" [JUL 2023] https://t.co/DMzy87DOMf
Salt gargle can fight bacteria in the mouth. Going to try to find out if Strep A or Meningitis are resistant.https://t.co/VtcONxCwCAIts like we are reliving the past over and over haha.https://t.co/ijuTFpVlOI
"may kill some, but does not kill all, mouth and throat bacteria. However, [ā¦] help bring bacteria to the surface of the gums, teeth, and throat. Once the bacteria is brought to the surface, some of it washes away when a person spits the salt water out." https://t.co/cgyog9G677
Oh neat, Streptococcus Mutans (causes teeth decay) can be killed effectively with salt rinse? I wonder if this has replicated.https://t.co/XJuFqF7W9r
This article isn't helpful for learning about bacterial throat infections, but neat that someone did a proper trial on covid + salt gargle and found positive results. Also that it may be healing mucosal membranes! That is useful. https://t.co/qbPIHnIIpv https://t.co/brECy7kNeX
Probably pretty important to figure this Strep A thing out. Even if it doesn't lead to death, reoccurring infections can trigger the still controversial "pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection" (PANDAS)https://t.co/SetccGg5OT
My autistic special interest? Autism."Some scientists say an immune condition called PANDAS affects as many as 1 in 200 children who have traits similar to those of autism. But many experts contest that figure ā and even the conditionās very existence." https://t.co/kQbmroQXAU
I've asked the same sort of question before to myself... What if we can cure PANDAS by fixing gut bacteria.https://t.co/2Ps90LNGvm
@chaosprime @deafitist @GENIC0N @rivatez If PANDAS is real... and dog rose is found as an effective treatment.The next question ought to be: What is it doing to the gut bacteria makes the body produce antibodies?Further: does this relate to Riva's ideas?https://t.co/pbKL9s764K
"However, communicable infectious disease exposure may be causing noncommunicable chronic conditions much more than we think."https://t.co/oGos0UOZkWhttps://t.co/E9fLZVDrUv https://t.co/O4jTfsPKS2
Are we overlooking an interaction between Strep A and an effect behind Covid induced Mucormycosis?"Bacteria that have high affinities of adhesion to salivary pellicle, such as species of Streptococcus and Actinomyces, are primary colonizers of teeth."https://t.co/kPGiVvUlND
It's amazing how often Strep Mutans and Candida Albicans show up in the same paper talking about biofilms. Here we see that I was right to expect dog rose as having synergistic action on this space.https://t.co/vOSFeO9eH9
Looks like I'm adding cinnamon and clove to my toothpaste, and makin sure I replenish Lactobacillus acidophilus in my gut. https://t.co/hBJ8dXnjXa
It seems that the reason why many children's teeth rot out of their head is they drink milk from a cow and get bottle-rot. This may be due to promoting too much oral Lactobacillus?https://t.co/6pyFZuVKXF
I am rethinking how to destroy biofilm.https://t.co/qLsyCbEHYr
I am rethinking how to keep our teeth clean.https://t.co/20WC5srn3s
@MongoTheGeek @eigenrobot There is so much work in the early 1900s nutrition research that have biased our thinking on dental carries. We really ought rethink it in the light of oral bacteria's role in digestion, blood pressure, and Alzheimer's.https://t.co/CoOYOq3y0I
And how to eat rocks; but that's an entirely different never ending story.https://t.co/3rWjnROWCW
I found a bacteria that eats rocks. Was thinking about what it would take to make them compatible with the human digestion system. As one does. All this really has given me is a better understanding of how to clean my toilet. https://t.co/c7D473RTWh https://t.co/TssNdDE4IK
Ok. Long shot... But I bet Covid related gut dysbiosis impairs Nitric Oxide recycling from the gut and that changes the oral environment.This would promote pathogenic strains that would normally be kept at bay. And it will promote Strep A + related.https://t.co/QjGH60AEbq
Impaired NO recycling could also explain long covid associated muscle wasting problems. https://t.co/wTqp97fp0l
"We conclude that eNO is increased in active IBD and correlates with the activity of the disease; furthermore, we found a negative correlation between spirometry and disease activity in patients with CD." [2002]https://t.co/MpIPuEtAQz https://t.co/QFV9r20Iyx
The body stops doing eNO during covid infection. Why? The body doesn't want any more ACE receptors, Covid wants more to infect them."Can Exhaled Nitric Oxide Be a Biomarker for Hospitalized and Post-COVID-19 Patients?" [2021]https://t.co/uU8xlpy1oH https://t.co/grpABM1mSz
"(ACE) inhibitors increase NO production both directly and indirectly by preventing production of [ANGII] (which diminishes NO production) and inhibiting the degradation of bradykinin (which stimulates local release of NO)." https://t.co/2GknlWN3yjNo ace inhibition, no NO.
A prediction from this is we should see Anti-CD24 Antibodies in some people as well as possibly other antibodies associated with Nitric Oxide pathways driving over active immune state ala:https://t.co/vEw7gswxGJ
Its important to separate the acute from teh long term effects of covid. In the acute state with risk of death from pneumonia in a hospital, ACE activators may help. Its like the body pushes itself too far into protection mode to point of hurting itself. https://t.co/ibdLksMF9P
This is especially so when you have a SARS cuz the spike proteins itself is harder to recognize for the immune system already. A poorly targeted response may lead to autoantibodies by mistake.https://t.co/2KsWgrv6Xo
The immune cells doesn't know anything initially about covid. Or if it does, it'd based on past experiences & needs to learn it to pattern match.Immune system is vaguely like image classifiers. It works on taste-testing receptor sites & surface glycans.https://t.co/KKKqaLQq4c
This is way way more likely if your B and T cells aren't well differentiated -> they'll just aim their anger in the general direction of the inflammation.Poor targeting is basically autoimmunity.https://t.co/QUsB4qFW28
Nitric Oxide signaling plays a huge role in blood pressure regulation, especially related to exertion. SO expecting something around this space to be impaired as fall out from infection seems reasonable.https://t.co/3U7Mtr2ikH
What happens if this unexpected phenomena fails to take place, or is reverted?"finding was completely unexpected, [...] Prior to our study, IgA cells had not been shown to reside in the dura mater under steady state conditions."https://t.co/3ZVHxoBX7Nhttps://t.co/6wjvFGCN66
The immune system is constantly learning (and unlearning) new adaptive strategies.Its really fun to think about the immune system as a really elaborate image classifier because it also implies that it could get something akin to "catastrophic forgetting.https://t.co/TMuROu09gA
Measles does something like that."The discovery that measles depletes peopleās antibody repertoires, partially obliterating immune memory to most previously encountered pathogens, supports the immune amnesia hypothesis."https://t.co/KCgmTCtXf7
What else could change antibodies?"This study indicates that itās not simply the presence or absence of antibodies that matter; rather, the amount and type of antibodies that may play a defining role in the development of a protective immune response," https://t.co/rf9o5AypEw
Could your mom be giving you autoantibodies that make the your brain grow wrong?https://t.co/dCQn46a4pf
Could you be inheriting antibodies from your environment based on what you eat?https://t.co/5Bz0ksdVoK
Who knows!https://t.co/km83mWiWgJ
@Quancth @TheSpiffingBrit A study from last year, from University of Berm, suggests humans may have a similar process." indicating that the intestinal microbes direct the development of our antibodies before we get a serious infection and this process is certainly not random"https://t.co/Xs6EwKpZOg
Ants are kinda cool.https://t.co/JOG3MW2y5W
Got a bad case of 'member berries right now.https://t.co/eXgYdjS3W6
Did you know that antibiotics seem to make the covid vaccines not work as well? Seems to me it's rather important to have your gut be healthy if you wanna mount an immune defense.https://t.co/7NvBvuT1wM
Did you know that NOD2 is suspected of being one of the drivers of Crohn's disease?https://t.co/wUwwlGAVqF
Why I was struggling to get a vaccine response all these years -> persistent gut inflammation tied to TLR4 and NOD2"Modulation of immune responses to vaccination by the microbiota: implications and potential mechanism" [MAY 2021]https://t.co/9plFXmduwYhttps://t.co/P0rNJQ3fDZ https://t.co/Nz1cHMcJyS
I wasn't anti-vax. In fact I was trying to figure out why vaccines never seemed to work for me and my family.It was because of our autoimmune disease impacting B and T cell differentiation. My immune system wasn't learning to identify viruses.https://t.co/fbE1RIuasD
We neglect the guts roll in this:"We provide a comprehensive review of the relationship between SARS-CoV-2, NOD2 and ubiquitination. COVID-19 infection partly results from host inborn errors and genetic factors and can lead to autoinflammatory disease" https://t.co/06Yni1CexJ
What if you modulate ubiquination via gut bacteria by aiding in lipid health?https://t.co/zF0QHffSmC
@QunolOfficial I think they are helping to bind/cleave it ala "Coenzyme Q10 in the serum is largely found bound to the lipoprotein transport of low-density lipoprotein (LDL) cholesterol and does not circulate in any appreciable concentration as an unbound form." https://t.co/ddGO1Jejic
Might be useful to figure out."The study of ubiquitination has become essential to learning about hostāpathogen interactions, and a better understanding [...] will contribute to vaccine development and effective treatment of diseases." https://t.co/oqCbKJR7Zi
Anyone want that delicious disease X? If we get measles, yellow fever, and malaria all spreading at the same time we'll be absolutely fucked. https://t.co/RZ6Nol98Ylhttps://t.co/KdVTvOUaOq
"Growing evidence shows that the composition of the intestinal microbiota, which is known to play an important role in the development and regulation of immune responses, influences responses to vaccination"https://t.co/QmK354m2E8https://t.co/GseTOa7Z96
@Maxiimiliano_L @DavidRCrowe Do we have a answer for what causes SIDS yet?"We propose a new hypothesis that the infant gut microbiome plays an important role in SIDS during the period critical to both gut flora aturation/development and vulnerability to SIDS" https://t.co/s2VoWeteyJ
Did you know that if your gut is messed up you don't get a healthy response to vaccines, and might succumb to disorders with B and T cell differentiation problems?Oh look, a study from NASA on why even with quarantine people still seem to get space flu.https://t.co/OZoC5V5Cw1
Who could have guessed? https://t.co/UH7rfoCl7y
I wasn't anti-vax. In fact I was trying to figure out why vaccines never seemed to work for me and my family.It was because of our autoimmune disease impacting B and T cell differentiation. My immune system wasn't learning to identify viruses.https://t.co/fbE1RIuasD
Man, if someone figured this out, maybe they could reverse engineer a gut bacteria cure for type II diabetes *cough*https://t.co/5qC5JHq8Aq
what could be going on here?"Accumulating evidence suggests that B and T cell alterations precede the loss of insulin sensitivity in adipose tissue and contribute to the general pro-inflammatory drift observed in T2D" [2019]https://t.co/0v0zjslb3O https://t.co/MCevrQVMwP
Fix your mucus layer so you can support healthy microbiome. Fix your microbiome so you can support a healthy mucus layer. Get your body to produce a gradient of H2O2 to destroy viruses on contact.https://t.co/w5ZHAkuSN5
Gotta get to space!https://t.co/WjtntcM5q8
Fix the Gut-Lung axis. š«š¦ > "This review provides current insights into the interplay between the intestinal microbiota and the immune system, focusing particularly on its intermediary function in vaccine efficacy." [AUG 2024]https://t.co/iFwH1i8PdShttps://t.co/oPCdCyhYjB https://t.co/zsKtdcnPKj
"The aim of this narrative review is to explore the intricate interactions between the microbiota and the immune system in response to vaccines, highlighting the state of the art in gut microbiota modulation as a novel therapeutic approach" [OCT 2023] https://t.co/pFpyC38CgL
Found some corroborating articles from 2005 on the same(?) study. > "If we really want to make a difference and control influenza, we simply have to change the policy. We have to vaccinate large numbers of children" https://t.co/lgKEABSPydhttps://t.co/UCTrkGU4KN
"But in older adults, this response is weakened by age-related damage to a molecule, TRAF3, that signals immune cells to make interferon. Without that signal, and another involving antiviral genes, resistance to flu falls short" https://t.co/nSBp9Ntnqehttps://t.co/lfQKRGHTZC
> "These findings suggest a paradigm shift: The microbiome may be essential for vaccine success. And microbiota-targeted interventions could one day be standard alongside early-life immunizationsāespecially for antibiotic-exposed newborns." https://t.co/J9jIkWGUyN
(direct link: https://t.co/pSRTKIigWy )