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Everything in grims thread is true.Can we go deeper?"Altogether, these data demonstrate a circadian clock in a non-cyanobacterial prokaryote and suggest the human circadian system may regulate its microbiome through the entrainment of bacterial clocks"https://t.co/ZRsfjfF94l https://t.co/jrL6a3ji4I
What if we're missing something. A feedback loop?https://t.co/1M0UnOtObd
Just ordered a light therapy lamp:https://t.co/8ZzOXemQhIand blue light blocking glasses:https://t.co/OShd1vAhupNot much evidence it helps with S.A.D. but seem it might help with general depression, and could help me with Hypernychthemeria.Been saving up for a few months.
"Altogether, these findings demonstrate that [spore-forming bacteria] are important modulators of host 5-HT, and further highlight a key role for host-microbiota interactions in regulating fundamental 5-HT-related biological processes."https://t.co/loKa9Od7yI
Where does the serotonin the gut bacteria produce in the morning come from?We always draw this as a straight line.https://t.co/6ZfjJ6xIDY https://t.co/9mvNivZzaG
It's cortisol. Cortisol is a signaling hormone that gut bacteria use to regulate this space.https://t.co/hxr4acaiWh
Stress keeps me up. Sleep deprivation makes me have funny ideas.I wondered if I could play with it to boost creativity.It worked.https://t.co/SfkROwc0xT
I went for years living in the woods, running around barefoot ('grounding'). Not watching tv, going outside when the sun arose and trying to sleep at night.It didn't help me or my mom.https://t.co/AyJq1Fggm9
@CaloriesProper I lived in a campground without electricity for months on end, (and my mom has this too), so I don't think its a blue light issue for me.Fasting does seem to help with jet-lag when I try to break out of the non-24, but I doesn't seem to actually entrain me to 24 hour day.
I lived on a farm in the backwoods of Vermont (South Rygate area) for at least a year, as well as that campground. We grew vegetables and ate pretty well for a while (step-dad hunted). https://t.co/WbhsaaZD20
@timspector @sleepdiplomat I experimented with this for a month without any result. Traced it to some weird blue-light mutations in my eyes and I suspect causes a lower response in my internal circadian rhythm. Been having lots of luck tweaking microbiome instead. Finally cracking lifelong non-24 disorder.
What was missing?Do you need both healthy gut bacteria function & sunlight rhythms to entrain the gut to the daily cycle?https://t.co/EG1VCcwHhq
@theolearns @DrJackKruse I think mitochondria stuff is involved with my low muscle mass - like my body was constantly destroying and never able to get into muscle repair mode. Since fixing that, I've been gaining muscle and burning fat just sitting on my ass. Related: Low grip strength common in autism.
If we can mess with plants by artificially changing sunlight cycles and have them 'wake up' and get 'jet lag' as they attempt to synchronize with varying light levels thru the day... What happens to their soil microbiota?https://t.co/edOKtfkSIr
Gut bacteria is a missing piece of this puzzle.https://t.co/LVTsZUKubU
"[...] suggesting that sleep disturbances can be mediated, at least in part, by [intermittent hypoxia]-induced alterations in [gut microbiome]." [2020] https://t.co/CiGnEACYNa🙄
Melatonin (and sleep's) impact on glucose control needs to be considered with respect to cortisol's role in blood sugar regulation.https://t.co/9BIwvyFvMi
I've only spent the last ~8 years of my life trying to fix my own autism. What do I know?https://t.co/qeC4zpCuw3
"suggest a pathway of communication between certain gut bacteria and brain metabolites, by way of a compound in the blood known as cortisol. And unexpectedly, the finding provides a potential mechanism to explain the characteristics of autism."https://t.co/kkgs12NwRN
My sleep has been weird lately. I'm not surprised, but it is strange.https://t.co/cmEch0V4AE
Sometime toward the end (and one of the reasons why we moved from the farm), my mom was having strange health issues. I was too.https://t.co/aMU9ItCZ9M
That was the first year my mom was in a wheelchair. Apparently she had tried to kill her self shortly before and was in a mental institution for a month or two. She probably had M.S. symptoms but didn't realize it.I learned later that school had lead in the water supply.
But I'd been having sleep issues since before I can remember. So has my mom, so it isn't like these things correlate.If anything it suggest that gut bacteria problems perhaps predispose people toward having health events. I can't be sure.
I can't be certain what caused health issues, but it certainly wasn't due to blue light or lack of grounding. The house had very little electricity. We literally had oil lamps and a fireplace. It was so dark on that mountain at night I could see the stars.No mold either IIRC.
Fresh healthy food, fresh air, sunlight, and all the outdoors I could handle for more than long enough to see a shift in epigenetic expression. Didn't change anything with regard to circadian rhythm. Still had a wonky sleep schedule.
40 acers of property and 2 acres of fresh unpolluted field. Huge garden. We even had room for turkeys! I'd walk thru the woods and explore for hours during the summer. Fed deer by hand.But if the moon was out, I was awake. There's more going on here.
Nobody here but us chickens."Butyrate may act as one of the signals to mediate blue-light-induced small intestinal development and mucosal barrier integrity enhancement and promote cell proliferation via the GPR43/Gi/PI3K/AKT/p-GSK-3β/β-catenin pathway."https://t.co/gWctmL6mxd
That study published Jan 29 2022 sure looks like something I'd have predicted.https://t.co/ZdsPCwUmpo
"This review focuses on the potential effects of lithium, as a potential therapeutic strategy, on [Parkinson's Disease] [...] Lithium medication downregulates GSK-3beta, the main inhibitor of the WNT/β-catenin pathway. " [2021] https://t.co/IMW1rM2jfy https://t.co/4zi3el4yvk
Just trying to fix the epigenetic signaling pathways related to brain development that show up as modulating gut development in chickens.https://t.co/MwT8nALwWh
the brain in your butt. The ENS.https://t.co/2DWWRMQV1j
The microbiota are analsurgeons. It's like neurosurgery, but thru the application of growth factors and epigenetic remodeling.https://t.co/OzjpW20e0v
Bobtail squid?https://t.co/UdslB31G0X
The bobtail squid's light organ doens't develop if the bacteria is not present. I think this is partly why stuff like allergic reactions and autism seem to be associated with soil bacteria and interactions with farm animals in childhood. Also why Type 1 is linked with C-sections.
We don't look for these interactions in the chicken because we are focused on the host and not the holobiont.Amazing how many of these lines of research are being rethought.https://t.co/ARtjVLWb2Y https://t.co/QiHKOxkb0E
"Metabolomic analysis revealed that blue light heightened cysteine and methionine metabolism, and increased serum taurine and primary bile acid levels, as well as up-regulating the metabolites L-carnitine and glutamine." [in ducks] https://t.co/ld1tUiK2bKhttps://t.co/VV03YBRt5y
@Apex_Evolution "probiotics increased the prevalence of bifidobacteria in the gut microbiota, as well as folate, and B12 levels, and decreased plasma homocysteine [suggests] a close relationship between gut microbiome composition and the methionine-homocysteine cycle." https://t.co/PFK5UmbanW
*ultimape plays microbial detoxification card, it's super effective*https://t.co/yPv78DBUPr
"However, it is not clear how the host's clock regulates the microbiome. Here, we demonstrate at least one species of commensal bacterium from the human gastrointestinal system, Enterobacter aerogenes, is sensitive to the neurohormone melatonin" https://t.co/ZRsfjfWJVT
"Taken together, our results suggest that melatonin may be used as a probiotic agent to reverse HFD-induced gut microbiota dysbiosis and help us to gain a better understanding of the mechanisms governing the various melatonin beneficial effects."https://t.co/eJAtFw1tmW
"showed that stress and [sleep deprivation] could affect intestinal dysbiosis and increase colitogenic microbiota [...] Melatonin treatment brought recovery of melatonin concentration in colon tissue and modulating dysbiosis of intestinal microbiota." https://t.co/GrbojkrmUQ
"The results of the neurotransmitter and short-chain fatty acid determination revealed that the effect on the zebrafish in the [germ free] group could not achieve that on the zebrafish in the melatonin group after adding the same dose of melatonin." https://t.co/jMEFRq73sV
I am now learning about Kynurenine. I wanna know why B6 makes me get diarrhea and not NAD+.https://t.co/TM6lyahubWhttps://t.co/IPTRwHc0C7 https://t.co/yVc1byj6Oe
Looks like some of the NAD+ papers have been flagged for cloned images and other fraud adjacent science fuckery.Maybe I shouldn't care so much about NAD and focus on Sirtins like I've been doing.https://t.co/NAR7QsjiXb https://t.co/eLnfd5jXnp
Lots of bullshit in the antiaging space."While a particular metabolic pathway shows potential to slow down the aging process, new research indicates a downside: That same pathway may drive brain cancer."https://t.co/QlyNZXSqiD
@strixalucos huh"We didn't directly demonstrate that taking NAD+ precursors makes tumors grow faster, but one implication of our work is that if you want to take anti-aging NAD+ precursors, you might want to keep in mind that we don't yet understand all the risks."https://t.co/1a6DwRDwOA
Miracle Milk.https://t.co/LlE8NajVpS
Did you know breast milk contains butyrate and melatonin on top of the prebiotic colostrum? It varies thru the day too.Works well to feed bacteria & calm the child's immune system during the first few months of their life when their natural antibody system hasn't bootstrapped.
"The participants living with HIV essentially experience the one-hour disruption associated with switching to daylight savings time, but every single morning"https://t.co/biUaTlIXCM (h/t @cole_tucker)https://t.co/W9OicrAjCj