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With a community of multiple sclerosis and relapsing MS stories available to her, Lydia stays on top of her disease. Click to learn about a once-daily pill for MS. https://t.co/7R9929RKx3 https://t.co/KNCXGvv0jA
@wegohealth ZEPOSIA® (ozanimod) " It acts as a sphingosine-1-phosphate (S1P) receptor agonist, sequestering lymphocytes to peripheral lymphoid organs and away from their sites of chronic inflammation." https://t.co/37Ok0LIsNE
@wegohealth "The new owner of the product, Bristol Myers Squibb, received FDA approval [...] March 26, 2020, [...] relapsing forms of multiple sclerosis, including relapsing-remitting multiple sclerosis, active secondary progressive multiple sclerosis, and clinically isolated syndrome."
@wegohealth "Health Union, the leader in building online health solutions for people living with chronic conditions, [...] has acquired WEGO Health, the world's largest network of patient leaders - advocates, community leaders, creators and influencers." https://t.co/nRGkxMQ5EE
@wegohealth That drug is interesting. It seems it is also being targeted as a therapy for crohn's disease. https://t.co/JrQO6witPl
@wegohealth I will be spending the next few hours exploring SIP pathways to see if there are dietary or microbiota that can impact this without needing to pay $18,000 a year.I'd also like to learn how it impacts the brain during pregnancy.https://t.co/0nx4uc7y5R
@wegohealth There is a suspicion that S1P is a cannabinoid receptor. It's why I believe cannabis has been able to alleviate some of my crohn's and M.S. symptoms.https://t.co/VI4YbzNgMH
@wegohealth Yes. This drug is probably acting on the same space."provides evidence that the SK1/S1P regulatory-axis is necessary for the rapid hypotension induced by anandamide. Generation of S1P in response to anandamide likely activates S1P1" https://t.co/ZXxtFRQX4C
@wegohealth Anandamide is an 'endocannabinoid', meaning it is a chemical produced by our bodies that hits the cannabinoid receptors.What are the chances! It also impairs lymphocyte migration like S1P.https://t.co/r3BCuCsEgL
@wegohealth So can I get the same impact of that drug by improving my bile function and absorption of precursors for the natural production of endocannabinoids, and in turn hit S1P via diet?Probably.https://t.co/sUUtPvaj9U
@wegohealth Sure hope you guys tested that against gestational defects. Lots of women get M.S."We have demonstrated that an increased level of SphK2/S1P is involved in the spatial learning and memory impairments of autism" https://t.co/UBQFacHIA1
@wegohealth Gosh, Progressive Multifocal Leukoencephalopathy sounds awful. Sure would hate to take a drug that lowers the immune system in the brain, then having that cause a virus to get in and infect all my myelin. I'm already worried about ties to Epstein-Barr there.
@wegohealth I'm not an expert on drugs by any means, do you know what "during organogenesis resulted in a marked increase in embryofetal mortality at the highest dose tested and increased fetal malformations" means? Kinda sounds bad.https://t.co/fNib7l8lXA
@wegohealth oh, it looks like you mention that in your long list of things that shouldn't be taken along with it.Its kinda spooky that I can just predict this stuff should exist after literally being obsessed with genetics for the past 30 years. https://t.co/pCEmalbtsr
