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A weird thing popped up while looking up the paper on how 'Klebsiella pneumoniae' can produce alcoholhttps://t.co/7ugbnbSY26 https://t.co/TKlJGtsuUC
A different bacteria can enhance impact?"identified a cell-destroying toxin called cytolysin produced by select strains of [Enterococcus faecalis] as the likely reason that some patients with alcoholic liver disease had severe symptoms."https://t.co/ARqYxY4D8p
I am not certain if that chemical is same as "Vibrio Cholerae Cytolysin" one, but that has some weird aspects to it too."An additional domain in the VCC toxin is related to plant lectins, conferring additional target cell specificity to the toxin." https://t.co/TAjdq5JZgt
This suggests to me that gut bacteria may be producing something similar to what Covid already may be doing.That lectin thing shows up in other Covid related research. It is cited as possibly one of factors for how gut bacteria may be impacting outcomes https://t.co/oybvQtFkOx
That paper is a bit hard to read due to some language barriers, but this is the thing they cite. On how lectins may be enhancing SARS-CoV-2: https://t.co/L5xyGgXjNQ
I had previously fingered Alcohol Use Disorders as being tied to poor bile function, and suspected that may be the cause for problems there. But bacterial production of cytotoxin might be the real thing driving this? https://t.co/VF6M0efNTF
That E. Faecalis cytolysin isn't that novel. There's a paper on it from 2003."of interest because its activities enhance enterococcal virulence in infection models and, in epidemiological studies, it has been associated with patient mortality." https://t.co/TQriqQY6Br
That opportunistic aspect seems to be something going on with Covid as well.With Enterococcal species causing infections in the blood stream. https://t.co/PSNJLBEmtW
And we also have a case report of someone having a secondary bacterial infection of Enterococcus Faecalis.https://t.co/ahKAXGePKm
I'd be curious if there is something about what Covid is doing to the body that impacts Cholesterol-dependent cytolysins in particular, or if is a more generic issue of cell destruction.https://t.co/ietqoSwD3k
Lipid dysfunction in general seems to be a commonality across risk factors.There are some alarming shifts in cholesterol that I saw that alarmed me due to my own focus on cholesterol's role in myelin formation.https://t.co/slrezzXvVv
"With recovery [...] the serum lipid levels return towards levels present prior to infection. In patients that failed to survive, [lipids] were lower at admission to the hospital and continued to decline during the hospitalization." https://t.co/A14T2knUyK
I like when someone else sees the same pattern as me.https://t.co/ZDriHEusua