š§µ View Thread
š§µ Thread (62 tweets)
What's the deal with anti-psychotics also causing hallucinations? https://t.co/oWcTSJZFi4what does "anti-psychotic" mean?https://t.co/qutKwuRcCV
I can't make heads or tails of what they are supposed to do.https://t.co/9pofgJxmcb
It seems they suppress the immune system and make people not have as much energy (H2S = impact mitochondrial function). It would explain why they impact sperm too?https://t.co/3mmuJO8fvP
Are antipsychotics a form of forced sterilization?"Sperm concentration and progressive motility were significantly reduced in subjects treated with antipsychotics compared to the untreated controls and to the other classes of psychotropics (p < 0.05)."https://t.co/PVwiIsljZV
It's amazing how many drugs hit GABA-A, act as sedatives, make you sleepy, are "antipsychotic" and then some how make have hallucinations.How many schizophrenic hallucinations are just from the meds people are given?https://t.co/L3iVQN9omN
Whoops, all assumptions."first generation antipsychotics did not appear until the 1950s, an important consideration given that antipsychotics are often cited as the culprit behind GI pathologies in schizophrenia, as described in a later section."https://t.co/kwHTyUKqWG https://t.co/uPC2h14xOy
What happens if a schizophrenic person has a state of mania and then their dose of antipsychotics is increased? I bet that fucks people up just like over-doing Ambien.https://t.co/XQBvJrhN8y
"Dose-dependent effects of antipsychotics on efficacy and adverse effects in schizophrenia[...] further investigations with larger sample sizes and more robust study designs that focus on each antipsychotic agent are needed." [March 26 2021]https://t.co/E8xp447503
Gosh, repetitive behaviors sure are annoying. Lets medicate this poor bastard.Whoops, turns out Aripiprazole is dose dependent.https://t.co/XoxQcb7L1D
How many people are given antipsychotics and then get absolutely fucked up because no one bothered to check genetic risk factors for poor metabolism?https://t.co/ny1rS8FjKR
Sure wish there was some explanation for why schizophrenia is a risk factor for diabetes.https://t.co/y5TlD7j7zs https://t.co/AugF5tSmkY
That's cool tho. Give people some funny antipsychotics! But we can't get tests on butyrate cuz it smells too much like butter.https://t.co/QjcJb4FISH
Oh boy. I already been down this path before huh.https://t.co/8W1SGR55lg
risperidone literally increases the levels of butyrate..."Increased serum levels of butyric acid might be associated with a favorable treatment response in drug-naĆÆve, first episode schizophrenia. The clinical implications of our findings were discussed"https://t.co/6cxpdm6FcH
Gonna be funny if you can treat schizophrenia with Taurine and Butyrate.https://t.co/4mowoCts7R
The three main conditions I focus on: Autism, Alzheimer's, and Schizophrenia are all mediated by taurine. They are also all conditions that have massive oxidative stress.So if Taurine helps here... is that one of the mechanisms of action?https://t.co/G1N2hQDZKT
Oh yeah, did you know that butyrate promotes mucus production that Akkermansia muciniphila likes to live in.Cannabis is a common self-medication for schizophrenia. Increases that one too!https://t.co/LuD6ZbIgXz
"The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option" [2017]citation 5 is on Akkermansia Muciniphilait also mentions other fun neurological disorder.https://t.co/5LjFAAL4ND https://t.co/rpo7a8zb4Z
Can we, uh, get people's guts tested and try to treat with diet before we just dump a bunch of pharmaceutical drugs in while praying the person doesn't get Tardive dyskinesia?https://t.co/i74pmNGC21
Do you ever wonder if treatment resistant schizophrenia is actually autism?Or what if the reason why the meds weren't working was because this is all mediated thru gut microbiota metabolism factors and this assumption is wrong? https://t.co/6fOkkY1Pij https://t.co/pBHVGpPhSY
Sure is weird how often drugs that act like other drugs with dimentia risk factors are given to people with schizophrenia.Did you know diabetes type II is a risk factor for Alzheimer's.Sure wish there was some way to predict this somehow.https://t.co/1QmZYFy2ao
These are just sub items under that schizo list right now."quantitative meta-analysis suggested that subjects with schizophrenia were associated with a significantly greater risk of dementia incidence (RR 2.29; 95% CI 1.35ā3.88) than those without." https://t.co/xzBYWbJ1aA
Wish there was some way of working on this space without spending tons and tons of money on pharmaceuticals that drive perverse outcomes.https://t.co/sngivMUskC
"transplanting a totally new human gut microbiota in one shot, which is referred to as FMT, is likely to strongly improve the efficacy of microbiota-orientated treatments in MD and schizophrenia and maintain the effect over time." ĀÆ\_(ć)_/ĀÆ https://t.co/Ged7u2Twxj
Remember, schizophrenia isn't real.https://t.co/DOtfut7vG7 https://t.co/7s9y51SoDJ
Ah yes, the identity mental illness growth industry. Invest in medical labels today!" When āautistics,ā āhoarders,ā āthe obese,ā or āparanoid schizophrenicsā emerge as new subjects, so do new types of experts identifying, assessing, and treating them." https://t.co/D41PX5Hp5b
My hallucinations are telling me it's all in my head.https://t.co/eQMyorTEck
"Amber began mocking and tormenting him. She also reminded House that every option would be terrible for him: Schizophrenia meant that he could never work again as a physician, while Multiple Sclerosis or stopping Vicodin would cause him severe pain."https://t.co/zKWh1Cz5rn
Or maybe in my butt. I hear there are a lot of brain cells in my butt.https://t.co/kxzxfCMrNC
@Mangan150 I also managed to predict that a medication that impacts TH17 levels in multiple sclerosis is also being shown to reverse schizophrenia in mouse models. It'd be neat to figure out what gut bacteria are needed to do the same thing. https://t.co/6DszkwB9ToSo there's that.
Its all made up, and the points don't matter. You'll believe what you want to believe and decry me as a demon for being against medication.https://t.co/HDJ1fIm0mu
I regret to inform Asperger's isn't real. You actually mean to say Asperger's monster. Or rather Eugen Bleuler's "childhood schizophrenia", or Leo Kanner's "Autistic disturbances of affective contact" but viewed thru lens of medical billing and eugenics https://t.co/nZwyLsIA4w
I don't know about you, but apophenia is something I try to avoid. Seeing things that don't exist is generally considered a bad thing. Maybe the medical field needs some antipsychotics of their own.https://t.co/og1nbJx038
I have no idea what that means, but I can make up associations between similar phenomena to link ideas together. That's what we do w/ diagnostic labels all the time -> draw sand lines to divi people up into buckets so we can treat them.Apophenia is great. *mic drop*
I look at all of this and hallucinate "mammalian incomplete hibernation syndrome" and suddenly an entire mTOR pops out the other side.https://t.co/LRpgp4wNC6
Oh look, an entire medical hypothesis about schizophrenia being driven by dysfunctional mTOR.https://t.co/HnyVpsvlhG
"a variety of neuropsychiatric alterations encompassing neurodegeneration, brain tumors, brain ischemia, epilepsy, autism, mood disorders, drugs of abuse, and schizophrenia. mTOR has been widely implicated in synaptic plasticity and autophagy activation." https://t.co/G3YlIRwDdm https://t.co/yHvCdPbpnr
"antipsychotic drugs are antagonists of the D2 dopamine receptor (D2R), including the typical antipsychotic haloperidol. Haloperidol stimulates the kinase Akt, which can activate the translation-stimulating pathway mediated by the kinase complex mTORC1" https://t.co/R4IHxUJwiz https://t.co/GV7MoTDyTO
"The involvement of mTORC1 signaling in schizophrenia has been suggested by genetic and biochemical studies conducted in schizophrenic patients. Indeed, mutations of the Akt1 gene on chromosome 14q22ā32 are associated with genetic form" https://t.co/tacJuaaKdr https://t.co/wVIrknYifj
Therapist: Apophenia isnt real, and can't hurt you.The Apophenia: https://t.co/UzkHHpKYNa
"Even if dopamine hyperactivity is the primary cause, certain types of schizophrenia might be characterized by increased activity in certain brain areas while others are characterized by reduced activity in certain brain areas." https://t.co/qIRsTrBMNX
Dopamine, controlled via mTORC1/mTORC2 in my brain?It's more likely than you'd think.https://t.co/nGlwfUgSUj
Oh hey, that was published 8 days ago. Neat.Here's me thinking about this last year https://t.co/fJx6uaEBsc
Yes. I believe that I am taking into account the dopamine hypothesis while modeling this space under the lens of mTOR and gut bacteria.https://t.co/SApRhff7kZ
In fact, I think we need to take a closer look at the dopamine hypothesis in a number of different disorders thru that lens.https://t.co/cTVlry3Boi
I see things differently.https://t.co/DsvQsYCBN7
In fact I used to see things all the time.They stopped after fixing my gut.https://t.co/cLf0OaxYop
Do you ever reverse engineer seeing angles/demons/ghosts/aliens and find out that the reason you feel sane is because this stuff is so normal you don't freak out when you see hallucinations?Meditate in a dark area with low food for a few days and bam:https://t.co/FvLYl0Xo0r
Try taurine for the anxiety, instead of alcohol.https://t.co/WkvvoDLk02
@adam__jun The desire to lie as a symptom of avoidance & anxiety around social shame driven by malfunctioning GABA https://t.co/GH3GOXTSbtThat is self-medicated with alcohol, but burns out the receptors https://t.co/GJmJ4YaEG9due to excess glutamate signaling https://t.co/RIgGWC2Mwpš
There aren't many good solutions for the negative symptoms of schizophrenia.https://t.co/c1oGR3Z6FA
I'm having success with a bunch of herbal stuff I found while exploring midwife history and traditional ways of dealing with irregular menstrual cycles. This matches up with weird findings about how Gensing & Black Cohosh also seem to reduce negative symptoms of schizophrenia.
"From fish oil to keto, here are nine research-backed natural remedies for schizophrenia that you can discuss with your treatment team."https://t.co/jw84rBxqh9
Herbal stuff can work on the gut. It helped me.https://t.co/R6z8OUhF2z
Tell me please, what happens if you fix your gut so your body naturally regulates all the interesting chemicals like butyrate, various endocannabinoids, gaba, glutamate and other things essential for bile function / nutrient absorption? https://t.co/GNG4A9pPwb
Had to figure this out myself.https://t.co/MlnstatuLZ
Did you know that Taurine can help with hepatic injury from Acetaminophen. https://t.co/AwQg8tuU1yhttps://t.co/QgELBRkooe
At least in rats."Results suggest that taurine might be a potential therapeutic candidate against APAP-induced acute nephrotoxicity."https://t.co/mvatgGR0GG
Milk Thistle is neat here.https://t.co/NFTVGBfNy3
"Silymarin, a flavonoid complex extracted from the seeds of Silybum marianum (commonly known as āmilk thistleā; family - Asteraceae), is recognized as a hepato-protective agent of herbal origin in Europe, USA and other countries."https://t.co/m7Wozrjb6I
"Milk thistle enhanced nerve growth factor (NGF)-induced neurite outgrowth in PC-12 neural cells and prolonged their survival in culture. Milk thistle extract also protected cultured rat hippocampal neurons against oxidative stress-induced cell death." https://t.co/N6o73xfzqp
"Furthermore, silibinin treatment increased the levels of brain-derived neurotrophic factor (BDNF), serotonin (5-HT) and norepinephrine (NE) in the prefrontal cortex and hippocampus. Our study provides new insight into the protective effects of silibinin" https://t.co/VnPXJAdQvJ
BDNF shows up in Alzheimers, Autism, and Schizophrenia, as well as many forms of depression.You can trace the effects across papers and see that it's all the same constellation. Liver damage / Bile problems seems to be a proximate cause from my vantage.https://t.co/ZLvi6Apx24
I am whispered this in my dreams.https://t.co/J9R5kYRIRi
Sonic dwells within me and gives me blessings of insight."Our findings are the first to report a correlation between SHH, BDNF and OFR in autistic children, suggesting a pathological role of oxidative stress and SHH in autism spectrum disorders."https://t.co/a7WvZimxwM
I noticed that when I've found something interesting I sometimes snap my fingers without thinking. My brain appears to be signaling "pay attention to this" and it is being expressed thru a body movement.So... "OH SNAP" encodes this in my twitter web.https://t.co/lzp0bUFvpA
"BDNF expression was found to be reduced in the hippocampus and cortex of germ-free āgnotobioticā mice, and the reduction in the expression of BDNF was found to specifically associate with increased anxiety and progressive cognitive dysfunction"https://t.co/eztAbDnjZdOH SNAP
Automatic behaviors are really wild when you realize they're basically a physical manifestation of synesthesia acting thru a different sensory modality.https://t.co/JauAu1mwnE
I can think better if I pace and let my body just move. I realized that many of the odd ticks that happen when i'm stressed are actually reflections of underlying motor-language connections. Its like my body has it's own proxy language.https://t.co/jFvDifpbM6
It's like entire synesthetic webs of connections light up.If you saw me in real life during it, you'd see what amounts to a schizophrenic person pacing around muttering to himself + acting out physical manifestations of language.I have to write to get them out of my head.
Are they Tourrettes? Schizophrenia?https://t.co/sDvle5OogtADHD? https://t.co/Pr5wIatPojAn M.S. related complication? ( I was getting "writer's cramp") https://t.co/EQ33P9l599Or just really aggressive pantomiming?
Interestingly, like the clanging behavior I was having before. I can turn it off and on now at will. Its not something that happens involuntarily any more.It feels like I've learned to control a superpower https://t.co/hJjrgI8DgN
@WilliamAEden @visakanv @chriswaterguy if you encode keywords into your tweets, you can use your mind's associative indexing and rhyming ability to quickly narrow down a space.Its basically "prolly trees" https://t.co/2Qzk9caaQw method applied to mesh topologies.https://t.co/dRWofzxyNw
"Comparing 26 people with schizophrenia to 22 people without this condition, the researchers of the above study were correctly able to diagnose 89% of participants with schizophrenia by monitoring for language changes." https://t.co/c3Dt0gosMihttps://t.co/5AK5ZIVSn8
I likely stopped some kind of brain inflammation.https://t.co/7e2nhdiaFU
"At least 69% of individuals with a diagnosis of ASD have been known to have neuroinflammation or encephalitis [...] may damage fetal or childrenās brain cells, eventually leading to children falling into an autistic or regressive state." https://t.co/sNFedrJ6Fonice.
Specifically that driven by Crohn's Disease.https://t.co/kxzxfCMrNC
@Mangan150 I also managed to predict that a medication that impacts TH17 levels in multiple sclerosis is also being shown to reverse schizophrenia in mouse models. It'd be neat to figure out what gut bacteria are needed to do the same thing. https://t.co/6DszkwB9ToSo there's that.
I don't bother looking at schizophrenia stuff anymore because it is absolutely trivial to extrapolate any findings I get in the overlap of M.S. and Autism and translate them directly into Schiz.https://t.co/zVbVnHHiyt https://t.co/ibv4njxAiy
@PaulWhiteleyPhD You wouldn't believe number of notes I have on mTOR signaling problems in this space related to autism and multiple sclerosis / neurodegenerative disorders.I literally did not even bother looking at schizophrenia. I just assumed connection would exist.https://t.co/HnyVpsvlhG
I still can't get over the fact that you gotta spend 1.78 million dollars to test if a specific formula of prebiotics impacts schizophrenia. https://t.co/J3nJGKxJFQ
> "Milk Thistle : Silybum marianum. Also known as "sow-thistle," this herb was likely one of the original bitter herbs." https://t.co/wSk8JF7ZQC
> "Further, milk thistle is said to be one of the most effective herbs at stimulating the production and flow of bile" https://t.co/2RFeYIJ4Dw
Thank you @DollyZoom66 for you continued wisdom.The more I learn about how plants work, the faster I get at spotting other mechanisms of action.https://t.co/FPP1cg9M5i
I know this pathway already, but hadn't confirmed up until now that the Phenolic Compounds in bitter plants improve bile function!Apigenin etc. potentially explains why authentic olive oil is what to seek out for helping w/ schiz + cholesterol function. https://t.co/wKbciAs5O1
@DollyZoom66 Gonna go dig up some bitters.https://t.co/f9GCH3j8XD
@NgoloTesla @nutrition_facts I figured out that I could fix my cholesterol function by eating bitter plants that hit TRPA1, and it's something that you'll only learn if you follow vegan foragers who need to do that to remove plant toxins without destroying liver/kidney.
@DollyZoom66 Its amazing how much bile health and alcoholism are tied to weird aging factors."Our findings indicate that alcohol consumption may shorten telomere length. There are implications for age-related diseases." https://t.co/DzpVp5RuPvhttps://t.co/PMAJVBQll6
"results support previous findings of telomere shortening with chronic alcohol exposures and show both an effect of [Alcohol Use Disorder] on [Telomere Length] that is independent of age"https://t.co/Gm8WhjmpqMMcAffee was very knowlegeable on plants.https://t.co/Xfpxwn3BCh
Loss of bile production is one of the longer term side effects of drinking lots of alcohol. I wonder if that would work.Looks like he also avoided processed meats and had a low fat selection diet. That would avoid issues from poor bile function. https://t.co/ZJ6XYoU2WP
Butyrate helps improve telomere length.https://t.co/7NqXz2KBr5No one talks about this.https://t.co/DDFEtFZ3e4 https://t.co/U8Ebee2SYG
I've been experimenting lately to see if I can harbor acetate making microbes in my gut. Neutralizing small amounts of alcohol & turning it into acetate & eventually butryate should super-power my gut health. Butryate producers need lactate as well. https://t.co/cNUkQscgWg